π-Delocalized β-carbolinium cations as potential antimalarials

Kiyosei Takasu, Tsubasa Shimogama, Chalerm Saiin, Hye Sook Kim, Yusuke Wataya, Masataka Ihara

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Several β-carboline compounds including natural products and their corresponding salts were synthesized and evaluated for antimalarial activity and cytotoxicity levels. Quaternary carbolinium cations showed much higher potencies than neutral β-carbolines and a good correlation was observed between π-delocalized lipophilic cationic structure and antimalarial efficacy.

Original languageEnglish
Pages (from-to)1689-1692
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number7
DOIs
Publication statusPublished - Apr 1 2004

Keywords

  • Antimalarials
  • DLC's
  • Selective toxicity
  • Total synthesis
  • β-Carbolines

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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