α-tocopherol sensitizes human leukemia HL-60 cells to apoptosis induced by benzyl isothiocyanate

Naomi Abe; Tomomi Shimizu; Noriyuki Miyoshi; Yoshiyuki Murata; Yoshimasa Nakamura

doi:10.1271/bbb.110665

α-tocopherol sensitizes human leukemia HL-60 cells to apoptosis induced by benzyl isothiocyanate

Naomi Abe, Tomomi Shimizu, Noriyuki Miyoshi, Yoshiyuki Murata, Yoshimasa Nakamura

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

Pre-treatment with α-tocopherol (α-Toc) potentiated cytotoxicity induction by benzyl isothiocyanate (BITC). Biochemical events related to apoptosis, such as DNA ladder formation and caspase-3 activation, were also enhanced by α-Toc. These results suggest a significant role of the caspase-3 pathway in apoptosis induction regulated by α-Toc in combination.

Original language	English
Pages (from-to)	381-383
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	76
Issue number	2
DOIs	https://doi.org/10.1271/bbb.110665
Publication status	Published - 2012

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Keywords

α-tocopherol
Apoptosis
Benzyl isothiocyanate
Caspase-3
HL-60 cells

ASJC Scopus subject areas

Biotechnology
Biochemistry
Molecular Biology
Applied Microbiology and Biotechnology
Analytical Chemistry
Organic Chemistry

Cite this

Abe, N., Shimizu, T., Miyoshi, N., Murata, Y., & Nakamura, Y. (2012). α-tocopherol sensitizes human leukemia HL-60 cells to apoptosis induced by benzyl isothiocyanate. Bioscience, Biotechnology and Biochemistry, 76(2), 381-383. https://doi.org/10.1271/bbb.110665

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abstract = "Pre-treatment with α-tocopherol (α-Toc) potentiated cytotoxicity induction by benzyl isothiocyanate (BITC). Biochemical events related to apoptosis, such as DNA ladder formation and caspase-3 activation, were also enhanced by α-Toc. These results suggest a significant role of the caspase-3 pathway in apoptosis induction regulated by α-Toc in combination.",

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AU - Nakamura, Yoshimasa

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Access to Document

10.1271/bbb.110665