β-pseudouridine, a beer component, reduces radiation-induced chromosome aberrations in human lymphocytes

Manami Monobe, Sakae Arimoto-Kobayashi, Koichi Ando

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

We previously found that drinking beer reduces chromosome aberrations in blood lymphocytes that were collect and irradiated in vitro. In this study, human whole-blood was in vitro exposed to 200kVp X-rays or 50keV/μm carbon ions in the presence or absence of beer, ethanol and β-pseudouridine (one of the beer components). All three agents reduced the chromosome aberrations (dicentric) caused by either X-rays or carbon ions of 4Gy. The maximum protection for X-rays by ethanol, beer and β-pseudouridine was 64, 26 and 34%, respectively, while the maximum protection for carbon-ion by ethanol, beer and β-pseudouridine was 22, 26 and 32%, respectively. It is concluded that β-pseudouridine, a nucleoside present in tRNA, is a potent protector against damage caused by radiation with direct and indirect actions.

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume538
Issue number1-2
DOIs
Publication statusPublished - Jul 8 2003

Keywords

  • Beer
  • Carbon ions
  • Chromosome aberration
  • X-rays
  • β-Pseudouridine

ASJC Scopus subject areas

  • Genetics
  • Health, Toxicology and Mutagenesis

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