1H and 10B NMR and MRI investigation of boron- and gadolinium-boron compounds in boron neutron capture therapy

M. Bonora; M. Corti; F. Borsa; S. Bortolussi; N. Protti; D. Santoro; S. Stella; S. Altieri; C. Zonta; A. M. Clerici; L. Cansolino; C. Ferrari; P. Dionigi; A. Porta; G. Zanoni; G. Vidari

doi:10.1016/j.apradiso.2011.02.021

1H and 10B NMR and MRI investigation of boron- and gadolinium-boron compounds in boron neutron capture therapy

M. Bonora, M. Corti, F. Borsa, S. Bortolussi, N. Protti, D. Santoro, S. Stella, S. Altieri, C. Zonta, A. M. Clerici, L. Cansolino, C. Ferrari, P. Dionigi, A. Porta, G. Zanoni, G. Vidari

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

¹⁰B molecular compounds suitable for Boron Neutron Capture Therapy (BNCT) are tagged with a Gd(III) paramagnetic ion. The newly synthesized molecule, Gd-BPA, is investigated as contrast agent in Magnetic Resonance Imaging (MRI) with the final aim of mapping the boron distribution in tissues. Preliminary Nuclear Magnetic Resonance (NMR) measurements, which include ¹H and ¹⁰B relaxometry in animal tissues, proton relaxivity of the paramagnetic Gd-BPA molecule in water and its absorption in tumoral living cells, are reported.

Original language	English
Pages (from-to)	1702-1705
Number of pages	4
Journal	Applied Radiation and Isotopes
Volume	69
Issue number	12
DOIs	https://doi.org/10.1016/j.apradiso.2011.02.021
Publication status	Published - Dec 2011
Externally published	Yes

ASJC Scopus subject areas

Radiation

Access to Document

10.1016/j.apradiso.2011.02.021

Cite this

Bonora, M., Corti, M., Borsa, F., Bortolussi, S., Protti, N., Santoro, D., Stella, S., Altieri, S., Zonta, C., Clerici, A. M., Cansolino, L., Ferrari, C., Dionigi, P., Porta, A., Zanoni, G., & Vidari, G. (2011). 1H and 10B NMR and MRI investigation of boron- and gadolinium-boron compounds in boron neutron capture therapy. Applied Radiation and Isotopes, 69(12), 1702-1705. https://doi.org/10.1016/j.apradiso.2011.02.021

Bonora, M, Corti, M, Borsa, F, Bortolussi, S, Protti, N, Santoro, D, Stella, S, Altieri, S, Zonta, C, Clerici, AM, Cansolino, L, Ferrari, C, Dionigi, P, Porta, A, Zanoni, G & Vidari, G 2011, '1H and 10B NMR and MRI investigation of boron- and gadolinium-boron compounds in boron neutron capture therapy', Applied Radiation and Isotopes, vol. 69, no. 12, pp. 1702-1705. https://doi.org/10.1016/j.apradiso.2011.02.021

@article{7e7a168b93814524835bc38d2460a75f,

title = "1H and 10B NMR and MRI investigation of boron- and gadolinium-boron compounds in boron neutron capture therapy",

abstract = "10B molecular compounds suitable for Boron Neutron Capture Therapy (BNCT) are tagged with a Gd(III) paramagnetic ion. The newly synthesized molecule, Gd-BPA, is investigated as contrast agent in Magnetic Resonance Imaging (MRI) with the final aim of mapping the boron distribution in tissues. Preliminary Nuclear Magnetic Resonance (NMR) measurements, which include 1H and 10B relaxometry in animal tissues, proton relaxivity of the paramagnetic Gd-BPA molecule in water and its absorption in tumoral living cells, are reported.",

author = "M. Bonora and M. Corti and F. Borsa and S. Bortolussi and N. Protti and D. Santoro and S. Stella and S. Altieri and C. Zonta and Clerici, {A. M.} and L. Cansolino and C. Ferrari and P. Dionigi and A. Porta and G. Zanoni and G. Vidari",

note = "Funding Information: This research has been supported by CARIPLO Foundation, Bando 2008, Ricerca Scientifica e tecnologica su Materiali Avanzati , progetto 2227 .",

year = "2011",

month = dec,

doi = "10.1016/j.apradiso.2011.02.021",

language = "English",

volume = "69",

pages = "1702--1705",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier Limited",

number = "12",

}

TY - JOUR

T1 - 1H and 10B NMR and MRI investigation of boron- and gadolinium-boron compounds in boron neutron capture therapy

AU - Bonora, M.

AU - Corti, M.

AU - Borsa, F.

AU - Bortolussi, S.

AU - Protti, N.

AU - Santoro, D.

AU - Stella, S.

AU - Altieri, S.

AU - Zonta, C.

AU - Clerici, A. M.

AU - Cansolino, L.

AU - Ferrari, C.

AU - Dionigi, P.

AU - Porta, A.

AU - Zanoni, G.

AU - Vidari, G.

N1 - Funding Information: This research has been supported by CARIPLO Foundation, Bando 2008, Ricerca Scientifica e tecnologica su Materiali Avanzati , progetto 2227 .

PY - 2011/12

Y1 - 2011/12

N2 - 10B molecular compounds suitable for Boron Neutron Capture Therapy (BNCT) are tagged with a Gd(III) paramagnetic ion. The newly synthesized molecule, Gd-BPA, is investigated as contrast agent in Magnetic Resonance Imaging (MRI) with the final aim of mapping the boron distribution in tissues. Preliminary Nuclear Magnetic Resonance (NMR) measurements, which include 1H and 10B relaxometry in animal tissues, proton relaxivity of the paramagnetic Gd-BPA molecule in water and its absorption in tumoral living cells, are reported.

AB - 10B molecular compounds suitable for Boron Neutron Capture Therapy (BNCT) are tagged with a Gd(III) paramagnetic ion. The newly synthesized molecule, Gd-BPA, is investigated as contrast agent in Magnetic Resonance Imaging (MRI) with the final aim of mapping the boron distribution in tissues. Preliminary Nuclear Magnetic Resonance (NMR) measurements, which include 1H and 10B relaxometry in animal tissues, proton relaxivity of the paramagnetic Gd-BPA molecule in water and its absorption in tumoral living cells, are reported.

UR - http://www.scopus.com/inward/record.url?scp=80055074140&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80055074140&partnerID=8YFLogxK

U2 - 10.1016/j.apradiso.2011.02.021

DO - 10.1016/j.apradiso.2011.02.021

M3 - Article

C2 - 21371896

AN - SCOPUS:80055074140

SN - 0969-8043

VL - 69

SP - 1702

EP - 1705

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 12

ER -

1H and 10B NMR and MRI investigation of boron- and gadolinium-boron compounds in boron neutron capture therapy

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this