Tsutomu Ono

2005

Development of mammalian cell-enclosing subsieve-size agarose capsules (<100 μm) for cell therapy

Sakai, S., Kawabata, K., Ono, T., Ijima, H. & Kawakami, K., Aug 1 2005, In : Biomaterials. 26, 23, p. 4786-4792 7 p.

Research output: Contribution to journal › Article

Enhanced angiogenesis in bFGF-containing scaffold promoted viability of enclosed hepatocytes and maintained hepatospecific glycogen storage capacity

Takei, T., Ijima, H., Sakai, S., Ono, T. & Kawakami, K., Nov 20 2005, In : JOURNAL OF CHEMICAL ENGINEERING OF JAPAN. 38, 11, p. 913-917 5 p.

Research output: Contribution to journal › Article

5 Citations (Scopus)

Enhancement of liver-specific functions of primary rat hepatocytes co-cultured with bone marrow cells on tissue culture-treated polystyrene surfaces

Ijima, H., Murakami, S., Matsuo, T., Takei, T., Ono, T. & Kawakami, K., Aug 1 2005, In : Journal of Artificial Organs. 8, 2, p. 104-109 6 p.

Research output: Contribution to journal › Article

10 Citations (Scopus)

Higher viscous solution induces smaller droplets for cell-enclosing capsules in a co-flowing stream

Sakai, S., Kawabata, K., Ono, T., Ijima, H. & Kawakami, K., May 1 2005, In : Biotechnology Progress. 21, 3, p. 994-997 4 p.

Research output: Contribution to journal › Article

11 Citations (Scopus)

Nonaggregating refolding of ribonuclease A using reverse micellar dialysis

Ono, T., Nagatomo, M., Nagao, T., Ijima, H. & Kawakami, K., Feb 5 2005, In : Biotechnology and Bioengineering. 89, 3, p. 290-295 6 p.

Research output: Contribution to journal › Article

10 Citations (Scopus)

Transition of mechanical property of porous alginate scaffold with cells during culture period

Sakai, S., Masuhara, H., Yamada, Y., Ono, T., Ijima, H. & Kawakami, K., Jan 1 2005, In : Journal of Bioscience and Bioengineering. 100, 1, p. 127-129 3 p.

Research output: Contribution to journal › Article

18 Citations (Scopus)

2004

Behavior of enclosed sol- and gel-alginates in vivo

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., Dec 1 2004, In : Biochemical Engineering Journal. 22, 1, p. 19-24 6 p.

Research output: Contribution to journal › Article

14 Citations (Scopus)

Development of co-culture system of hepatocytes with bone marrow cells for expression and maintenance of hepatic functions

Murakami, S., Ijima, H., Ono, T. & Kawakami, K., Feb 2004, In : International Journal of Artificial Organs. 27, 2, p. 118-126 9 p.

Research output: Contribution to journal › Article

14 Citations (Scopus)

DNA extraction by cationic reverse micelles

Goto, M., Momota, A. & Ono, T., May 1 2004, In : Journal of Chemical Engineering of Japan. 37, 5, p. 662-668 7 p.

Research output: Contribution to journal › Article

19 Citations (Scopus)

Hydrothermal synthesis of porous hydroxyapatite plates from gypsum: Use as an animal cell culture substratum

Ijima, H., Nakashima, M., Furuta, S., Ono, T. & Kawakami, K., Apr 1 2004, In : JOURNAL OF CHEMICAL ENGINEERING OF JAPAN. 37, 4, p. 531-535 5 p.

Research output: Contribution to journal › Article

1 Citation (Scopus)

Hydroxyapatite for use as an animal cell culture substratum obtained by an alternate soaking process

Ijima, H., Ohchi, T., Ono, T. & Kawakami, K., Aug 15 2004, In : Biochemical Engineering Journal. 20, 2-3, p. 155-161 7 p.

Research output: Contribution to journal › Article

11 Citations (Scopus)

MIN6 cells-enclosing aminopropyl-silicate membrane templated by alginate gels differences in guluronic acid content

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., Feb 11 2004, In : International Journal of Pharmaceutics. 270, 1-2, p. 65-73 9 p.

Research output: Contribution to journal › Article

13 Citations (Scopus)

Preparation of Mammalian Cell-Enclosing Subsieve-Sized Capsules (< 100 μm) in a Coflowing Stream

Sakai, S., Kawabata, K., Ono, T., Ijima, H. & Kawakami, K., Apr 20 2004, In : Biotechnology and Bioengineering. 86, 2, p. 168-173 6 p.

Research output: Contribution to journal › Article

29 Citations (Scopus)

2003

Enhancement of protease activity in transesterification of glycidol with vinyl n-butyrate by entrapment into alkyl-substituted silicates and pretreatment with a substrate

Kawakami, K., Matsui, Y., Ono, T. & Ijima, H., Feb 1 2003, In : Biocatalysis and Biotransformation. 21, 1, p. 49-52 4 p.

Research output: Contribution to journal › Article

7 Citations (Scopus)

Modification of porous aminopropyl-silicate microcapsule membrane by electrically-bonded external anionic polymers

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., Aug 11 2003, In : Journal of Biomaterials Science, Polymer Edition. 14, 7, p. 643-652 10 p.

Research output: Contribution to journal › Article

12 Citations (Scopus)

Proliferation and insulin secretion function of mouse insulinoma cells encapsulated in alginate/sol-gel synthesized aminopropyl-silicate/alginate microcapsule

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., Sep 1 2003, In : Journal of Sol-Gel Science and Technology. 28, 2, p. 267-272 6 p.

Research output: Contribution to journal › Article

29 Citations (Scopus)

2002

Activation of protease by sol-gel entrapment into organically modified hybrid silicates

Furukawa, S. Y., Ono, T., Ijima, H. & Kawakami, K., Feb 12 2002, In : Biotechnology Letters. 24, 1, p. 13-16 4 p.

Research output: Contribution to journal › Article

13 Citations (Scopus)

Alginate/aminopropyl-silicate/alginate membrane immunoisolatability and insulin secretion of encapsulated islets

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., Apr 22 2002, In : Biotechnology Progress. 18, 2, p. 401-403 3 p.

Research output: Contribution to journal › Article

23 Citations (Scopus)

Aminopropyl-silicate membrane for microcapsule-shaped bioartificial organs: Control of molecular permeability

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., Jun 15 2002, In : Journal of Membrane Science. 202, 1-2, p. 73-80 8 p.

Research output: Contribution to journal › Article

20 Citations (Scopus)

Effect of imprinting sol-gel immobilized lipase with chiral template substrates in esterification of (R)-(+)- and (S)-(-)-glycidol

Furukawa, S. Y., Ono, T., Ijima, H. & Kawakami, K., Mar 7 2002, In : Journal of Molecular Catalysis - B Enzymatic. 17, 1, p. 23-28 6 p.

Research output: Contribution to journal › Article

36 Citations (Scopus)

In vitro and in vivo evaluation of alginate/sol-gel synthesized aminopropyl-silicate/alginate membrane for bioartificial pancreas

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., Aug 7 2002, In : Biomaterials. 23, 21, p. 4177-4183 7 p.

Research output: Contribution to journal › Article

78 Citations (Scopus)

Permeability of alginate/sol-gel synthesized aminopropyl-silicate/alginate membrane templated by calcium-alginate gel

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., Aug 1 2002, In : Journal of Membrane Science. 205, 1-2, p. 183-189 7 p.

Research output: Contribution to journal › Article

18 Citations (Scopus)

Permeability of a sol-gel synthesized aminopropyl-silicate-titanate hybrid membrane for the microcapsule-shaped bioartificial pancreas

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., Jan 1 2002, In : Journal of Artificial Organs. 5, 1, p. 54-59 6 p.

Research output: Contribution to journal › Article

1 Citation (Scopus)

2001

Catalytic oxidation of o-phenylenediamine by cytochrome c encapsulated in reversed micelles

Ono, T., Kawakami, K., Goto, M. & Furusaki, S., Jan 22 2001, In : Journal of Molecular Catalysis - B Enzymatic. 11, 4-6, p. 955-959 5 p.

Research output: Contribution to journal › Article

18 Citations (Scopus)

Control of Transport Characteristic of Membrane by Multi-layering of Polyelectrolyte Complex Toward Microcapsule-shaped Bioartificial Pancreas

Saka, S., Ono, T., Ijima, H. & Kawakami, K., 2001, In : Kagaku Kogaku Ronbunshu. 27, 2, p. 165-168 4 p.

Research output: Contribution to journal › Article

1 Citation (Scopus)

Enhancement of activity of sol-gel immobilized lipase in organic media by pretreatment with substrate analogues

Furukawa, S. Y., Ono, T., Ijima, H. & Kawakami, K., Sep 28 2001, In : Journal of Molecular Catalysis - B Enzymatic. 15, 1-3, p. 65-70 6 p.

Research output: Contribution to journal › Article

14 Citations (Scopus)

Evaluating the performance of a hybrid artificial liver support system with a recoverable hepatic failure rat model

Ijima, H., Noguchi, A., Katsuno, T., Ono, T., Nakazawa, K., Funatsu, K. & Kawakami, K., Jan 1 2001, In : Annals of the New York Academy of Sciences. 944, p. 344-349 6 p.

Research output: Contribution to journal › Article

4 Citations (Scopus)

Newly developed aminopropyl-silicate immunoisolation membrane for a microcapsule-shaped bioartificial pancreas

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., Jan 1 2001, In : Annals of the New York Academy of Sciences. 944, p. 277-283 7 p.

Research output: Contribution to journal › Article

15 Citations (Scopus)

Selective Extraction of Active α-Chymotrypsin by Reversed Micelles

Goto, M., Korenaga, M., Ono, T. & Furusaki, S., Jan 1 2001, In : KAGAKU KOGAKU RONBUNSHU. 27, 2, p. 181-185 5 p.

Research output: Contribution to journal › Article

Synthesis and transport characterization of alginate/aminopropyl-silicate/alginate microcapsule: Application to bioartificial pancreas

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., Aug 22 2001, In : Biomaterials. 22, 21, p. 2827-2834 8 p.

Research output: Contribution to journal › Article

83 Citations (Scopus)

2000

Catalytic capabilities of lipase immobilized into organically modified silicates by sol-gel method

Furukawa, S. Y., Ono, T., Ijima, H. & Kawakami, K., Dec 1 2000, In : KAGAKU KOGAKU RONBUNSHU. 26, 6, p. 885-886 2 p.

Research output: Contribution to journal › Article

4 Citations (Scopus)

Control of molecular weight cut-off immunoisolation by multilayering glycol chitosan-alginate polyion complex on alginate-based microcapsules

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., Jan 1 2000, In : Journal of Microencapsulation. 17, 6, p. 691-699 9 p.

Research output: Contribution to journal › Article

45 Citations (Scopus)

Important parameters affecting efficiency of protein refolding by reversed micelles

Goto, M., Hashimoto, Y., Fujita, T. A., Ono, T. & Furusaki, S., Dec 1 2000, In : Biotechnology Progress. 16, 6, p. 1079-1085 7 p.

Research output: Contribution to journal › Article

22 Citations (Scopus)

1999

Extraction of DNA by reversed micelles

Goto, M., Ono, T., Horiuchi, A. & Furusaki, S., Jan 1 1999, In : JOURNAL OF CHEMICAL ENGINEERING OF JAPAN. 32, 1, p. 123-125 3 p.

Research output: Contribution to journal › Article

31 Citations (Scopus)

Reversed micelles as novel protein refolding media

Goto, M., Ono, T. & Furusaki, S., Dec 1 1999, In : ACS Symposium Series. 740, p. 374-383 10 p.

Research output: Contribution to journal › Article

1998

Catalytic properties of novel reversed micellar system on trans-esterification by α-chymotrypsin in organic media

Iskandar, L., Ono, T., Kamiya, N., Goto, M., Nakashio, F. & Furusaki, S., Sep 1998, In : Biochemical Engineering Journal. 2, 1, p. 29-33 5 p.

Research output: Contribution to journal › Article

11 Citations (Scopus)

Extraction and activity of chymotrypsin using AOT-DOLPA mixed reversed micellar systems

Goto, M., Ishikawa, Y., Ono, T., Nakashio, F. & Alan Hatton, T., Sep 1 1998, In : Biotechnology Progress. 14, 5, p. 729-734 6 p.

Research output: Contribution to journal › Article

32 Citations (Scopus)

Factors affecting protein transfer into surfactant-isooctane solution: A case study of extraction behavior of chemically modified cytochrome c

Ono, T. & Goto, M., Jan 1 1998, In : Biotechnology Progress. 14, 6, p. 903-908 6 p.

Research output: Contribution to journal › Article

8 Citations (Scopus)

Protein refolding by reversed micelles utilizing solid-liquid extraction technique

Hashimoto, Y., Ono, T., Goto, M. & Hatton, T. A., Mar 5 1998, In : Biotechnology and Bioengineering. 57, 5, p. 620-623 4 p.

Research output: Contribution to journal › Article

49 Citations (Scopus)

1997

Design of surfactants suitable for protein extraction by reversed micelles

Goto, M., Ono, T., Nakashio, F. & Hatton, T. A., Apr 5 1997, In : Biotechnology and Bioengineering. 54, 1, p. 26-32 7 p.

Research output: Contribution to journal › Article

60 Citations (Scopus)

1996

Effect of organic solvents on extraction behaviour of cytochrome c using reversed micellar solutions

Ono, T., Miyazaki, T., Goto, M. & Nakashio, F., Dec 1 1996, In : Solvent Extraction Research and Development. 1996, 3, p. 1-9 9 p.

Research output: Contribution to journal › Article

7 Citations (Scopus)

Extraction behavior of hemoglobin using reversed micelles by dioleyl phosphoric acid

Ono, T., Goto, M., Nakashio, F. & Hatton, T. A., Nov 1 1996, In : Biotechnology Progress. 12, 6, p. 793-800 8 p.

Research output: Contribution to journal › Article

48 Citations (Scopus)

Novel immobilized enzymes utilizing reversed micellar solutions as an optical resolution tool

Ono, T., Goto, M., Nakashio, F. & Hatton, T. A., Aug 1 1996, In : JOURNAL OF CHEMICAL ENGINEERING OF JAPAN. 29, 4, p. 695-701 7 p.

Research output: Contribution to journal › Article

2 Citations (Scopus)

Reversed micelles recognize an active protein

Goto, M., Ono, T., Nakashio, F. & Hatton, T. A., Jan 1 1996, In : Biotechnology Techniques. 10, 3, p. 141-144 4 p.

Research output: Contribution to journal › Article

3 Citations (Scopus)

1995

Protein Extraction by New Reversed Micelles with Di(Tridecyl) Phosphoric Acid

Goto, M., Kuroki, M., Ono, T. & Nakashio, F. U., Jan 1 1995, In : Separation Science and Technology. 30, 1, p. 89-99 11 p.

Research output: Contribution to journal › Article

10 Citations (Scopus)