If you made any changes in Pure these will be visible here soon.

Research Output 1990 2019

  • 1104 Citations
  • 21 h-Index
  • 54 Article
  • 2 Comment/debate
  • 2 Review article
  • 1 Chapter
Filter
Article
Article
1 Citation (Scopus)

2-aminoethoxydiphenyl borate provides an anti-oxidative effect and mediates cardioprotection during ischemia reperfusion in mice

Morihara, H., Obana, M., Tanaka, S., Kawakatsu, I., Tsuchiyama, D., Mori, S., Suizu, H., Ishida, A., Kimura, R., Tsuchimochi, I., Maeda, M., Yoshimitsu, T., Fujio, Y. & Nakayama, H., Dec 1 2017, In : PLoS One. 12, 12, e0189948.

Research output: Contribution to journalArticle

borates
ischemia
Reperfusion
Ischemia
mice
44 Citations (Scopus)

An approach to the synthesis of CP-263,114: Complementary routes to the bicyclic ring system via two kinds of fragmentation reaction

Yoshimitsu, T., Yanagiya, M. & Nagaoka, H., Jul 9 1999, In : Tetrahedron Letters. 40, 28, p. 5215-5218 4 p.

Research output: Contribution to journalArticle

CP 263114
alkoxyl radical
7 Citations (Scopus)

A new route to platencin via decarboxylative radical cyclization

Moustafa, G. A. I., Saku, Y., Aoyama, H. & Yoshimitsu, T., Dec 25 2014, In : Chemical Communications. 50, 99, p. 15706-15709 4 p.

Research output: Contribution to journalArticle

Cyclization
Esterification
Antibiotics
Biological Products
Pyridine
22 Citations (Scopus)

A new synthesis of (-)-mesembrine employing sharpless AD reaction and new radical-initiated reaction

Yoshimitsu, T. & Ogasawara, K., 1996, In : Heterocycles. 42, 1, p. 135-139 5 p.

Research output: Contribution to journalArticle

Lactones
Alkaloids
Acetates
Carbon
mesembrine
23 Citations (Scopus)

A new synthetic route for construction of the core of Zaragozic acids

Koshimizu, H., Baba, T., Yoshimitsu, T. & Nagaoka, H., Apr 2 1999, In : Tetrahedron Letters. 40, 14, p. 2777-2780 4 p.

Research output: Contribution to journalArticle

Derivatives
Acids
7-oxabicyclo(2.2.1)heptane
12 Citations (Scopus)

An integrated approach to the discovery of potent agelastatin A analogues for brain tumors: Chemical synthesis and biological, physicochemical and CNS pharmacokinetic analyses

Li, Z., Shigeoka, D., Caulfield, T. R., Kawachi, T., Qiu, Y., Kamon, T., Arai, M., Tun, H. W. & Yoshimitsu, T., Jul 2013, In : MedChemComm. 4, 7, p. 1093-1098 6 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Neurology
Brain Neoplasms
Tumors
Brain
32 Citations (Scopus)

Asymmetric Dihydroxylation of a Meso-Symmetric Cyclic Diene Using AD-Mix Reagents: A New Enantiocontrolled Route to Conduritol E

Takano, S., Yoshimitsu, T. & Ogasawara, K., Jan 1 1994, In : Journal of Organic Chemistry. 59, 1, p. 54-57 4 p.

Research output: Contribution to journalArticle

Enantioselectivity
Derivatives
Substrates
conduritol E
33 Citations (Scopus)

Asymmetric synthesis of the core structure of (-)-CP-263,114

Yoshimitsu, T., Yanagisawa, S. & Nagaoka, H., Nov 16 2000, In : Organic Letters. 2, 23, p. 3751-3754 4 p.

Research output: Contribution to journalArticle

fragmentation
synthesis
matrices
CP 263114
42 Citations (Scopus)

Asymmetric total synthesis of (+)-danicalipin A

Yoshimitsu, T., Nakatani, R., Kobayashi, A. & Tanaka, T., Mar 4 2011, In : Organic Letters. 13, 5, p. 908-911 4 p.

Research output: Contribution to journalArticle

Biological Products
fragments
synthesis
products
configurations
45 Citations (Scopus)

Asymmetric total synthesis of (+)-Hexachlorosulfolipid, a cytotoxin isolated from adriatic mussels

Yoshimitsu, T., Fukumoto, N., Nakatani, R., Kojima, N. & Tanaka, T., Aug 20 2010, In : Journal of Organic Chemistry. 75, 16, p. 5425-5437 13 p.

Research output: Contribution to journalArticle

Cytotoxins
Chlorinated Hydrocarbons
Epoxy Compounds
Lipids
hexachlorosulfolipid

Compounds, compositions, and methods of agelastatin alkaloids: patent evaluation of WO2015042239 (A1)

Yoshimitsu, T. & Tun, H. W., Feb 1 2017, In : Expert Opinion on Therapeutic Patents. 27, 2, p. 113-119 7 p.

Research output: Contribution to journalArticle

Therapeutic Uses
Hematologic Neoplasms
Alkaloids
Biomimetics
Porifera
10 Citations (Scopus)

Convergent synthesis of fluorescence-labeled probes of Annonaceous acetogenins and visualization of their cell distribution

Kojima, N., Morioka, T., Urabe, D., Yano, M., Suga, Y., Maezaki, N., Ohashi-Kobayashi, A., Fujimoto, Y., Maeda, M., Yamori, T., Yoshimitsu, T. & Tanaka, T., Dec 15 2010, In : Bioorganic and Medicinal Chemistry. 18, 24, p. 8630-8641 12 p.

Research output: Contribution to journalArticle

Acetogenins
Benzethonium
Alkynes
Visualization
Fluorescence
10 Citations (Scopus)

Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines

Kojima, N., Suga, Y., Hayashi, H., Yamori, T., Yoshimitsu, T. & Tanaka, T., Oct 1 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 19, p. 5745-5749 5 p.

Research output: Contribution to journalArticle

Benzethonium
Lactones
Human Activities
Acetogenins
Cells
19 Citations (Scopus)

Dichlorination of olefins with NCS/Ph3P

Kamada, Y., Kitamura, Y., Tanaka, T. & Yoshimitsu, T., Mar 14 2013, In : Organic and Biomolecular Chemistry. 11, 10, p. 1598-1601 4 p.

Research output: Contribution to journalArticle

dichlorides
Chlorine
Alkenes
alkenes
chlorine
4 Citations (Scopus)

Diversity Oriented Synthesis of Allocolchicinoids with Fluoro and/or Oxygen Substituent(s) on the C-Ring from a Single Common Intermediate

Takubo, K., Furutsu, K., Ide, T., Nemoto, H., Ueda, Y., Tsujikawa, K., Ikawa, T., Yoshimitsu, T. & Akai, S., Mar 1 2016, In : European Journal of Organic Chemistry. 2016, 8, p. 1562-1576 15 p.

Research output: Contribution to journalArticle

Cells
analogs
Oxygen
rings
oxygen
22 Citations (Scopus)

Double C-H functionalization in sequential order: Direct synthesis of polycyclic compounds by a palladium-catalyzed C-H alkenylation-arylation cascade

Ohno, H., Iuchi, M., Kojima, N., Yoshimitsu, T., Fujii, N. & Tanaka, T., Apr 23 2012, In : Chemistry - A European Journal. 18, 17, p. 5352-5360 9 p.

Research output: Contribution to journalArticle

Alkenylation
Polycyclic Compounds
Palladium
Aniline
Derivatives
47 Citations (Scopus)

Enantiocontrolled synthesis of polychlorinated hydrocarbon motifs: A nucleophilic multiple chlorination process revisited

Yoshimitsu, T., Fukumoto, N. & Tanaka, T., Jan 16 2009, In : Journal of Organic Chemistry. 74, 2, p. 696-702 7 p.

Research output: Contribution to journalArticle

Chlorination
Halogenation
Hydrocarbons
Epoxy Compounds
Halogens
2 Citations (Scopus)

Enantioconvergent route to a functionalized quinane system

Yoshimitsu, T., Ohshiba, Y. & Ogasawara, K., 1994, In : Synthesis. 10, p. 1029-1031 3 p.

Research output: Contribution to journalArticle

Enantiomers
Lipases
Lipase
1 Citation (Scopus)
Aromatization
Cyclization
Cytotoxicity
Light
Halogenation
2 Citations (Scopus)

Endeavors to access molecular complexity: Strategic use of free radicals in natural product synthesis

Yoshimitsu, T., 2014, In : Chemical Record. 14, 2, p. 268-279 12 p.

Research output: Contribution to journalArticle

Biological Products
Free radicals
Free Radicals
Organic Chemistry
Synthetic Chemistry Techniques
15 Citations (Scopus)

Formal synthesis of (-)-agelastatin A: An iron(II)-mediated cyclization strategy

Shigeoka, D., Kamon, T. & Yoshimitsu, T., May 3 2013, In : Beilstein Journal of Organic Chemistry. 9, p. 860-865 6 p.

Research output: Contribution to journalArticle

Cyclization
Iron
Alkaloids
agelastatin A
37 Citations (Scopus)

Hydroxyalkylation of α-C-H bonds of tetrahydrofuran with aldehydes in the presence of triethylborane and tert-butyl hydroperoxide

Yoshimitsu, T., Arano, Y. & Nagaoka, H., Jan 24 2003, In : Journal of Organic Chemistry. 68, 2, p. 625-627 3 p.

Research output: Contribution to journalArticle

tert-Butylhydroperoxide
Aldehydes
Cyclic Ethers
tetrahydrofuran
triethylborane
12 Citations (Scopus)

Intramolecular iron(ii)-catalyzed aminobromination of allyl N-tosyloxycarbamates

Kamon, T., Shigeoka, D., Tanaka, T. & Yoshimitsu, T., Mar 28 2012, In : Organic and Biomolecular Chemistry. 10, 12, p. 2363-2365 3 p.

Research output: Contribution to journalArticle

Oxazolidinones
Iron
iron
39 Citations (Scopus)
Acetogenins
Polyketides
Aldehydes
Methanol
Air
12 Citations (Scopus)

New route to the synthesis of the illudane skeleton by Michael-Michael- elimination reaction

Tokuzaki, K., Kanemitu, Y., Yoshimitsu, T. & Nagaoka, H., Jul 29 2000, In : Tetrahedron Letters. 41, 31, p. 5923-5926 4 p.

Research output: Contribution to journalArticle

Skeleton
pantolactone
11 Citations (Scopus)

Pharmacokinetics of Agelastatin A in the central nervous system

Li, Z., Kamon, T., Personett, D. A., Caulfield, T., Copland, J. A., Yoshimitsu, T. & Tun, H. W., Feb 2012, In : MedChemComm. 3, 2, p. 233-237 5 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Neurology
Osteopontin
Central Nervous System
Brain Neoplasms
12 Citations (Scopus)

Potent growth inhibitory activity of (±)-platencin towards multi-drug-resistant and extensively drug-resistant Mycobacterium tuberculosis

Moustafa, G. A. I., Nojima, S., Yamano, Y., Aono, A., Arai, M., Mitarai, S., Tanaka, T. & Yoshimitsu, T., 2013, In : MedChemComm. 4, 4, p. 720-723 4 p.

Research output: Contribution to journalArticle

Extensively Drug-Resistant Tuberculosis
Mycobacterium smegmatis
Mycobacterium
Mycobacterium tuberculosis
Multidrug-Resistant Tuberculosis
7 Citations (Scopus)

Practical Chiral Route to Muscarine and its Three Diastereomers

Ohshiba, Y., Yoshimitsu, T. & Ogasawara, K., 1995, In : Chemical and Pharmaceutical Bulletin. 43, 6, p. 1067-1069 3 p.

Research output: Contribution to journalArticle

Muscarine
Stereoisomerism
Alkaloids
27 Citations (Scopus)

Practical preparation of optically active O-benzylglycidol from optically active epichlorohydrin

Takano, S., Sekiguchi, Y., Setoh, M., Yoshimitsu, T., Inomata, K., Takahashi, M. & Ogasawara, K., Sep 1 1990, In : Heterocycles. 31, 9, p. 1715-1719 5 p.

Research output: Contribution to journalArticle

glycidol
Epichlorohydrin
32 Citations (Scopus)

Radical fixation of functionalized carbon resources: α-sp 3C - H carbamoylation of tertiary amines with aryl isocyanates

Yoshimitsu, T., Matsuda, K., Nagaoka, H., Tsukamoto, K. & Tanaka, T., Nov 22 2007, In : Organic Letters. 9, 24, p. 5115-5118 4 p.

Research output: Contribution to journalArticle

Isocyanates
Carbon Cycle
isocyanates
Amines
resources
60 Citations (Scopus)

Radical hydroxyalkylation of C-H bond adjacent to nitrogen of tertiary amides, ureas, and amines

Yoshimitsu, T., Arano, Y. & Nagaoka, H., Aug 24 2005, In : Journal of the American Chemical Society. 127, 33, p. 11610-11611 2 p.

Research output: Contribution to journalArticle

Aldehydes
Amides
Urea
Amines
Nitrogen
36 Citations (Scopus)

Radical α-C-H hydroxyalkylation of ethers and acetal

Yoshimitsu, T., Arano, Y. & Nagaoka, H., Mar 18 2005, In : Journal of Organic Chemistry. 70, 6, p. 2342-2345 4 p.

Research output: Contribution to journalArticle

Acetals
Ethers
Aldehydes
Oxygen
Air

Regioselective Rearrangement of 4,4-Disubstituted 2-Hydroxycyclohexa-2,5-Dienones under Deoxyfluorination Conditions

Takubo, K., Mohamed, A., Ide, T., Saito, K., Ikawa, T., Yoshimitsu, T. & Akai, S., Dec 15 2017, In : Journal of Organic Chemistry. 82, 24, p. 13141-13151 11 p.

Research output: Contribution to journalArticle

Regioselectivity
Phenols
Phenol
Carbon
Acids
4 Citations (Scopus)

Ru(II)-Catalyzed C-H Aminocarbonylation of N -(Hetero)aryl-7-azaindoles with Isocyanates

Jeong, T., Lee, S. H., Chun, R., Han, S., Han, S. H., Jeon, Y. U., Park, J., Yoshimitsu, T., Mishra, N. K. & Kim, I. S., Apr 20 2018, In : Journal of Organic Chemistry. 83, 8, p. 4641-4649 9 p.

Research output: Contribution to journalArticle

Isocyanates
Ruthenium
Carboxylic Acids
Functional groups
Amines
2 Citations (Scopus)

Stereoconvergent route to chiral cyclohexenone building blocks: Formal synthesis of (-)-dysidiolide

Moustafa, G. A. I., Kamada, Y., Tanaka, T. & Yoshimitsu, T., Nov 21 2012, In : Organic and Biomolecular Chemistry. 10, 43, p. 8609-8615 7 p.

Research output: Contribution to journalArticle

Stereoisomerism
activity (biology)
routes
synthesis
dysidiolide
5 Citations (Scopus)

Stereoselective α-quaternization of 3-methoxycycloalk-2-enones via 1,4-diastereoinduction of alkoxy dienolates

Moustafa, G. A. I., Kamada, Y., Tanaka, T. & Yoshimitsu, T., Jan 20 2012, In : Journal of Organic Chemistry. 77, 2, p. 1202-1207 6 p.

Research output: Contribution to journalArticle

Alkylation
Chelation
Hydroxyl Radical
alkoxyl radical
Biological Products
Free Radicals
Nitrogen
Carbon
Carbamates
14 Citations (Scopus)

Structure-activity relationships of hybrid annonaceous acetogenins: Powerful growth inhibitory effects of their connecting groups between heterocycle and hydrophobic carbon chain bearing THF ring on human cancer cell lines

Kojima, N., Fushimi, T., Tatsukawa, T., Yoshimitsu, T., Tanaka, T., Yamori, T., Dan, S., Iwasaki, H. & Yamashita, M., 2013, In : European Journal of Medicinal Chemistry. 63, p. 833-839 7 p.

Research output: Contribution to journalArticle

Bearings (structural)
Acetogenins
Structure-Activity Relationship
Carbon
Cells
13 Citations (Scopus)

Studies of the asymmetric total synthesis of clavilactone D by the 'lariat' cyclization strategy

Yoshimitsu, T., Nojima, S., Hashimoto, M., Tsukamoto, K. & Tanaka, T., 2009, In : Synthesis. 17, p. 2963-2969 7 p.

Research output: Contribution to journalArticle

Cyclization
Lactones
Scaffolds
Protein-Tyrosine Kinases
clavilactone D
20 Citations (Scopus)

Studies on the total synthesis of (-)-CP-263,114

Yoshimitsu, T., Sasaki, S., Arano, Y. & Nagaoka, H., Dec 24 2004, In : Journal of Organic Chemistry. 69, 26, p. 9262-9268 7 p.

Research output: Contribution to journalArticle

Dehydrogenation
Chemical properties
alkoxyl radical
CP 263114
51 Citations (Scopus)

Synthesis of (-)-muricatacin via α- and α′-C-H bond functionalization of tetrahydrofuran

Yoshimitsu, T., Makino, T. & Nagaoka, H., Sep 19 2003, In : Journal of Organic Chemistry. 68, 19, p. 7548-7550 3 p.

Research output: Contribution to journalArticle

Oxidation
tetrahydrofuran
muricatacin
12 Citations (Scopus)

Synthesis of (±)-aphanorphine: a new approach to tricyclic 3-benzazepine scaffold using two radical C-C bond-forming reactions

Yoshimitsu, T., Atsumi, C., Iimori, E., Nagaoka, H. & Tanaka, T., Jul 21 2008, In : Tetrahedron Letters. 49, 29-30, p. 4473-4475 3 p.

Research output: Contribution to journalArticle

Benzazepines
Skeleton
Scaffolds
Nitrogen
Air
9 Citations (Scopus)

Synthesis of chaetomellic anhydride A, A potent inhibitor of ras protein farnesyltransferase

Yoshimitsu, T., Arano, Y., Kaji, T., Ino, T., Nagaoka, H. & Tanaka, T., Jan 1 2009, In : Heterocycles. 77, 1, p. 179-186 8 p.

Research output: Contribution to journalArticle

Carboxylation
ras Proteins
Anhydrides
Palladium
Maleic Anhydrides
14 Citations (Scopus)

Synthesis of the CD ring system of paclitaxel by atom-transfer radical annulation reaction

Yoshimitsu, T., Nakajima, H. & Nagaoka, H., Nov 18 2002, In : Tetrahedron Letters. 43, 47, p. 8587-8590 4 p.

Research output: Contribution to journalArticle

Paclitaxel
Glucose
Atoms
11 Citations (Scopus)

The Mitsunobu Reaction of 1,2-O-Benzylideneconduritol E: A New Route to Conduritol F

Yoshimitsu, T. & Ogasawara, K., Mar 1 1995, In : Synlett. 1995, 3, p. 257-259 3 p.

Research output: Contribution to journalArticle

4-nitrobenzoic acid
conduritol F
56 Citations (Scopus)

Total synthesis of (-)-agelastatin A

Yoshimitsu, T., Ino, T. & Tanaka, T., 2008, In : Organic Letters. 10, 23, p. 5457-5460 4 p.

Research output: Contribution to journalArticle

Cyclization
ureas
hydrolysis
routes
Oxazolidinones
1 Citation (Scopus)

Total synthesis of (-)-agelastatin A: An SH2′ radical azidation strategy

Tsuchimochi, I., Kitamura, Y., Aoyama, H., Akai, S., Nakai, K. & Yoshimitsu, T., Jan 1 2018, In : Chemical Communications. 54, 71, p. 9893-9896 4 p.

Research output: Contribution to journalArticle

Ether
Ethers
Alkaloids
Alkenes
Olefins
48 Citations (Scopus)

Total Synthesis of (+)-Muconin

Yoshimitsu, T., Makino, T. & Nagaoka, H., Mar 19 2004, In : Journal of Organic Chemistry. 69, 6, p. 1993-1998 6 p.

Research output: Contribution to journalArticle

Acetogenins
Cytotoxicity
Tumors
Cells
Oxidation
31 Citations (Scopus)

Total synthesis of (±)-kainic acid: A photochemical C-H carbamoylation approach

Kamon, T., Irifune, Y., Tanaka, T. & Yoshimitsu, T., May 20 2011, In : Organic Letters. 13, 10, p. 2674-2677 4 p.

Research output: Contribution to journalArticle

alkaloids
Kainic Acid
activity (biology)
Alkaloids
Proline
36 Citations (Scopus)

Total synthesis of (±)-platencin

Yoshimitsu, T., Nojima, S., Hashimoto, M. & Tanaka, T., Jul 15 2011, In : Organic Letters. 13, 14, p. 3698-3701 4 p.

Research output: Contribution to journalArticle

Carbon
carbon
Cyclization
synthesis
Titanium