α-tocopherol sensitizes human leukemia HL-60 cells to apoptosis induced by benzyl isothiocyanate

Naomi Abe; Tomomi Shimizu; Noriyuki Miyoshi; Yoshiyuki Murata; Yoshimasa Nakamura

doi:10.1271/bbb.110665

α-tocopherol sensitizes human leukemia HL-60 cells to apoptosis induced by benzyl isothiocyanate

Naomi Abe, Tomomi Shimizu, Noriyuki Miyoshi, Yoshiyuki Murata, Yoshimasa Nakamura

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Pre-treatment with α-tocopherol (α-Toc) potentiated cytotoxicity induction by benzyl isothiocyanate (BITC). Biochemical events related to apoptosis, such as DNA ladder formation and caspase-3 activation, were also enhanced by α-Toc. These results suggest a significant role of the caspase-3 pathway in apoptosis induction regulated by α-Toc in combination.

Original language	English
Pages (from-to)	381-383
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	76
Issue number	2
DOIs	https://doi.org/10.1271/bbb.110665
Publication status	Published - 2012

Keywords

Apoptosis
Benzyl isothiocyanate
Caspase-3
HL-60 cells
α-tocopherol

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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title = "α-tocopherol sensitizes human leukemia HL-60 cells to apoptosis induced by benzyl isothiocyanate",

abstract = "Pre-treatment with α-tocopherol (α-Toc) potentiated cytotoxicity induction by benzyl isothiocyanate (BITC). Biochemical events related to apoptosis, such as DNA ladder formation and caspase-3 activation, were also enhanced by α-Toc. These results suggest a significant role of the caspase-3 pathway in apoptosis induction regulated by α-Toc in combination.",

keywords = "Apoptosis, Benzyl isothiocyanate, Caspase-3, HL-60 cells, α-tocopherol",

author = "Naomi Abe and Tomomi Shimizu and Noriyuki Miyoshi and Yoshiyuki Murata and Yoshimasa Nakamura",

year = "2012",

doi = "10.1271/bbb.110665",

language = "English",

volume = "76",

pages = "381--383",

journal = "Bioscience, Biotechnology and Biochemistry",

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T1 - α-tocopherol sensitizes human leukemia HL-60 cells to apoptosis induced by benzyl isothiocyanate

AU - Abe, Naomi

AU - Shimizu, Tomomi

AU - Miyoshi, Noriyuki

AU - Murata, Yoshiyuki

AU - Nakamura, Yoshimasa

PY - 2012

Y1 - 2012

N2 - Pre-treatment with α-tocopherol (α-Toc) potentiated cytotoxicity induction by benzyl isothiocyanate (BITC). Biochemical events related to apoptosis, such as DNA ladder formation and caspase-3 activation, were also enhanced by α-Toc. These results suggest a significant role of the caspase-3 pathway in apoptosis induction regulated by α-Toc in combination.

AB - Pre-treatment with α-tocopherol (α-Toc) potentiated cytotoxicity induction by benzyl isothiocyanate (BITC). Biochemical events related to apoptosis, such as DNA ladder formation and caspase-3 activation, were also enhanced by α-Toc. These results suggest a significant role of the caspase-3 pathway in apoptosis induction regulated by α-Toc in combination.

KW - Apoptosis

KW - Benzyl isothiocyanate

KW - Caspase-3

KW - HL-60 cells

KW - α-tocopherol

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DO - 10.1271/bbb.110665

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EP - 383

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

SN - 0916-8451

IS - 2

ER -

α-tocopherol sensitizes human leukemia HL-60 cells to apoptosis induced by benzyl isothiocyanate

Abstract

Keywords

ASJC Scopus subject areas

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