Abstract
Pre-treatment with α-tocopherol (α-Toc) potentiated cytotoxicity induction by benzyl isothiocyanate (BITC). Biochemical events related to apoptosis, such as DNA ladder formation and caspase-3 activation, were also enhanced by α-Toc. These results suggest a significant role of the caspase-3 pathway in apoptosis induction regulated by α-Toc in combination.
| Original language | English |
|---|---|
| Pages (from-to) | 381-383 |
| Number of pages | 3 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 76 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2012 |
Keywords
- Apoptosis
- Benzyl isothiocyanate
- Caspase-3
- HL-60 cells
- α-tocopherol
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry
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Cite this
Abe, N., Shimizu, T., Miyoshi, N., Murata, Y., & Nakamura, Y. (2012). α-tocopherol sensitizes human leukemia HL-60 cells to apoptosis induced by benzyl isothiocyanate. Bioscience, Biotechnology and Biochemistry, 76(2), 381-383. https://doi.org/10.1271/bbb.110665