• 9306 Citations
  • 45 h-Index
1983 …2019
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Research Output 1983 2019

2019

Acquired resistance mechanisms to afatinib in HER2-amplified gastric cancer cells

Yoshioka, T., Shien, K., Takeda, T., Takahashi, Y., Kurihara, E., Ogoshi, Y., Namba, K., Torigoe, H., Sato, H., Tomida, S., Yamamoto, H., Sou, J., Fujiwara, T. & Toyooka, S., Jan 1 2019, In : Cancer Science.

Research output: Contribution to journalArticle

Open Access
Stomach Neoplasms
Cell Line
BIBW 2992
human ERBB2 protein
Drug Resistance
1 Citation (Scopus)

Activation of AZIN1 RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancer

Takeda, S., Shigeyasu, K., Okugawa, Y., Yoshida, K., Mori, Y., Yano, S., Noma, K., Umeda, Y., Kondo, Y., Kishimoto, H., Teranishi, F., Nagasaka, T., Tazawa, H., Kagawa, S., Fujiwara, T. & Goel, A., Mar 1 2019, In : Cancer Letters. 444, p. 127-135 9 p.

Research output: Contribution to journalArticle

RNA Editing
Colorectal Neoplasms
Fibroblasts
Tumor Microenvironment
Neoplasms

A novel combination cancer therapy with iron chelator targeting cancer stem cells via suppressing stemness

Katsura, Y., Ohara, T., Noma, K., Ninomiya, T., Kashima, H., Kato, T., Sato, H., Komoto, S., Narusaka, T., Tomono, Y., Xing, B., Chen, Y., Tazawa, H., Kagawa, S., Shirakawa, Y., Kasai, T., Seno, M., Matsukawa, A. & Fujiwara, T., Feb 1 2019, In : Cancers. 11, 2, 177.

Research output: Contribution to journalArticle

Open Access
Neoplastic Stem Cells
Chelating Agents
Iron
Neoplasms
Stem Cells
3 Citations (Scopus)

Cancer-associated fibroblasts (CAFs) promote the lymph node metastasis of esophageal squamous cell carcinoma

Kashima, H., Noma, K., Ohara, T., Kato, T., Katsura, Y., Komoto, S., Sato, H., Katsube, R., Ninomiya, T., Tazawa, H., Shirakawa, Y. & Fujiwara, T., Feb 15 2019, In : International Journal of Cancer. 144, 4, p. 828-840 13 p.

Research output: Contribution to journalArticle

Esophageal Neoplasms
Lymph Nodes
Neoplasm Metastasis
Tumor Microenvironment
Neoplasms

Clinical impact of sarcopenia on gastric cancer

Kuwada, K., Kuroda, S., Kikuchi, S., Yoshida, R., Nishizaki, M., Kagawa, S. & Fujiwara, T., May 1 2019, In : Anticancer research. 39, 5, p. 2241-2249 9 p.

Research output: Contribution to journalReview article

Open Access
Sarcopenia
Stomach Neoplasms
Muscle Strength
Weight Loss
Neoplasms

Current status of site-specific cancer registry system for the clinical researches: aiming for future contribution by the assessment of present medical care

Hirata, K., Imamura, M., Fujiwara, T., Fukui, T., Furukawa, T., Gotoh, M., Hakamada, K., Ishiguro, M., Kakeji, Y., Konno, H., Miyata, H., Mori, M., Okita, K., Sato, M., Shibata, A., Takemasa, I., Unno, M., Yokoi, K., Nishidate, T. & Nishiyama, M., Jan 1 2019, In : International Journal of Clinical Oncology.

Research output: Contribution to journalArticle

Registries
Research
Neoplasms
Conflict of Interest
Informatics

Detection of circulating microRNAs with Ago2 complexes to monitor the tumor dynamics of colorectal cancer patients during chemotherapy

Fuji, T., Umeda, Y., Nyuya, A., Taniguchi, F., Kawai, T., Yasui, K., Toshima, T., Yoshida, K., Fujiwara, T., Goel, A. & Nagasaka, T., Jan 1 2019, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

MicroRNAs
Colorectal Neoplasms
Drug Therapy
Neoplasms
Biomarkers
Esophageal Neoplasms

Higher human lymphocyte antigen class I expression in early-stage cancer cells leads to high sensitivity for cytotoxic T lymphocytes

Akazawa, Y., Nobuoka, D., Takahashi, M., Yoshikawa, T., Shimomura, M., Mizuno, S., Fujiwara, T., Nakamoto, Y. & Nakatsura, T., Jun 1 2019, In : Cancer Science. 110, 6, p. 1842-1852 11 p.

Research output: Contribution to journalArticle

Open Access
Histocompatibility Antigens Class I
Cytotoxic T-Lymphocytes
Lymphocytes
Neoplasms
Hepatocellular Carcinoma
1 Citation (Scopus)

PD-L1 expression combined with microsatellite instability/CD8+ tumor infiltrating lymphocytes as a useful prognostic biomarker in gastric cancer

Morihiro, T., Kuroda, S., Kanaya, N., Kakiuchi, Y., Kubota, T., Aoyama, K., Tanaka, T., Kikuchi, S., Nagasaka, T., Nishizaki, M., Kagawa, S., Tazawa, H. & Fujiwara, T., Mar 15 2019, In : Scientific reports. 9, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Tumor-Infiltrating Lymphocytes
Microsatellite Instability
Stomach Neoplasms
Biomarkers
Ligands

Photoimmunotherapy for cancer-associated fibroblasts targeting fibroblast activation protein in human esophageal squamous cell carcinoma

Watanabe, S., Noma, K., Ohara, T., Kashima, H., Sato, H., Kato, T., Urano, S., Katsube, R., Hashimoto, Y., Tazawa, H., Kagawa, S., Shirakawa, Y., Kobayashi, H. & Fujiwara, T., Jan 1 2019, In : Cancer Biology and Therapy.

Research output: Contribution to journalArticle

Fibroblasts
Phototherapy
Proteins
Therapeutics
Photosensitizing Agents
Hepatitis B Surface Antigens
End Stage Liver Disease
Liver
Liver Transplantation
Vaccination

The clinicopathological differences of sporadic non-ampullary duodenal epithelial neoplasm depending on tumor location

Matsueda, K., Kanzaki, H., Matsueda, K., Nasu, J., Yoshioka, M., Nakagawa, M., Inoue, M., Inaba, T., Imagawa, A., Takatani, M., Takenaka, R., Suzuki, S., Tomoda, J., Yagi, T., Fujiwara, T., Tanaka, T. & Okada, H., Jan 1 2019, In : Journal of Gastroenterology and Hepatology (Australia).

Research output: Contribution to journalArticle

Duodenal Neoplasms
Glandular and Epithelial Neoplasms
Carcinoma
Neoplasms
Adenoma
2018
4 Citations (Scopus)

Accuracy of four mononucleotide-repeat markers for the identification of DNA mismatch-repair deficiency in solid tumors

Takehara, Y., Nagasaka, T., Nyuya, A., Haruma, T., Haraga, J., Mori, Y., Nakamura, K., Fujiwara, T., Boland, C. R. & Goel, A., Jan 12 2018, In : Journal of Translational Medicine. 16, 1, 5.

Research output: Contribution to journalArticle

DNA Repair-Deficiency Disorders
DNA Mismatch Repair
Tumors
Repair
DNA

A multicenter observational study on the clinicopathological features of gastric cancer in young patients

Kono, Y., Kanzaki, H., Tsuzuki, T., Takatani, M., Nasu, J., Kawai, D., Takenaka, R., Tanaka, T., Iwamuro, M., Kawano, S., Kawahara, Y., Fujiwara, T. & Okada, H., Jan 1 2018, (Accepted/In press) In : Journal of Gastroenterology.

Research output: Contribution to journalArticle

Multicenter Studies
Stomach Neoplasms
Observational Studies
Helicobacter pylori
Helicobacter Infections
5 Citations (Scopus)

Antitumor activity of pan-HER inhibitors in HER2-positive gastric cancer

Yoshioka, T., Shien, K., Namba, K., Torigoe, H., Sato, H., Tomida, S., Yamamoto, H., Asano, H., Sou, J., Tsukuda, K., Nagasaka, T., Fujiwara, T. & Toyooka, S., Apr 1 2018, In : Cancer Science. 109, 4, p. 1166-1176 11 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Somatomedin Receptors
Pharmaceutical Preparations
Cell Line
Therapeutics
Tricuspid Valve Insufficiency
Living Donors
Liver Transplantation
Pulmonary Artery
Pressure
6 Citations (Scopus)

AZIN1 RNA editing confers cancer stemness and enhances oncogenic potential in colorectal cancer

Shigeyasu, K., Okugawa, Y., Toden, S., Miyoshi, J., Toiyama, Y., Nagasaka, T., Takahashi, N., Kusunoki, M., Takayama, T., Yamada, Y., Fujiwara, T., Chen, L. & Goel, A., Jun 21 2018, In : JCI insight. 3, 12

Research output: Contribution to journalArticle

Open Access
RNA Editing
Colorectal Neoplasms
Neoplasms
Inosine
Adenosine Deaminase
2 Citations (Scopus)

BRAF V600E mutation is a predictive indicator of upfront chemotherapy for stage IV colorectal cancer

Morikawa, T., Inada, R., Nagasaka, T., Mori, Y., Kishimoto, H., Kawai, T., Umeda, Y., Mishima, H., Goel, A. & Fujiwara, T., Feb 1 2018, In : Oncology Letters. 15, 2, p. 2195-2201 7 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Drug Therapy
Mutation
Exons
Neoplasms
18 Citations (Scopus)

Cancer-associated fibroblasts affect intratumoral CD8þ and Foxp3þ T cells via IL6 in the tumor microenvironment

Kato, T., Noma, K., Ohara, T., Kashima, H., Katsura, Y., Sato, H., Komoto, S., Katsube, R., Ninomiya, T., Tazawa, H., Shirakawa, Y. & Fujiwara, T., Oct 1 2018, In : Clinical Cancer Research. 24, 19, p. 4820-4833 14 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Tumor-Infiltrating Lymphocytes
Interleukin-6
T-Lymphocytes
Neoplasms
1 Citation (Scopus)

Clinical characteristics and management of gastric tube cancer after esophagectomy

Shirakawa, Y., Noma, K., Maeda, N., Ninomiya, T., Tanabe, S., Kikuchi, S., Kuroda, S., Nishizaki, M., Kagawa, S., Kawahara, Y., Okada, H. & Fujiwara, T., Mar 27 2018, (Accepted/In press) In : Esophagus. p. 1-10 10 p.

Research output: Contribution to journalArticle

Esophagectomy
Esophageal Neoplasms
Stomach Neoplasms
Thorax
Neoplasms

Clinical outcomes of women with ovarian metastases of colorectal cancer treated with oophorectomy with respect to their somatic mutation profiles

Mori, Y., Nyuya, A., Yasui, K., Toshima, T., Kawai, T., Taniguchi, F., Kimura, K., Inada, R., Nishizaki, M., Haraga, J., Nakamura, K., Umeda, Y., Kishimoto, H., Fujiwara, T., Katata, Y., Yamaguchi, Y. & Nagasaka, T., Jan 1 2018, In : Oncotarget. 9, 23, p. 16477-16488 12 p.

Research output: Contribution to journalArticle

Ovariectomy
Colorectal Neoplasms
Neoplasm Metastasis
Mutation
Survival

Clinicopathological features of breast cancer in Japanese female patients with Lynch syndrome

Kanaya, N., Tanakaya, K., Yamasaki, R., Arata, T., Shigeyasu, K., Aoki, H., Morito, T., Sanaii, H., Akagi, K. & Fujiwara, T., Jan 1 2018, (Accepted/In press) In : Breast Cancer.

Research output: Contribution to journalArticle

Hereditary Nonpolyposis Colorectal Neoplasms
Breast Neoplasms
Progesterone Receptors
Estrogen Receptors
Tumor-Infiltrating Lymphocytes

Current status of projects for developing cancer-related clinical practice guidelines in Japan and recommendations for the future

Imamura, M., Hirata, K., Unno, M., Kamiya, K., Gotoh, M., Konno, H., Shibata, A., Sugihara, K., Takahashi, A., Nishiyama, M., Hakamada, K., Fukui, T., Furukawa, T., Mizushima, T., Mizuma, M., Miyata, H., Mori, M., Takemasa, I., Mizuguchi, T. & Fujiwara, T., Jan 1 2018, (Accepted/In press) In : International Journal of Clinical Oncology.

Research output: Contribution to journalArticle

Practice Guidelines
Japan
Organizations
Budgets
Guidelines
4 Citations (Scopus)

Detection of circulating tumor cells in cervical cancer using a conditionally replicative adenovirus targeting telomerase-positive cells

Takakura, M., Matsumoto, T., Nakamura, M., Mizumoto, Y., Myojyo, S., Yamazaki, R., Iwadare, J., Bono, Y., Orisaka, S., Obata, T., Iizuka, T., Kagami, K., Nakayama, K., Hayakawa, H., Sakurai, F., Mizuguchi, H., Urata, Y., Fujiwara, T., Kyo, S., Sasagawa, T. & 1 others, Fujiwara, H., Jan 1 2018, In : Cancer Science. 109, 1, p. 231-240 10 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Telomerase
Adenoviridae
Uterine Cervical Neoplasms
Keratins
3 Citations (Scopus)
Pancreaticoduodenectomy
Randomized Controlled Trials
Length of Stay
Quality of Life
Costs and Cost Analysis
3 Citations (Scopus)

HER2-targeted gold nanoparticles potentially overcome resistance to trastuzumab in gastric cancer

Kubota, T., Kuroda, S., Kanaya, N., Morihiro, T., Aoyama, K., Kakiuchi, Y., Kikuchi, S., Nishizaki, M., Kagawa, S., Tazawa, H. & Fujiwara, T., Aug 1 2018, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 14, 6, p. 1919-1929 11 p.

Research output: Contribution to journalArticle

Gold
Nanoparticles
Stomach Neoplasms
Antibodies
Tumors

Heterogeneity of Epigenetic and Epithelial Mesenchymal Transition Marks in Hepatocellular Carcinoma with Keratin 19 Proficiency

Yokomichi, N., Nishida, N., Umeda, Y., Taniguchi, F., Yasui, K., Toshima, T., Mori, Y., Nyuya, A., Tanaka, T., Yamada, T., Yagi, T., Fujiwara, T., Yamaguchi, Y., Goel, A., Kudo, M. & Nagasaka, T., Jan 1 2018, (Accepted/In press) In : Liver Cancer.

Research output: Contribution to journalArticle

Keratin-19
Epithelial-Mesenchymal Transition
Epigenomics
Hepatocellular Carcinoma
decitabine

Integrated fluorescent cytology with nano-biologics in peritoneally disseminated gastric cancer

Watanabe, M., Kagawa, S., Kuwada, K., Hashimoto, Y., Shigeyasu, K., Ishida, M., Sakamoto, S., Ito, A., Kikuchi, S., Kuroda, S., Kishimoto, H., Tomida, S., Yoshida, R., Tazawa, H., Urata, Y. & Fujiwara, T., Jan 1 2018, (Accepted/In press) In : Cancer Science.

Research output: Contribution to journalArticle

Biological Products
Stomach Neoplasms
Cell Biology
Precision Medicine
Recurrence
Budd-Chiari Syndrome
Venae Cavae
Living Donors
Inferior Vena Cava
Transplantation
8 Citations (Scopus)

Novel evidence for a PIWI-interacting RNA (piRNA) as an oncogenic mediator of disease progression, and a potential prognostic biomarker in colorectal cancer

Weng, W., Liu, N., Toiyama, Y., Kusunoki, M., Nagasaka, T., Fujiwara, T., Wei, Q., Qin, H., Lin, H., Ma, Y. & Goel, A., Jan 30 2018, In : Molecular Cancer. 17, 1, 16.

Research output: Contribution to journalArticle

Disease Progression
Colorectal Neoplasms
Biomarkers
RNA
Untranslated RNA
3 Citations (Scopus)
Hepatectomy
Nutritional Status
Hepatocellular Carcinoma
Nutrition Assessment
Mortality
Transplantation (surgical)
Transplants
Pediatrics
Living Donors
Liver

Prolonged epigastric pain caused by a leaf stem embedded in the gastric wall

Yoshioka, T., Iwamuro, M., Takeda, H. & Fujiwara, T., Jan 1 2018, In : Internal Medicine. 57, 17, p. 2497-2500 4 p.

Research output: Contribution to journalArticle

Foreign Bodies
Stomach
Digestive System Endoscopy
Pain
Mustard Plant
Patient-Controlled Analgesia
Epidural Analgesia
Gastrectomy
Postoperative Pain
Surgery

Risk Analysis for Invasive Fungal Infection after Living Donor Liver Transplantation: Which Patient Needs Potent Prophylaxis?

Utsumi, M., Umeda, Y., Yagi, T., Nagasaka, T., Shinoura, S., Yoshida, R., Nobuoka, D., Kuise, T., Fuji, T., Takagi, K., Takaki, A. & Fujiwara, T., Apr 12 2018, (Accepted/In press) In : Digestive Surgery.

Research output: Contribution to journalArticle

Living Donors
Liver Transplantation
Transplants
Liver
Trichosporon
4 Citations (Scopus)
Sarcopenia
Stomach Neoplasms
Comorbidity
Cause of Death
Multivariate Analysis
2 Citations (Scopus)
Metformin
Safety
Neoplasms
Programmed Cell Death 1 Receptor
Pharmacokinetics

The Elucidation of Tumor Immunosuppression Affected by Cancer-Associated Fibroblasts

Kato, T., Noma, K., Katsura, Y., Sato, H., Kohmoto, S., Ninomiya, T., Ohara, T., Tazawa, H., Kagawa, S., Shirakawa, Y. & Fujiwara, T., Sep 1 2018, In : Gan to kagaku ryoho. Cancer & chemotherapy. 45, 9, p. 1279-1281 3 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Immunosuppression
Tumor-Infiltrating Lymphocytes
Neoplasms
Immunotherapy
2 Citations (Scopus)
Epithelial-Mesenchymal Transition
Pancreatic Neoplasms
Macrophages
Neoplasms
Tumor Microenvironment

The Outcome of Complex Hepato-Pancreato-Biliary Surgery for Elderly Patients: A Propensity Score Matching Analysis

Takagi, K., Umeda, Y., Yoshida, R., Nobuoka, D., Kuise, T., Fushimi, T., Fujiwara, T. & Yagi, T., Jun 26 2018, (Accepted/In press) In : Digestive Surgery. p. 1-8 8 p.

Research output: Contribution to journalArticle

Propensity Score
Morbidity
Mortality
Comorbidity
Multivariate Analysis
2017
3 Citations (Scopus)

A multi-institution phase II study of docetaxel and S-1 in combination with trastuzumab for HER2-positive advanced gastric cancer (DASH study)

Kagawa, S., Muraoka, A., Kambara, T., Nakayama, H., Hamano, R., Tanaka, N., Noma, K., Tanakaya, K., Kishimoto, H., Shigeyasu, K., Kuroda, S., Kikuchi, S., Kuwada, K., Nishizaki, M., Shirakawa, Y. & Fujiwara, T., Dec 30 2017, (Accepted/In press) In : Cancer Chemotherapy and Pharmacology. p. 1-6 6 p.

Research output: Contribution to journalArticle

docetaxel
Stomach Neoplasms
Disease-Free Survival
Febrile Neutropenia
Chemotherapy
Pancreaticoduodenectomy
Digestive System
Mesentery
Pancreaticojejunostomy
Superior Mesenteric Artery

A novel “shrug technique” for totally implantable venous access devices via the external jugular vein: A consecutive series of 254 patients

Kagawa, T., Ueyama, S., Kobayashi, T., Okabayashi, H., Kuroda, S. & Fujiwara, T., Mar 1 2017, In : Journal of Surgical Oncology. 115, 3, p. 291-295 5 p.

Research output: Contribution to journalArticle

Jugular Veins
Equipment and Supplies
Subclavian Vein
Catheterization
5 Citations (Scopus)

Cell-cycle-dependent drug-resistant quiescent cancer cells induce tumor angiogenesis after chemotherapy as visualized by real-time FUCCI imaging

Yano, S., Takehara, K., Tazawa, H., Kishimoto, H., Urata, Y., Kagawa, S., Fujiwara, T. & Hoffman, R. M., Mar 4 2017, In : Cell Cycle. 16, 5, p. 406-414 9 p.

Research output: Contribution to journalArticle

Ubiquitination
Cell Cycle
Fluorescence
Drug Therapy
Pharmaceutical Preparations
102 Citations (Scopus)

Circular RNA ciRS-7 — A promising prognostic biomarker and a potential therapeutic target in colorectal cancer

Weng, W., Wei, Q., Toden, S., Yoshida, K., Nagasaka, T., Fujiwara, T., Cai, S., Qin, H., Ma, Y. & Goel, A., Jul 15 2017, In : Clinical Cancer Research. 23, 14, p. 3918-3928 11 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Biomarkers
Therapeutics
Mucous Membrane
HCT116 Cells
Propensity Score
Colorectal Neoplasms
Costs and Cost Analysis
Postoperative Hemorrhage
Colorectal Surgery
2 Citations (Scopus)

Comparison of tumor recurrence after resection of highly- and poorly-metastatic triple-negative breast cancer in orthotopic nude-mouse models

Yano, S., Takehara, K., Kishimoto, H., Tazawa, H., Urata, Y., Kagawa, S., Fujiwara, T., Bouvet, M. & Hoffman, R. M., Jan 1 2017, In : Anticancer Research. 37, 1, p. 57-60 4 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Nude Mice
Recurrence
Neoplasms
Light

Description of LECS from a view point of a surgeon

Nishizaki, M., Okada, H. & Fujiwara, T., 2017, In : Journal of Japanese Society of Gastroenterology. 114, 2, p. 218-223 6 p.

Research output: Contribution to journalReview article

Gastroscopy
Gastrointestinal Stromal Tumors
Gastric Mucosa
Laparoscopy
Stomach Neoplasms