(3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents

Masahiro Nomura, Susumu Kinoshita, Hiroya Satoh, Toshio Maeda, Koji Murakami, Masaki Tsunoda, Hiroyuki Miyachi, Katsuya Awano

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

A series of 3-[(2,4-dioxothiazolidin-5-yl)methyl]benzamide derivatives was prepared as part of a search for antidiabetic agents. A structure- activity relationship study of these compounds led to the identification of 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[4- (trifluoromethyl)phenyl]methyl]benzamide (KRP-297) as a candidate drug for the treatment of diabetes mellitus.

Original languageEnglish
Pages (from-to)533-538
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number4
DOIs
Publication statusPublished - Feb 22 1999
Externally publishedYes

Fingerprint

Structure-Activity Relationship
Hypoglycemic Agents
Diabetes Mellitus
Lead compounds
Medical problems
Pharmaceutical Preparations
Derivatives
benzamide
MK0767
5-((2,4-dioxo-5-thiazolidinyl)methyl)-2-methoxy-N-((4-(trifluoromethyl)phenyl)methyl)benzamide
thiazolidine-2,4-dione

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

(3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents. / Nomura, Masahiro; Kinoshita, Susumu; Satoh, Hiroya; Maeda, Toshio; Murakami, Koji; Tsunoda, Masaki; Miyachi, Hiroyuki; Awano, Katsuya.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 9, No. 4, 22.02.1999, p. 533-538.

Research output: Contribution to journalArticle

Nomura, M, Kinoshita, S, Satoh, H, Maeda, T, Murakami, K, Tsunoda, M, Miyachi, H & Awano, K 1999, '(3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents', Bioorganic and Medicinal Chemistry Letters, vol. 9, no. 4, pp. 533-538. https://doi.org/10.1016/S0960-894X(99)00039-6
Nomura, Masahiro ; Kinoshita, Susumu ; Satoh, Hiroya ; Maeda, Toshio ; Murakami, Koji ; Tsunoda, Masaki ; Miyachi, Hiroyuki ; Awano, Katsuya. / (3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents. In: Bioorganic and Medicinal Chemistry Letters. 1999 ; Vol. 9, No. 4. pp. 533-538.
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