γδ T cells as regulators of airway hyperresponsiveness

Michael Lahn, Arihiko Kanehiro, Katsuyuki Takeda, Anatole Konowal, Rebecca L. O'Brien, Erwin W. Gelfand, Willi K. Born

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Airway responsiveness (AR) is determined by complex mechanisms reflecting lung responses to airborne stimuli. Murine studies have identified a number of potential factors modulating AR and thus have contributed to the current understanding of these mechanisms. In allergic inflammation, immune cells, in particularαβ T cells, have emerged as important contributors to increased AR. We have found that in contrast to αβ T cells, γδ T cells can have a negative regulatory effect on AR. Here, we review the current studies on γδ T cells in allergic inflammation and discuss their role in modulating AR. We propose that γδ T cells exhibit different immune properties depending on the type of stimulus and inflammation. These differential immune properties appear to be associated with specific γδ T cell subsets, which control AR to airborne stimuli. In particular, our recent data indicate that the Vγ4+T cell subset acts as an important negative regulator of AR and contributes to maintaining normal lung function in mice.

Original languageEnglish
Pages (from-to)203-210
Number of pages8
JournalInternational Archives of Allergy and Immunology
Volume125
Issue number3
DOIs
Publication statusPublished - 2001
Externally publishedYes

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Keywords

  • αβ T cells
  • γδ T Cells
  • Airway hyperresponsiveness
  • Allergy
  • Antigen presentation
  • Inflammation
  • Lung
  • Non-classical MHC class I

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Lahn, M., Kanehiro, A., Takeda, K., Konowal, A., O'Brien, R. L., Gelfand, E. W., & Born, W. K. (2001). γδ T cells as regulators of airway hyperresponsiveness. International Archives of Allergy and Immunology, 125(3), 203-210. https://doi.org/10.1159/000053817