12T061A and 12T061C, two new julichrome family compounds, as radical scavengers from Streptomyces sp

Toshikazu Komoda, Naoko Saeki, Yoshitaka Koseki, Hiromasa Kiyota

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We identified two new radical scavengers, 12T061A (1, C19H20O7) and 12T061C (2, C20H22O7), from a culture of the Streptomyces sp. Spectroscopic analysis indicated that these compounds are new julichrome family compounds. Compounds 1 and 2 showed radical-scavenging activity with an ED50 of 370 μM and 18 μM, respectively. Moreover, 1 showed tumor cell growth suppressive activity in HepG2 cells, (IC50: 3.6 μM); however, no suppressive activity was shown in 2 (IC50: > 100 μM).

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalJournal of General and Applied Microbiology
Volume62
Issue number1
DOIs
Publication statusPublished - Feb 29 2016

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Streptomyces
Inhibitory Concentration 50
Hep G2 Cells
Growth
Neoplasms

Keywords

  • DPPH radical scavenger
  • Julichrome
  • Tumor cell growth suppressive activity

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology

Cite this

12T061A and 12T061C, two new julichrome family compounds, as radical scavengers from Streptomyces sp. / Komoda, Toshikazu; Saeki, Naoko; Koseki, Yoshitaka; Kiyota, Hiromasa.

In: Journal of General and Applied Microbiology, Vol. 62, No. 1, 29.02.2016, p. 1-6.

Research output: Contribution to journalArticle

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