4-methylcatechol, a potent inducer of nerve growth factor synthesis, protects spiral ganglion neurons from aminoglycoside ototoxicity - Preliminary report

Nobuhiko Kimura, Kazunori Nishizaki, Yorihisa Orita, Yu Masuda

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The degeneration of spiral ganglion neurons after hair cell destruction following aminoglycoside ototoxicity is associated not only with the direct effect on the neurons, but also with a loss of neurotrophic factors provided by auditory hair cells. The neurotrophic factors, including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), have been reported to be effective in enhancing neuronal survival against aminoglycoside ototoxicity in vivo. To determine whether 4- methylcatechol (4-MC), a potent inducer of nerve growth factor synthesis, can protect spiral ganglion neurons after aminoglycoside treatment in vivo, we studied the spiral ganglion neurons of gentamicin (GM)-treated mice with or without 4-MC administration. We found that the number of surviving spiral ganglion neurons of 4-MC-treated animals was significantly greater than for those treated with GM alone. Our results suggest that 4-MC promotes synthesis of NGF (and/or other neurotrophins), which enhances spiral ganglion neuron survival after gentamicin treatment.

Original languageEnglish
Pages (from-to)12-15
Number of pages4
JournalActa Oto-Laryngologica, Supplement
Issue number540
Publication statusPublished - Jul 28 1999

Keywords

  • 4-methylcatechol
  • Aminoglycoside
  • Neurotrophins
  • Spiral ganglion neuron

ASJC Scopus subject areas

  • Otorhinolaryngology

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