4-Nitrobenzyl group for protection of hydroxyl functions

Koichi Kukase, Hideo Tanaka, Sigeru Toriib, Shoichi Kusumoto

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


Versatile use of 4-nitrobenzyl group for protection of hydroxyl functions is described. It can be removed selectively in the presence of other benzyl-type protecting groups such as benzyl and 4-methoxybenzyl via reduction into 4-aminobenzyl group followed by electrochemical oxidation. Very clean oxidative cleavage of 4-aminobenzyl group could also be effected with 2,3-dichloro-5,6-dicyanobenzoquinone after N-acetylation.

Original languageEnglish
Pages (from-to)389-392
Number of pages4
JournalTetrahedron Letters
Issue number3
Publication statusPublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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