Abstract
We have examined the effect of 2,3 dimercapto-1-propanol (DMP), which is known as an anti-heavy metal-poisoning drug, against human immunodeficiency virus type 1 (HIV-1). We demonstrate that DMP inhibited transactivation directed by tat protein, which is a metal containing transcriptional transactivating factor and also interfered with viral production. Furthermore, treatment and pretreatment of cells with DMP strongly reduced their sensitivity for HIV-1 infection through unknown mechanisms. These results indicate that DMP reveals pleuripotent effects on HIV-1 infection and production in vitro and thus may provide an exploitable hypothesis for designing new drugs against AIDS.
| Original language | English |
|---|---|
| Pages (from-to) | 919-927 |
| Number of pages | 9 |
| Journal | AIDS Research and Human Retroviruses |
| Volume | 6 |
| Issue number | 7 |
| Publication status | Published - 1990 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
- Virology
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2,3 Dimercapto-1-propanol inhibits HIV-1 tat activity, viral production, and infectivity in vitro. / Kubota, Satoshi; El-Farrash, M. A.; Maki, M.; Harada, S.; Hatanaka, M.
In: AIDS Research and Human Retroviruses, Vol. 6, No. 7, 1990, p. 919-927.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 2,3 Dimercapto-1-propanol inhibits HIV-1 tat activity, viral production, and infectivity in vitro
AU - Kubota, Satoshi
AU - El-Farrash, M. A.
AU - Maki, M.
AU - Harada, S.
AU - Hatanaka, M.
PY - 1990
Y1 - 1990
N2 - We have examined the effect of 2,3 dimercapto-1-propanol (DMP), which is known as an anti-heavy metal-poisoning drug, against human immunodeficiency virus type 1 (HIV-1). We demonstrate that DMP inhibited transactivation directed by tat protein, which is a metal containing transcriptional transactivating factor and also interfered with viral production. Furthermore, treatment and pretreatment of cells with DMP strongly reduced their sensitivity for HIV-1 infection through unknown mechanisms. These results indicate that DMP reveals pleuripotent effects on HIV-1 infection and production in vitro and thus may provide an exploitable hypothesis for designing new drugs against AIDS.
AB - We have examined the effect of 2,3 dimercapto-1-propanol (DMP), which is known as an anti-heavy metal-poisoning drug, against human immunodeficiency virus type 1 (HIV-1). We demonstrate that DMP inhibited transactivation directed by tat protein, which is a metal containing transcriptional transactivating factor and also interfered with viral production. Furthermore, treatment and pretreatment of cells with DMP strongly reduced their sensitivity for HIV-1 infection through unknown mechanisms. These results indicate that DMP reveals pleuripotent effects on HIV-1 infection and production in vitro and thus may provide an exploitable hypothesis for designing new drugs against AIDS.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025150770&partnerID=8YFLogxK
M3 - Article
C2 - 2202353
AN - SCOPUS:0025150770
VL - 6
SP - 919
EP - 927
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
SN - 0889-2229
IS - 7
ER -