Abstract
We tested the peroxisome proliferator-activated receptor (PPAR)δ agonistic activity of a Garcinia mangostana pericarp extract to develop a treatment for the metabolic syndrome, and demonstrated -mangostin to be an active compound on the basis of a luciferase reporter gene assay. γ-Mangostin induced the expression of the uncoupling protein-3 (UCP-3) gene which is related to energy expenditure and fat metabolism in L6 cells. We showed that -mangostin is a dual agonist that activates both PPARδ and PPARα. γ-Mangostin also induced the expression of acyl-CoA synthase and carnitine palmitoyl-transferase 1A genes in HepG2 cells. These results suggest the potential of γ-mangostin as a preventive agent of the metabolic syndrome.
| Original language | English |
|---|---|
| Pages (from-to) | 2430-2435 |
| Number of pages | 6 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 77 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 1 2013 |
Keywords
- Dual agonist
- Garcinia mangostanapericarp
- PPARα
- PPARδ
- γ-mangostin
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry
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Cite this
Matsuura, N., Gamo, K., Miyachi, H., Iinuma, M., Kawada, T., Takahashi, N., Akao, Y., & Tosa, H. (2013). γ-Mangostin from garcinia mangostana pericarps as a dual agonist that activates both PPARα and PPARδ. Bioscience, Biotechnology and Biochemistry, 77(12), 2430-2435. https://doi.org/10.1271/bbb.130541