TY - JOUR
T1 - β-pseudouridine, a beer component, reduces radiation-induced chromosome aberrations in human lymphocytes
AU - Monobe, Manami
AU - Arimoto-Kobayashi, Sakae
AU - Ando, Koichi
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid from the Ministry of Education, Science, Sports and Culture of Japan and by the Special Coordination Funds for Research Project with Heavy Ions at the National Institute of Radiological Sciences–Heavy-ion Medical Accelerator in Chiba (NIRS-HIMAC). We would like to thank Dr. Y. Furusawa for his helpful comments.
PY - 2003/7/8
Y1 - 2003/7/8
N2 - We previously found that drinking beer reduces chromosome aberrations in blood lymphocytes that were collect and irradiated in vitro. In this study, human whole-blood was in vitro exposed to 200kVp X-rays or 50keV/μm carbon ions in the presence or absence of beer, ethanol and β-pseudouridine (one of the beer components). All three agents reduced the chromosome aberrations (dicentric) caused by either X-rays or carbon ions of 4Gy. The maximum protection for X-rays by ethanol, beer and β-pseudouridine was 64, 26 and 34%, respectively, while the maximum protection for carbon-ion by ethanol, beer and β-pseudouridine was 22, 26 and 32%, respectively. It is concluded that β-pseudouridine, a nucleoside present in tRNA, is a potent protector against damage caused by radiation with direct and indirect actions.
AB - We previously found that drinking beer reduces chromosome aberrations in blood lymphocytes that were collect and irradiated in vitro. In this study, human whole-blood was in vitro exposed to 200kVp X-rays or 50keV/μm carbon ions in the presence or absence of beer, ethanol and β-pseudouridine (one of the beer components). All three agents reduced the chromosome aberrations (dicentric) caused by either X-rays or carbon ions of 4Gy. The maximum protection for X-rays by ethanol, beer and β-pseudouridine was 64, 26 and 34%, respectively, while the maximum protection for carbon-ion by ethanol, beer and β-pseudouridine was 22, 26 and 32%, respectively. It is concluded that β-pseudouridine, a nucleoside present in tRNA, is a potent protector against damage caused by radiation with direct and indirect actions.
KW - Beer
KW - Carbon ions
KW - Chromosome aberration
KW - X-rays
KW - β-Pseudouridine
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U2 - 10.1016/S1383-5718(03)00094-9
DO - 10.1016/S1383-5718(03)00094-9
M3 - Article
C2 - 12834758
AN - SCOPUS:0037756730
SN - 1383-5718
VL - 538
SP - 93
EP - 99
JO - Mutation Research - Genetic Toxicology and Environmental Mutagenesis
JF - Mutation Research - Genetic Toxicology and Environmental Mutagenesis
IS - 1-2
ER -