α1-adrenergic receptor antagonists induce production of IL-18 and expression of ICAM-1 and CD40 in human monocytes

Hideo Kohka Takahashi, Hiromi Iwagaki, Ryuji Tamura, Goutarou Katsuno, Dong Xue, Sachi Sugita, Shuji Mori, Tadashi Yoshino, Noriaki Tanaka, Masahiro Nishibori

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The activation of T cells plays a role in antitumor response. Monocytes activate T cells by inducing the cell-to-cell interaction that involves the engagement of adhesion molecules with their ligands, and the production of IL-18. The authors examined the effect of the quinazoline-based α1-adrenergic receptor antagonists bunazosin, doxazosin, prazosin, and terazosin on the expression of adhesion molecules such as ICAM-1, B7.1, B7.2, CD40, and CD40L on monocytes isolated from human peripheral blood mononuclear cells. Doxazosin, prazosin, and terazosin induced the expression of ICAM-1 and CD40 but had no effect on the expression of B7.1, B7.2, and CD40L. Moreover, IL-18 was detected in the medium of incubated monocytes treated with doxazosin, prazosin, and terazosin. Bunazosin did not affect adhesion molecule expression and IL-18 production, suggesting that the chemical structure of quinazoline might not be related to the effect of doxazosin, prazosin, and terazosin. Although caspase-1 inhibitor completely abolished the production of IL-18, anti-IL-18 mAb and caspase-1 inhibitor partially inhibited the increase in ICAM-1 and CD40 expression induced by doxazosin, prazosin, and terazosin. Doxazosin, prazosin, and terazosin can induce monocyte activation with a specific pattern of expression of adhesion molecules and IL-18 production, and this may lead to T-cell activation through the cell-to-cell interaction. The activation of T cells induced by the increase of the expression of ICAM-1 and CD40 and the production of IL-18 may be involved in the anti-cancer effects of doxazosin, prazosin, and terazosin.

Original languageEnglish
Pages (from-to)40-43
Number of pages4
JournalJournal of Immunotherapy
Volume28
Issue number1
Publication statusPublished - Jan 2005

Fingerprint

Terazosin
Doxazosin
Interleukin-18
Adrenergic Antagonists
Prazosin
Intercellular Adhesion Molecule-1
Monocytes
Quinazolines
T-Lymphocytes
CD40 Ligand
Cell Communication

Keywords

  • α1-antagonists
  • CD40
  • ICAM-1
  • IL-18
  • Monocytes

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology
  • Immunology

Cite this

α1-adrenergic receptor antagonists induce production of IL-18 and expression of ICAM-1 and CD40 in human monocytes. / Takahashi, Hideo Kohka; Iwagaki, Hiromi; Tamura, Ryuji; Katsuno, Goutarou; Xue, Dong; Sugita, Sachi; Mori, Shuji; Yoshino, Tadashi; Tanaka, Noriaki; Nishibori, Masahiro.

In: Journal of Immunotherapy, Vol. 28, No. 1, 01.2005, p. 40-43.

Research output: Contribution to journalArticle

Takahashi, HK, Iwagaki, H, Tamura, R, Katsuno, G, Xue, D, Sugita, S, Mori, S, Yoshino, T, Tanaka, N & Nishibori, M 2005, 'α1-adrenergic receptor antagonists induce production of IL-18 and expression of ICAM-1 and CD40 in human monocytes', Journal of Immunotherapy, vol. 28, no. 1, pp. 40-43.
Takahashi HK, Iwagaki H, Tamura R, Katsuno G, Xue D, Sugita S et al. α1-adrenergic receptor antagonists induce production of IL-18 and expression of ICAM-1 and CD40 in human monocytes. Journal of Immunotherapy. 2005 Jan;28(1):40-43.
Takahashi, Hideo Kohka ; Iwagaki, Hiromi ; Tamura, Ryuji ; Katsuno, Goutarou ; Xue, Dong ; Sugita, Sachi ; Mori, Shuji ; Yoshino, Tadashi ; Tanaka, Noriaki ; Nishibori, Masahiro. / α1-adrenergic receptor antagonists induce production of IL-18 and expression of ICAM-1 and CD40 in human monocytes. In: Journal of Immunotherapy. 2005 ; Vol. 28, No. 1. pp. 40-43.
@article{9a1a28b66c194af09837b225401ba3bc,
title = "α1-adrenergic receptor antagonists induce production of IL-18 and expression of ICAM-1 and CD40 in human monocytes",
abstract = "The activation of T cells plays a role in antitumor response. Monocytes activate T cells by inducing the cell-to-cell interaction that involves the engagement of adhesion molecules with their ligands, and the production of IL-18. The authors examined the effect of the quinazoline-based α1-adrenergic receptor antagonists bunazosin, doxazosin, prazosin, and terazosin on the expression of adhesion molecules such as ICAM-1, B7.1, B7.2, CD40, and CD40L on monocytes isolated from human peripheral blood mononuclear cells. Doxazosin, prazosin, and terazosin induced the expression of ICAM-1 and CD40 but had no effect on the expression of B7.1, B7.2, and CD40L. Moreover, IL-18 was detected in the medium of incubated monocytes treated with doxazosin, prazosin, and terazosin. Bunazosin did not affect adhesion molecule expression and IL-18 production, suggesting that the chemical structure of quinazoline might not be related to the effect of doxazosin, prazosin, and terazosin. Although caspase-1 inhibitor completely abolished the production of IL-18, anti-IL-18 mAb and caspase-1 inhibitor partially inhibited the increase in ICAM-1 and CD40 expression induced by doxazosin, prazosin, and terazosin. Doxazosin, prazosin, and terazosin can induce monocyte activation with a specific pattern of expression of adhesion molecules and IL-18 production, and this may lead to T-cell activation through the cell-to-cell interaction. The activation of T cells induced by the increase of the expression of ICAM-1 and CD40 and the production of IL-18 may be involved in the anti-cancer effects of doxazosin, prazosin, and terazosin.",
keywords = "α1-antagonists, CD40, ICAM-1, IL-18, Monocytes",
author = "Takahashi, {Hideo Kohka} and Hiromi Iwagaki and Ryuji Tamura and Goutarou Katsuno and Dong Xue and Sachi Sugita and Shuji Mori and Tadashi Yoshino and Noriaki Tanaka and Masahiro Nishibori",
year = "2005",
month = "1",
language = "English",
volume = "28",
pages = "40--43",
journal = "Journal of Immunotherapy",
issn = "1524-9557",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - α1-adrenergic receptor antagonists induce production of IL-18 and expression of ICAM-1 and CD40 in human monocytes

AU - Takahashi, Hideo Kohka

AU - Iwagaki, Hiromi

AU - Tamura, Ryuji

AU - Katsuno, Goutarou

AU - Xue, Dong

AU - Sugita, Sachi

AU - Mori, Shuji

AU - Yoshino, Tadashi

AU - Tanaka, Noriaki

AU - Nishibori, Masahiro

PY - 2005/1

Y1 - 2005/1

N2 - The activation of T cells plays a role in antitumor response. Monocytes activate T cells by inducing the cell-to-cell interaction that involves the engagement of adhesion molecules with their ligands, and the production of IL-18. The authors examined the effect of the quinazoline-based α1-adrenergic receptor antagonists bunazosin, doxazosin, prazosin, and terazosin on the expression of adhesion molecules such as ICAM-1, B7.1, B7.2, CD40, and CD40L on monocytes isolated from human peripheral blood mononuclear cells. Doxazosin, prazosin, and terazosin induced the expression of ICAM-1 and CD40 but had no effect on the expression of B7.1, B7.2, and CD40L. Moreover, IL-18 was detected in the medium of incubated monocytes treated with doxazosin, prazosin, and terazosin. Bunazosin did not affect adhesion molecule expression and IL-18 production, suggesting that the chemical structure of quinazoline might not be related to the effect of doxazosin, prazosin, and terazosin. Although caspase-1 inhibitor completely abolished the production of IL-18, anti-IL-18 mAb and caspase-1 inhibitor partially inhibited the increase in ICAM-1 and CD40 expression induced by doxazosin, prazosin, and terazosin. Doxazosin, prazosin, and terazosin can induce monocyte activation with a specific pattern of expression of adhesion molecules and IL-18 production, and this may lead to T-cell activation through the cell-to-cell interaction. The activation of T cells induced by the increase of the expression of ICAM-1 and CD40 and the production of IL-18 may be involved in the anti-cancer effects of doxazosin, prazosin, and terazosin.

AB - The activation of T cells plays a role in antitumor response. Monocytes activate T cells by inducing the cell-to-cell interaction that involves the engagement of adhesion molecules with their ligands, and the production of IL-18. The authors examined the effect of the quinazoline-based α1-adrenergic receptor antagonists bunazosin, doxazosin, prazosin, and terazosin on the expression of adhesion molecules such as ICAM-1, B7.1, B7.2, CD40, and CD40L on monocytes isolated from human peripheral blood mononuclear cells. Doxazosin, prazosin, and terazosin induced the expression of ICAM-1 and CD40 but had no effect on the expression of B7.1, B7.2, and CD40L. Moreover, IL-18 was detected in the medium of incubated monocytes treated with doxazosin, prazosin, and terazosin. Bunazosin did not affect adhesion molecule expression and IL-18 production, suggesting that the chemical structure of quinazoline might not be related to the effect of doxazosin, prazosin, and terazosin. Although caspase-1 inhibitor completely abolished the production of IL-18, anti-IL-18 mAb and caspase-1 inhibitor partially inhibited the increase in ICAM-1 and CD40 expression induced by doxazosin, prazosin, and terazosin. Doxazosin, prazosin, and terazosin can induce monocyte activation with a specific pattern of expression of adhesion molecules and IL-18 production, and this may lead to T-cell activation through the cell-to-cell interaction. The activation of T cells induced by the increase of the expression of ICAM-1 and CD40 and the production of IL-18 may be involved in the anti-cancer effects of doxazosin, prazosin, and terazosin.

KW - α1-antagonists

KW - CD40

KW - ICAM-1

KW - IL-18

KW - Monocytes

UR - http://www.scopus.com/inward/record.url?scp=19944428889&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=19944428889&partnerID=8YFLogxK

M3 - Article

C2 - 15614043

AN - SCOPUS:19944428889

VL - 28

SP - 40

EP - 43

JO - Journal of Immunotherapy

JF - Journal of Immunotherapy

SN - 1524-9557

IS - 1

ER -