2,3 Dimercapto-1-propanol inhibits HIV-1 tat activity, viral production, and infectivity in vitro

Satoshi Kubota, M. A. El-Farrash, M. Maki, S. Harada, M. Hatanaka

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We have examined the effect of 2,3 dimercapto-1-propanol (DMP), which is known as an anti-heavy metal-poisoning drug, against human immunodeficiency virus type 1 (HIV-1). We demonstrate that DMP inhibited transactivation directed by tat protein, which is a metal containing transcriptional transactivating factor and also interfered with viral production. Furthermore, treatment and pretreatment of cells with DMP strongly reduced their sensitivity for HIV-1 infection through unknown mechanisms. These results indicate that DMP reveals pleuripotent effects on HIV-1 infection and production in vitro and thus may provide an exploitable hypothesis for designing new drugs against AIDS.

Original languageEnglish
Pages (from-to)919-927
Number of pages9
JournalAIDS Research and Human Retroviruses
Volume6
Issue number7
Publication statusPublished - 1990
Externally publishedYes

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Dimercaprol
1-Propanol
HIV-1
Virus Diseases
tat Gene Products
Anti-HIV Agents
Transcriptional Activation
Metals
Pharmaceutical Preparations
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

2,3 Dimercapto-1-propanol inhibits HIV-1 tat activity, viral production, and infectivity in vitro. / Kubota, Satoshi; El-Farrash, M. A.; Maki, M.; Harada, S.; Hatanaka, M.

In: AIDS Research and Human Retroviruses, Vol. 6, No. 7, 1990, p. 919-927.

Research output: Contribution to journalArticle

Kubota, Satoshi ; El-Farrash, M. A. ; Maki, M. ; Harada, S. ; Hatanaka, M. / 2,3 Dimercapto-1-propanol inhibits HIV-1 tat activity, viral production, and infectivity in vitro. In: AIDS Research and Human Retroviruses. 1990 ; Vol. 6, No. 7. pp. 919-927.
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