γ-Mangostin from garcinia mangostana pericarps as a dual agonist that activates both PPARα and PPARδ

Nobuyasu Matsuura; Kanae Gamo; Hiroyuki Miyachi; Munekazu Iinuma; Teruo Kawada; Nobuyuki Takahashi; Yukihiro Akao; Hideki Tosa

doi:10.1271/bbb.130541

γ-Mangostin from garcinia mangostana pericarps as a dual agonist that activates both PPARα and PPARδ

Nobuyasu Matsuura, Kanae Gamo, Hiroyuki Miyachi, Munekazu Iinuma, Teruo Kawada, Nobuyuki Takahashi, Yukihiro Akao, Hideki Tosa

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

We tested the peroxisome proliferator-activated receptor (PPAR)δ agonistic activity of a Garcinia mangostana pericarp extract to develop a treatment for the metabolic syndrome, and demonstrated -mangostin to be an active compound on the basis of a luciferase reporter gene assay. γ-Mangostin induced the expression of the uncoupling protein-3 (UCP-3) gene which is related to energy expenditure and fat metabolism in L6 cells. We showed that -mangostin is a dual agonist that activates both PPARδ and PPARα. γ-Mangostin also induced the expression of acyl-CoA synthase and carnitine palmitoyl-transferase 1A genes in HepG2 cells. These results suggest the potential of γ-mangostin as a preventive agent of the metabolic syndrome.

Original language	English
Pages (from-to)	2430-2435
Number of pages	6
Journal	Bioscience, Biotechnology and Biochemistry
Volume	77
Issue number	12
DOIs	https://doi.org/10.1271/bbb.130541
Publication status	Published - 2013

Keywords

Dual agonist
Garcinia mangostanapericarp
PPARα
PPARδ
γ-mangostin

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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title = "γ-Mangostin from garcinia mangostana pericarps as a dual agonist that activates both PPARα and PPARδ",

abstract = "We tested the peroxisome proliferator-activated receptor (PPAR)δ agonistic activity of a Garcinia mangostana pericarp extract to develop a treatment for the metabolic syndrome, and demonstrated -mangostin to be an active compound on the basis of a luciferase reporter gene assay. γ-Mangostin induced the expression of the uncoupling protein-3 (UCP-3) gene which is related to energy expenditure and fat metabolism in L6 cells. We showed that -mangostin is a dual agonist that activates both PPARδ and PPARα. γ-Mangostin also induced the expression of acyl-CoA synthase and carnitine palmitoyl-transferase 1A genes in HepG2 cells. These results suggest the potential of γ-mangostin as a preventive agent of the metabolic syndrome.",

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author = "Nobuyasu Matsuura and Kanae Gamo and Hiroyuki Miyachi and Munekazu Iinuma and Teruo Kawada and Nobuyuki Takahashi and Yukihiro Akao and Hideki Tosa",

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doi = "10.1271/bbb.130541",

language = "English",

volume = "77",

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journal = "Bioscience, Biotechnology and Biochemistry",

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T1 - γ-Mangostin from garcinia mangostana pericarps as a dual agonist that activates both PPARα and PPARδ

AU - Matsuura, Nobuyasu

AU - Gamo, Kanae

AU - Miyachi, Hiroyuki

AU - Iinuma, Munekazu

AU - Kawada, Teruo

AU - Takahashi, Nobuyuki

AU - Akao, Yukihiro

AU - Tosa, Hideki

N1 - Funding Information: This work was supported by a matched fund subsidy for private universities from the Ministry of Education, Culture, Sports, Science and Technology (MEXT).

PY - 2013

Y1 - 2013

N2 - We tested the peroxisome proliferator-activated receptor (PPAR)δ agonistic activity of a Garcinia mangostana pericarp extract to develop a treatment for the metabolic syndrome, and demonstrated -mangostin to be an active compound on the basis of a luciferase reporter gene assay. γ-Mangostin induced the expression of the uncoupling protein-3 (UCP-3) gene which is related to energy expenditure and fat metabolism in L6 cells. We showed that -mangostin is a dual agonist that activates both PPARδ and PPARα. γ-Mangostin also induced the expression of acyl-CoA synthase and carnitine palmitoyl-transferase 1A genes in HepG2 cells. These results suggest the potential of γ-mangostin as a preventive agent of the metabolic syndrome.

AB - We tested the peroxisome proliferator-activated receptor (PPAR)δ agonistic activity of a Garcinia mangostana pericarp extract to develop a treatment for the metabolic syndrome, and demonstrated -mangostin to be an active compound on the basis of a luciferase reporter gene assay. γ-Mangostin induced the expression of the uncoupling protein-3 (UCP-3) gene which is related to energy expenditure and fat metabolism in L6 cells. We showed that -mangostin is a dual agonist that activates both PPARδ and PPARα. γ-Mangostin also induced the expression of acyl-CoA synthase and carnitine palmitoyl-transferase 1A genes in HepG2 cells. These results suggest the potential of γ-mangostin as a preventive agent of the metabolic syndrome.

KW - Dual agonist

KW - Garcinia mangostanapericarp

KW - PPARα

KW - PPARδ

KW - γ-mangostin

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γ-Mangostin from garcinia mangostana pericarps as a dual agonist that activates both PPARα and PPARδ

Abstract

Keywords

ASJC Scopus subject areas

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