2,3 Dimercapto-1-Propanol Inhibits HIV-1 tat Activity, Viral Production, and Infectivity In Vitro

Satoshi Kubota; Mohamed A. Farrash; Masatoshi Maki; Shinji Harada; Masakazu Hatanaka

doi:10.1089/aid.1990.6.919

2,3 Dimercapto-1-Propanol Inhibits HIV-1 tat Activity, Viral Production, and Infectivity In Vitro

Satoshi Kubota, Mohamed A. Farrash, Masatoshi Maki, Shinji Harada, Masakazu Hatanaka

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

We have examined the effect of 2,3 dimercapto-1-propanol (DMP), which is known as an anti-heavy metal-poisoning drug, against human immunodeficiency virus type 1 (HIV-1). We demonstrate that DMP inhibited transactivation directed by tat protein, which is a metal containing transcriptional transactivating factor and also interfered with viral production. Furthermore, treatment and pretreatment of cells with DMP strongly reduced their sensitivity for HIV-1 infection through unknown mechanisms. These results indicate that DMP reveals pleuripotent effects on HIV-1 infection and production in vitro and thus may provide an exploitable hypothesis for designing new drugs against AIDS.

Original language	English
Pages (from-to)	919-927
Number of pages	9
Journal	AIDS Research and Human Retroviruses
Volume	6
Issue number	7
DOIs	https://doi.org/10.1089/aid.1990.6.919
Publication status	Published - Jul 1990
Externally published	Yes

ASJC Scopus subject areas

Immunology
Virology
Infectious Diseases

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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10.1089/aid.1990.6.919

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title = "2,3 Dimercapto-1-Propanol Inhibits HIV-1 tat Activity, Viral Production, and Infectivity In Vitro",

abstract = "We have examined the effect of 2,3 dimercapto-1-propanol (DMP), which is known as an anti-heavy metal-poisoning drug, against human immunodeficiency virus type 1 (HIV-1). We demonstrate that DMP inhibited transactivation directed by tat protein, which is a metal containing transcriptional transactivating factor and also interfered with viral production. Furthermore, treatment and pretreatment of cells with DMP strongly reduced their sensitivity for HIV-1 infection through unknown mechanisms. These results indicate that DMP reveals pleuripotent effects on HIV-1 infection and production in vitro and thus may provide an exploitable hypothesis for designing new drugs against AIDS.",

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AU - Maki, Masatoshi

AU - Harada, Shinji

AU - Hatanaka, Masakazu

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AB - We have examined the effect of 2,3 dimercapto-1-propanol (DMP), which is known as an anti-heavy metal-poisoning drug, against human immunodeficiency virus type 1 (HIV-1). We demonstrate that DMP inhibited transactivation directed by tat protein, which is a metal containing transcriptional transactivating factor and also interfered with viral production. Furthermore, treatment and pretreatment of cells with DMP strongly reduced their sensitivity for HIV-1 infection through unknown mechanisms. These results indicate that DMP reveals pleuripotent effects on HIV-1 infection and production in vitro and thus may provide an exploitable hypothesis for designing new drugs against AIDS.

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2,3 Dimercapto-1-Propanol Inhibits HIV-1 tat Activity, Viral Production, and Infectivity In Vitro

Abstract

ASJC Scopus subject areas

UN SDGs

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