• 2937 Citations
  • 29 h-Index
19992020

Research output per year

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Research Output

2020

18F-labeled, PSMA-targeted radiotracers: Leveraging the advantages of radiofluorination for prostate cancer molecular imaging

Werner, R. A., Derlin, T., Lapa, C., Sheikbahaei, S., Higuchi, T., Giesel, F. L., Behr, S., Drzezga, A., Kimura, H., Buck, A. K., Bengel, F. M., Pomper, M. G., Gorin, M. A. & Rowe, S. P., 2020, In : Theranostics. 10, 1, p. 1-16 16 p.

Research output: Contribution to journalReview article

Open Access
6 Citations (Scopus)

Cytotoxic T Lymphocytes Regenerated from iPS Cells Have Therapeutic Efficacy in a Patient-Derived Xenograft Solid Tumor Model

Kashima, S., Maeda, T., Masuda, K., Nagano, S., Inoue, T., Takeda, M., Kono, Y., Kobayashi, T., Saito, S., Higuchi, T., Ichise, H., Kobayashi, Y., Iwaisako, K., Terada, K., Agata, Y., Numakura, K., Saito, M., Narita, S., Yasukawa, M., Ogawa, O. & 2 others, Habuchi, T. & Kawamoto, H., Apr 24 2020, In : iScience. 23, 4, 100998.

Research output: Contribution to journalArticle

Open Access

Initial Evaluation of AF78: a Rationally Designed Fluorine-18-Labelled PET Radiotracer Targeting Norepinephrine Transporter

Chen, X., Fritz, A., Werner, R. A., Nose, N., Yagi, Y., Kimura, H., Rowe, S. P., Koshino, K., Decker, M. & Higuchi, T., Jun 1 2020, In : Molecular Imaging and Biology. 22, 3, p. 602-611 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Microstructural white matter changes following gait training with Hybrid Assistive Limb initiated within 1 week of stroke onset

Ando, D., Yokota, C., Koshino, K., Yasuno, F., Sato, T., Yamamoto, A., Odani, H., Nakajima, T., Higuchi, T. & Tatsumi, E., Aug 15 2020, In : Journal of the neurological sciences. 415, 116939.

Research output: Contribution to journalArticle

Recent advances in radiotracers targeting norepinephrine transporter: structural development and radiolabeling improvements

Chen, X., Kudo, T., Lapa, C., Buck, A. & Higuchi, T., Jun 1 2020, In : Journal of Neural Transmission. 127, 6, p. 851-873 23 p.

Research output: Contribution to journalReview article

Open Access

Recent paradigm shifts in molecular cardiac imaging—Establishing precision cardiology through novel 18F-labeled PET radiotracers

Werner, R. A., Chen, X., Rowe, S. P., Lapa, C., Javadi, M. S. & Higuchi, T., Jan 2020, In : Trends in Cardiovascular Medicine. 30, 1, p. 11-19 9 p.

Research output: Contribution to journalReview article

Open Access
4 Citations (Scopus)

Semiquantitative Parameters in PSMA-Targeted PET Imaging with [18F]DCFPyL: Impact of Tumor Burden on Normal Organ Uptake

Werner, R. A., Bundschuh, R. A., Bundschuh, L., Lapa, C., Yin, Y., Javadi, M. S., Buck, A. K., Higuchi, T., Pienta, K. J., Pomper, M. G., Lodge, M. A., Gorin, M. A. & Rowe, S. P., Feb 1 2020, In : Molecular Imaging and Biology. 22, 1, p. 190-197 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Synthesis of 18F-labeled streptozotocin derivatives and an in-vivo kinetics study using positron emission tomography

Arimitsu, K., Yagi, Y., Koshino, K., Nishito, Y., Higuchi, T., Yasui, H. & Kimura, H., Sep 1 2020, In : Bioorganic and Medicinal Chemistry Letters. 30, 17, 127400.

Research output: Contribution to journalArticle

2019

18 F-NaF-PET/CT for the detection of bone metastasis in prostate cancer: a meta-analysis of diagnostic accuracy studies

Sheikhbahaei, S., Jones, K. M., Werner, R. A., Salas-Fragomeni, R. A., Marcus, C. V., Higuchi, T., Rowe, S. P., Solnes, L. B. & Javadi, M. S., Jan 1 2019, (Accepted/In press) In : Annals of nuclear medicine.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Comparison of two software systems for quantification of myocardial blood flow in patients with hypertrophic cardiomyopathy

Yalcin, H., Valenta, I., Zhao, M., Tahari, A., Lu, D. Y., Higuchi, T., Yalcin, F., Kucukler, N., Soleimanifard, Y., Zhou, Y., Pomper, M. G., Abraham, T. P., Tsui, B., Lodge, M. A., Schindler, T. H. & Roselle Abraham, M., Aug 15 2019, In : Journal of Nuclear Cardiology. 26, 4, p. 1243-1253 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Correction to: Comparison of two software systems for quantification of myocardial blood flow in patients with hypertrophic cardiomyopathy (Journal of Nuclear Cardiology, (2019), 26, 4, (1243-1253), 10.1007/s12350-017-1155-x)

Yalcin, H., Valenta, I., Zhao, M., Tahari, A., Lu, D. Y., Higuchi, T., Yalcin, F., Kucukler, N., Soleimanifard, Y., Zhou, Y., Pomper, M. G., Abraham, T. P., Tsui, B., Lodge, M. A., Schindler, T. H. & Abraham, M. R., Aug 15 2019, In : Journal of Nuclear Cardiology. 26, 4, 1 p.

Research output: Contribution to journalComment/debate

Open Access

CXCR4-directed imaging in solid tumors

Werner, R. A., Kircher, S., Higuchi, T., Kircher, M., Schirbel, A., Wester, H. J., Buck, A. K., Pomper, M. G., Rowe, S. P. & Lapa, C., 2019, In : Frontiers in Oncology. 9, AUG, 770.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Detection of increased intracerebral lactate in a mouse model of Leigh syndrome using proton MR spectroscopy

Takahashi, Y., Kioka, H., Shintani, Y., Ohki, A., Takashima, S., Sakata, Y., Higuchi, T. & Saito, S., May 2019, In : Magnetic Resonance Imaging. 58, p. 38-43 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
8 Citations (Scopus)

Efficient gallium-68 radiolabeling reaction of DOTA derivatives using a resonant-type microwave reactor

Yagi, Y., Shimizu, Y., Arimitsu, K., Nakamoto, Y., Higuchi, T., Togashi, K. & Kimura, H., Mar 2019, In : Journal of Labelled Compounds and Radiopharmaceuticals. 62, 3, p. 132-138 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Follow-up of lesions with equivocal radiotracer uptake on PSMA-targeted PET in patients with prostate cancer: Predictive values of the PSMA-RADS-3A and PSMA-RADS-3B categories

Yin, Y., Werner, R. A., Higuchi, T., Lapa, C., Pienta, K. J., Pomper, M. G., Gorin, M. A. & Rowe, S. P., Apr 1 2019, In : Journal of Nuclear Medicine. 60, 4, p. 511-516 6 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

From the Reading Room to the Courtroom—The Use of Molecular Radionuclide Imaging in Criminal Trials

Werner, R. A., Savoie, B., Javadi, M. S., Pomper, M. G., Higuchi, T., Lapa, C. & Rowe, S. P., Nov 2019, In : Journal of the American College of Radiology. 16, 11, p. 1612-1617 6 p.

Research output: Contribution to journalArticle

Impact of aging on semiquantitative uptake parameters in normal rated clinical baseline [123I]Ioflupane single photon emission computed tomography/computed tomography

Werner, R. A., Lapa, C., Sheikhbahaei, S., Marcus, C., Solnes, L. B., Du, Y., Leal, J. P., Buck, A. K., Higuchi, T., Rowe, S. P. & Javadi, M. S., Oct 1 2019, In : Nuclear medicine communications. 40, 10, p. 1001-1004 4 p.

Research output: Contribution to journalArticle

Impact of Tumor Burden on Quantitative [68Ga] DOTATOC Biodistribution

Werner, R. A., Hänscheid, H., Leal, J. P., Javadi, M. S., Higuchi, T., Lodge, M. A., Buck, A. K., Pomper, M. G., Lapa, C. & Rowe, S. P., Aug 15 2019, In : Molecular Imaging and Biology. 21, 4, p. 790-798 9 p.

Research output: Contribution to journalArticle

Open Access

Longitudinal 18F-FDG PET imaging in a rat model of autoimmune myocarditis

Werner, R. A., Wakabayashi, H., Bauer, J., Schütz, C., Zechmeister, C., Hayakawa, N., Javadi, M. S., Lapa, C., Jahns, R., Ergün, S., Jahns, V. & Higuchi, T., Apr 1 2019, In : European Heart Journal Cardiovascular Imaging. 20, 4, p. 467-474 8 p.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Moving into the next era of PET myocardial perfusion imaging: introduction of novel 18 F-labeled tracers

Werner, R. A., Chen, X., Rowe, S. P., Lapa, C., Javadi, M. S. & Higuchi, T., Mar 1 2019, In : International Journal of Cardiovascular Imaging. 35, 3, p. 569-577 9 p.

Research output: Contribution to journalReview article

Open Access
5 Citations (Scopus)

Neurite orientation dispersion and density imaging for evaluating the severity of neonatal hypoxic-ischemic encephalopathy in rats

Ohki, A., Saito, S., Hata, J., Okano, H. J., Higuchi, T. & Fukuchi, K., Oct 2019, In : Magnetic Resonance Imaging. 62, p. 214-219 6 p.

Research output: Contribution to journalArticle

Novel Functional Renal PET Imaging with 18F-FDS in Human Subjects

Werner, R. A., Ordonez, A. A., Sanchez-Bautista, J., Marcus, C., Lapa, C., Rowe, S. P., Pomper, M. G., Leal, J. P., Lodge, M. A., Javadi, M. S., Jain, S. K. & Higuchi, T., May 1 2019, In : Clinical Nuclear Medicine. 44, 5, p. 410-411 2 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Novel structured reporting systems for theranostic radiotracers

Werner, R. A., Bundschuh, R. A., Bundschuh, L., Fanti, S., Javadi, M. S., Higuchi, T., Weich, A., Pienta, K. J., Buck, A. K., Pomper, M. G., Gorin, M. A., Herrmann, K., Lapa, C. & Rowe, S. P., May 1 2019, In : Journal of Nuclear Medicine. 60, 5, p. 577-584 8 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Pre-therapy Somatostatin Receptor-Based Heterogeneity Predicts Overall Survival in Pancreatic Neuroendocrine Tumor Patients Undergoing Peptide Receptor Radionuclide Therapy

Werner, R. A., Ilhan, H., Lehner, S., Papp, L., Zsótér, N., Schatka, I., Muegge, D. O., Javadi, M. S., Higuchi, T., Buck, A. K., Bartenstein, P., Bengel, F., Essler, M., Lapa, C. & Bundschuh, R. A., Jun 17 2019, In : Molecular Imaging and Biology. 21, 3, p. 582-590 9 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Roles of the mesenchymal stromal/stem cell marker meflin in cardiac tissue repair and the development of diastolic dysfunction

Hara, A., Kobayashi, H., Asai, N., Saito, S., Higuchi, T., Kato, K., Okumura, T., Bando, Y. K., Takefuji, M., Mizutani, Y., Miyai, Y., Saito, S., Maruyama, S., Maeda, K., Ouchi, N., Nagasaka, A., Miyata, T., Mii, S., Kioka, N., Worthley, D. L. & 3 others, Murohara, T., Takahashi, M. & Enomoto, A., Aug 2 2019, In : Circulation research. 125, 4, p. 414-430 17 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Stability of Distribution of F18 Flurpiridaz After Transient Coronary Occlusion in Pigs

Werner, R. A., Koshino, K., Arimitsu, K., Lapa, C., Javadi, M. S., Rowe, S. P., Nose, N., Kimura, H., Fukushima, K. & Higuchi, T., Nov 2019, In : JACC: Cardiovascular Imaging. 12, 11P1, p. 2269-2271 3 p.

Research output: Contribution to journalLetter

The next era of renal radionuclide imaging: novel PET radiotracers

Werner, R. A., Chen, X., Lapa, C., Koshino, K., Rowe, S. P., Pomper, M. G., Javadi, M. S. & Higuchi, T., Aug 1 2019, In : European Journal of Nuclear Medicine and Molecular Imaging. 46, 9, p. 1773-1786 14 p.

Research output: Contribution to journalReview article

5 Citations (Scopus)

Ventricular Distribution Pattern of the Novel Sympathetic Nerve PET Radiotracer 18F-LMI1195 in Rabbit Hearts

Werner, R. A., Wakabayashi, H., Chen, X., Hayakawa, N., Lapa, C., Rowe, S. P., Javadi, M. S., Robinson, S. & Higuchi, T., Dec 1 2019, In : Scientific reports. 9, 1, 17026.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Visual and semiquantitative accuracy in clinical baseline 123I-Ioflupane SPECT/CT imaging

Werner, R. A., Marcus, C., Sheikhbahaei, S., Solnes, L. B., Leal, J. P., Du, Y., Rowe, S. P., Higuchi, T., Buck, A. K., Lapa, C. & Javadi, M. S., Jan 1 2019, In : Clinical Nuclear Medicine. 44, 1, p. 1-3 3 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Volumetric and texture analysis of pretherapeutic 18 F-FDG PET can predict overall survival in medullary thyroid cancer patients treated with Vandetanib

Werner, R. A., Bundschuh, R. A., Higuchi, T., Javadi, M. S., Rowe, S. P., Zsótér, N., Kroiss, M., Fassnacht, M., Buck, A. K., Kreissl, M. C. & Lapa, C., Feb 15 2019, In : Endocrine. 63, 2, p. 293-300 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2018

18F-Labeled Derivatives of Irbesartan for Angiotensin II Receptor PET Imaging

Hoffmann, M., Chen, X., Hirano, M., Arimitsu, K., Kimura, H., Higuchi, T. & Decker, M., Dec 6 2018, In : ChemMedChem. 13, 23, p. 2546-2557 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A Voice From the Past: Rediscovering the Virchow Node With Prostate-specific Membrane Antigen-targeted 18F-DCFPyL Positron Emission Tomography Imaging

Werner, R. A., Andree, C., Javadi, M. S., Lapa, C., Buck, A. K., Higuchi, T., Pomper, M. G., Gorin, M. A., Rowe, S. P. & Pienta, K. J., Jul 2018, In : Urology. 117, p. 18-21 4 p.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Correction to: Pre-therapy Somatostatin Receptor-Based Heterogeneity Predicts Overall Survival in Pancreatic Neuroendocrine Tumor Patients Undergoing Peptide Receptor Radionuclide Therapy (Molecular Imaging and Biology, (2018), 10.1007/s11307-018-1252-5)

Werner, R. A., Ilhan, H., Lehner, S., Papp, L., Zsótér, N., Schatka, I., Muegge, D. O., Javadi, M. S., Higuchi, T., Buck, A. K., Bartenstein, P., Bengel, F., Essler, M., Lapa, C. & Bundschuh, R. A., Dec 1 2018, In : Molecular Imaging and Biology. 20, 6, 1 p.

Research output: Contribution to journalComment/debate

Open Access
1 Citation (Scopus)

Development of a dynamic micro RI imaging system for single cells

Hirumi, G., Nishikido, F., Tashima, H., Wakizaka, H., Higuchi, T., Haneishi, H. & Yamaya, T., Nov 12 2018, 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017 - Conference Proceedings. Institute of Electrical and Electronics Engineers Inc., 8533008. (2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017 - Conference Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Functional renal imaging with 2-deoxy-2- 18 F-Fluorosorbitol PET in rat models of renal disorders

Werner, R. A., Wakabayashi, H., Chen, X., Hirano, M., Shinaji, T., Lapa, C., Rowe, S. P., Javadi, M. S. & Higuchi, T., May 1 2018, In : Journal of Nuclear Medicine. 59, 5, p. 828-832 5 p.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Generative Adversarial Networks for the Creation of Realistic Artificial Brain Magnetic Resonance Images

Kazuhiro, K., Werner, R. A., Toriumi, F., Javadi, M. S., Pomper, M. G., Solnes, L. B., Verde, F., Higuchi, T. & Rowe, S. P., Dec 1 2018, In : Tomography (Ann Arbor, Mich.). 4, 4, p. 159-163 5 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Impact of novel antidepressants on cardiac 123 I Metaiodobenzyl guanidine uptake: Experimental studies on SK-N-SH cells and healthy rabbits

Werner, R. A., Kobayashi, R., Javadi, M. S., Köck, Z., Wakabayashi, H., Unterecker, S., Nakajima, K., Lapa, C., Menke, A. & Higuchi, T., Jul 1 2018, In : Journal of Nuclear Medicine. 59, 7, p. 1099-1103 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Interobserver agreement for the standardized reporting system PSMA-RADS 1.0 on18F-DCFPYL PET/CT imaging

Werner, R. A., Bundschuh, R. A., Bundschuh, L., Javadi, M. S., Leal, J. P., Higuchi, T., Pienta, K. J., Buck, A. K., Pomper, M. G., Gorin, M. A., Lapa, C. & Rowe, S. P., Dec 1 2018, In : Journal of Nuclear Medicine. 59, 12, p. 1857-1864 8 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Left Ventricular Diastolic Dysfunction in a Rat Model of Diabetic Cardiomyopathy using ECG-gated 18F-FDG PET

Werner, R. A., Eissler, C., Hayakawa, N., Arias-Loza, P., Wakabayashi, H., Javadi, M. S., Chen, X., Shinaji, T., Lapa, C., Pelzer, T. & Higuchi, T., Dec 1 2018, In : Scientific reports. 8, 1, 17631.

Research output: Contribution to journalArticle

Open Access

L-Serine-modified polyamidoamine dendrimer as a highly potent renal targeting drug carrier

Matsuura, S., Katsumi, H., Suzuki, H., Hirai, N., Hayashi, H., Koshino, K., Higuchi, T., Yagi, Y., Kimura, H., Sakane, T. & Yamamoto, A., Oct 9 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 41, p. 10511-10516 6 p.

Research output: Contribution to journalArticle

Open Access

Metabolic substrate shift in human induced pluripotent stem cells during cardiac differentiation: Functional assessment using in vitro radionuclide uptake assay

Nose, N., Werner, R. A., Ueda, Y., Günther, K., Lapa, C., Javadi, M. S., Fukushima, K., Edenhofer, F. & Higuchi, T., Oct 15 2018, In : International Journal of Cardiology. 269, p. 229-234 6 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Molecular imaging reporting and data systems (MI-RADS): a generalizable framework for targeted radiotracers with theranostic implications

Werner, R. A., Bundschuh, R. A., Bundschuh, L., Javadi, M. S., Higuchi, T., Weich, A., Sheikhbahaei, S., Pienta, K. J., Buck, A. K., Pomper, M. G., Gorin, M. A., Lapa, C. & Rowe, S. P., Oct 1 2018, In : Annals of nuclear medicine. 32, 8, p. 512-522 11 p.

Research output: Contribution to journalReview article

Open Access
11 Citations (Scopus)

Novel 18F-Labeled PET Imaging Agent FV45 Targeting the Renin-Angiotensin System

Chen, X., Hirano, M., Werner, R. A., Decker, M. & Higuchi, T., Sep 4 2018, In : ACS Omega. 3, 9, p. 10460-10470 11 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Predictive value of 18 F-FDG PET in patients with advanced medullary thyroid carcinoma treated with vandetanib

Werner, R. A., Schmid, J. S., Higuchi, T., Javadi, M. S., Rowe, S. P., Märkl, B., Aulmann, C., Fassnacht, M., Kroiss, M., Reiners, C., Buck, A. K., Kreissl, M. C. & Lapa, C., May 1 2018, In : Journal of Nuclear Medicine. 59, 5, p. 756-761 6 p.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

SPECT vs. PET in cardiac innervation imaging: clash of the titans

Werner, R. A., Chen, X., Hirano, M., Rowe, S. P., Lapa, C., Javadi, M. S. & Higuchi, T., Aug 1 2018, In : Clinical and Translational Imaging. 6, 4, p. 293-303 11 p.

Research output: Contribution to journalReview article

Open Access
11 Citations (Scopus)

SSTR-RADS version 1.0 as a reporting system for SSTR PET imaging and selection of potential PRRT candidates: A proposed standardization framework

Werner, R. A., Solnes, L. B., Javadi, M. S., Weich, A., Gorin, M. A., Pienta, K. J., Higuchi, T., Buck, A. K., Pomper, M. G., Rowe, S. P. & Lapa, C., Jul 1 2018, In : Journal of Nuclear Medicine. 59, 7, p. 1085-1091 7 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Subcellular storage and release mode of the novel 18F-labeled sympathetic nerve PET tracer LMI1195

Chen, X., Werner, R. A., Lapa, C., Nose, N., Hirano, M., Javadi, M. S., Robinson, S. & Higuchi, T., 2018, In : EJNMMI Research. 8, 12.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

The Impact of Ageing on 11C-Hydroxyephedrine Uptake in the Rat Heart

Werner, R. A., Chen, X., Maya, Y., Eissler, C., Hirano, M., Nose, N., Wakabayashi, H., Lapa, C., Javadi, M. S. & Higuchi, T., Dec 1 2018, In : Scientific reports. 8, 1, 11120.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)