1,2,4,5-tetraoxacycloalkanes: Synthesis and antimalarial activity

A. Masuyama; J. M. Wu; M. Nojima; H. S. Kim; Y. Wataya

doi:10.2174/138955705774575255

1,2,4,5-tetraoxacycloalkanes: Synthesis and antimalarial activity

A. Masuyama, J. M. Wu, M. Nojima, H. S. Kim, Y. Wataya

Research output: Contribution to journal › Review article › peer-review

34 Citations (Scopus)

Abstract

In this short review the methods of preparation of novel 1,2,4,5-tetraoxacycloalkanes and the related peroxides are summarized, with the emphasis on the usefulness of 1,1-bishydroperoxides as the precursor. Also, their antimalarial activities in vitro and in vivo are discussed.

Original language	English
Pages (from-to)	1035-1043
Number of pages	9
Journal	Mini-Reviews in Medicinal Chemistry
Volume	5
Issue number	11
DOIs	https://doi.org/10.2174/138955705774575255
Publication status	Published - Nov 2005

Keywords

1,2,4,5-tetraoxacycloalkanes
1,2,5,6-tetraoxacycloalkanes
1,2,6,7- tetraoxaspiro[7.11]nonadecane
Antimalarial activity
Cyclization methods
Medium-sized cyclic peroxides
P. berghei
P. falciparum

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Drug Discovery
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/138955705774575255

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title = "1,2,4,5-tetraoxacycloalkanes: Synthesis and antimalarial activity",

abstract = "In this short review the methods of preparation of novel 1,2,4,5-tetraoxacycloalkanes and the related peroxides are summarized, with the emphasis on the usefulness of 1,1-bishydroperoxides as the precursor. Also, their antimalarial activities in vitro and in vivo are discussed.",

keywords = "1,2,4,5-tetraoxacycloalkanes, 1,2,5,6-tetraoxacycloalkanes, 1,2,6,7- tetraoxaspiro[7.11]nonadecane, Antimalarial activity, Cyclization methods, Medium-sized cyclic peroxides, P. berghei, P. falciparum",

author = "A. Masuyama and Wu, {J. M.} and M. Nojima and Kim, {H. S.} and Y. Wataya",

year = "2005",

month = nov,

doi = "10.2174/138955705774575255",

language = "English",

volume = "5",

pages = "1035--1043",

journal = "Mini-Reviews in Medicinal Chemistry",

issn = "1389-5575",

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number = "11",

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TY - JOUR

T1 - 1,2,4,5-tetraoxacycloalkanes

T2 - Synthesis and antimalarial activity

AU - Masuyama, A.

AU - Wu, J. M.

AU - Nojima, M.

AU - Kim, H. S.

AU - Wataya, Y.

PY - 2005/11

Y1 - 2005/11

N2 - In this short review the methods of preparation of novel 1,2,4,5-tetraoxacycloalkanes and the related peroxides are summarized, with the emphasis on the usefulness of 1,1-bishydroperoxides as the precursor. Also, their antimalarial activities in vitro and in vivo are discussed.

AB - In this short review the methods of preparation of novel 1,2,4,5-tetraoxacycloalkanes and the related peroxides are summarized, with the emphasis on the usefulness of 1,1-bishydroperoxides as the precursor. Also, their antimalarial activities in vitro and in vivo are discussed.

KW - 1,2,4,5-tetraoxacycloalkanes

KW - 1,2,5,6-tetraoxacycloalkanes

KW - 1,2,6,7- tetraoxaspiro[7.11]nonadecane

KW - Antimalarial activity

KW - Cyclization methods

KW - Medium-sized cyclic peroxides

KW - P. berghei

KW - P. falciparum

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U2 - 10.2174/138955705774575255

DO - 10.2174/138955705774575255

M3 - Review article

C2 - 16307532

AN - SCOPUS:26944458138

SN - 1389-5575

VL - 5

SP - 1035

EP - 1043

JO - Mini-Reviews in Medicinal Chemistry

JF - Mini-Reviews in Medicinal Chemistry

IS - 11

ER -

1,2,4,5-tetraoxacycloalkanes: Synthesis and antimalarial activity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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