2-Diphenylphosphanyl-4-pyridyl(dimethyl)amine as an effective ligand for the ruthenium(II) complex catalyzed homogeneous hydration of nitriles under neutral conditions

Makoto Muranaka, Isao Hyodo, Wataru Okumura, Toshiyuki Oshiki

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

New homogeneous catalyst comprised of [Ru(methallyl)2(cod)] (cod = 1,5-cyclooctadiene) (1) and 2-diphenylphosphanyl-4-pyridyl(dimethyl)amine (2) is shown to efficiently catalyze the hydration of various nitriles under neutral conditions. The hydration proceeds in the presence of 0.5 mol% of the ruthenium catalyst at 80 °C in 1,2-dimethoxyethane solution and the corresponding amide is obtained within few hours without the formation of byproducts. Comparison of some phosphine ligands for the hydration reveals that the dimethylamino moiety of 2 improves the catalytic performance dramatically.

Original languageEnglish
Pages (from-to)552-555
Number of pages4
JournalCatalysis Today
Volume164
Issue number1
DOIs
Publication statusPublished - Apr 30 2011

Keywords

  • Amides
  • Homogeneous catalysis
  • Hydration
  • Nitrile
  • Phosphine
  • Ruthenium

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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