γ-Mangostin from garcinia mangostana pericarps as a dual agonist that activates both PPARα and PPARδ

Nobuyasu Matsuura; Kanae Gamo; Hiroyuki Miyachi; Munekazu Iinuma; Teruo Kawada; Nobuyuki Takahashi; Yukihiro Akao; Hideki Tosa

doi:10.1271/bbb.130541

γ-Mangostin from garcinia mangostana pericarps as a dual agonist that activates both PPARα and PPARδ

Nobuyasu Matsuura, Kanae Gamo, Hiroyuki Miyachi, Munekazu Iinuma, Teruo Kawada, Nobuyuki Takahashi, Yukihiro Akao, Hideki Tosa

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article

14 Citations (Scopus)

Abstract

We tested the peroxisome proliferator-activated receptor (PPAR)δ agonistic activity of a Garcinia mangostana pericarp extract to develop a treatment for the metabolic syndrome, and demonstrated -mangostin to be an active compound on the basis of a luciferase reporter gene assay. γ-Mangostin induced the expression of the uncoupling protein-3 (UCP-3) gene which is related to energy expenditure and fat metabolism in L6 cells. We showed that -mangostin is a dual agonist that activates both PPARδ and PPARα. γ-Mangostin also induced the expression of acyl-CoA synthase and carnitine palmitoyl-transferase 1A genes in HepG2 cells. These results suggest the potential of γ-mangostin as a preventive agent of the metabolic syndrome.

Original language	English
Pages (from-to)	2430-2435
Number of pages	6
Journal	Bioscience, Biotechnology and Biochemistry
Volume	77
Issue number	12
DOIs	https://doi.org/10.1271/bbb.130541
Publication status	Published - 2013

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Keywords

γ-mangostin
Dual agonist
Garcinia mangostanapericarp
PPARα
PPARδ

ASJC Scopus subject areas

Biotechnology
Biochemistry
Molecular Biology
Applied Microbiology and Biotechnology
Analytical Chemistry
Organic Chemistry

Cite this

Matsuura, N., Gamo, K., Miyachi, H., Iinuma, M., Kawada, T., Takahashi, N., Akao, Y., & Tosa, H. (2013). γ-Mangostin from garcinia mangostana pericarps as a dual agonist that activates both PPARα and PPARδ. Bioscience, Biotechnology and Biochemistry, 77(12), 2430-2435. https://doi.org/10.1271/bbb.130541

γ-Mangostin from garcinia mangostana pericarps as a dual agonist that activates both PPARα and PPARδ. / Matsuura, Nobuyasu; Gamo, Kanae; Miyachi, Hiroyuki; Iinuma, Munekazu; Kawada, Teruo; Takahashi, Nobuyuki; Akao, Yukihiro; Tosa, Hideki.

In: Bioscience, Biotechnology and Biochemistry, Vol. 77, No. 12, 2013, p. 2430-2435.

Research output: Contribution to journal › Article

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Access to Document

10.1271/bbb.130541