π-Delocalized β-carbolinium cations as potential antimalarials

Kiyosei Takasu, Tsubasa Shimogama, Chalerm Saiin, Hye-Sook Kim, Yusuke Wataya, Masataka Ihara

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Several β-carboline compounds including natural products and their corresponding salts were synthesized and evaluated for antimalarial activity and cytotoxicity levels. Quaternary carbolinium cations showed much higher potencies than neutral β-carbolines and a good correlation was observed between π-delocalized lipophilic cationic structure and antimalarial efficacy.

Original languageEnglish
Pages (from-to)1689-1692
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number7
DOIs
Publication statusPublished - Apr 2004

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Carbolines
Antimalarials
Cations
Cytotoxicity
Biological Products
Salts

Keywords

  • β-Carbolines
  • Antimalarials
  • DLC's
  • Selective toxicity
  • Total synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

π-Delocalized β-carbolinium cations as potential antimalarials. / Takasu, Kiyosei; Shimogama, Tsubasa; Saiin, Chalerm; Kim, Hye-Sook; Wataya, Yusuke; Ihara, Masataka.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 14, No. 7, 04.2004, p. 1689-1692.

Research output: Contribution to journalArticle

Takasu, Kiyosei ; Shimogama, Tsubasa ; Saiin, Chalerm ; Kim, Hye-Sook ; Wataya, Yusuke ; Ihara, Masataka. / π-Delocalized β-carbolinium cations as potential antimalarials. In: Bioorganic and Medicinal Chemistry Letters. 2004 ; Vol. 14, No. 7. pp. 1689-1692.
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