β 2‐GPI‐dependent and independent binding of anticardiolipin antibodies in patients with recurrent spontaneous abortions

Nobuaki Ozawa, Tsunehisa Makino, Hidehiko Matsubayashi, Tomotoshi Hosokawa, Ken‐Ichi ‐I Someya, Shiro Nozawa, Eiji Matsuura

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We measured anticardiolipin antibodies (aCL) in plasma samples from 214 women with a history of recurrent spontaneous abortions by an enzyme‐linked immunosorbent assay (ELISA) utilizing solid phase cardiolipin (CL) and β2‐glycoprotein I (β2‐GPI). Sixteen patients (7.5%) were positive for β2‐GPI‐dependent aCL. Though β2‐GPI appeared to enhance the binding of aCL, β2‐GPI‐independent aCL were also observed in these patients (4.7%). The patients were classified into three groups on the basis of their medical history, and analysis of data of individual groups revealed that the incidence of β2‐GPI‐dependent aCL was significantly higher in patients who had experienced at least one fetal loss in the second or third trimester. © 1994 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)255-259
Number of pages5
JournalJournal of Clinical Laboratory Analysis
Volume8
Issue number5
DOIs
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

Anticardiolipin Antibodies
Habitual Abortion
Spontaneous Abortion
Immunosorbents
Cardiolipins
Third Pregnancy Trimester
Second Pregnancy Trimester
Assays
History
Plasmas
Incidence

Keywords

  • antiphospholipid syndrome
  • cofactor
  • habitual abortion
  • SLE (systemic lupus erythematosus)
  • thrombosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Hematology
  • Public Health, Environmental and Occupational Health
  • Clinical Biochemistry
  • Medical Laboratory Technology
  • Biochemistry, medical
  • Microbiology (medical)

Cite this

β 2‐GPI‐dependent and independent binding of anticardiolipin antibodies in patients with recurrent spontaneous abortions. / Ozawa, Nobuaki; Makino, Tsunehisa; Matsubayashi, Hidehiko; Hosokawa, Tomotoshi; Someya, Ken‐Ichi ‐I; Nozawa, Shiro; Matsuura, Eiji.

In: Journal of Clinical Laboratory Analysis, Vol. 8, No. 5, 1994, p. 255-259.

Research output: Contribution to journalArticle

Ozawa, Nobuaki ; Makino, Tsunehisa ; Matsubayashi, Hidehiko ; Hosokawa, Tomotoshi ; Someya, Ken‐Ichi ‐I ; Nozawa, Shiro ; Matsuura, Eiji. / β 2‐GPI‐dependent and independent binding of anticardiolipin antibodies in patients with recurrent spontaneous abortions. In: Journal of Clinical Laboratory Analysis. 1994 ; Vol. 8, No. 5. pp. 255-259.
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