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• 2021

  Antibacterial effect of amino acid–silver complex loaded montmorillonite incorporated in dental acrylic resin

  Yoshihara, K., Nagaoka, N., Umeno, A., Sonoda, A., Obika, H., Yoshida, Y., Meerbeek, B. V. & Makita, Y., Mar 2 2021, In: Materials. 14, 6, 1442.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• Antibacterial effects of disulfiram in helicobacter pylori

  Kobatake, T., Ogino, K., Sakae, H., Gotoh, K., Watanabe, A., Matsushita, O., Okada, H. & Yokota, K., 2021, In: Infection and Drug Resistance. 14, p. 1757-1764 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  8 Citations (Scopus)

• Antibodies Against the Clock Proteins Period and Cryptochrome Reveal the Neuronal Organization of the Circadian Clock in the Pea Aphid

  Colizzi, F. S., Beer, K., Cuti, P., Deppisch, P., Martínez Torres, D., Yoshii, T. & Helfrich-Förster, C., Jul 2 2021, In: Frontiers in Physiology. 12, 705048.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  6 Citations (Scopus)

• Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance

  Yamazaki, C. M., Yamaguchi, A., Anami, Y., Xiong, W., Otani, Y., Lee, J., Ueno, N. T., Zhang, N., An, Z. & Tsuchikama, K., Dec 1 2021, In: Nature communications. 12, 1, 3528.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  29 Citations (Scopus)

• Anti-demineralization effects of dental adhesive-composites on enamel–root dentin junction

  Lai, Y. J., Takahashi, R., Lin, P. Y., Kuo, L., Zhou, Y., Matin, K., Chiang, Y. C., Shimada, Y. & Tagami, J., Oct 1 2021, In: Polymers. 13, 19, 3327.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  4 Citations (Scopus)

• Anti-disturbance control of a quadrotor manipulator with tiltable rotors based on integral sliding mode control

  Yi, S., Watanabe, K. & Nagai, I., Nov 2021, In: Artificial Life and Robotics. 26, 4, p. 513-522 10 p.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Antiferromagnetic spin fluctuations and superconductivity in NbRh2B2 and TaRh2B2 with a chiral crystal structure

  Matano, K., Ogura, R., Fountaine, M., Jeschke, H. O., Kawasaki, S. & Zheng, G. Q., Dec 1 2021, In: Physical Review B. 104, 22, 224508.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Anti-high mobility group box 1 monoclonal antibody suppressed hyper-permeability and cytokine production in human pulmonary endothelial cells infected with influenza A virus

  Namba, T., Tsuge, M., Yashiro, M., Saito, Y., Liu, K., Nishibori, M., Morishima, T. & Tsukahara, H., Dec 2021, In: Inflammation Research. 70, 10-12, p. 1101-1111 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  3 Citations (Scopus)

• Anti-IL17 antibody Secukinumab therapy is associated with ossification in giant cell tumor of bone: a case report of pathologic similarities and therapeutic potential similar to Denosumab

  Chandler, A., Bartelstein, M. K., Fujiwara, T., Antonescu, C. R., Healey, J. H. & Vaynrub, M., Dec 2021, In: BMC Musculoskeletal Disorders. 22, 1, 320.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• Anti-inflammatory effect on colitis and modulation of microbiota by fermented plant extract supplementation

  Sugimoto, M., Watanabe, T., Takaoka, M., Suzuki, K., Murakami, T., Murakami, N. & Sumikawa, S., Jun 2021, In: Fermentation. 7, 2, 55.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Citation (Scopus)

• Antimicrobial prescription practices for outpatients with acute respiratory tract infections: A retrospective, multicenter, medical record-based study

  Ishida, T., Hagiya, H., Honda, H., Nakano, Y., Ogawa, H., Obika, M., Ueda, K., Kataoka, H., Hanayama, Y. & Otsuka, F., Nov 2021, In: PloS one. 16, 11 November, e0259633.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Antimutagenic, anti-inflammatory, and antioxidative activities of the juice of Vitis ficifolia var. Ganebu, a woody vine in the grape family, known as Ryukyu-ganebu in Japan

  Arimoto-Kobayashi, S., Hida, R., Fujii, N. & Mochioka, R., Dec 2021, In: Genes and Environment. 43, 1, 50.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• ANTI-OPPRESSIVE GLOBAL CITIZENSHIP EDUCATION THEORY AND PRACTICE IN PRE-SERVICE TEACHER EDUCATION

  Carroll, S. M., Sep 1 2021, In: Policy and Practice. 2021, 33, p. 7-26 20 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Anti-oxidants in astrocytes as target of neuroprotection for parkinson’s disease

  Asanuma, M. & Miyazaki, I., 2021, In: Folia Pharmacologica Japonica. 156, 1, p. 14-20 7 p.

  Research output: Contribution to journal › Article › peer-review

• Anti-PD-1 antibody monotherapy versus anti-PD-1 plus anti-CTLA-4 combination therapy as first-line immunotherapy in unresectable or metastatic mucosal melanoma: a retrospective, multicenter study of 329 Japanese cases (JMAC study)

  Nakamura, Y., Namikawa, K., Yoshikawa, S., Kiniwa, Y., Maekawa, T., Yamasaki, O., Isei, T., Matsushita, S., Nomura, M., Nakai, Y., Fukushima, S., Saito, S., Takenouchi, T., Tanaka, R., Kato, H., Otsuka, A., Matsuya, T., Baba, N., Nagase, K., Inozume, T., & 11 othersFujimoto, N., Kuwatsuka, Y., Onishi, M., Kaneko, T., Onuma, T., Umeda, Y., Ogata, D., Takahashi, A., Otsuka, M., Teramoto, Y. & Yamazaki, N., Dec 2021, In: ESMO Open. 6, 6, 100325.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  10 Citations (Scopus)

• Anti-proteinase 3 antineutrophil cytoplasmic antibody reflects disease activity and predicts the response to steroid therapy in ulcerative colitis

  Aoyama, Y., Inaba, T., Takahashi, S., Yasuhara, H., Hiraoka, S., Morimoto, T., Colvin, H. S., Wato, M., Ando, M., Nakamura, S., Mizobuchi, K. & Okada, H., Dec 2021, In: BMC Gastroenterology. 21, 1, 325.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Citation (Scopus)

• Anti-TIGIT differentially affects sepsis survival in immunologically experienced versus previously naive hosts

  Sun, Y., Anyalebechi, J. C., Sun, H., Yumoto, T., Xue, M., Liu, D., Liang, Z., Coopersmith, C. M. & Ford, M. L., Mar 8 2021, In: JCI Insight. 6, 5, e141245.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  5 Citations (Scopus)

• Antiviral mechanism of preclinical antimalarial compounds possessing multiple antiviral activities

  Gu, W., Ueda, Y., Dansako, H., Satoh, S. & Kato, N., May 2021, In: FASEB BioAdvances. 3, 5, p. 356-373 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• A numerical study on the exact onset of flow instabilities in thermo-solutal Marangoni convection driven by opposing forces in a half-zone liquid bridge under zero gravity

  Laknath, R., Mendis, A., Sekimoto, A., Okano, Y., Minakuchi, H. & Dost, S., Aug 20 2021, In: JOURNAL OF CHEMICAL ENGINEERING OF JAPAN. 54, 8, p. 424-430 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Citation (Scopus)

• An Unusual Perpendicular Metallacycle Intermediate is the Origin of Branch Selectivity in the Rh(II)-Catalyzed C-H Alkylation of Aryl Sulfonamides with Vinylsilanes

  Yamazaki, K., Rej, S., Ano, Y. & Chatani, N., Dec 13 2021, In: Organometallics. 40, 23, p. 3935-3942 8 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Apalutamide-induced exanthematous drug eruption displaying spongiotic dermatitis successfully treated with dose reduction

  Kawakami, Y., Mitsui, M., Takamoto, H. & Yamamoto, Y., Aug 2021, In: International Journal of Dermatology. 60, 8, p. e315-e317

  Research output: Contribution to journal › Letter › peer-review
  6 Citations (Scopus)

• A Parameter Optimization Method for Fingerprint-Based Indoor Localization System Using IEEE 802.15.4 Devices

  Huo, Y., Puspitaningayu, P., Funabiki, N., Hamazaki, K., Kuribayashi, M. & Kojima, K., Jun 25 2021, 2021 3rd International Conference on Computer Communication and the Internet, ICCCI 2021. Institute of Electrical and Electronics Engineers Inc., p. 136-140 5 p. 9486801. (2021 3rd International Conference on Computer Communication and the Internet, ICCCI 2021).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
  5 Citations (Scopus)

• A patient with human coronavirus NL63 falsely diagnosed with COVID-19; Lesson learned for the importance of definitive diagnosis

  Otsuka, Y., Hagiya, H., Nakano, Y., Omura, D., Hasegawa, K., Yamada, H., Iio, K., Honda, T. & Otsuka, F., Jul 2021, In: Journal of Infection and Chemotherapy. 27, 7, p. 1126-1128 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  3 Citations (Scopus)

• A pet/ct volumetric parameter predicts prognosis of non-small cell lung cancer treated using preoperative chemoradiotherapy and surgery: A retrospective case series study

  Katsui, K., Ogata, T., Tada, A., Watanabe, K., Yoshio, K., Kuroda, M., Kiura, K., Hiraki, T., Toyooka, S. & Kanazawa, S., 2021, In: Molecular and Clinical Oncology. 14, 4, p. 1-8 8 p., 73.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• A phase I/II study of osimertinib in EGFR exon 20 insertion mutation-positive non-small cell lung cancer

  Yasuda, H., Ichihara, E., Sakakibara-Konishi, J., Zenke, Y., Takeuchi, S., Morise, M., Hotta, K., Sato, M., Matsumoto, S., Tanimoto, A., Matsuzawa, R., Kiura, K., Takashima, Y., Yano, S., Koyama, J., Fukushima, T., Hamamoto, J., Terai, H., Ikemura, S., Takemura, R., & 2 othersGoto, K. & Soejima, K., Dec 2021, In: Lung Cancer. 162, p. 140-146 7 p.

  Research output: Contribution to journal › Article › peer-review
  11 Citations (Scopus)

• A Phase II, Multicenter, Randomized, Placebo-Controlled Study of Benralizumab, a Humanized Anti-IL-5R Alpha Monoclonal Antibody, in Patients With Eosinophilic Chronic Rhinosinusitis

  Takabayashi, T., Asaka, D., Okamoto, Y., Himi, T., Haruna, S., Yoshida, N., Kondo, K., Yoshikawa, M., Sakuma, Y., Shibata, K., Suzuki, M., Kobayashi, M., Kawata, R., Tsuzuki, K., Okano, M., Higaki, T., Takeno, S., Kodama, S., Yonekura, S., Saito, H., & 3 othersNozaki, A., Otori, N. & Fujieda, S., Nov 2021, In: American Journal of Rhinology and Allergy. 35, 6, p. 861-870 10 p.

  Research output: Contribution to journal › Article › peer-review
  15 Citations (Scopus)

• A phase III, multicenter, single-arm study to assess the utility of indocyanine green fluorescent lymphography in the treatment of secondary lymphedema

  Akita, S., Unno, N., Maegawa, J., Kimata, Y., Ota, Y., Yabuki, Y., Shinaoka, A., Sano, M., Ohnishi, F., Sakuma, H., Nuri, T., Ozawa, Y., Shiko, Y., Kawasaki, Y., Hanawa, M., Fujii, Y., Imanishi, E., Fujiwara, T., Hanaoka, H. & Mitsukawa, N., 2021, (Accepted/In press) In: Journal of Vascular Surgery: Venous and Lymphatic Disorders.

  Research output: Contribution to journal › Article › peer-review
  2 Citations (Scopus)

• A phase II study of FOLFOXIRI plus bevacizumab as initial chemotherapy for patients with untreated metastatic colorectal cancer: TRICC1414 (BeTRI)

  Shinozaki, K., Yamada, T., Nasu, J., Matsumoto, T., Yuasa, Y., Shiraishi, T., Nagano, H., Moriyama, I., Fujiwara, T., Miguchi, M., Yoshida, R., Nozaka, K., Tanioka, H., Nagasaka, T., Kurisu, Y., Kobayashi, M., Tsuchihashi, K., Inukai, M., Kikuchi, T. & Nishina, T., Feb 2021, In: International Journal of Clinical Oncology. 26, 2, p. 399-408 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  3 Citations (Scopus)

• A Piloting Study of Measuring Effectiveness of Virtual Reality in Understanding a New Concept in Educational Support Systems

  Taniuchi, S., Kawahara, K. & Sasakura, M., Jul 2021, Information Visualisation: AI and Visual Analytics and Data Science, IV 2021. Banissi, E., Ursyn, A., McK. Bannatyne, M. W., Pires, J. M., Datia, N., Huang, M. L., Huang, W., Nguyen, Q. V., Nazemi, K., Kovalerchuk, B., Counsell, J., Agapiou, A., Khosrow-Shahi, F., Chau, H-W., Li, M., Laing, R., Bouali, F., Venturini, G., Temperini, M. & Sarfraz, M. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 176-180 5 p. (Proceedings of the International Conference on Information Visualisation; vol. 2021-July).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• A pilot study of seamless regeneration of bone and cartilage in knee joint regeneration using honeycomb tcp

  Takabatake, K., Tsujigiwa, H., Yoshida, A., Furumatsu, T., Kawai, H., Oo, M. W., Nakano, K. & Nagatsuka, H., Dec 1 2021, In: Materials. 14, 23, 7225.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Citation (Scopus)

• Apocrine Hidrocystoma of the External Auditory Canal in a Child

  Tachibana, T., Sasaki, T., Wani, Y., Naoi, Y., Kataoka, Y., Nishizaki, K. & Ando, M., Sep 1 2021, In: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 42, 8, p. e1181-e1183

  Research output: Contribution to journal › Article › peer-review
  2 Citations (Scopus)

• Apolipoprotein a2 isoforms: New insight into the risk of myocardial infarction

  Hisamatsu, T., 2021, In: Journal of atherosclerosis and thrombosis. 28, 5, p. 469-470 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Citation (Scopus)

• A posterior shiny-corner lesion of the tibia is observed in the early phase after medial meniscus posterior root tear

  Okazaki, Y., Furumatsu, T., Kajiki, Y., Hiranaka, T., Kintaka, K., Kodama, Y., Kamatsuki, Y. & Ozaki, T., 2021, (Accepted/In press) In: European Journal of Orthopaedic Surgery and Traumatology.

  Research output: Contribution to journal › Article › peer-review
  2 Citations (Scopus)

• Applicability Investigation of Transmission Power Optimization Method for Concurrently Communicating Access-Points Using Channel Bonding and Non-Bonding in WLAN

  Akhter, F., Funabiki, N., Briantoro, H., Ismael Munene, K., Rahman, M. & Kuribayashi, M., 2021, Proceedings - 4th International Conference on Vocational Education and Electrical Engineering: Strengthening Engagement with Communities through Artificial Intelligence Application in Education, Electrical Engineering and Information Technology, ICVEE 2021. Institute of Electrical and Electronics Engineers Inc., (Proceedings - 4th International Conference on Vocational Education and Electrical Engineering: Strengthening Engagement with Communities through Artificial Intelligence Application in Education, Electrical Engineering and Information Technology, ICVEE 2021).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Application of an Electrochemical Microflow Reactor for Cyanosilylation: Machine Learning-Assisted Exploration of Suitable Reaction Conditions for Semi-Large-Scale Synthesis

  Sato, E., Fujii, M., Tanaka, H., Mitsudo, K., Kondo, M., Takizawa, S., Sasai, H., Washio, T., Ishikawa, K. & Suga, S., Nov 19 2021, In: Journal of Organic Chemistry. 86, 22, p. 16035-16044 10 p.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Application of convolutional neural networks for evaluating the depth of invasion of early gastric cancer based on endoscopic images

  Hamada, K., Kawahara, Y., Tanimoto, T., Ohto, A., Toda, A., Aida, T., Yamasaki, Y., Gotoda, T., Ogawa, T., Abe, M., Okanoue, S., Takei, K., Kikuchi, S., Kuroda, S., Fujiwara, T. & Okada, H., 2021, (Accepted/In press) In: Journal of Gastroenterology and Hepatology (Australia).

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)

• Application of CRISPR/Cas9 to visualize defined genomic sequences in fixed chromosomes and nuclei

  Ishii, T., Nagaki, K. & Houben, A., Jan 1 2021, Cytogenomics. Elsevier, p. 147-153 7 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
  8 Citations (Scopus)

• Application of gasification technology to CO₂ reduction as a reliable technology

  Kawamoto, K., 2021, In: Proceedings of the Air and Waste Management Association's Annual Conference and Exhibition, AWMA. 2021-June

  Research output: Contribution to journal › Conference article › peer-review

• Application of multivariate morphometrics to delimit three Japanese species of Arisaema sect. Pistillata (Araceae)

  Matsumoto, T. K., Sep 2021, In: Nordic Journal of Botany. 39, 9, NJB12583.

  Research output: Contribution to journal › Article › peer-review

• Application of wood-utilized synthesized copper-based particle for the improvement of wear resistance of epoxy resin

  Matsumoto, N., Maeda, M., Nakatani, Y., Omiya, Y. & Kinoshita, H., 2021, In: Tribology Online. 15, 5, p. 388-395 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Applications of Grammar-Concept Understanding and Value Trace Problems to Novice Students for C Programming Learning

  Funabiki, N., Lu, X., Shwe, S. H. M., Htet, E. E., Kyaw, H. H. S., Ueda, K. & Kao, W. C., 2021, 2021 IEEE International Conference on Consumer Electronics-Taiwan, ICCE-TW 2021. Institute of Electrical and Electronics Engineers Inc., (2021 IEEE International Conference on Consumer Electronics-Taiwan, ICCE-TW 2021).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
  2 Citations (Scopus)

• Appropriate use of cancer comprehensive genome profiling assay using circulating tumor DNA

  The Working Group of a Joint Task Force of Three Academic Societies for the Promotion of Cancer Genomic Medicine, Sep 2021, In: Cancer Science. 112, 9, p. 3911-3917 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  8 Citations (Scopus)

• A Property Management System Using Image Recognition by YOLO

  Miyamoto, T., Fukushima, R., Harada, K., Yoshimoto, K., Kodera, Y., Kusaka, T. & Nogami, Y., 2021, 2021 IEEE International Conference on Consumer Electronics-Taiwan, ICCE-TW 2021. Institute of Electrical and Electronics Engineers Inc., (2021 IEEE International Conference on Consumer Electronics-Taiwan, ICCE-TW 2021).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• A Proposal for Testing Physical Random Numbers Using Stochastic Process

  Sato, R., Kodera, Y., Kusaka, T. & Nogami, Y., 2021, 2021 IEEE International Conference on Consumer Electronics-Taiwan, ICCE-TW 2021. Institute of Electrical and Electronics Engineers Inc., (2021 IEEE International Conference on Consumer Electronics-Taiwan, ICCE-TW 2021).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
  1 Citation (Scopus)

• A Proposal of Advanced Widgets Learning Topic for Interactive Application in Android Programming Learning Assistance System

  Syaifudin, Y. W., Funabiki, N., Kuribayashi, M. & Kao, W. C., May 2021, In: SN Computer Science. 2, 3, 172.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• A Proposal of Air-Conditioning Guidance System Using Discomfort Index

  Huda, S., Funabiki, N., Kuribayashi, M., Sudibyo, R. W., Ishihara, N. & Kao, W. C., 2021, Advances on Broad-Band Wireless Computing, Communication and Applications - Proceedings of the 15th International Conference on Broad-Band and Wireless Computing, Communication and Applications, BWCCA 2020. Barolli, L., Matsuo, K., Takizawa, M., Enokido, T. & Chen, H-C. (eds.). Springer Science and Business Media Deutschland GmbH, p. 154-165 12 p. (Lecture Notes in Networks and Systems; vol. 159 LNNS).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  Open Access
  4 Citations (Scopus)

• A Proposal of Code Modification Problem for Web Client Programming Using JavaScript

  Wai, K. H., Funabiki, N., Mon, K. T., Mar Shwe, S. H., Sandi Kyaw, H. H. & Lin, K. S., 2021, Proceedings - 2021 9th International Symposium on Computing and Networking, CANDAR 2021. Institute of Electrical and Electronics Engineers Inc., p. 196-202 7 p. (Proceedings - 2021 9th International Symposium on Computing and Networking, CANDAR 2021).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
  1 Citation (Scopus)

• A Proposal of Dynamic Job Scheduling Algorithm Considering CPU Core Utilization for User-PC Computing System

  Kamoyedji, A., Funabiki, N., Htet, H. & Kuribayashi, M., 2021, Proceedings - 2021 9th International Symposium on Computing and Networking Workshops, CANDARW 2021. Institute of Electrical and Electronics Engineers Inc., p. 268-271 4 p. (Proceedings - 2021 9th International Symposium on Computing and Networking Workshops, CANDARW 2021).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
  1 Citation (Scopus)

• A Proposal of Grammar-Concept Understanding Problem in Java Programming Learning Assistant System

  Aung, S. T., Funabiki, N., Syaifudin, Y. W., Kyaw, H. H. S., Aung, S. L., Dim, N. K. & Kao, W. C., Nov 2021, In: Journal of Advances in Information Technology. 12, 4, p. 342-350 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  11 Citations (Scopus)

• A proposal of recommendation function for element fill-in-Blank problems in java programming learning assistant system

  Wint, S. S. & Funabiki, N., 2021, In: International Journal of Web Information Systems. 17, 2, p. 140-152 13 p.

  Research output: Contribution to journal › Article › peer-review