(3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents

Masahiro Nomura; Susumu Kinoshita; Hiroya Satoh; Toshio Maeda; Koji Murakami; Masaki Tsunoda; Hiroyuki Miyachi; Katsuya Awano

doi:10.1016/S0960-894X(99)00039-6

(3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents

Masahiro Nomura, Susumu Kinoshita, Hiroya Satoh, Toshio Maeda, Koji Murakami, Masaki Tsunoda, Hiroyuki Miyachi, Katsuya Awano

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article

105 Citations (Scopus)

Abstract

A series of 3-[(2,4-dioxothiazolidin-5-yl)methyl]benzamide derivatives was prepared as part of a search for antidiabetic agents. A structure- activity relationship study of these compounds led to the identification of 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[4- (trifluoromethyl)phenyl]methyl]benzamide (KRP-297) as a candidate drug for the treatment of diabetes mellitus.

Original language	English
Pages (from-to)	533-538
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	4
DOIs	https://doi.org/10.1016/S0960-894X(99)00039-6
Publication status	Published - Feb 22 1999

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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Nomura, M., Kinoshita, S., Satoh, H., Maeda, T., Murakami, K., Tsunoda, M., Miyachi, H., & Awano, K. (1999). (3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents. Bioorganic and Medicinal Chemistry Letters, 9(4), 533-538. https://doi.org/10.1016/S0960-894X(99)00039-6

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abstract = "A series of 3-[(2,4-dioxothiazolidin-5-yl)methyl]benzamide derivatives was prepared as part of a search for antidiabetic agents. A structure- activity relationship study of these compounds led to the identification of 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[4- (trifluoromethyl)phenyl]methyl]benzamide (KRP-297) as a candidate drug for the treatment of diabetes mellitus.",

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AU - Maeda, Toshio

AU - Murakami, Koji

AU - Tsunoda, Masaki

AU - Miyachi, Hiroyuki

AU - Awano, Katsuya

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