1,2,4,5-tetraoxacycloalkanes: Synthesis and antimalarial activity

A. Masuyama, J. M. Wu, M. Nojima, Hye-Sook Kim, Y. Wataya

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

In this short review the methods of preparation of novel 1,2,4,5-tetraoxacycloalkanes and the related peroxides are summarized, with the emphasis on the usefulness of 1,1-bishydroperoxides as the precursor. Also, their antimalarial activities in vitro and in vivo are discussed.

Original languageEnglish
Pages (from-to)1035-1043
Number of pages9
JournalMini-Reviews in Medicinal Chemistry
Volume5
Issue number11
DOIs
Publication statusPublished - Nov 2005

    Fingerprint

Keywords

  • 1,2,4,5-tetraoxacycloalkanes
  • 1,2,5,6-tetraoxacycloalkanes
  • 1,2,6,7- tetraoxaspiro[7.11]nonadecane
  • Antimalarial activity
  • Cyclization methods
  • Medium-sized cyclic peroxides
  • P. berghei
  • P. falciparum

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemistry(all)
  • Pharmacology

Cite this