2,3 Dimercapto-1-Propanol Inhibits HIV-1 tat Activity, Viral Production, and Infectivity In Vitro

Satoshi Kubota, Mohamed A. Farrash, Masatoshi Maki, Shinji Harada, Masakazu Hatanaka

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We have examined the effect of 2,3 dimercapto-1-propanol (DMP), which is known as an anti-heavy metal-poisoning drug, against human immunodeficiency virus type 1 (HIV-1). We demonstrate that DMP inhibited transactivation directed by tat protein, which is a metal containing transcriptional transactivating factor and also interfered with viral production. Furthermore, treatment and pretreatment of cells with DMP strongly reduced their sensitivity for HIV-1 infection through unknown mechanisms. These results indicate that DMP reveals pleuripotent effects on HIV-1 infection and production in vitro and thus may provide an exploitable hypothesis for designing new drugs against AIDS.

Original languageEnglish
Pages (from-to)919-927
Number of pages9
JournalAIDS Research and Human Retroviruses
Volume6
Issue number7
DOIs
Publication statusPublished - Jul 1990
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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