Abstract
We have examined the effect of 2,3 dimercapto-1-propanol (DMP), which is known as an anti-heavy metal-poisoning drug, against human immunodeficiency virus type 1 (HIV-1). We demonstrate that DMP inhibited transactivation directed by tat protein, which is a metal containing transcriptional transactivating factor and also interfered with viral production. Furthermore, treatment and pretreatment of cells with DMP strongly reduced their sensitivity for HIV-1 infection through unknown mechanisms. These results indicate that DMP reveals pleuripotent effects on HIV-1 infection and production in vitro and thus may provide an exploitable hypothesis for designing new drugs against AIDS.
| Original language | English |
|---|---|
| Pages (from-to) | 919-927 |
| Number of pages | 9 |
| Journal | AIDS Research and Human Retroviruses |
| Volume | 6 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 1990 |
| Externally published | Yes |
ASJC Scopus subject areas
- Immunology
- Virology
- Infectious Diseases
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Cite this
Kubota, S., Farrash, M. A., Maki, M., Harada, S., & Hatanaka, M. (1990). 2,3 Dimercapto-1-Propanol Inhibits HIV-1 tat Activity, Viral Production, and Infectivity In Vitro. AIDS Research and Human Retroviruses, 6(7), 919-927. https://doi.org/10.1089/aid.1990.6.919