TY - JOUR
T1 - 2,3 Dimercapto-1-Propanol Inhibits HIV-1 tat Activity, Viral Production, and Infectivity In Vitro
AU - Kubota, Satoshi
AU - Farrash, Mohamed A.
AU - Maki, Masatoshi
AU - Harada, Shinji
AU - Hatanaka, Masakazu
PY - 1990/7
Y1 - 1990/7
N2 - We have examined the effect of 2,3 dimercapto-1-propanol (DMP), which is known as an anti-heavy metal-poisoning drug, against human immunodeficiency virus type 1 (HIV-1). We demonstrate that DMP inhibited transactivation directed by tat protein, which is a metal containing transcriptional transactivating factor and also interfered with viral production. Furthermore, treatment and pretreatment of cells with DMP strongly reduced their sensitivity for HIV-1 infection through unknown mechanisms. These results indicate that DMP reveals pleuripotent effects on HIV-1 infection and production in vitro and thus may provide an exploitable hypothesis for designing new drugs against AIDS.
AB - We have examined the effect of 2,3 dimercapto-1-propanol (DMP), which is known as an anti-heavy metal-poisoning drug, against human immunodeficiency virus type 1 (HIV-1). We demonstrate that DMP inhibited transactivation directed by tat protein, which is a metal containing transcriptional transactivating factor and also interfered with viral production. Furthermore, treatment and pretreatment of cells with DMP strongly reduced their sensitivity for HIV-1 infection through unknown mechanisms. These results indicate that DMP reveals pleuripotent effects on HIV-1 infection and production in vitro and thus may provide an exploitable hypothesis for designing new drugs against AIDS.
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U2 - 10.1089/aid.1990.6.919
DO - 10.1089/aid.1990.6.919
M3 - Article
C2 - 2202353
AN - SCOPUS:0025150770
VL - 6
SP - 919
EP - 927
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
SN - 0889-2229
IS - 7
ER -
