• 10096 Citations
  • 47 h-Index
1983 …2020

Research output per year

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Research Output

2020

Association of dental occlusal support with the Prognostic Nutritional Index in patients with esophageal cancer who underwent esophagectomy

Yamanaka-Kohno, R., Shirakawa, Y., Inoue-Minakuchi, M., Yokoi, A., Muro, M., Kosaki, H., Tanabe, S., Fujiwara, T. & Morita, M., 2020, (Accepted/In press) In : Esophagus.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

DV200 Index for Assessing RNA Integrity in Next-Generation Sequencing

Matsubara, T., Sou, J., Morita, M., Uwabo, T., Tomida, S., Fujiwara, T., Kanazawa, S., Toyooka, S. & Hirasawa, A., Jan 1 2020, In : BioMed research international. 2020, 9349132.

Research output: Contribution to journalArticle

Open Access

Elimination of MYCN-Amplified Neuroblastoma Cells by Telomerase-Targeted Oncolytic Virus via MYCN Suppression

Tanimoto, T., Tazawa, H., Ieda, T., Nouso, H., Tani, M., Oyama, T., Urata, Y., Kagawa, S., Noda, T. & Fujiwara, T., Sep 25 2020, In : Molecular Therapy - Oncolytics. 18, p. 14-23 10 p.

Research output: Contribution to journalArticle

Open Access

Exploratory open-label clinical study to determine the S-588410 cancer peptide vaccine-induced tumor-infiltrating lymphocytes and changes in the tumor microenvironment in esophageal cancer patients

Daiko, H., Marafioti, T., Fujiwara, T., Shirakawa, Y., Nakatsura, T., Kato, K., Puccio, I., Hikichi, T., Yoshimura, S., Nakagawa, T., Furukawa, M., Stoeber, K., Nagira, M., Ide, N. & Kojima, T., 2020, (Accepted/In press) In : Cancer Immunology, Immunotherapy.

Research output: Contribution to journalArticle

Open Access

Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody

Kanaya, N., Kuroda, S., Kakiuchi, Y., Kumon, K., Tsumura, T., Hashimoto, M., Morihiro, T., Kubota, T., Aoyama, K., Kikuchi, S., Nishizaki, M., Kagawa, S., Tazawa, H., Mizuguchi, H., Urata, Y. & Fujiwara, T., Mar 4 2020, In : Molecular Therapy. 28, 3, p. 794-804 11 p.

Research output: Contribution to journalArticle

Induction chemoradiotherapy including docetaxel, cisplatin, and 5-fluorouracil for locally advanced esophageal cancer

Hashimoto, M., Shirakawa, Y., Maeda, N., Tanabe, S., Noma, K., Sakurama, K., Katsui, K., Nishizaki, M. & Fujiwara, T., Apr 1 2020, In : Esophagus. 17, 2, p. 127-134 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer

Koujima, T., Tazawa, H., Ieda, T., Araki, H., Fushimi, T., Shoji, R., Kuroda, S., Kikuchi, S., Yoshida, R., Umeda, Y., Teraishi, F., Urata, Y., Mizuguchi, H. & Fujiwara, T., Jun 26 2020, In : Molecular Therapy - Oncolytics. 17, p. 107-117 11 p.

Research output: Contribution to journalArticle

Open Access
2019

Acquired resistance mechanisms to afatinib in HER2-amplified gastric cancer cells

Yoshioka, T., Shien, K., Takeda, T., Takahashi, Y., Kurihara, E., Ogoshi, Y., Namba, K., Torigoe, H., Sato, H., Tomida, S., Yamamoto, H., Soh, J., Fujiwara, T. & Toyooka, S., Jan 1 2019, In : Cancer Science. 110, 8, p. 2549-2557 9 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Activation of AZIN1 RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancer

Takeda, S., Shigeyasu, K., Okugawa, Y., Yoshida, K., Mori, Y., Yano, S., Noma, K., Umeda, Y., Kondo, Y., Kishimoto, H., Teraishi, F., Nagasaka, T., Tazawa, H., Kagawa, S., Fujiwara, T. & Goel, A., Mar 1 2019, In : Cancer Letters. 444, p. 127-135 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

A multicenter observational study on the clinicopathological features of gastric cancer in young patients

Kono, Y., Kanzaki, H., Tsuzuki, T., Takatani, M., Nasu, J., Kawai, D., Takenaka, R., Tanaka, T., Iwamuro, M., Kawano, S., Kawahara, Y., Fujiwara, T. & Okada, H., May 1 2019, In : Journal of Gastroenterology. 54, 5, p. 419-426 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

A novel combination cancer therapy with iron chelator targeting cancer stem cells via suppressing stemness

Katsura, Y., Ohara, T., Noma, K., Ninomiya, T., Kashima, H., Kato, T., Sato, H., Komoto, S., Narusaka, T., Tomono, Y., Xing, B., Chen, Y., Tazawa, H., Kagawa, S., Shirakawa, Y., Kasai, T., Seno, M., Matsukawa, A. & Fujiwara, T., Feb 2019, In : Cancers. 11, 2, 177.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Cancer-associated fibroblasts (CAFs) promote the lymph node metastasis of esophageal squamous cell carcinoma

Kashima, H., Noma, K., Ohara, T., Kato, T., Katsura, Y., Komoto, S., Sato, H., Katsube, R., Ninomiya, T., Tazawa, H., Shirakawa, Y. & Fujiwara, T., Feb 15 2019, In : International Journal of Cancer. 144, 4, p. 828-840 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Clinical impact of sarcopenia on gastric cancer

Kuwada, K., Kuroda, S., Kikuchi, S., Yoshida, R., Nishizaki, M., Kagawa, S. & Fujiwara, T., May 1 2019, In : Anticancer research. 39, 5, p. 2241-2249 9 p.

Research output: Contribution to journalReview article

Open Access
7 Citations (Scopus)
1 Citation (Scopus)

Current status of projects for developing cancer-related clinical practice guidelines in Japan and recommendations for the future

Imamura, M., Hirata, K., Unno, M., Kamiya, K., Gotoh, M., Konno, H., Shibata, A., Sugihara, K., Takahashi, A., Nishiyama, M., Hakamada, K., Fukui, T., Furukawa, T., Mizushima, T., Mizuma, M., Miyata, H., Mori, M., Takemasa, I., Mizuguchi, T. & Fujiwara, T., Feb 15 2019, In : International Journal of Clinical Oncology. 24, 2, p. 189-195 7 p.

Research output: Contribution to journalArticle

Current status of site-specific cancer registry system for the clinical researches: aiming for future contribution by the assessment of present medical care

Hirata, K., Imamura, M., Fujiwara, T., Fukui, T., Furukawa, T., Gotoh, M., Hakamada, K., Ishiguro, M., Kakeji, Y., Konno, H., Miyata, H., Mori, M., Okita, K., Sato, M., Shibata, A., Takemasa, I., Unno, M., Yokoi, K., Nishidate, T. & Nishiyama, M., Sep 13 2019, In : International Journal of Clinical Oncology. 24, 9, p. 1161-1168 8 p.

Research output: Contribution to journalArticle

Detection of circulating microRNAs with Ago2 complexes to monitor the tumor dynamics of colorectal cancer patients during chemotherapy

Fuji, T., Umeda, Y., Nyuya, A., Taniguchi, F., Kawai, T., Yasui, K., Toshima, T., Yoshida, K., Fujiwara, T., Goel, A. & Nagasaka, T., May 1 2019, In : International Journal of Cancer. 144, 9, p. 2169-2180 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
13 Citations (Scopus)

Heterogeneity of Epigenetic and Epithelial Mesenchymal Transition Marks in Hepatocellular Carcinoma with Keratin 19 Proficiency

Yokomichi, N., Nishida, N., Umeda, Y., Taniguchi, F., Yasui, K., Toshima, T., Mori, Y., Nyuya, A., Tanaka, T., Yamada, T., Yagi, T., Fujiwara, T., Yamaguchi, Y., Goel, A., Kudo, M. & Nagasaka, T., Jul 1 2019, In : Liver Cancer. 8, 4, p. 239-254 16 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Higher human lymphocyte antigen class I expression in early-stage cancer cells leads to high sensitivity for cytotoxic T lymphocytes

Akazawa, Y., Nobuoka, D., Takahashi, M., Yoshikawa, T., Shimomura, M., Mizuno, S., Fujiwara, T., Nakamoto, Y. & Nakatsura, T., Jun 1 2019, In : Cancer Science. 110, 6, p. 1842-1852 11 p.

Research output: Contribution to journalArticle

Open Access

Intraperitoneal cancer-immune microenvironment promotes peritoneal dissemination of gastric cancer

Sakamoto, S., Kagawa, S., Kuwada, K., Ito, A., Kajioka, H., Kakiuchi, Y., Watanabe, M., Kagawa, T., Yoshida, R., Kikuchi, S., Kuroda, S., Tazawa, H. & Fujiwara, T., Dec 2 2019, In : OncoImmunology. 8, 12, e1671760.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Multicenter retrospective study to evaluate the efficacy and safety of the double-flap technique as antireflux esophagogastrostomy after proximal gastrectomy (rD-FLAP Study)

Kuroda, S., Choda, Y., Otsuka, S., Ueyama, S., Tanaka, N., Muraoka, A., Hato, S., Kimura, T., Tanakaya, K., Kikuchi, S., Tanabe, S., Noma, K., Nishizaki, M., Kagawa, S., Shirakawa, Y., Kamikawa, Y. & Fujiwara, T., Jan 2019, In : Annals of Gastroenterological Surgery. 3, 1, p. 96-103 8 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Multidisciplinary oncolytic virotherapy for gastrointestinal cancer

Fujiwara, T., Jul 2019, In : Annals of Gastroenterological Surgery. 3, 4, p. 396-404 9 p.

Research output: Contribution to journalReview article

Open Access

PD-L1 expression combined with microsatellite instability/CD8+ tumor infiltrating lymphocytes as a useful prognostic biomarker in gastric cancer

Morihiro, T., Kuroda, S., Kanaya, N., Kakiuchi, Y., Kubota, T., Aoyama, K., Tanaka, T., Kikuchi, S., Nagasaka, T., Nishizaki, M., Kagawa, S., Tazawa, H. & Fujiwara, T., Dec 1 2019, In : Scientific reports. 9, 1, 4633.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Photoimmunotherapy for cancer-associated fibroblasts targeting fibroblast activation protein in human esophageal squamous cell carcinoma

Watanabe, S., Noma, K., Ohara, T., Kashima, H., Sato, H., Kato, T., Urano, S., Katsube, R., Hashimoto, Y., Tazawa, H., Kagawa, S., Shirakawa, Y., Kobayashi, H. & Fujiwara, T., Jan 1 2019, In : Cancer Biology and Therapy. 20, 9, p. 1234-1248 15 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Predictive Factors for Successful Vaccination Against Hepatitis B Surface Antigen in Patients Who Have Undergone Orthotopic Liver Transplantation

Ikeda, A., Takaki, A., Yasunaka, T., Oyama, A., Adachi, T., Wada, N., Ohnishi, H., Ikeda, F., Shiraha, H., Yoshida, K., Kuise, T., Nobuoka, D., Yoshida, R., Umeda, Y., Yagi, T., Fujiwara, T. & Okada, H., Feb 1 2019, In : Acta medica Okayama. 73, 1, p. 41-50 10 p.

Research output: Contribution to journalArticle

Randomised phase II trial of mFOLFOX6 plus bevacizumab versus mFOLFOX6 plus cetuximab as first-line treatment for colorectal liver metastasis (ATOM trial)

Oki, E., Emi, Y., Yamanaka, T., Uetake, H., Muro, K., Takahashi, T., Nagasaka, T., Hatano, E., Ojima, H., Manaka, D., Kusumoto, T., Katayose, Y., Fujiwara, T., Yoshida, K., Unno, M., Hyodo, I., Tomita, N., Sugihara, K. & Maehara, Y., Jul 30 2019, In : British Journal of Cancer. 121, 3, p. 222-229 8 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

The clinicopathological differences of sporadic non-ampullary duodenal epithelial neoplasm depending on tumor location

Matsueda, K., Kanzaki, H., Matsueda, K., Nasu, J., Yoshioka, M., Nakagawa, M., Inoue, M., Inaba, T., Imagawa, A., Takatani, M., Takenaka, R., Suzuki, S., Tomoda, J., Yagi, T., Fujiwara, T., Tanaka, T. & Okada, H., Sep 1 2019, In : Journal of Gastroenterology and Hepatology (Australia). 34, 9, p. 1540-1544 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The Outcome of Complex Hepato-Pancreato-Biliary Surgery for Elderly Patients: A Propensity Score Matching Analysis

Takagi, K., Umeda, Y., Yoshida, R., Nobuoka, D., Kuise, T., Fushimi, T., Fujiwara, T. & Yagi, T., Jun 1 2019, In : Digestive Surgery. 36, 4, p. 323-330 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Visualization of epithelial-mesenchymal transition in an inflammatory microenvironment–colorectal cancer network

Ieda, T., Tazawa, H., Okabayashi, H., Yano, S., Shigeyasu, K., Kuroda, S., Ohara, T., Noma, K., Kishimoto, H., Nishizaki, M., Kagawa, S., Shirakawa, Y., Saitou, T., Imamura, T. & Fujiwara, T., Dec 1 2019, In : Scientific reports. 9, 1, 16378.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Accuracy of four mononucleotide-repeat markers for the identification of DNA mismatch-repair deficiency in solid tumors

Takehara, Y., Nagasaka, T., Nyuya, A., Haruma, T., Haraga, J., Mori, Y., Nakamura, K., Fujiwara, T., Boland, C. R. & Goel, A., Jan 12 2018, In : Journal of Translational Medicine. 16, 1, 5.

Research output: Contribution to journalArticle

9 Citations (Scopus)

A multi-institution phase II study of docetaxel and S-1 in combination with trastuzumab for HER2-positive advanced gastric cancer (DASH study)

Kagawa, S., Muraoka, A., Kambara, T., Nakayama, H., Hamano, R., Tanaka, N., Noma, K., Tanakaya, K., Kishimoto, H., Shigeyasu, K., Kuroda, S., Kikuchi, S., Kuwada, K., Nishizaki, M., Shirakawa, Y. & Fujiwara, T., Feb 1 2018, In : Cancer Chemotherapy and Pharmacology. 81, 2, p. 387-392 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Antitumor activity of pan-HER inhibitors in HER2-positive gastric cancer

Yoshioka, T., Shien, K., Namba, K., Torigoe, H., Sato, H., Tomida, S., Yamamoto, H., Asano, H., Soh, J., Tsukuda, K., Nagasaka, T., Fujiwara, T. & Toyooka, S., Apr 2018, In : Cancer Science. 109, 4, p. 1166-1176 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2 Citations (Scopus)

AZIN1 RNA editing confers cancer stemness and enhances oncogenic potential in colorectal cancer

Shigeyasu, K., Okugawa, Y., Toden, S., Miyoshi, J., Toiyama, Y., Nagasaka, T., Takahashi, N., Kusunoki, M., Takayama, T., Yamada, Y., Fujiwara, T., Chen, L. & Goel, A., Jun 21 2018, In : JCI Insight. 3, 12

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

BRAF V600E mutation is a predictive indicator of upfront chemotherapy for stage IV colorectal cancer

Morikawa, T., Inada, R., Nagasaka, T., Mori, Y., Kishimoto, H., Kawai, T., Umeda, Y., Mishima, H., Goel, A. & Fujiwara, T., Feb 2018, In : Oncology Letters. 15, 2, p. 2195-2201 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Cancer-associated fibroblasts affect intratumoral CD8þ and Foxp3þ T cells via IL6 in the tumor microenvironment

Kato, T., Noma, K., Ohara, T., Kashima, H., Katsura, Y., Sato, H., Komoto, S., Katsube, R., Ninomiya, T., Tazawa, H., Shirakawa, Y. & Fujiwara, T., Oct 1 2018, In : Clinical Cancer Research. 24, 19, p. 4820-4833 14 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Clinical characteristics and management of gastric tube cancer after esophagectomy

Shirakawa, Y., Noma, K., Maeda, N., Ninomiya, T., Tanabe, S., Kikuchi, S., Kuroda, S., Nishizaki, M., Kagawa, S., Kawahara, Y., Okada, H. & Fujiwara, T., Mar 27 2018, (Accepted/In press) In : Esophagus. p. 1-10 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Clinical outcomes of women with ovarian metastases of colorectal cancer treated with oophorectomy with respect to their somatic mutation profiles

Mori, Y., Nyuya, A., Yasui, K., Toshima, T., Kawai, T., Taniguchi, F., Kimura, K., Inada, R., Nishizaki, M., Haraga, J., Nakamura, K., Umeda, Y., Kishimoto, H., Fujiwara, T., Katata, Y., Yamaguchi, Y. & Nagasaka, T., 2018, In : Oncotarget. 9, 23, p. 16477-16488 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Clinicopathological features of breast cancer in Japanese female patients with Lynch syndrome

Kanaya, N., Tanakaya, K., Yamasaki, R., Arata, T., Shigeyasu, K., Aoki, H., Morito, T., Sanaii, H., Akagi, K. & Fujiwara, T., Jan 1 2018, (Accepted/In press) In : Breast Cancer.

Research output: Contribution to journalArticle

Detection of circulating tumor cells in cervical cancer using a conditionally replicative adenovirus targeting telomerase-positive cells

Takakura, M., Matsumoto, T., Nakamura, M., Mizumoto, Y., Myojyo, S., Yamazaki, R., Iwadare, J., Bono, Y., Orisaka, S., Obata, T., Iizuka, T., Kagami, K., Nakayama, K., Hayakawa, H., Sakurai, F., Mizuguchi, H., Urata, Y., Fujiwara, T., Kyo, S., Sasagawa, T. & 1 others, Fujiwara, H., Jan 2018, In : Cancer Science. 109, 1, p. 231-240 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

HER2-targeted gold nanoparticles potentially overcome resistance to trastuzumab in gastric cancer

Kubota, T., Kuroda, S., Kanaya, N., Morihiro, T., Aoyama, K., Kakiuchi, Y., Kikuchi, S., Nishizaki, M., Kagawa, S., Tazawa, H. & Fujiwara, T., Aug 2018, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 14, 6, p. 1919-1929 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Integrated fluorescent cytology with nano-biologics in peritoneally disseminated gastric cancer

Watanabe, M., Kagawa, S., Kuwada, K., Hashimoto, Y., Shigeyasu, K., Ishida, M., Sakamoto, S., Ito, A., Kikuchi, S., Kuroda, S., Kishimoto, H., Tomida, S., Yoshida, R., Tazawa, H., Urata, Y. & Fujiwara, T., Oct 2018, In : Cancer Science. 109, 10, p. 3263-3271 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
1 Citation (Scopus)