γ-Mangostin from garcinia mangostana pericarps as a dual agonist that activates both PPARα and PPARδ

Nobuyasu Matsuura, Kanae Gamo, Hiroyuki Miyachi, Munekazu Iinuma, Teruo Kawada, Nobuyuki Takahashi, Yukihiro Akao, Hideki Tosa

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We tested the peroxisome proliferator-activated receptor (PPAR)δ agonistic activity of a Garcinia mangostana pericarp extract to develop a treatment for the metabolic syndrome, and demonstrated -mangostin to be an active compound on the basis of a luciferase reporter gene assay. γ-Mangostin induced the expression of the uncoupling protein-3 (UCP-3) gene which is related to energy expenditure and fat metabolism in L6 cells. We showed that -mangostin is a dual agonist that activates both PPARδ and PPARα. γ-Mangostin also induced the expression of acyl-CoA synthase and carnitine palmitoyl-transferase 1A genes in HepG2 cells. These results suggest the potential of γ-mangostin as a preventive agent of the metabolic syndrome.

Original languageEnglish
Pages (from-to)2430-2435
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Volume77
Issue number12
DOIs
Publication statusPublished - 2013

Keywords

  • Dual agonist
  • Garcinia mangostanapericarp
  • PPARα
  • PPARδ
  • γ-mangostin

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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  • Cite this

    Matsuura, N., Gamo, K., Miyachi, H., Iinuma, M., Kawada, T., Takahashi, N., Akao, Y., & Tosa, H. (2013). γ-Mangostin from garcinia mangostana pericarps as a dual agonist that activates both PPARα and PPARδ. Bioscience, Biotechnology and Biochemistry, 77(12), 2430-2435. https://doi.org/10.1271/bbb.130541