• 1581 Citations
  • 22 h-Index
1981 …2020

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Article
2020

Effect of asfotase alfa on muscle weakness in a Japanese adult patient of hypophosphatasia with low ALP levels

Koyama, H., Yasuda, S., Kakoi, S., Ohata, Y., Shimizu, Y., Hasegawa, C., Hayakawa, A., Akiyama, T., Yagi, T., Aotani, D., Imaeda, K., Ozono, K., Kataoka, H. & Tanaka, T., Mar 15 2020, In : Internal Medicine. 59, 6, p. 811-815 5 p.

Research output: Contribution to journalArticle

Open Access

Identification of new biomarkers of pyridoxine-dependent epilepsy by GC/MS-based urine metabolomics

Kuhara, T., Akiyama, T., Ohse, M., Koike, T., Shibasaki, J., Imai, K. & Cooper, A. J. L., 2020, (Accepted/In press) In : Analytical Biochemistry. 113739.

Research output: Contribution to journalArticle

Laboratory changes during adrenocorticotropic hormone therapy associated with renal calcified lesions

Miyahara, H., Akiyama, T., Hasegawa, K., Akiyama, M., Oka, M., Kobayashi, K. & Tsukahara, H., May 1 2020, In : Pediatrics International. 62, 5, p. 587-592 6 p.

Research output: Contribution to journalArticle

Seizure detection algorithms in critically ill children: A comparative evaluation

Din, F., Ganesan, S. L., Akiyama, T., Stewart, C. P., Ochi, A., Otsubo, H., Go, C. & Hahn, C. D., Apr 1 2020, In : Critical care medicine. p. 545-552 8 p.

Research output: Contribution to journalArticle

Vitamin B6 in acute encephalopathy with biphasic seizures and late reduced diffusion

Akiyama, T., Toda, S., Kimura, N., Mogami, Y., Hanaoka, Y., Tokorodani, C., Ito, T., Miyahara, H., Hyodo, Y. & Kobayashi, K., May 2020, In : Brain and Development. 42, 5, p. 402-407 6 p.

Research output: Contribution to journalArticle

2019

A case of dihydropyrimidinase deficiency incidentally detected by urine metabolome analysis

Tsuchiya, H., Akiyama, T., Kuhara, T., Nakajima, Y., Ohse, M., Kurahashi, H., Kato, T., Maeda, Y., Yoshinaga, H. & Kobayashi, K., Mar 2019, In : Brain and Development. 41, 3, p. 280-284 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Clinical and genetic aspects of mild hypophosphatasia in Japanese patients

Yokoi, K., Nakajima, Y., Shinkai, Y., Sano, Y., Imamura, M., Akiyama, T., Yoshikawa, T., Ito, T. & Kurahashi, H., Dec 2019, In : Molecular Genetics and Metabolism Reports. 21, 100515.

Research output: Contribution to journalArticle

Open Access

Findings of amplitude-integrated electroencephalogram recordings and serum vitamin B6 metabolites in perinatal lethal hypophosphatasia during enzyme replacement therapy

Ishiguro, T., Sugiyama, Y., Ueda, K., Muramatsu, Y., Tsuda, H., Kotani, T., Michigami, T., Tachikawa, K., Akiyama, T. & Hayakawa, M., Sep 2019, In : Brain and Development. 41, 8, p. 721-725 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Genomic backgrounds of Japanese patients with undiagnosed neurodevelopmental disorders

Yamamoto, T., Imaizumi, T., Yamamoto-Shimojima, K., Lu, Y., Yanagishita, T., Shimada, S., Chong, P. F., Kira, R., Ueda, R., Ishiyama, A., Takeshita, E., Momosaki, K., Ozasa, S., Akiyama, T., Kobayashi, K., Oomatsu, H., Kitahara, H., Yamaguchi, T., Imai, K., Kurahashi, H. & 4 others, Okumura, A., Oguni, H., Seto, T. & Okamoto, N., Oct 2019, In : Brain and Development. 41, 9, p. 776-782 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

High-frequency oscillations in a spectrum of pediatric epilepsies characterized by sleep-activated spikes in scalp EEG

Ohuchi, Y., Akiyama, T., Matsuhashi, M. & Kobayashi, K., Oct 2019, In : Clinical Neurophysiology. 130, 10, p. 1971-1980 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The Effect of S-Adenosylmethionine Treatment on Neurobehavioral Phenotypes in Lesch-Nyhan Disease: A Case Report

Momosaki, K., Kido, J., Matsumoto, S., Taniguchi, A., Akiyama, T., Sawada, T., Ozasa, S. & Nakamura, K., Sep 1 2019, In : Case Reports in Neurology. 11, 3, p. 256-264 9 p.

Research output: Contribution to journalArticle

Open Access
2018

A case of perinatal hypophosphatasia with a novel mutation in the ALPL gene: Clinical course and review of the literature

Oyachi, M., Harada, D., Sakamoto, N., Ueyama, K., Kondo, K., Kishimoto, K., Izui, M., Nagamatsu, Y., Kashiwagi, H., Yamamuro, M., Tamura, M., Kikuchi, S., Akiyama, T., Michigami, T., Seino, Y. & Namba, N., 2018, In : clinical pediatric endocrinology. 27, 3, p. 179-186 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

A case of vitamin B6-responsive West syndrome caused by severe traumatic brain injury

Inoue, T., Akiyama, T., Hanaoka, Y., Oka, M. & Kobayashi, K., 2018, In : Epilepsy and Seizure. 10, 1, p. 114-119 6 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Differential diagnosis of nonepileptic twilight state with convulsive manifestations after febrile seizures

Miyahara, H., Akiyama, T., Waki, K. & Arakaki, Y., Oct 2018, In : Brain and Development. 40, 9, p. 781-785 5 p.

Research output: Contribution to journalArticle

Pyridoxal 5′-phosphate and related metabolites in hypophosphatasia: Effects of enzyme replacement therapy

Akiyama, T., Kubota, T., Ozono, K., Michigami, T., Kobayashi, D., Takeyari, S., Sugiyama, Y., Noda, M., Harada, D., Namba, N., Suzuki, A., Utoyama, M., Kitanaka, S., Uematsu, M., Mitani, Y., Matsunami, K., Takishima, S., Ogawa, E. & Kobayashi, K., Sep 2018, In : Molecular Genetics and Metabolism. 125, 1-2, p. 174-180 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Strong coupling between slow oscillations and wide fast ripples in children with epileptic spasms: Investigation of modulation index and occurrence rate

Iimura, Y., Jones, K., Takada, L., Shimizu, I., Koyama, M., Hattori, K., Okazawa, Y., Nonoda, Y., Asano, E., Akiyama, T., Go, C., Ochi, A., Snead, O. C., Donner, E. J., Rutka, J. T., Drake, J. M. & Otsubo, H., Mar 2018, In : Epilepsia. 59, 3, p. 544-554 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2017

A Japanese case of β-ureidopropionase deficiency with dysmorphic features

Akiyama, T., Shibata, T., Yoshinaga, H., Kuhara, T., Nakajima, Y., Kato, T., Maeda, Y., Ohse, M., Oka, M., Kageyama, M. & Kobayashi, K., Jan 1 2017, In : Brain and Development. 39, 1, p. 58-61 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Complex observation of scalp fast (40–150 Hz) oscillations in West syndrome and related disorders with structural brain pathology

Kobayashi, K., Endoh, F., Agari, T., Akiyama, T., Akiyama, M., Hayashi, Y., Shibata, T., Hanaoka, Y., Oka, M., Yoshinaga, H. & Date, I., Jun 1 2017, In : Epilepsia Open. 2, 2, p. 260-266 7 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Epileptogenic high-frequency oscillations skip the motor area in children with multilobar drug-resistant epilepsy

Iimura, Y., Jones, K., Hattori, K., Okazawa, Y., Noda, A., Hoashi, K., Nonoda, Y., Asano, E., Akiyama, T., Go, C., Ochi, A., Snead, O. C., Donner, E. J., Rutka, J. T., Drake, J. M. & Otsubo, H., Jul 1 2017, In : Clinical Neurophysiology. 128, 7, p. 1197-1205 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Importance of the multisystem follow-up in patients with tuberous sclerosis complex

Yoshinaga, H., Oka, M., Akiyama, T., Endoh, F., Akiyama, M., Hayashi, Y., Shibata, T., Hanaoka, Y. & Kobayashi, K., 2017, In : NO TO HATTATSU. 49, 1, p. 5-9 5 p.

Research output: Contribution to journalArticle

Measurement of pyridoxal 5′-phosphate, pyridoxal, and 4-pyridoxic acid in the cerebrospinal fluid of children

Akiyama, T., Akiyama, M., Hayashi, Y., Shibata, T., Hanaoka, Y., Toda, S., Imai, K., Hamano, S. I., Okanishi, T., Yoshinaga, H. & Kobayashi, K., Mar 1 2017, In : Clinica Chimica Acta. 466, p. 1-5 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Pyridoxal 5′-phosphate, pyridoxal, and 4-pyridoxic acid in the paired serum and cerebrospinal fluid of children

Akiyama, T., Hayashi, Y., Hanaoka, Y., Shibata, T., Akiyama, M., Tsuchiya, H., Yamaguchi, T. & Kobayashi, K., Sep 2017, In : Clinica Chimica Acta. 472, p. 118-122 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Severe leukoencephalopathy with cortical involvement and peripheral neuropathy due to FOLR1 deficiency

Kobayashi, Y., Tohyama, J., Akiyama, T., Magara, S., Kawashima, H., Akasaka, N., Nakashima, M., Saitsu, H. & Matsumoto, N., Mar 1 2017, In : Brain and Development. 39, 3, p. 266-270 5 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Simultaneous measurement of monoamine metabolites and 5-methyltetrahydrofolate in the cerebrospinal fluid of children

Akiyama, T., Hayashi, Y., Hanaoka, Y., Shibata, T., Akiyama, M., Nakamura, K., Tsuyusaki, Y., Kubota, M., Yoshinaga, H. & Kobayashi, K., Feb 1 2017, In : Clinica Chimica Acta. 465, p. 5-10 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2016

A study on spike focus dependence of high-frequency activity in idiopathic focal epilepsy in childhood

Shibata, T., Yoshinaga, H., Akiyama, T. & Kobayashi, K., 2016, In : Epilepsia Open. 1, 3-4, p. 121-129 9 p.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Determination of CSF 5-methyltetrahydrofolate in children and its application for defects of folate transport and metabolism

Akiyama, M., Akiyama, T., Kanamaru, K., Kuribayashi, M., Tada, H., Shiokawa, T., Toda, S., Imai, K., Kobayashi, Y., Tohyama, J., Sakakibara, T., Yoshinaga, H. & Kobayashi, K., Sep 1 2016, In : Clinica Chimica Acta. 460, p. 120-125 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
3 Citations (Scopus)

Magnetoencephalography spike sources interrelate the extensive epileptogenic zone of tuberous sclerosis complex

Okanishi, T., Akiyama, T., Mayo, E., Honda, Y., Ueda-Kawada, C., Nakajima, M., Homma, Y., Ochi, A., Go, C., Widjaja, E., Chuang, S. H., Rutka, J. T., Drake, J., Snead, O. C. & Otsubo, H., Nov 1 2016, In : Epilepsy Research. 127, p. 302-310 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Predictive factors for relapse of epileptic spasms after adrenocorticotropic hormone therapy in West syndrome

Hayashi, Y., Yoshinaga, H., Akiyama, T., Endoh, F., Ohtsuka, Y. & Kobayashi, K., Jan 1 2016, In : Brain and Development. 38, 1, p. 32-39 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

SSADH deficiency possibly associated with enzyme activity-reducing SNPs

Akiyama, T., Osaka, H., Shimbo, H., Kuhara, T., Shibata, T., Kobayashi, K., Kurosawa, K. & Yoshinaga, H., 2016, In : Brain and Development. 38, 9, p. 871-874 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2015

Action potentials contribute to epileptic high-frequency oscillations recorded with electrodes remote from neurons

Kobayashi, K., Akiyama, T., Ohmori, I., Yoshinaga, H. & Gotman, J., May 1 2015, In : Clinical Neurophysiology. 126, 5, p. 873-881 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

A storm of fast (40-150Hz) oscillations hypsarrhythmia in West syndrome

Kobayashi, K., Akiyama, T., Oka, M., Endoh, F. & Yoshinaga, H., Jan 1 2015, In : Annals of Neurology. 77, 1, p. 58-67 10 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Epilepsy surgery for refractory focal epilepsy based on the analysis of high frequency oscillations with intracranial electroencephalography: A case report

Kondo, A., Akiyama, T., Agari, T., Oka, M., Kobayashi, Y., Hayashi, Y., Shibata, T., Shinji, Y., Kobayashi, K., Yoshinaga, H. & Date, I., 2015, In : Japanese Journal of Neurosurgery. 24, 1, p. 32-39 8 p.

Research output: Contribution to journalArticle

Open Access

Manifestation of both emetic seizures and sylvian seizures in the same patients with benign partial epilepsy

Yoshinaga, H., Kobayashi, K., Shibata, T., Inoue, T., Oka, M. & Akiyama, T., Jan 1 2015, In : Brain and Development. 37, 1, p. 13-17 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Phenotypic Variability in Childhood of Skeletal Muscle Sodium Channelopathies

Yoshinaga, H., Sakoda, S., Shibata, T., Akiyama, T., Oka, M., Yuan, J. H., Takashima, H., Takahashi, M. P., Kitamura, T., Murakami, N. & Kobayashi, K., May 1 2015, In : Pediatric Neurology. 52, 5, p. 504-508 5 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Progressive brain atrophy in Schinzel-Giedion syndrome with a SETBP1 mutation

Takeuchi, A., Okamoto, N., Fujinaga, S., Morita, H., Shimizu, J., Akiyama, T., Ninomiya, S., Takanashi, J. I. & Kubo, T., Aug 1 2015, In : European Journal of Medical Genetics. 58, 8, p. 369-371 3 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Spatial relationship between fast and slow components of ictal activities and interictal epileptiform discharges in epileptic spasms

Akiyama, T., Akiyama, M., Kobayashi, K., Okanishi, T., Boelman, C. G., Nita, D. A., Ochi, A., Go, C. Y., Snead, O. C., Rutka, J. T., Drake, J. M., Chuang, S. & Otsubo, H., Sep 1 2015, In : Clinical Neurophysiology. 126, 9, p. 1684-1691 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Total folate and 5-methyltetrahydrofolate in the cerebrospinal fluid of children: Correlation and reference values

Akiyama, T., Tada, H., Shiokawa, T., Kobayashi, K. & Yoshinaga, H., Nov 1 2015, In : Clinical Chemistry and Laboratory Medicine. 53, 12, p. 2009-2014 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Trend figures assist with untrained emergency electroencephalogram interpretation

Kobayashi, K., Yunoki, K., Zensho, K., Akiyama, T., Oka, M. & Yoshinaga, H., May 1 2015, In : Brain and Development. 37, 5, p. 487-494 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2014

A Japanese adult case of guanidinoacetate methyltransferase deficiency

Akiyama, T., Osaka, H., Shimbo, H., Nakajiri, T., Kobayashi, K., Oka, M., Endoh, F. & Yoshinaga, H., 2014, In : JIMD Rep. 12, p. 65-69 5 p.

Research output: Contribution to journalArticle

CSF/plasma ratios of amino acids: Reference data and transports in children

Akiyama, T., Kobayashi, K., Higashikage, A., Sato, J. & Yoshinaga, H., Jan 2014, In : Brain and Development. 36, 1, p. 3-9 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Dynamic modulation of epileptic high frequency oscillations by the phase of slower cortical rhythms

Ibrahim, G. M., Wong, S. M., Anderson, R. A., Singh-Cadieux, G., Akiyama, T., Ochi, A., Otsubo, H., Okanishi, T., Valiante, T. A., Donner, E., Rutka, J. T., Snead, O. C. & Doesburg, S. M., Jan 1 2014, In : Experimental Neurology. 251, p. 30-38 9 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Five pediatric cases of ictal fear with variable outcomes

Akiyama, M., Kobayashi, K., Inoue, T., Akiyama, T. & Yoshinaga, H., Oct 1 2014, In : Brain and Development. 36, 9, p. 758-763 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Genotype-phenotype correlations in alternating hemiplegia of childhood

Sasaki, M., Ishii, A., Saito, Y., Morisada, N., Iijima, K., Takada, S., Araki, A., Tanabe, Y., Arai, H., Yamashita, S., Ohashi, T., Oda, Y., Ichiseki, H., Hirabayashi, S., Yasuhara, A., Kawawaki, H., Kimura, S., Shimono, M., Narumiya, S., Suzuki, M. & 14 others, Yoshida, T., Oyazato, Y., Tsuneishi, S., Ozasa, S., Yokochi, K., Dejima, S., Akiyama, T., Kishi, N., Kira, R., Ikeda, T., Oguni, H., Zhang, B., Tsuji, S. & Hirose, S., Feb 11 2014, In : Neurology. 82, 6, p. 482-490 9 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Interictal high frequency oscillations correlating with seizure outcome in patients with widespread epileptic networks in tuberous sclerosis complex

Okanishi, T., Akiyama, T., Tanaka, S. I., Mayo, E., Mitsutake, A., Boelman, C., Go, C., Snead, O. C., Drake, J., Rutka, J., Ochi, A. & Otsubo, H., Oct 1 2014, In : Epilepsia. 55, 10, p. 1602-1610 9 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)
2013

Clinical implications of preceding positive spikes in patients with benign partial epilepsy and febrile seizures

Yoshinaga, H., Kobayashi, K., Akiyama, T., Shibata, T., Endoh, F. & Ohtsuka, Y., Apr 2013, In : Brain and Development. 35, 4, p. 299-306 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Cortical contribution to scalp EEG gamma rhythms associated with epileptic spasms

Kobayashi, K., Miya, K., Akiyama, T., Endoh, F., Oka, M., Yoshinaga, H. & Ohtsuka, Y., Sep 1 2013, In : Brain and Development. 35, 8, p. 762-770 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Early surgical intervention for pediatric intractable epilepsy: What is the role of pediatric neurologists?

Akiyama, T., May 1 2013, In : NO TO HATTATSU. 45, 3, p. 211-215 5 p.

Research output: Contribution to journalArticle