• 1581 Citations
  • 22 h-Index
19952019
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Research Output 1995 2019

  • 1581 Citations
  • 22 h-Index
  • 96 Article
  • 12 Conference contribution
  • 1 Review article
2007
3 Citations (Scopus)

Phase inversion temperature (Pit) method utilized preparation of o/w nano-emulsion by microreactor system

Kubota, J., Kato, A. & Ono, T., 2007, 2007 AIChE Annual Meeting.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Emulsification
Emulsions
Temperature
Ether
Polyethylene glycols
2006
6 Citations (Scopus)

Effect of diglucosamine on the entrapment of protein into liposomes

Murakami, S., Ono, T., Sakai, S., Ijima, H. & Kawakami, K., Jul 2006, In : Journal of Liposome Research. 16, 2, p. 103-112 10 p.

Research output: Contribution to journalArticle

Liposomes
Disaccharides
Bovine Serum Albumin
Proteins
Particle Size

Effects of lipid composition on entrapment of proteins into phosphatidylglycerol-containing liposomes

Murakami, S., Fujita, T., Ono, T., Sakai, S., Ijima, H. & Kawakami, K., 2006, In : Kagaku Kogaku Ronbunshu. 32, 6, p. 514-517 4 p.

Research output: Contribution to journalArticle

Phosphatidylglycerols
Liposomes
Lipids
Proteins
Chemical analysis

Fabrication of a silica monolith micro-bioreactor entrapping highly activated lipase by a two-step sol-gel method

Kawakami, K., Abe, D., Urakawa, T., Sakai, S., Ono, T. & Ijima, H., 2006, CHISA 2006 - 17th International Congress of Chemical and Process Engineering.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lipases
Bioreactors
Lipase
Silicon Dioxide
Sol-gel process
32 Citations (Scopus)

Fabrication of endothelialized tube in collagen gel as starting point for self-developing capillary-like network to construct three-dimensional organs in vitro

Takei, T., Sakai, S., Ono, T., Ijima, H. & Kawakami, K., Sep 5 2006, In : Biotechnology and Bioengineering. 95, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Collagen
Gels
Endothelial cells
Fabrication
Endothelial Cells

Peculiar thermo-responsive property of poly(aspartic acid) derivative having succinimide residue

Tanimoto, F., Ono, T., Kitamura, Y. & Yoshizawa, H., 2006, Polymer Preprints, Japan. 2 ed. Vol. 55. p. 4803 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Derivatives
Acids
Phase transitions
Polymer solutions
Chemical analysis
16 Citations (Scopus)

Peroxidative catalytic behavior of cytochrome c solubilized in reverse micelles

Ono, T. & Goto, M., Feb 15 2006, In : Biochemical Engineering Journal. 28, 2, p. 156-160 5 p.

Research output: Contribution to journalArticle

Micelles
Cytochromes c
Peroxidase
Proteins
Heme

Preparation of biodegradable polymeric microspheres using polymeric dispersants with poly(lactic acid) segments

Muranaka, M., Ono, T., Kitamura, Y. & Yoshizawa, H., 2006, Polymer Preprints, Japan. 2 ed. Vol. 55. p. 3466 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lactic acid
Microspheres
Ring opening polymerization
Copolymerization
Copolymers

Preparation of poly(succinimide) microcapsules with pH-response of drug release

Nishino, S., Ono, T., Kitamura, Y., Kishida, A. & Yoshizawa, H., 2006, AIChE Annual Meeting, Conference Proceedings.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

irinotecan
Emulsions
Capsules
Evaporation
Scanning electron microscopy

Protein encapsulation into thermo-responsive biodegradable nanospheres

Ono, T., Tanimoto, F., Miwake, H. & Yoshizawa, H., 2006, AIChE Annual Meeting, Conference Proceedings.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nanospheres
Encapsulation
Proteins
Polymers
Denaturation
2005
46 Citations (Scopus)

Development and characterization of a silica monolith immobilized enzyme micro-bioreactor

Kawakami, K., Sera, Y., Sakai, S., Ono, T. & Ijima, H., Jan 5 2005, In : Industrial and Engineering Chemistry Research. 44, 1, p. 236-240 5 p.

Research output: Contribution to journalArticle

Immobilized Enzymes
Bioreactors
Silicon Dioxide
bioreactor
Enzymes
68 Citations (Scopus)

Development of mammalian cell-enclosing subsieve-size agarose capsules (

Sakai, S., Kawabata, K., Ono, T., Ijima, H. & Kawakami, K., Aug 2005, In : Biomaterials. 26, 23, p. 4786-4792 7 p.

Research output: Contribution to journalArticle

Sepharose
Paraffins
Capsules
Mineral Oil
Cells
3 Citations (Scopus)

Enhanced angiogenesis in bFGF-containing scaffold promoted viability of enclosed hepatocytes and maintained hepatospecific glycogen storage capacity

Takei, T., Ijima, H., Sakai, S., Ono, T. & Kawakami, K., Nov 20 2005, In : Journal of Chemical Engineering of Japan. 38, 11, p. 913-917 5 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Fibroblasts
Glycogen
Scaffolds
Rats
10 Citations (Scopus)

Enhancement of liver-specific functions of primary rat hepatocytes co-cultured with bone marrow cells on tissue culture-treated polystyrene surfaces

Ijima, H., Murakami, S., Matsuo, T., Takei, T., Ono, T. & Kawakami, K., Aug 2005, In : Journal of Artificial Organs. 8, 2, p. 104-109 6 p.

Research output: Contribution to journalArticle

Tissue culture
Polystyrenes
Bone Marrow Cells
Liver
Rats
11 Citations (Scopus)

Higher viscous solution induces smaller droplets for cell-enclosing capsules in a co-flowing stream

Sakai, S., Kawabata, K., Ono, T., Ijima, H. & Kawakami, K., May 2005, In : Biotechnology Progress. 21, 3, p. 994-997 4 p.

Research output: Contribution to journalArticle

droplets
Capsules
Viscosity
viscosity
aqueous solutions
10 Citations (Scopus)

Nonaggregating refolding of ribonuclease A using reverse micellar dialysis

Ono, T., Nagatomo, M., Nagao, T., Ijima, H. & Kawakami, K., Feb 5 2005, In : Biotechnology and Bioengineering. 89, 3, p. 290-295 6 p.

Research output: Contribution to journalArticle

Pancreatic Ribonuclease
Dialysis
Glutathione Disulfide
Protein Refolding
Ultrafiltration
18 Citations (Scopus)

Transition of mechanical property of porous alginate scaffold with cells during culture period

Sakai, S., Masuhara, H., Yamada, Y., Ono, T., Ijima, H. & Kawakami, K., 2005, In : Journal of Bioscience and Bioengineering. 100, 1, p. 127-129 3 p.

Research output: Contribution to journalArticle

Alginate
Scaffolds (biology)
Cell culture
Cell Culture Techniques
Scaffolds
2004
14 Citations (Scopus)

Behavior of enclosed sol- and gel-alginates in vivo

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., Dec 2004, In : Biochemical Engineering Journal. 22, 1, p. 19-24 6 p.

Research output: Contribution to journalArticle

Alginates
Alginate
Polymethyl Methacrylate
Sols
Gels
14 Citations (Scopus)

Development of co-culture system of hepatocytes with bone marrow cells for expression and maintenance of hepatic functions

Murakami, S., Ijima, H., Ono, T. & Kawakami, K., Feb 2004, In : International Journal of Artificial Organs. 27, 2, p. 118-126 9 p.

Research output: Contribution to journalArticle

Coculture Techniques
Cell culture
Bone Marrow Cells
Hepatocytes
Bone
19 Citations (Scopus)

DNA extraction by cationic reverse micelles

Goto, M., Momota, A. & Ono, T., May 2004, In : Journal of Chemical Engineering of Japan. 37, 5, p. 662-668 7 p.

Research output: Contribution to journalArticle

Micelles
DNA
Cationic surfactants
Surface-Active Agents
Surface active agents
Animal cell culture
Hydrothermal synthesis
Gypsum
Chemical engineering
Hydroxyapatite
1 Citation (Scopus)

Hydrothermal synthesis of porous hydroxyapatite plates from gypsum: Use as an animal cell culture substratum

Ijima, H., Nakashima, M., Furuta, S., Ono, T. & Kawakami, K., Apr 2004, In : Journal of Chemical Engineering of Japan. 37, 4, p. 531-535 5 p.

Research output: Contribution to journalArticle

Animal cell culture
Calcium Sulfate
Hydrothermal synthesis
Gypsum
Durapatite
11 Citations (Scopus)

Hydroxyapatite for use as an animal cell culture substratum obtained by an alternate soaking process

Ijima, H., Ohchi, T., Ono, T. & Kawakami, K., Aug 15 2004, In : Biochemical Engineering Journal. 20, 2-3, p. 155-161 7 p.

Research output: Contribution to journalArticle

Animal cell culture
Durapatite
Hydroxyapatite
Cell Culture Techniques
CHO Cells

Mammalian cell encapsulation in monodisperse subsieve-sized (

Sakai, S., Kawabata, K., Ono, T., Ijima, H. & Kawakami, K., 2004, Transactions - 7th World Biomaterials Congress. p. 1510 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Encapsulation
Cells
Drop breakup
Polymer solutions
Metabolites
12 Citations (Scopus)

MIN6 cells-enclosing aminopropyl-silicate membrane templated by alginate gels differences in guluronic acid content

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., Feb 11 2004, In : International Journal of Pharmaceutics. 270, 1-2, p. 65-73 9 p.

Research output: Contribution to journalArticle

Silicates
Gels
Membranes
Capsules
Alginates
29 Citations (Scopus)

Preparation of Mammalian Cell-Enclosing Subsieve-Sized Capsules (<100 μm) in a Coflowing Stream

Sakai, S., Kawabata, K., Ono, T., Ijima, H. & Kawakami, K., Apr 20 2004, In : Biotechnology and Bioengineering. 86, 2, p. 168-173 6 p.

Research output: Contribution to journalArticle

Sodium alginate
Needles
Capsules
Cells
Mineral Oil
2003
7 Citations (Scopus)
glycidol
Silicates
Butyrates
Transesterification
Peptide Hydrolases
11 Citations (Scopus)

Modification of porous aminopropyl-silicate microcapsule membrane by electrically-bonded external anionic polymers

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., 2003, In : Journal of Biomaterials Science, Polymer Edition. 14, 7, p. 643-652 10 p.

Research output: Contribution to journalArticle

Silicates
Capsules
Biocompatibility
Polymers
Membranes
27 Citations (Scopus)
Silicates
insulin
secretions
Insulin
Alginate
2002
13 Citations (Scopus)

Activation of protease by sol-gel entrapment into organically modified hybrid silicates

Furukawa, S. Y., Ono, T., Ijima, H. & Kawakami, K., 2002, In : Biotechnology Letters. 24, 1, p. 13-16 4 p.

Research output: Contribution to journalArticle

Silicates
Polymethyl Methacrylate
Diatomaceous Earth
Sol-gels
Peptide Hydrolases
23 Citations (Scopus)

Alginate/aminopropyl-silicate/alginate membrane immunoisolatability and insulin secretion of encapsulated islets

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., 2002, In : Biotechnology Progress. 18, 2, p. 401-403 3 p.

Research output: Contribution to journalArticle

calcium alginate
Silicates
insulin secretion
alginates
silicates
19 Citations (Scopus)

Aminopropyl-silicate membrane for microcapsule-shaped bioartificial organs: Control of molecular permeability

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., Jun 15 2002, In : Journal of Membrane Science. 202, 1-2, p. 73-80 8 p.

Research output: Contribution to journalArticle

Bioartificial Organs
Silicates
organs
Capsules
Permeability
36 Citations (Scopus)

Effect of imprinting sol-gel immobilized lipase with chiral template substrates in esterification of (R)-(+)- and (S)-(-)-glycidol

Furukawa, S. Y., Ono, T., Ijima, H. & Kawakami, K., Mar 7 2002, In : Journal of Molecular Catalysis B: Enzymatic. 17, 1, p. 23-28 6 p.

Research output: Contribution to journalArticle

glycidol
Esterification
Lipases
Polymethyl Methacrylate
Lipase
76 Citations (Scopus)

In vitro and in vivo evaluation of alginate/sol-gel synthesized aminopropyl-silicate/alginate membrane for bioartificial pancreas

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., 2002, In : Biomaterials. 23, 21, p. 4177-4183 7 p.

Research output: Contribution to journalArticle

Silicates
Alginate
Polymethyl Methacrylate
Sol-gels
Pancreas
16 Citations (Scopus)

Permeability of alginate/sol-gel synthesized aminopropyl-silicate/alginate membrane templated by calcium-alginate gel

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., Aug 1 2002, In : Journal of Membrane Science. 205, 1-2, p. 183-189 7 p.

Research output: Contribution to journalArticle

Silicates
Alginate
Polymethyl Methacrylate
Sol-gels
calcium
1 Citation (Scopus)

Permeability of a sol-gel synthesized aminopropyl-silicate-titanate hybrid membrane for the microcapsule-shaped bioartificial pancreas

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., 2002, In : Journal of Artificial Organs. 5, 1, p. 54-59 6 p.

Research output: Contribution to journalArticle

Silicates
Alginate
Polymethyl Methacrylate
Capsules
Sol-gels
2001
18 Citations (Scopus)

Catalytic oxidation of o-phenylenediamine by cytochrome c encapsulated in reversed micelles

Ono, T., Kawakami, K., Goto, M. & Furusaki, S., Jan 22 2001, In : Journal of Molecular Catalysis B: Enzymatic. 11, 4-6, p. 955-959 5 p.

Research output: Contribution to journalArticle

Catalytic oxidation
Micelles
Cytochromes c
Proteins
Peroxidases
1 Citation (Scopus)

Control of Transport Characteristic of Membrane by Multi-layering of Polyelectrolyte Complex Toward Microcapsule-shaped Bioartificial Pancreas

Saka, S., Ono, T., Ijima, H. & Kawakami, K., 2001, In : Kagaku Kogaku Ronbunshu. 27, 2, p. 165-168 4 p.

Research output: Contribution to journalArticle

Polyelectrolytes
Capsules
Membranes
Alginate
Globulins
14 Citations (Scopus)

Enhancement of activity of sol-gel immobilized lipase in organic media by pretreatment with substrate analogues

Furukawa, S. Y., Ono, T., Ijima, H. & Kawakami, K., Sep 28 2001, In : Journal of Molecular Catalysis B: Enzymatic. 15, 1-3, p. 65-70 6 p.

Research output: Contribution to journalArticle

Lipases
Polymethyl Methacrylate
Lipase
Sol-gels
Gels
4 Citations (Scopus)

Evaluating the performance of a hybrid artificial liver support system with a recoverable hepatic failure rat model

Ijima, H., Noguchi, A., Katsuno, T., Ono, T., Nakazawa, K., Funatsu, K. & Kawakami, K., 2001, In : Annals of the New York Academy of Sciences. 944, p. 344-349 6 p.

Research output: Contribution to journalArticle

Artificial Liver
Liver Failure
Liver
Rats
Warm Ischemia
14 Citations (Scopus)

Newly developed aminopropyl-silicate immunoisolation membrane for a microcapsule-shaped bioartificial pancreas

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., 2001, In : Annals of the New York Academy of Sciences. 944, p. 277-283 7 p.

Research output: Contribution to journalArticle

Silicates
Capsules
Pancreas
Membranes
Gels

Selective extraction of active α-chymotrypsin by reversed micelles

Goto, M., Korenaga, M., Ono, T. & Furusaki, S., 2001, In : Kagaku Kogaku Ronbunshu. 27, 2, p. 184-185 2 p.

Research output: Contribution to journalArticle

Chymotrypsin
Micelles
Phosphoric acid
Proteins
Anionic surfactants
80 Citations (Scopus)

Synthesis and transport characterization of alginate/aminopropyl-silicate/alginate microcapsule: Application to bioartificial pancreas

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., 2001, In : Biomaterials. 22, 21, p. 2827-2834 8 p.

Research output: Contribution to journalArticle

Silicates
Alginate
Capsules
Pancreas
Gels
2000
4 Citations (Scopus)

Catalytic capabilities of lipase immobilized into organically modified silicates by sol-gel method

Furukawa, S. Y., Ono, T., Ijima, H. & Kawakami, K., 2000, In : Kagaku Kogaku Ronbunshu. 26, 6, p. 885-886 2 p.

Research output: Contribution to journalArticle

Silicates
Lipases
Lipase
Sol-gel process
Diatomaceous Earth
45 Citations (Scopus)

Control of molecular weight cut-off immunoisolation by multilayering glycol chitosan-alginate polyion complex on alginate-based microcapsules

Sakai, S., Ono, T., Ijima, H. & Kawakami, K., 2000, In : Journal of Microencapsulation. 17, 6, p. 691-699 9 p.

Research output: Contribution to journalArticle

Alginate
Glycols
Chitosan
globulins
Capsules
21 Citations (Scopus)

Important parameters affecting efficiency of protein refolding by reversed micelles

Goto, M., Hashimoto, Y., Fujita, T. A., Ono, T. & Furusaki, S., 2000, In : Biotechnology Progress. 16, 6, p. 1079-1085 7 p.

Research output: Contribution to journalArticle

Protein Refolding
Micelles
micelles
Pancreatic Ribonuclease
Proteins
1999
31 Citations (Scopus)

Extraction of DNA by reversed micelles

Goto, M., Ono, T., Horiuchi, A. & Furusaki, S., 1999, In : Journal of Chemical Engineering of Japan. 32, 1, p. 123-125 3 p.

Research output: Contribution to journalArticle

Micelles
DNA
Cationic surfactants
Deoxyribonucleotides
Coulomb interactions

Reversed micelles as novel protein refolding media

Goto, M., Ono, T. & Furusaki, S., 1999, In : ACS Symposium Series. 740, p. 374-383 10 p.

Research output: Contribution to journalArticle

Micelles
Pancreatic Ribonuclease
Proteins
Liquids
Surface-Active Agents
1998
11 Citations (Scopus)

Catalytic properties of novel reversed micellar system on trans-esterification by α-chymotrypsin in organic media

Iskandar, L., Ono, T., Kamiya, N., Goto, M., Nakashio, F. & Furusaki, S., Sep 1998, In : Biochemical Engineering Journal. 2, 1, p. 29-33 5 p.

Research output: Contribution to journalArticle

Esterification
Transesterification
Chymotrypsin
Micelles
Sodium