α2 integrin +807 polymorphism in drug-induced gingival overgrowth

M. Ogino, J. Kido, M. Bando, N. Hayashi, C. Wada, T. Nagata, F. Nishimura, Y. Soga, S. Takashiba, T. Kubota, M. Itagaki, Y. Shimada, H. Tai, H. Yoshie, N. Yamazaki, Y. Shinohara, M. Kataoka

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Abstract

α2 integrin on fibroblasts is reported to play an important role in the induction of drug-induced gingival overgrowth, which is characterized by excessive accumulation of type I collagen in gingival connective tissue. Silent polymorphism 807 T/C within the α2 integrin gene is associated with high/low α2 integrin expression. The aim of this study was to test the hypothesis that expression of α2 integrin 807 T/C polymorphism correlates with drug-induced gingival overgrowth. A case-control study comparing 136 subjects taking calcium channel blockers (72 with vs. 64 without drug-induced gingival overgrowth) demonstrated that the frequency of the +807 C allele was significantly higher in the case group than in the controls (odds ratio, 3.61; 95% confidence interval, 2.14 - 6.10; P < 0.05). The present findings suggest that the α2 +807 C allele is one of the genetic risk factors for drug-induced gingival overgrowth.

Original languageEnglish
Pages (from-to)1183-1186
Number of pages4
JournalJournal of dental research
Volume84
Issue number12
DOIs
Publication statusPublished - Dec 1 2005

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Keywords

  • Collagen phagocytosis
  • Drug-induced gingival overgrowth
  • SNP
  • α2 integrin

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Ogino, M., Kido, J., Bando, M., Hayashi, N., Wada, C., Nagata, T., Nishimura, F., Soga, Y., Takashiba, S., Kubota, T., Itagaki, M., Shimada, Y., Tai, H., Yoshie, H., Yamazaki, N., Shinohara, Y., & Kataoka, M. (2005). α2 integrin +807 polymorphism in drug-induced gingival overgrowth. Journal of dental research, 84(12), 1183-1186. https://doi.org/10.1177/154405910508401217