• 1438 Citations
  • 20 h-Index
1978 …2018
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Research Output 1978 2018

  • 1438 Citations
  • 20 h-Index
  • 112 Article
  • 1 Chapter
  • 1 Review article
2004
9 Citations (Scopus)

Thymic myoid cells as a myasthenogenic antigen and antigen-presenting cells

Matsumoto, M. Y., Matsuo, H., Oka, T., Fukudome, T., Hayashi, K., Shiraishi, H., Motomura, M., Shibuya, N. & Ayabe, H., May 2004, In : Journal of Neuroimmunology. 150, 1-2, p. 80-87 8 p.

Research output: Contribution to journalArticle

Cholinergic Receptors
Antigen-Presenting Cells
Thymus Gland
Myasthenia Gravis
Antigens
2003
57 Citations (Scopus)

Activated Proliferation of B-Cell Lymphomas/Leukemias with the SHP1 Gene Silencing by Aberrant CpG Methylation

Koyama, M., Oka, T., Oouchida, M., Nakatani, Y., Nishiuchi, R., Yoshino, T., Hayashi, K., Akagi, T. & Seino, Y., Dec 2003, In : Laboratory Investigation. 83, 12, p. 1849-1858 10 p.

Research output: Contribution to journalArticle

B-Cell Leukemia
Gene Silencing
B-Cell Lymphoma
Methylation
Marginal Zone B-Cell Lymphoma
20 Citations (Scopus)

Rabbit model for human EBV-associated hemophagocytic syndrome (HPS): Sequential autopsy analysis and characterization of IL-2-dependent cell lines established from Herpesvirus papio-induced fatal rabbit lymphoproliferative diseases with HPS

Hayashi, K., Jin, Z., Onoda, S., Joko, H., Teramoto, N., Ohara, N., Oda, W., Tanaka, T., Liu, Y. X., Koirala, T. R., Oka, T., Kondo, E., Yoshino, T., Takahashi, K. & Akagi, T., May 1 2003, In : American Journal of Pathology. 162, 5, p. 1721-1736 16 p.

Research output: Contribution to journalArticle

Hemophagocytic Lymphohistiocytosis
Papio
Herpesviridae
Human Herpesvirus 4
Interleukin-2
Non-Receptor Type 6 Protein Tyrosine Phosphatase
Gene Silencing
Lymphoma
Leukemia
Methylation
10 Citations (Scopus)

Therapeutic trials for a rabbit model of EBV-associated Hemophagocytic Syndrome (HPS): Effects of vidarabine or CHOP, and development of Herpesvirus papio (HVP)-negative lymphomas surrounded by HVP-infected lymphoproliferative disease

Hayashi, K., Joko, H., Koirala, T. R., Onoda, S., Jin, Z. S., Munemasa, M., Ohara, N., Oda, W., Tanaka, T., Oka, T., Kondo, E., Yoshino, T., Takahashi, K., Yamada, M. & Akagi, T., Oct 2003, In : Histology and Histopathology. 18, 4, p. 1155-1168 14 p.

Research output: Contribution to journalArticle

Vidarabine
Hemophagocytic Lymphohistiocytosis
Papio
Herpesviridae
Human Herpesvirus 4
2002

Expression of heat shock protein 60 in normal and neoplastic human lymphoid tissues.

Oka, T., 2002, In : J Clin Exp Hematopathol. 42, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

166 Citations (Scopus)

Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas

Oka, T., Oouchida, M., Koyama, M., Ogama, Y., Takada, S., Nakatani, Y., Tanaka, T., Yoshino, T., Hayashi, K., Ohara, N., Kondo, E., Takahashi, K., Tsuchiyama, J., Tanimoto, M., Shimizu, K. & Akagi, T., Nov 15 2002, In : Cancer Research. 62, 22, p. 6390-6394 5 p.

Research output: Contribution to journalArticle

Non-Receptor Type 6 Protein Tyrosine Phosphatase
Gene Silencing
Methylation
Tyrosine
Lymphoma
2001
28 Citations (Scopus)

An animal model for human EBV-associated hemophagocytic syndrome: Herpesvirus papio frequently induces fatal lymphoproliferative disorders with hemophagocytic syndrome in rabbits

Hayashi, K., Ohara, N., Teramoto, N., Onoda, S., Chen, H. L., Oka, T., Kondo, E., Yoshino, T., Takahashi, K., Yates, J. & Akagi, T., 2001, In : American Journal of Pathology. 158, 4, p. 1533-1542 10 p.

Research output: Contribution to journalArticle

Hemophagocytic Lymphohistiocytosis
Lymphoproliferative Disorders
Papio
Herpesviridae
Human Herpesvirus 4
23 Citations (Scopus)

Loss of expression of α4β7 integrin and L-selectin is associated with high-grade progression of low-grade MALT lymphoma

Liu, Y. X., Yoshino, T., Ohara, N., Oka, T., Jin, Z. S., Hayashi, K. & Akagi, T., 2001, In : Modern Pathology. 14, 8, p. 798-805 8 p.

Research output: Contribution to journalArticle

L-Selectin
Marginal Zone B-Cell Lymphoma
Integrins
Non-Hodgkin's Lymphoma
Cell Adhesion Molecules
23 Citations (Scopus)

Morphological interactions of interdigitating dendritic cells with B and T cells in human mesenteric lymph nodes

Takahashi, K., Kenji, A., Norihiro, T., Eisaku, K., Oka, T., Kazuhiko, H., Yoshino, T. & Tadaatsu, A., Jul 2001, In : American Journal of Pathology. 159, 1, p. 131-138 8 p.

Research output: Contribution to journalArticle

Dendritic Cells
B-Lymphocytes
Lymph Nodes
T-Lymphocytes
Immunoglobulin D

Myasthenogenisity of thymic myoid cell.

Oka, T., 2001, In : J. Neuroimmunol. 118, p. 163-163 1 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Recent advances in DNA microarrays.

Nakanishi, T., Oka, T. & Akagi, T., Dec 2001, In : Acta Medica Okayama. 55, 6, p. 319-328 10 p.

Research output: Contribution to journalArticle

Microarrays
Oligonucleotide Array Sequence Analysis
Gene expression
Genes
Biological Science Disciplines
100 Citations (Scopus)

Reduction of hematopoietic cell-specific tyrosine phosphatase SHP-1 gene expression in natural killer cell lymphoma and various types of lymphomas/leukemias: Combination Analysis with cDNA expression array and tissue microarray

Oka, T., Yoshino, T., Hayashi, K., Ohara, N., Nakanishi, T., Yamaai, Y., Hiraki, A., Sogawa, C., Kondo, E., Teramoto, N., Takahashi, K., Tsuchiyama, J. & Akagi, T., 2001, In : American Journal of Pathology. 159, 4, p. 1495-1505 11 p.

Research output: Contribution to journalArticle

Non-Receptor Type 6 Protein Tyrosine Phosphatase
Oligonucleotide Array Sequence Analysis
Natural Killer Cells
Lymphoma
Leukemia
2000
3 Citations (Scopus)

Characterization of Epstein-Barr virus-infected mantle cell lymphoma lines

Jin, Z., Teramoto, N., Yoshino, T., Takada, K., Oka, T., Hayashi, K. & Akagi, T., 2000, In : Acta Medica Okayama. 54, 5, p. 193-200 8 p.

Research output: Contribution to journalArticle

Mantle-Cell Lymphoma
Human Herpesvirus 4
Viruses
Cell Line
Epstein-Barr Virus Infections
7 Citations (Scopus)

Differentiation of rat thymic myoid progenitor cell line established by coculture with human T-lymphotropic virus type-I-producing human T cells

Oka, T., Hayashi, K., Nakaoka, Y., Ohtsuki, Y. & Akagi, T., 2000, In : Cell and Tissue Research. 300, 1, p. 119-127 9 p.

Research output: Contribution to journalArticle

T-cells
Coculture Techniques
Viruses
Muscle
Rats
22 Citations (Scopus)

Epstein-Barr virus infection to Epstein-Barr virus-negative nasopharyngeal carcinoma cell line TW03 enhances its tumorigenicity

Teramoto, N., Maeda, A., Kobayashi, K., Hayashi, K., Oka, T., Takahashi, K., Takada, K., Klein, G. & Akagi, T., Mar 2000, In : Laboratory Investigation. 80, 3, p. 303-312 10 p.

Research output: Contribution to journalArticle

Epstein-Barr Virus Infections
Human Herpesvirus 4
Cell Line
Severe Combined Immunodeficiency
Nasopharyngeal carcinoma
7 Citations (Scopus)

Sequence analysis and variation of EBNA-1 in Epstein-Barr virus-related herpesvirus of cynomolgus monkey

Ohara, N., Hayashi, K., Teramoto, N., Oka, T., Fujimoto, K., Yoshikawa, Y., Castanos-Velez, E., Biberfeld, P. & Akagi, T., Aug 2000, In : Intervirology. 43, 2, p. 102-106 5 p.

Research output: Contribution to journalArticle

Epstein-Barr Virus Nuclear Antigens
Macaca fascicularis
Herpesviridae
Human Herpesvirus 4
Sequence Analysis
1999
18 Citations (Scopus)

Cyno-EBV (EBV-related herpesvirus from cynomolgus macaques) induces rabbit malignant lymphomas and their tumor cell lines frequently show specific chromosomal abnormalities

Hayashi, K., Chen, H. L., Yanai, H., Koirala, T. R., Ohara, N., Teramoto, N., Oka, T., Yoshino, T., Takahashi, K., Miyamoto, K., Fujimoto, K., Yoshikawa, Y. & Akagi, T., Jul 1999, In : Laboratory Investigation. 79, 7, p. 823-835 13 p.

Research output: Contribution to journalArticle

Herpesviridae
Macaca
Tumor Cell Line
Human Herpesvirus 4
Chromosome Aberrations
1998
70 Citations (Scopus)

Characterization of a novel human natural killer-cell line (NK-YS) established from natural killer cell lymphoma/leukemia associated with Epstein-Barr virus infection

Tsuchiyama, J., Yoshino, T., Mori, M., Kondoh, E., Oka, T., Akagi, T., Hiraki, A., Nakayama, H., Shibuya, A., Ma, Y., Kawabata, T., Okada, S. & Harada, M., Aug 15 1998, In : Blood. 92, 4, p. 1374-1383 10 p.

Research output: Contribution to journalArticle

Epstein-Barr Virus Infections
Viruses
Natural Killer Cells
Lymphoma
Leukemia
31 Citations (Scopus)

Evidence for specific immune response against P210 BCR-ABL in long-term remission CML patients treated with interferon

Oka, T., Sastry, K. J., Nehete, P., Schapiro, S. J., Guo, J. Q., Talpaz, M. & Arlinghaus, R. B., 1998, In : Leukemia. 12, 2, p. 155-163 9 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Interferons
Cell Extracts
Interferon-alpha
Cytogenetics
13 Citations (Scopus)

P53 protein expression in Non-HodgKins lymphomas is infrequently related to p53 gene mutation

Oka, T., 1998, In : Pathol. Int.. 48, p. 15-21 7 p.

Research output: Contribution to journalArticle

1997
9 Citations (Scopus)

Analysis of the Genome of an Epstein-Barr-Virus (EBV)-Related Herpesvirus in a Cynomolgus Monkey Cell Line (Si-IIA)

Ino, H., Hayashi, K., Yanai, H., Teramoto, N., Koirala, T. R., Chen, H. L., Oka, T., Yoshino, T., Takahashi, K. & Akagi, T., Aug 1997, In : Acta Medica Okayama. 51, 4, p. 207-212 6 p.

Research output: Contribution to journalArticle

Macaca fascicularis
Herpesviridae
Human Herpesvirus 4
Viruses
Genes
1996
3 Citations (Scopus)

Metastatic potential of lymphoma/leukemia cell lines in SCID mice is closely related to expression of CD44

Kawasaki, N., Matsuo, Y., Yoshino, T., Yanai, H., Oka, T., Teramoto, N., Liu, C., Kondo, E., Minowada, J. & Akagi, T., Oct 1996, In : Japanese Journal of Cancer Research. 87, 10, p. 1070-1077 8 p.

Research output: Contribution to journalArticle

SCID Mice
L-Selectin
Lymphoma
Leukemia
Neoplasm Metastasis
1995
1 Citation (Scopus)

A case of adult human herpesvirus-6 associated hemophagocytic syndrome recovered from acute liver failure

Oka, T., Shinzaki, H., Torimoto, Y., Hasebe, C., Fujimoto, Y., Mizuno, M., Kohda, H., Hirai, K., Takemori, N., Sekiya, C. & Kohgo, Y., 1995, In : Japanese Journal of Gastroenterology. 92, 8, p. 1194-1199 6 p.

Research output: Contribution to journalArticle

1993
53 Citations (Scopus)

Aberrant expression of the p53 tumor suppressor gene in adult T-cell leukemia and HTLV-I-infected cells

Yamato, K., Oka, T., Hiroi, M., Iwahara, Y., Sugito, S., Tsuchida, N. & Miyoshi, I., Jan 1993, In : Japanese Journal of Cancer Research. 84, 1, p. 4-8 5 p.

Research output: Contribution to journalArticle

Adult T Cell Leukemia Lymphoma
Human T-lymphotropic virus 1
Tumor Suppressor Genes
Cell Line
Missense Mutation
17 Citations (Scopus)

Morphological characterization of a new human epithelioid sarcoma cell line, ES020488, in vitro and in vivo

Sonobe, H., Furihata, M., Iwata, J., Oka, T., Ohtsuki, Y., Hamasato, S. & Fujimoto, S., Dec 1993, In : Virchows Archiv B Cell Pathology Including Molecular Pathology. 63, 1, p. 219-225 7 p.

Research output: Contribution to journalArticle

Epithelioid Cells
Sarcoma
Cell Line
Euchromatin
Neoplasms
1992
71 Citations (Scopus)

Establishment and characterization of a new human synovial sarcoma cell line, HS-SY-II

Sonobe, H., Manabe, Y., Furihata, M., Iwata, J., Oka, T., Ohtsuki, Y., Mizobuchi, H., Yamamoto, H., Kumano, O. & Abe, S., 1992, In : Laboratory Investigation. 67, 4, p. 498-505 8 p.

Research output: Contribution to journalArticle

Synovial Sarcoma
Cell Line
Sarcoma
Immunohistochemistry
Pseudopodia
5 Citations (Scopus)

Inhibitory effects of human interferons on the immortalization of human, but not rabbit, T lymphocytes by human T-lymphotropic virus type-I (HTLV-I)

Oka, T., Iwata, J., Furihata, M., Sonobe, H., Miyoshi, I. & Ohtsuki, Y., 1992, In : International Journal of Cancer. 51, 6, p. 915-920 6 p.

Research output: Contribution to journalArticle

Interferons
Rabbits
Viruses
T-Lymphocytes
Lymphocytes
17 Citations (Scopus)

Phenotypic progression of a rat lymphoid cell line immortalized by human T-lymphotropic virus type I to induce lymphoma/leukemia-like disease in rats

Oka, T., Sonobe, H., Iwata, J., Kubonishi, I., Satoh, H., Takata, M., Tanaka, Y., Tateno, M., Tozawa, H., Mori, S., Yoshiki, T. & Ohtsuki, Y., Nov 1992, In : Journal of Virology. 66, 11, p. 6686-6694 9 p.

Research output: Contribution to journalArticle

lymphoma
leukemia
Lymphoma
Leukemia
cell lines

Plant defence and molecular evolution.

Oka, T., 1992, In : The Heredity,. 46, p. 51-57 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Similarity, in molecular structure and function, between the plant toxin purothionin and the mammalian pore-forming proteins

Oka, T., Murata, Y., Nakanishi, T., Yoshizumi, H., Hayashida, H., Ohtsuki, Y., Toyoshima, K. & Hakura, A., 1992, In : Molecular Biology and Evolution. 9, 4, p. 707-715 9 p.

Research output: Contribution to journalArticle

Porins
phytotoxins
Molecular Structure
chemical structure
Molecular structure
1991

Adult T-cell leukemia/lymphoma with skin lesions similar to mycosis fungoides.(共著)

Oka, T., 1991, In : Rinshou Hifu. 45, p. 17-21 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Characterization of two human lymphoid cell lines producing human T-lymphotropic virus type I (HTLV-I) isolated from patients with HTLV-I-associated myelopathy or encephalopathy

Iwata, J., Oka, T., Furihata, M., Sonobe, H., Matsubayashi, K., Uemura, Y., Miyoshi, I. & Ohtsuki, Y., Mar 1991, In : Archives of Virology. 118, 1-2, p. 101-112 12 p.

Research output: Contribution to journalArticle

Spinal Cord Diseases
Brain Diseases
Lymphocytes
Viruses
Cell Line
10 Citations (Scopus)

Morphological characterization of a newly established human osteosarcoma cell line, HS-Os-1, revealing its distinct osteoblastic nature

Sonobe, H., Mizobuchi, H., Manabe, Y., Furihata, M., Iwata, J., Hikita, T., Oka, T., Ohtsuki, Y. & Goto, T., Dec 1991, In : Virchows Archiv B Cell Pathology Including Molecular Pathology. 60, 1, p. 181-187 7 p.

Research output: Contribution to journalArticle

Osteosarcoma
Cell Line
Neoplasms
Cytoplasm
Polyribosomes

Single cilium in human leukemic cells heterotransplanted into hamsters

Ohtsuki, Y., Kubonishi, I., Sonobe, H., Iwata, J., Oka, T. & Miyoshi, I., 1991, In : Acta Anatomica. 141, 1, p. 42-45 4 p.

Research output: Contribution to journalArticle

Cilia
Heterografts
Cricetinae
Cell Line
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
1990
1 Citation (Scopus)

Characterization of flat revertants isolated from cells transformed by Abelson murine leukemia virus (Ab-MuLV)

Oka, T., Yutsudo, M., Inoue, H., Higuchi, F. & Hakura, A., Dec 1990, In : Journal of Cellular Physiology. 145, 3, p. 428-433 6 p.

Research output: Contribution to journalArticle

Abelson murine leukemia virus
abl Genes
Viruses
Oncogene Proteins v-abl
Helper Viruses
1 Citation (Scopus)

Establishment and characterization of a cell line, HS-Os-1 derived from an osteoblastic type of human osteosarcoma

Sonobe, H., Mizobuchi, H., Manabe, Y., Furihata, M., Iwata, J., Hikita, T., Kiuna, O., Tanimoto, T., Oka, T. & Ohtsuki, Y., Jun 1990, In : Human cell : official journal of Human Cell Research Society. 3, 2, p. 148-151 4 p.

Research output: Contribution to journalArticle

Osteosarcoma
Cell Line
Nude Mice
Euchromatin
Polyribosomes
5 Citations (Scopus)

Establishment and characterization of a human cell line, HS-MM, derived from a case of clear cell sarcoma

Sonobe, H., Manabe, Y., Furihata, M., Iwata, J., Hikita, T., Tanimoto, T., Kiuna, O., Oka, T., Ohtsuki, Y. & Mizobuchi, H., Dec 1990, In : Human cell : official journal of Human Cell Research Society. 3, 4, p. 352-356 5 p.

Research output: Contribution to journalArticle

Clear Cell Sarcoma
Cell Line
Melanoma
Amelanotic Melanoma
Euchromatin
19 Citations (Scopus)

Suppressive effects of interferons on the production and release of human T-lymphotropic virus type-I (HTLV-I)

Oka, T., Ohtsuki, Y., Sonobe, H., Furihata, M. & Miyoshi, I., Mar 1990, In : Archives of Virology. 115, 1-2, p. 63-73 11 p.

Research output: Contribution to journalArticle

Interferons
Viruses
RNA-Directed DNA Polymerase
Virion
Virus Assembly

Ultrastructural and immunoelectron microscopic observation of human T-lymphotropic virus type I (HTLV-I) with high voltage electron microscope

Ohtsuki, Y., Iwata, J., Furihata, M., Hikita, T., Mizobuchi, H., Manabe, Y., Oka, T., Ido, E., Sonobe, H. & Miyoshi, I., 1990, In : Journal of Clinical Electron Microscopy. 23, 4, p. 373-381 9 p.

Research output: Contribution to journalArticle

Electrons
Viruses
1989
2 Citations (Scopus)

Electron microscopic study of suppressive effects on the production of human T-lymphotropic virus type I (HTLV-I)1 with human interferons

Ohtsuki, Y., Oka, T., Furihata, M., Takahashi, K., Hayashi, K., Iwata, J., Hikita, T., Sonobe, H. & Miyoshi, I., 1989, In : Journal of Clinical Electron Microscopy. 22, 2, p. 205-213 9 p.

Research output: Contribution to journalArticle

Human T-lymphotropic virus 1
Interferons
Electrons
2 Citations (Scopus)

Immortalization of rat spleen and thymus T cells by human T-cell leukemia virus type I

Akagi, T., Takata, H., Yoshino, T., Teramoto, N., Yano, S. & Oka, T., 1989, In : Acta Medica Okayama. 43, 3, p. 143-150 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Inactivation and Activation of Inward Current During Adaptation to Potassium Ions in Paramecium Caudatum

Oka, T. & Nakaoka, Y., 1989, In : Cell Structure and Function. 14, 2, p. 209-216 8 p.

Research output: Contribution to journalArticle

Paramecium caudatum
Potassium
Ions
Membrane Potentials
Paramecium
1988
3 Citations (Scopus)

Immunocytochemical and ultrastructural characterization of human T-lymphotropic virus type I (HTLV-I)-producing rabbit lymphoid cell lines

Ohtsuki, Y., Miyoshi, I., Oka, T., Hayashi, K., Takahashi, K., Furihata, M., Iwata, J., Takeuchi, T. & Sonobe, H., Sep 1988, In : Archives of Virology. 100, 3-4, p. 245-254 10 p.

Research output: Contribution to journalArticle

Lymphocytes
Rabbits
Viruses
Cell Line
Simian T-lymphotropic virus 1