α-fetoprotein-producing endometrial adenocarcinoma without an obvious hepatoid component

Junichi Kodama, Noriko Seki, Hiroyuki Yanai, Tomoyuki Kusumoto, Keiichiro Nakamura, Atsushi Hongo, Yuji Hiramatsu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Endometrial carcinomas producing α-fetoprotein (AFP) are extremely rare. We report a case of AFP-producing, Grade 2 endometrioid adenocarcinoma without an obvious hepatoid component. A 59-year-old multiparous woman presented with abdominal swelling. The serum level of AFP was 1292.8 ng/ml. Magnetic resonance images of the pelvis showed a markedly enlarged uterus, with a tumor growing exophytically within the endometrial cavity. Total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed. The histopathological examination demonstrated a Stage IIA, Grade 2 endometrioid adenocarcinoma without an obvious hepatoid component. The endometrioid adenocarcinoma cells were partly positive for AFP immunoreactivity. The patient received adjuvant chemotherapy and was disease-free 60 months after the operation. This case confirms the existence of AFP-producing endometrioid adenocarcinomas without hepatoid features.

Original languageEnglish
Pages (from-to)243-245
Number of pages3
JournalOncology Letters
Volume1
Issue number2
DOIs
Publication statusPublished - Mar 2010

Keywords

  • Endometrial adenocarcinoma
  • Hepatoid
  • α-fetoprotein

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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