Abstract
Dietary intake of quercetin is suggested to be potentially beneficial for the prevention of various diseases. We examined the effect of α-oligoglucosylation of the sugar moiety of quercetin monoglucoside on its bioavailability in humans. Enzymatically modified isoquercitrin (EMIQ) was prepared by enzymatic deglycosylation and the subsequent of α-oligoglucosylation of quercetin 3-O-β-rutinode (rutin). The plasma level of quercetin metabolites was instantly increased by oral intake of EMIQ and its absorption efficiency was significantly higher than that of isoquercitrin (quercetin 3-O-β-glucoside; Q3G), and rutin. The profile of plasma quercetin metabolites after EMIQ consumption did not differ from that after Q3G consumption. The apparent log P of EMIQ indicated that EMIQ is more hydrophilic than Q3G but less than quercetin 3,4'-O-β-diglucoside. These data indicated that enzymatic α-oligoglucosylation to the sugar moiety is effective for enhancing the bioavailability of quercetin glucosides in humans.
Original language | English |
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Pages (from-to) | 91-97 |
Number of pages | 7 |
Journal | Archives of Biochemistry and Biophysics |
Volume | 501 |
Issue number | 1 |
DOIs | |
Publication status | Published - Sep 2010 |
Externally published | Yes |
Keywords
- Bioavailability
- EMIQ
- Human
- Quercetin
- α-Glucosylation
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology