• 4106 Citations
  • 32 h-Index
1987 …2020

Research output per year

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Research Output

  • 4106 Citations
  • 32 h-Index
  • 249 Article
  • 7 Review article
  • 4 Letter
  • 3 Comment/debate
2020

Antimicrobial and antibiofilm effects of abietic acid on cariogenic Streptococcus mutans

Ito, Y., Ito, T., Yamashiro, K., Mineshiba, F., Hirai, K., Omori, K., Yamamoto, T. & Takashiba, S., Jan 1 2020, In : Odontology. 108, 1, p. 57-65 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Efficacy and safety of PERIOdontal treatment versus usual care for Nonalcoholic liver disease: Protocol of the PERION multicenter, two-arm, open-label, randomized trial

Kamata, Y., Kessoku, T., Shimizu, T., Kobayashi, T., Kurihashi, T., Sato, S., Kuraji, S., Aoyama, N., Iwasaki, T., Takashiba, S., Hamada, N., Kodama, T., Tamura, T., Ino, S., Higurashi, T., Taguri, M., Yamanaka, T., Yoneda, M., Usuda, H., Wada, K. & 2 others, Nakajima, A. & Minabe, M., Mar 23 2020, In : Trials. 21, 1, 291.

Research output: Contribution to journalArticle

Open Access

Evaluation of the simulator with automatic irrigation control system designed for countermeasures of internal contamination in dental unit water lines

Okubo, K., Ito, T., Okamoto, K., Yamamoto, I., Mizutani, H., Kawata, Y., Shiota, Y., Ito, M., Nakamura, S., Tai, M., Yamamoto, T. & Takashiba, S., Jun 2020, In : Heliyon. 6, 6, e04132.

Research output: Contribution to journalArticle

Open Access

Functionalized Graphene Oxide Shields Tooth Dentin from Decalcification

Nizami, M. Z. I., Nishina, Y., Yamamoto, T., Shinoda-Ito, Y. & Takashiba, S., Feb 1 2020, In : Journal of dental research. 99, 2, p. 182-188 7 p.

Research output: Contribution to journalArticle

Graphene oxide: A new direction in dentistry

Nizami, M. Z. I., Takashiba, S. & Nishina, Y., Jun 2020, In : Applied Materials Today. 19, 100576.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Identification and Modification of Porphyromonas gingivalis Cysteine Protease, Gingipain, Ideal for Screening Periodontitis

Hirai, K., Yamaguchi-Tomikawa, T., Eguchi, T., Maeda, H. & Takashiba, S., Jun 5 2020, In : Frontiers in immunology. 11, 1017.

Research output: Contribution to journalArticle

Open Access

Isolation and identification of the antimicrobial substance included in tempeh using Rhizopus stolonifer NBRC 30816 for fermentation

Ito, M., Ito, T., Aoki, H., Nishioka, K., Shiokawa, T., Tada, H., Takeuchi, Y., Takeyasu, N., Yamamoto, T. & Takashiba, S., Jul 16 2020, In : International Journal of Food Microbiology. 325, 108645.

Research output: Contribution to journalArticle

Open Access

Microbiome composition comparison in oral and atherosclerotic plaque from patients with and without periodontitis

Isoshima, D., Yamashiro, K., Matsunaga, K., Taniguchi, M., Matsubara, T., Tomida, S., Ota, S., Sato, M., Shimoe, Y., Kohriyama, T., Arias, Z., Omori, K., Yamamoto, T. & Takashiba, S., 2020, (Accepted/In press) In : Odontology.

Research output: Contribution to journalArticle

Tailoring the interaction between graphene oxide and antibacterial pyridinium salts by terminal functional groups

Fujii, R., Okubo, K., Takashiba, S., Bianco, A. & Nishina, Y., Apr 30 2020, In : Carbon. 160, p. 204-210 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The fungal metabolite (+)-terrein abrogates osteoclast differentiation via suppression of the RANKL signaling pathway through NFATc1

Nakagawa, S., Omori, K., Nakayama, M., Mandai, H., Yamamoto, S., Kobayashi, H., Sako, H., Sakaida, K., Yoshimura, H., Ishii, S., Ibaragi, S., Hirai, K., Yamashiro, K., Yamamoto, T., Suga, S. & Takashiba, S., Jun 2020, In : International Immunopharmacology. 83, 106429.

Research output: Contribution to journalArticle

Open Access
2019

Acceleration of bone regeneration of horizontal bone defect in rats using collagen-binding basic fibroblast growth factor combined with collagen scaffolds

Nakamura, S., Ito, T., Okamoto, K., Mima, T., Uchida, K., Siddiqui, Y. D., Ito, M., Tai, M., Okubo, K., Yamashiro, K., Omori, K., Yamamoto, T., Matsushita, O. & Takashiba, S., Sep 1 2019, In : Journal of periodontology. 90, 9, p. 1043-1052 10 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Acute prevertebral abscesses caused by bacterial-infected traumatic tooth fractures

Matsunaga, K., Takemaru, M., Yamashiro, K., Yoshihara-Hirata, C., Inohara, K., Shimoe, Y., Tanaka, A., Kuriyama, M. & Takashiba, S., 2019, In : Acta medica Okayama. 73, 5, p. 449-456 8 p.

Research output: Contribution to journalArticle

Effectiveness and safety of low-concentrated ozonized water for the reduction of contamination in dental unit water lines

Okubo, K., Ito, T., Shiota, Y., Kawata, Y., Yamamoto, T. & Takashiba, S., Aug 2019, In : Heliyon. 5, 8, e02306.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Induction of migration of periodontal ligament cells by selective regulation of integrin subunits

Kawamura, M., Yamamoto, T., Yamashiro, K., Kochi, S., Yoshihara-Hirata, C., Ideguchi, H., Aoyagi, H., Omori, K. & Takashiba, S., Feb 1 2019, In : Journal of Cellular and Molecular Medicine. 23, 2, p. 1211-1223 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Molecular imaging assessment of periodontitis lesions in an experimental mouse model

Ideguchi, H., Yamashiro, K., Yamamoto, T., Shimoe, M., Hongo, S., Kochi, S., Yoshihara-Hirata, C., Aoyagi, H., Kawamura, M. & Takashiba, S., Feb 8 2019, In : Clinical Oral Investigations. 23, 2, p. 821-827 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Multidisciplinary clinical approach by sharing oral examination information to treat a diabetes patient with dysgeusia

Matsunaga, K., Yoshida, Y., Takemaru, M., Yamashiro, K., Monden, I., Inohara, K., Nakagawa, S., Maeda, E., Nakahama, K., Kohriyama, T. & Takashiba, S., May 2019, In : Clinical Case Reports. 7, 5, p. 877-880 4 p.

Research output: Contribution to journalArticle

Open Access

Resolvin D2 induces resolution of periapical inflammation and promotes healing of periapical lesions in rat periapical periodotitis

Siddiqui, Y. D., Omori, K., Ito, T., Yamashiro, K., Nakamura, S., Okamoto, K., Ono, M., Yamamoto, T., Dyke, T. E. V. & Takashiba, S., 2019, In : Frontiers in immunology. 10, FEB, 307.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Treatment of bucco-accessory root canal of a maxillary incisor with a combination of cone beam computed tomography and continuous supersonic wave condensation

Arias, Z., Cazas, I., Siddiqui, Y. D., Yamashiro, K., Takashiba, S. & Alam, M. K., Dec 2019, In : International Medical Journal. 26, 6, p. 510-512 3 p.

Research output: Contribution to journalArticle

2018

Anti-HMGB1 neutralizing antibody attenuates periodontal inflammation and bone resorption in a murine periodontitis model

Yoshihara-Hirata, C., Yamashiro, K., Yamamoto, T., Aoyagi, H., Ideguchi, H., Kawamura, M., Suzuki, R., Ono, M., Wake, H., Nishibori, M. & Takashiba, S., May 1 2018, In : Infection and Immunity. 86, 5, e00111-18.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Effects of Lectins on initial attachment of cariogenic Streptococcus mutans

Ito, T., Yoshida, Y., Shiota, Y., Ito, Y., Yamamoto, T. & Takashiba, S., Feb 1 2018, In : Glycoconjugate Journal. 35, 1, p. 41-51 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Effects of periodontal treatment on carotid intima-media thickness in patients with lifestyle-related diseases: Japanese prospective multicentre observational study

Periodontitis and Atherosclerosis Project-Tokyo and Chiba Consortiums, Jul 1 2018, In : Odontology. 106, 3, p. 316-327 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Expression of optineurin isolated from rat-injured dental pulp and the effects on inflammatory signals in normal rat kidney cells

Senoo, K., Yamashiro, K., Yamamoto, T., Myokai, F., Kawamura, M. & Takashiba, S., Apr 1 2018, In : Odontology. 106, 2, p. 135-144 10 p.

Research output: Contribution to journalArticle

Fungal metabolite (+)-terrein suppresses IL-6/sIL-6R-induced CSF1 secretion by inhibiting JAK1 phosphorylation in human gingival fibroblasts

Yamamoto, S., Omori, K., Mandai, H., Nakayama, M., Nakagawa, S., Kobayashi, H., Kunimine, T., Yoshimura, H., Sakaida, K., Sako, H., Ibaragi, S., Yamamoto, T., Maeda, H., Suga, S. & Takashiba, S., Nov 2018, In : Heliyon. 4, 11, e00979.

Research output: Contribution to journalArticle

1 Citation (Scopus)

HMGB1-induced inflammatory response promotes bone healing in murine tooth extraction socket

Aoyagi, H., Yamashiro, K., Hirata-Yoshihara, C., Ideguchi, H., Yamasaki, M., Kawamura, M., Yamamoto, T., Kochi, S., Wake, H., Nishibori, M. & Takashiba, S., Jul 2018, In : Journal of Cellular Biochemistry. 119, 7, p. 5481-5490 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Involvement of PM2.5-bound protein and metals in PM2.5-induced allergic airway inflammation in mice

Ogino, K., Nagaoka, K., Ito, T., Takemoto, K., Okuda, T., Nakayama, S. F., Ogino, N., Seki, Y., Hamada, H., Takashiba, S. & Fujikura, Y., Dec 6 2018, In : Inhalation Toxicology. 30, 13-14, p. 498-508 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

IS1598 (IsPg4) distributed to abscess-forming strains of Porphyromonas gingivalis may enhance virulence through upregulation of nrdD-like gene expression

Sonoi, N., Maeda, H., Murauchi, T., Yamamoto, T., Omori, K., Kokeguchi, S., Naruishi, K. & Takashiba, S., Jan 2018, In : New Microbiologica. 41, 1, p. 52-60 9 p.

Research output: Contribution to journalArticle

Modulation of microenvironment for controlling the fate of periodontal ligament cells: the role of Rho/ROCK signaling and cytoskeletal dynamics

Yamamoto, T., Ugawa, Y., Kawamura, M., Yamashiro, K., Kochi, S., Ideguchi, H. & Takashiba, S., Mar 1 2018, In : Journal of Cell Communication and Signaling. 12, 1, p. 369-378 10 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)

PET(18F-FDG)/CT検査を用いた慢性歯周炎患者における歯周組織炎症の評価

Translated title of the contribution: Assessment of Periodontal Inflammation in a Chronic Periodontitis Patient using PET (18F-FDG)/CT井手口英隆, 山城圭介, 下江正幸, 山本直史, 長島義之 & 高柴正悟, 2018, In : Nippon Shishubyo Gakkai kaishi. 60, 2, p. 105-116 12 p.

Research output: Contribution to journalArticle

The KCNQ1 gene polymorphism as a shared genetic risk for rheumatoid arthritis and chronic periodontitis in japanese adults: A pilot case-control study

Kobayashi, T., Kido, J. I., Ishihara, Y., Omori, K., Ito, S., Matsuura, T., Bando, T., Wada, J., Murasawa, A., Nakazono, K., Mitani, A., Takashiba, S., Nagata, T. & Yoshie, H., 2018, In : Journal of periodontology. 89, 3, p. 315-324 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

感染、炎症、機能の観点から見た口腔検査指標の歯周病治療に対する有用性: パイロット研究

畑中加珠, 片山広大, 井上裕貴, 坂井田京佑, 清水由梨香, 鈴木里紗, 高木美奈, 山本直史 & 高柴正悟, 2018, In : 日本口腔検査学会雑誌 = Journal of Japanese Society for Evidence and the Dental Professional : JJSEDP. 10, 1, p. 58-63 6 p.

Research output: Contribution to journalArticle

2017

Aggregatibacter actinomycetemcomitans regulates the expression of integrins and reduces cell adhesion via integrin α5 in human gingival epithelial cells

Kochi, S., Yamashiro, K., Hongo, S., Yamamoto, T., Ugawa, Y., Shimoe, M., Kawamura, M., Hirata-Yoshihara, C., Ideguchi, H., Maeda, H. & Takashiba, S., Dec 1 2017, In : Molecular and Cellular Biochemistry. 436, 1-2, p. 39-48 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Assessing the progression of chronic periodontitis using subgingival pathogen levels: A 24-month prospective multicenter cohort study

Kakuta, E., Nomura, Y., Morozumi, T., Nakagawa, T., Nakamura, T., Noguchi, K., Yoshimura, A., Hara, Y., Fujise, O., Nishimura, F., Kono, T., Umeda, M., Fukuda, M., Noguchi, T., Yoshinari, N., Fukaya, C., Sekino, S., Numabe, Y., Sugano, N., Ito, K. & 17 others, Kobayashi, H., Izumi, Y., Takai, H., Ogata, Y., Takano, S., Minabe, M., Makino-Oi, A., Saito, A., Abe, Y., Sato, S., Suzuki, F., Takahashi, K., Sugaya, T., Kawanami, M., Hanada, N., Takashiba, S. & Yoshie, H., Jan 16 2017, In : BMC Oral Health. 17, 1, 46.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Assessment of pathogenesis of infective endocarditis by plasma IgG antibody titer test against periodontal bacteria

Isoshima, D., Yamashiro, K., Matsunaga, K., Shinobe, M., Nakanishi, N., Nakanishi, I., Omori, K., Yamamoto, T. & Takashiba, S., Oct 2017, In : Clinical Case Reports. 5, 10, p. 1580-1586 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Rho-kinase regulates extracellular matrix-mediated osteogenic differentiation of periodontal ligament cells

Ugawa, Y., Yamamoto, T., Kawamura, M., Yamashiro, K., Shimoe, M., Tomikawa, K., Hongo, S., Maeda, H. & Takashiba, S., Jun 2017, In : Cell Biology International. 41, 6, p. 651-658 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Site-level progression of periodontal disease during a follow-up period

Nomura, Y., Morozumi, T., Nakagawa, T., Sugaya, T., Kawanami, M., Suzuki, F., Takahashi, K., Abe, Y., Sato, S., Makino-Oi, A., Saito, A., Takano, S., Minabe, M., Nakayama, Y., Ogata, Y., Kobayashi, H., Izumi, Y., Sugano, N., Ito, K., Sekino, S. & 18 others, Numabe, Y., Fukaya, C., Yoshinari, N., Fukuda, M., Noguchi, T., Kono, T., Umeda, M., Fujise, O., Nishimura, F., Yoshimura, A., Hara, Y., Nakamura, T., Noguchi, K., Kakuta, E., Hanada, N., Takashiba, S., Amitani, Y. & Yoshie, H., Dec 2017, In : PloS one. 12, 12, e0188670.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2016

Effects of new over-the-counter periodontal ointment-containing applicator with single-tuft brush on cytokine levels in gingival crevicular fluid during supportive periodontal therapy phase: A randomized double-blind clinical trial

Takeuchi-Hatanaka, K., Yasuda, T., Naruishi, K., Katsuragi-Fuke, K., Inubushi, J., Ootsuki, H., Maeda, H. & Takashiba, S., Jun 1 2016, In : Journal of Periodontal Research. 51, 3, p. 321-331 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Randomized Placebo-Controlled and Controlled Non-Inferiority Phase III Trials Comparing Trafermin, a Recombinant Human Fibroblast Growth Factor 2, and Enamel Matrix Derivative in Periodontal Regeneration in Intrabony Defects

Kitamura, M., Akamatsu, M., Kawanami, M., Furuichi, Y., Fujii, T., Mori, M., Kunimatsu, K., Shimauchi, H., Ogata, Y., Yamamoto, M., Nakagawa, T., Sato, S., Ito, K., Ogasawara, T., Izumi, Y., Gomi, K., Yamazaki, K., Yoshie, H., Fukuda, M., Noguchi, T. & 16 others, Takashiba, S., Kurihara, H., Nagata, T., Hamachi, T., Maeda, K., Yokota, M., Sakagami, R., Hara, Y., Noguchi, K., Furuuchi, T., Sasano, T., Imai, E., Ohmae, M., Koizumi, H., Watanuki, M. & Murakami, S., Apr 1 2016, In : Journal of Bone and Mineral Research. 31, 4, p. 806-814 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Salivary pathogen and serum antibody to assess the progression of chronic periodontitis: a 24-mo prospective multicenter cohort study

Morozumi, T., Nakagawa, T., Nomura, Y., Sugaya, T., Kawanami, M., Suzuki, F., Takahashi, K., Abe, Y., Sato, S., Makino-Oi, A., Saito, A., Takano, S., Minabe, M., Nakayama, Y., Ogata, Y., Kobayashi, H., Izumi, Y., Sugano, N., Ito, K., Sekino, S. & 17 others, Numabe, Y., Fukaya, C., Yoshinari, N., Fukuda, M., Noguchi, T., Kono, T., Umeda, M., Fujise, O., Nishimura, F., Yoshimura, A., Hara, Y., Nakamura, T., Noguchi, K., Kakuta, E., Hanada, N., Takashiba, S. & Yoshie, H., Dec 1 2016, In : Journal of Periodontal Research. 51, 6, p. 768-778 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Smad2 overexpression enhances adhesion of gingival epithelial cells

Hongo, S., Yamamoto, T., Yamashiro, K., Shimoe, M., Tomikawa, K., Ugawa, Y., Kochi, S., Ideguchi, H., Maeda, H. & Takashiba, S., Nov 1 2016, In : Archives of Oral Biology. 71, p. 46-53 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Synthetic terrein inhibits progression of head and neck cancer by suppressing angiogenin production

Shibata, A., Ibaragi, S., Mandai, H., Tsumura, T., Kishimoto, K., Okui, T., Hassan, N. M. M., Shimo, T., Omori, K., Hu, G. F., Takashiba, S., Suga, S. & Sasaki, A., 2016, In : Anticancer research. 36, 5, p. 2161-2168 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
1 Citation (Scopus)
2015

Analysis of the relationship between periodontal disease and atherosclerosis within a local clinical system: a cross-sectional observational pilot study

Kudo, C., Shin, W. S., Minabe, M., Harai, K., Kato, K., Seino, H., Goke, E., Sasaki, N., Fujino, T., Kuribayashi, N., Pearce, Y. O., Taira, M., Maeda, H. & Takashiba, S., Sep 23 2015, In : Odontology. 103, 3, p. 314-321 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Cut-off values of Functional Independence Measure scores for discharge destination

Naruishi, K., Kunita, A., Nagata, T., Takashiba, S. & Adachi, S., May 1 2015, In : Geriatrics and Gerontology International. 15, 5, p. 670-671 2 p.

Research output: Contribution to journalLetter

2 Citations (Scopus)

Group A. Consensus paper. Plaque control--home remedies practiced in developing countries

Ciancio, S., Slot, D. E. L., Van Dyke, T., Al Bayaty, F., Aswapati, N. W. A., Joshi, V., Kendall, K., Leung, K., Patel, N., Pradhan, S., Senevirante, C., Takashiba, S. & Vidhale, P., Jan 1 2015, In : Journal of the International Academy of Periodontology. 17, 1, p. 17-20 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
5 Citations (Scopus)
5 Citations (Scopus)