Abstract
(2-Pyridyldimethylsilyl)methyl lithium was found to react with organic bromides, aldehydes, ketones, and hydrosilanes in good to excellent yields. The resultant adducts were further oxidized with H2O2/KF to give the corresponding alcohols in excellent yields. Thus, this two-step transformation provides an efficient method for hydroxymethylation.
Original language | English |
---|---|
Pages (from-to) | 5537-5540 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 40 |
Issue number | 30 |
DOIs | |
Publication status | Published - Jul 1999 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry