α-Oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans

Kaeko Murota, Namiko Matsuda, Yasuaki Kashino, Yutaka Fujikura, Toshiyuki Nakamura, Yoji Kato, Ryosuke Shimizu, Syuji Okuyama, Hisashi Tanaka, Takatoshi Koda, Keiko Sekido, Junji Terao

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Dietary intake of quercetin is suggested to be potentially beneficial for the prevention of various diseases. We examined the effect of α-oligoglucosylation of the sugar moiety of quercetin monoglucoside on its bioavailability in humans. Enzymatically modified isoquercitrin (EMIQ) was prepared by enzymatic deglycosylation and the subsequent of α-oligoglucosylation of quercetin 3-O-β-rutinode (rutin). The plasma level of quercetin metabolites was instantly increased by oral intake of EMIQ and its absorption efficiency was significantly higher than that of isoquercitrin (quercetin 3-O-β-glucoside; Q3G), and rutin. The profile of plasma quercetin metabolites after EMIQ consumption did not differ from that after Q3G consumption. The apparent log P of EMIQ indicated that EMIQ is more hydrophilic than Q3G but less than quercetin 3,4'-O-β-diglucoside. These data indicated that enzymatic α-oligoglucosylation to the sugar moiety is effective for enhancing the bioavailability of quercetin glucosides in humans.

Original languageEnglish
Pages (from-to)91-97
Number of pages7
JournalArchives of Biochemistry and Biophysics
Volume501
Issue number1
DOIs
Publication statusPublished - Sep 2010
Externally publishedYes

Fingerprint

Quercetin
Glucosides
Sugars
Biological Availability
Metabolites
Plasmas
isoquercitrin

Keywords

  • α-Glucosylation
  • Bioavailability
  • EMIQ
  • Human
  • Quercetin

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology
  • Medicine(all)

Cite this

α-Oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans. / Murota, Kaeko; Matsuda, Namiko; Kashino, Yasuaki; Fujikura, Yutaka; Nakamura, Toshiyuki; Kato, Yoji; Shimizu, Ryosuke; Okuyama, Syuji; Tanaka, Hisashi; Koda, Takatoshi; Sekido, Keiko; Terao, Junji.

In: Archives of Biochemistry and Biophysics, Vol. 501, No. 1, 09.2010, p. 91-97.

Research output: Contribution to journalArticle

Murota, K, Matsuda, N, Kashino, Y, Fujikura, Y, Nakamura, T, Kato, Y, Shimizu, R, Okuyama, S, Tanaka, H, Koda, T, Sekido, K & Terao, J 2010, 'α-Oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans', Archives of Biochemistry and Biophysics, vol. 501, no. 1, pp. 91-97. https://doi.org/10.1016/j.abb.2010.06.036
Murota, Kaeko ; Matsuda, Namiko ; Kashino, Yasuaki ; Fujikura, Yutaka ; Nakamura, Toshiyuki ; Kato, Yoji ; Shimizu, Ryosuke ; Okuyama, Syuji ; Tanaka, Hisashi ; Koda, Takatoshi ; Sekido, Keiko ; Terao, Junji. / α-Oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans. In: Archives of Biochemistry and Biophysics. 2010 ; Vol. 501, No. 1. pp. 91-97.
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