(3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents

Masahiro Nomura, Susumu Kinoshita, Hiroya Satoh, Toshio Maeda, Koji Murakami, Masaki Tsunoda, Hiroyuki Miyachi, Katsuya Awano

Research output: Contribution to journalArticlepeer-review

112 Citations (Scopus)


A series of 3-[(2,4-dioxothiazolidin-5-yl)methyl]benzamide derivatives was prepared as part of a search for antidiabetic agents. A structure- activity relationship study of these compounds led to the identification of 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[4- (trifluoromethyl)phenyl]methyl]benzamide (KRP-297) as a candidate drug for the treatment of diabetes mellitus.

Original languageEnglish
Pages (from-to)533-538
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Issue number4
Publication statusPublished - Feb 22 1999

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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