γδ T cells are not essential for control of cutaneous Leishmania major infection in genetically resistant C57BL/6 mice

A. Satoskar, M. Okano, J. R. David

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

As γδ T cells are believed to be involved in host defense against Leishmania major, the role of γδ T cells in immunity against this parasite was investigated. The growth of L. major was measured in αβ (T cell receptor [TCR] α -/-) and γδ (TCR δ -/-) TCR-deficient C57BL/6 mice and compared with growth in control (C57BL/6) mice. While TCR α -/- mice developed nonhealing lesions containing large numbers of parasites following L. major infection, TCR δ -/- and C57BL/6 mice effectively controlled the infection. Following in vitro stimulation, lymph node cells from C57BL/6 mice produced significantly more interferon (IFN)-γ than those from TCR δ -/- mice during early and late phases of infection; however, both produced similar levels of IFN-γ at postinfection week 6. Culture supernatants from both TCR δ -/- and C57BL/6 mice contained interleukin-4, at postinfection week 2 only. These results indicate that γδ CD3 T cells are not essential for mediating protection against cutaneous L. major infection in C57BL/6 mice.

Original languageEnglish
Pages (from-to)1649-1652
Number of pages4
JournalJournal of Infectious Diseases
Volume176
Issue number6
DOIs
Publication statusPublished - Jan 1 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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