β2-Adrenergic receptor stimulation-induced immunosuppressive effects possibly through down-regulation of co-stimulatory molecules, ICAM-1, CD40 and CD14 on monocytes

K. Kuroki, H. K. Takahashi, H. Iwagaki, T. Murakami, M. Kuinose, S. Hamanaka, K. Minami, Masahiro Nishibori, N. Tanaka, K. Tanemoto

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We examined the effects of β2-adrenergic receptor (β2-AR) agonists on the expression of co-stimulatory molecules on lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells. The study found that β2-AR agonists inhibited the expression of intercellular adhesion molecule-1 (ICAM-1), CD40 and CD14 on monocytes, and that AR agonist activity was antagonized by the selective β2-AR antagonist, butoxamine. The selective β2-AR agonists salbutamol and terbutaline induced a similar co-stimulatory molecule expression pattern. The LPS-induced production of tumour necrosis factor-α. was inhibited by AR agonists, and this was also antagonized by butoxamine, and mimicked by salbutamol and terbutaline. The AR agonists also inhibited T-cell proliferation through β2-AR stimulation. This study clearly demonstrated that endogenous catecholamines elicited immunosuppressive effects through β2-AR stimulation, possibly due to down-regulation of the expression of ICAM-1, CD40 and CD14 on monocytes. These results suggested that the sympathetic nervous system might regulate the T-helper cell balance via the peripheral end-effectors of the stress system.

Original languageEnglish
Pages (from-to)465-483
Number of pages19
JournalJournal of International Medical Research
Volume32
Issue number5
Publication statusPublished - Sep 2004

Fingerprint

Adrenergic Agonists
Butoxamine
Intercellular Adhesion Molecule-1
Immunosuppressive Agents
Adrenergic Receptors
Terbutaline
Monocytes
Down-Regulation
Albuterol
Molecules
Lipopolysaccharides
Adrenergic Antagonists
T-cells
Sympathetic Nervous System
Cell proliferation
Neurology
End effectors
Helper-Inducer T-Lymphocytes
Catecholamines
Blood Cells

Keywords

  • Adrenergic receptor
  • CD40
  • Intercellular adhesion molecule-1 (ICAM-1)
  • Monocytes
  • Tumour necrosis factor (TNF)-α

ASJC Scopus subject areas

  • Medicine(all)

Cite this

β2-Adrenergic receptor stimulation-induced immunosuppressive effects possibly through down-regulation of co-stimulatory molecules, ICAM-1, CD40 and CD14 on monocytes. / Kuroki, K.; Takahashi, H. K.; Iwagaki, H.; Murakami, T.; Kuinose, M.; Hamanaka, S.; Minami, K.; Nishibori, Masahiro; Tanaka, N.; Tanemoto, K.

In: Journal of International Medical Research, Vol. 32, No. 5, 09.2004, p. 465-483.

Research output: Contribution to journalArticle

Kuroki, K, Takahashi, HK, Iwagaki, H, Murakami, T, Kuinose, M, Hamanaka, S, Minami, K, Nishibori, M, Tanaka, N & Tanemoto, K 2004, 'β2-Adrenergic receptor stimulation-induced immunosuppressive effects possibly through down-regulation of co-stimulatory molecules, ICAM-1, CD40 and CD14 on monocytes', Journal of International Medical Research, vol. 32, no. 5, pp. 465-483.
Kuroki, K. ; Takahashi, H. K. ; Iwagaki, H. ; Murakami, T. ; Kuinose, M. ; Hamanaka, S. ; Minami, K. ; Nishibori, Masahiro ; Tanaka, N. ; Tanemoto, K. / β2-Adrenergic receptor stimulation-induced immunosuppressive effects possibly through down-regulation of co-stimulatory molecules, ICAM-1, CD40 and CD14 on monocytes. In: Journal of International Medical Research. 2004 ; Vol. 32, No. 5. pp. 465-483.
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