1,2,4,5-tetraoxacycloalkanes: Synthesis and antimalarial activity

A. Masuyama, J. M. Wu, M. Nojima, Hye-Sook Kim, Y. Wataya

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

In this short review the methods of preparation of novel 1,2,4,5-tetraoxacycloalkanes and the related peroxides are summarized, with the emphasis on the usefulness of 1,1-bishydroperoxides as the precursor. Also, their antimalarial activities in vitro and in vivo are discussed.

Original languageEnglish
Pages (from-to)1035-1043
Number of pages9
JournalMini-Reviews in Medicinal Chemistry
Volume5
Issue number11
DOIs
Publication statusPublished - Nov 2005

Fingerprint

Peroxides
Antimalarials
In Vitro Techniques

Keywords

  • 1,2,4,5-tetraoxacycloalkanes
  • 1,2,5,6-tetraoxacycloalkanes
  • 1,2,6,7- tetraoxaspiro[7.11]nonadecane
  • Antimalarial activity
  • Cyclization methods
  • Medium-sized cyclic peroxides
  • P. berghei
  • P. falciparum

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemistry(all)
  • Pharmacology

Cite this

1,2,4,5-tetraoxacycloalkanes : Synthesis and antimalarial activity. / Masuyama, A.; Wu, J. M.; Nojima, M.; Kim, Hye-Sook; Wataya, Y.

In: Mini-Reviews in Medicinal Chemistry, Vol. 5, No. 11, 11.2005, p. 1035-1043.

Research output: Contribution to journalArticle

Masuyama, A. ; Wu, J. M. ; Nojima, M. ; Kim, Hye-Sook ; Wataya, Y. / 1,2,4,5-tetraoxacycloalkanes : Synthesis and antimalarial activity. In: Mini-Reviews in Medicinal Chemistry. 2005 ; Vol. 5, No. 11. pp. 1035-1043.
@article{cfa0303fc55e44569478651fe273c10f,
title = "1,2,4,5-tetraoxacycloalkanes: Synthesis and antimalarial activity",
abstract = "In this short review the methods of preparation of novel 1,2,4,5-tetraoxacycloalkanes and the related peroxides are summarized, with the emphasis on the usefulness of 1,1-bishydroperoxides as the precursor. Also, their antimalarial activities in vitro and in vivo are discussed.",
keywords = "1,2,4,5-tetraoxacycloalkanes, 1,2,5,6-tetraoxacycloalkanes, 1,2,6,7- tetraoxaspiro[7.11]nonadecane, Antimalarial activity, Cyclization methods, Medium-sized cyclic peroxides, P. berghei, P. falciparum",
author = "A. Masuyama and Wu, {J. M.} and M. Nojima and Hye-Sook Kim and Y. Wataya",
year = "2005",
month = "11",
doi = "10.2174/138955705774575255",
language = "English",
volume = "5",
pages = "1035--1043",
journal = "Mini-Reviews in Medicinal Chemistry",
issn = "1389-5575",
publisher = "Bentham Science Publishers B.V.",
number = "11",

}

TY - JOUR

T1 - 1,2,4,5-tetraoxacycloalkanes

T2 - Synthesis and antimalarial activity

AU - Masuyama, A.

AU - Wu, J. M.

AU - Nojima, M.

AU - Kim, Hye-Sook

AU - Wataya, Y.

PY - 2005/11

Y1 - 2005/11

N2 - In this short review the methods of preparation of novel 1,2,4,5-tetraoxacycloalkanes and the related peroxides are summarized, with the emphasis on the usefulness of 1,1-bishydroperoxides as the precursor. Also, their antimalarial activities in vitro and in vivo are discussed.

AB - In this short review the methods of preparation of novel 1,2,4,5-tetraoxacycloalkanes and the related peroxides are summarized, with the emphasis on the usefulness of 1,1-bishydroperoxides as the precursor. Also, their antimalarial activities in vitro and in vivo are discussed.

KW - 1,2,4,5-tetraoxacycloalkanes

KW - 1,2,5,6-tetraoxacycloalkanes

KW - 1,2,6,7- tetraoxaspiro[7.11]nonadecane

KW - Antimalarial activity

KW - Cyclization methods

KW - Medium-sized cyclic peroxides

KW - P. berghei

KW - P. falciparum

UR - http://www.scopus.com/inward/record.url?scp=26944458138&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26944458138&partnerID=8YFLogxK

U2 - 10.2174/138955705774575255

DO - 10.2174/138955705774575255

M3 - Article

C2 - 16307532

AN - SCOPUS:26944458138

VL - 5

SP - 1035

EP - 1043

JO - Mini-Reviews in Medicinal Chemistry

JF - Mini-Reviews in Medicinal Chemistry

SN - 1389-5575

IS - 11

ER -