α-tocopherol sensitizes human leukemia HL-60 cells to apoptosis induced by benzyl isothiocyanate

Naomi Abe, Tomomi Shimizu, Noriyuki Miyoshi, Yoshiyuki Murata, Yoshimasa Nakamura

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Pre-treatment with α-tocopherol (α-Toc) potentiated cytotoxicity induction by benzyl isothiocyanate (BITC). Biochemical events related to apoptosis, such as DNA ladder formation and caspase-3 activation, were also enhanced by α-Toc. These results suggest a significant role of the caspase-3 pathway in apoptosis induction regulated by α-Toc in combination.

Original languageEnglish
Pages (from-to)381-383
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume76
Issue number2
DOIs
Publication statusPublished - 2012

Keywords

  • Apoptosis
  • Benzyl isothiocyanate
  • Caspase-3
  • HL-60 cells
  • α-tocopherol

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Fingerprint Dive into the research topics of 'α-tocopherol sensitizes human leukemia HL-60 cells to apoptosis induced by benzyl isothiocyanate'. Together they form a unique fingerprint.

  • Cite this