Abstract
Versatile use of 4-nitrobenzyl group for protection of hydroxyl functions is described. It can be removed selectively in the presence of other benzyl-type protecting groups such as benzyl and 4-methoxybenzyl via reduction into 4-aminobenzyl group followed by electrochemical oxidation. Very clean oxidative cleavage of 4-aminobenzyl group could also be effected with 2,3-dichloro-5,6-dicyanobenzoquinone after N-acetylation.
| Original language | English |
|---|---|
| Pages (from-to) | 389-392 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 31 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1990 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Kukase, K., Tanaka, H., Toriib, S., & Kusumoto, S. (1990). 4-Nitrobenzyl group for protection of hydroxyl functions. Tetrahedron Letters, 31(3), 389-392. https://doi.org/10.1016/S0040-4039(00)94562-3