1,2,4,5-tetraoxacycloalkanes: Synthesis and antimalarial activity

A. Masuyama, J. M. Wu, M. Nojima, H. S. Kim, Y. Wataya

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)


In this short review the methods of preparation of novel 1,2,4,5-tetraoxacycloalkanes and the related peroxides are summarized, with the emphasis on the usefulness of 1,1-bishydroperoxides as the precursor. Also, their antimalarial activities in vitro and in vivo are discussed.

Original languageEnglish
Pages (from-to)1035-1043
Number of pages9
JournalMini-Reviews in Medicinal Chemistry
Issue number11
Publication statusPublished - Nov 2005


  • 1,2,4,5-tetraoxacycloalkanes
  • 1,2,5,6-tetraoxacycloalkanes
  • 1,2,6,7- tetraoxaspiro[7.11]nonadecane
  • Antimalarial activity
  • Cyclization methods
  • Medium-sized cyclic peroxides
  • P. berghei
  • P. falciparum

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Cancer Research


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