1-Deoxypaclitaxel and abeo-taxoids from the seeds of Taxus mairei

Qing Wen Shi, Yong Ming Zhao, Xiao Tang Si, Zuo Ping Li, Teiko Yamada, Hiromasa Kiyota

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A new paclitaxel derivative and two new 2(3→20)-abeo-taxoids were isolated from a methanol extract of the seeds of Taxus mairei, and their structures were established as 1-deoxypaclitaxel (1), 7β,10β- diacetoxy-2α,5α,13α-trihydroxy-2(3→20)-abeo-taxa-4(20), 11-dien-9-one (2), and 2α,13α-diacetoxy-10α-hydroxy- 2(3→20)-abeo-taxa-4(20),6,11-triene-5,9-dione (3) on the basis of spectroscopic data analysis. Taxane 1 is the first example of a paclitaxel analogue with a C-1β hydrogen substituent. Taxane 3 is an 2(3-→20)-abeo-taxane with a rare C-5 ketone and C-6 double bond.

Original languageEnglish
Pages (from-to)280-283
Number of pages4
JournalJournal of Natural Products
Volume69
Issue number2
DOIs
Publication statusPublished - Feb 2006
Externally publishedYes

Fingerprint

Taxus wallichiana var. mairei
Taxus
taxanes
Taxoids
Seed
Seeds
paclitaxel
Paclitaxel
seeds
seed extracts
ketones
Ketones
hydrogen
Methanol
Hydrogen
data analysis
methanol
Derivatives
taxane
1-deoxypaclitaxel

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

1-Deoxypaclitaxel and abeo-taxoids from the seeds of Taxus mairei. / Shi, Qing Wen; Zhao, Yong Ming; Si, Xiao Tang; Li, Zuo Ping; Yamada, Teiko; Kiyota, Hiromasa.

In: Journal of Natural Products, Vol. 69, No. 2, 02.2006, p. 280-283.

Research output: Contribution to journalArticle

Shi, Qing Wen ; Zhao, Yong Ming ; Si, Xiao Tang ; Li, Zuo Ping ; Yamada, Teiko ; Kiyota, Hiromasa. / 1-Deoxypaclitaxel and abeo-taxoids from the seeds of Taxus mairei. In: Journal of Natural Products. 2006 ; Vol. 69, No. 2. pp. 280-283.
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