9α,10α-Epoxyhexahydrocannabinol (9α,10α-EHHC) was found to be formed from Δ9-tetrahydrocannabinol (Δ9-THC) by liver microsomes of mice pretreated with phenobarbital. Further, pharmacological effects of 9α,10α-EHHC in mice were compared with those of Δ9-THC using catalepsy, hypothermia, pentobarbital-induced sleep prolongation and anticonvulsant activity against pentylenetetrazol as indices. 9α,10α-EHHC was approximately equipotent to Δ9-THC in the pharmacological indices except for catalepsy. The cataleptogenic effect of the epoxide was about 4 times as potent as the parent compound. From these results, it is suggested that 9α,10α-EHHC can contribute to the pharmacological effects of Δ9-THC as an active metabolite.
|Number of pages||7|
|Journal||Journal of Pharmacobio-Dynamics|
|Publication status||Published - 1983|
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