9α,10α-Epoxyhexahydrocannabinol formation from Δ9-tetrahydrocannabinol by liver microsomes of phenobarbital-treated mice and its pharmacological activities in mice

S. Narimatsu, I. Yamamoto, K. Watanabe, H. Yoshimura

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

9α,10α-Epoxyhexahydrocannabinol (9α,10α-EHHC) was found to be formed from Δ9-tetrahydrocannabinol (Δ9-THC) by liver microsomes of mice pretreated with phenobarbital. Further, pharmacological effects of 9α,10α-EHHC in mice were compared with those of Δ9-THC using catalepsy, hypothermia, pentobarbital-induced sleep prolongation and anticonvulsant activity against pentylenetetrazol as indices. 9α,10α-EHHC was approximately equipotent to Δ9-THC in the pharmacological indices except for catalepsy. The cataleptogenic effect of the epoxide was about 4 times as potent as the parent compound. From these results, it is suggested that 9α,10α-EHHC can contribute to the pharmacological effects of Δ9-THC as an active metabolite.

Original languageEnglish
Pages (from-to)558-564
Number of pages7
JournalJournal of Pharmacobio-Dynamics
Volume6
Issue number8
Publication statusPublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of '9α,10α-Epoxyhexahydrocannabinol formation from Δ9-tetrahydrocannabinol by liver microsomes of phenobarbital-treated mice and its pharmacological activities in mice'. Together they form a unique fingerprint.

Cite this