• 3286 Citations
  • 34 h-Index
19952020

Research output per year

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Research Output

  • 3286 Citations
  • 34 h-Index
  • 124 Article
2020

Bile acids aggravate nonalcoholic steatohepatitis and cardiovascular disease in SHRSP5/Dmcr rat model

Yamamoto, S., Sato, I., Fukuhama, N., Akiyama, N., Sakai, M., Kumazaki, S., Ran, S., Hirohata, S., Kitamori, K., Yamori, Y. & Watanabe, S., Jun 2020, In : Experimental and Molecular Pathology. 114, 104437.

Research output: Contribution to journalArticle

Deficiency of CD44 prevents thoracic aortic dissection in a murine model

Hatipoglu, O. F., Miyoshi, T., Yonezawa, T., Kondo, M., Amioka, N., Yoshida, M., Akagi, S., Nakamura, K., Hirohata, S. & Ito, H., Dec 1 2020, In : Scientific reports. 10, 1, 6869.

Research output: Contribution to journalArticle

Open Access
Open Access
2019
Open Access

Effects of Oral Anticoagulants on Patients with Atrial Fibrillation Aged 90 Years and Older: Comparison among Direct Oral Anticoagulant, Warfarin Anticoagulant, and Nonanticoagulation

Yamaji, H., Higashiya, S., Murakami, T., Hina, K., Kawamura, H., Murakami, M., Kamikawa, S., Hirohata, S. & Kusachi, S., Sep 1 2019, In : Journal of cardiovascular pharmacology. 74, 3, p. 246-254 9 p.

Research output: Contribution to journalArticle

Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1

Ohtsuki, T., Shinaoka, A., Kumagishi-Shinaoka, K., Asano, K., Hatipoglu, O. F., Inagaki, J., Takahashi, K., Oohashi, T., Nishida, K., Naruse, K. & Hirohata, S., Oct 15 2019, In : Experimental Cell Research. 383, 2, 111556.

Research output: Contribution to journalArticle

Open Access

Non-alcoholic steatohepatitis aggravates nitric oxide synthase inhibition-induced arteriosclerosis in SHRSP5/Dmcr rat model

Watanabe, S., Kumazaki, S., Yamamoto, S., Sato, I., Kitamori, K., Mori, M., Yamori, Y. & Hirohata, S., Jan 1 2019, (Accepted/In press) In : International Journal of Experimental Pathology.

Research output: Contribution to journalArticle

2 Citations (Scopus)
1 Citation (Scopus)
2018

Adjunctive left anterior line ablation induced left atrial dysfunction and dyssynchrony in atrial fibrillation ablation

Yamaji, H., Murakami, T., Hina, K., Higashiya, S., Kawamura, H., Murakami, M., Kamikawa, S., Hirohata, S. & Kusachi, S., Jan 1 2018, (Accepted/In press) In : Heart and Vessels.

Research output: Contribution to journalArticle

A high-fat and high-cholesterol diet induces cardiac fibrosis, vascular endothelial, and left ventricular diastolic dysfunction in shrsp5/dmcr rats

Watanabe, S., Kumazaki, S., Kusunoki, K., Inoue, T., Maeda, Y., Usui, S., Shinohata, R., Ohtsuki, T., Hirohata, S., Kusachi, S., Kitamori, K., Mori, M., Yamori, Y. & Oka, H., Jan 1 2018, In : Journal of Atherosclerosis and Thrombosis. 25, 5, p. 439-453 15 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Differences in activated clotting time and initial heparin dosage during atrial fibrillation ablation for patients with edoxaban compared with warfarin

Yamaji, H., Murakami, T., Hina, K., Higashiya, S., Kawamura, H., Murakami, M., Kamikawa, S., Hirohata, S. & Kusachi, S., Jun 1 2018, In : Journal of Cardiovascular Electrophysiology. 29, 6, p. 835-843 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

High molecular weight hyaluronan protects cartilage from degradation by inhibiting aggrecanase expression

Ohtsuki, T., Asano, K., Inagaki, J., Shinaoka, A., Kumagishi-Shinaoka, K., Cilek, M. Z., Hatipoglu, O. F., Oohashi, T., Nishida, K., Komatsubara, I. & Hirohata, S., Jan 1 2018, (Accepted/In press) In : Journal of Orthopaedic Research.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Host-produced ADAMTS4 inhibits early-stage tumor growth

Asano, K., Edamatsu, M., Hatipoglu, O. F., Inagaki, J., Ono, M., Ohtsuki, T., Oohashi, T. & Hirohata, S., Jan 1 2018, In : Acta Medica Okayama. 72, 3, p. 257-266 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2017

A rapid and precise method for measuring plasma apoE-rich HDL using polyethylene glycol and cation-exchange chromatography: a pilot study on the clinical significance of apoE-rich HDL measurements

Ikeda, T., Shinohata, R., Murakami, M., Hina, K., Kamikawa, S., Hirohata, S., Kusachi, S., Tamura, A. & Usui, S., Feb 1 2017, In : Clinica Chimica Acta. 465, p. 112-118 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Circulating adipocyte fatty acid-binding protein is a predictor of cardiovascular events in patients with stable angina undergoing percutaneous coronary intervention

Takagi, W., Miyoshi, T., Doi, M., Okawa, K., Nosaka, K., Nishibe, T., Matsuo, N., Hirohata, S. & Ito, H., Oct 10 2017, In : BMC Cardiovascular Disorders. 17, 1, 258.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Diverse functions of a disintegrin and metalloproteinase with thrombospondin motif-1

Hirohata, S., Inagaki, J. & Ohtsuki, T., 2017, In : Yakugaku Zasshi. 137, 7, p. 811-814 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Early initiation of eicosapentaenoic acid and statin treatment is associated with better clinical outcomes than statin alone in patients with acute coronary syndromes: 1-year outcomes of a randomized controlled study

Nosaka, K., Miyoshi, T., Iwamoto, M., Kajiya, M., Okawa, K., Tsukuda, S., Yokohama, F., Sogo, M., Nishibe, T., Matsuo, N., Hirohata, S., Ito, H. & Doi, M., Feb 1 2017, In : International Journal of Cardiology. 228, p. 173-179 7 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Stromal Versican Regulates Tumor Growth by Promoting Angiogenesis

Asano, K., Nelson, C. M., Nandadasa, S., Aramaki-Hattori, N., Lindner, D. J., Alban, T., Inagaki, J., Ohtsuki, T., Oohashi, T., Apte, S. S. & Hirohata, S., Dec 1 2017, In : Scientific reports. 7, 1, 17225.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2016

Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE-/- mice

Kumar, S., Chen, M., Li, Y., Wong, F. H. S., Thiam, C. W., Hossain, M. Z., Poh, K. K., Hirohata, S., Ogawa, H., Angeli, V. & Ge, R., Aug 5 2016, In : Scientific Reports. 6, 31130.

Research output: Contribution to journalArticle

21 Citations (Scopus)

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1

Yamamoto, K., Okano, H., Miyagawa, W., Visse, R., Shitomi, Y., Santamaria, S., Dudhia, J., Troeberg, L., Strickland, D. K., Hirohata, S. & Nagase, H., Dec 1 2016, In : Matrix Biology. 56, p. 57-73 17 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Subclavian steal syndrome: A case report and review of advances in diagnostic and treatment approaches

Komatsubara, I., Kondo, J., Akiyama, M., Takeuchi, H., Nogami, K., Usui, S., Hirohata, S. & Kusachi, S., Jan 1 2016, In : Cardiovascular Revascularization Medicine. 17, 1, p. 54-58 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2015

Eosinophil cationic protein shows survival effect on H9c2 cardiac myoblast cells with enhanced phosphorylation of ERK and Akt/GSK-3β under oxidative stress

Ishii, H., Kamikawa, S., Hirohata, S., Mizutani, A., Abe, K., Seno, M., Oohashi, T. & Ninomiya, Y., Jan 1 2015, In : Acta medica Okayama. 69, 3, p. 145-153 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Interleukin-1β induced nuclear factor-κB binds toa disintegrin-like and metalloproteinase with thrombospondin type 1 motif 9 promoter in human chondrosarcoma cells

Altuntas, A., Halacli, S. O., Cakmak, O., Erden, G., Akyol, S., Ugurcu, V., Hirohata, S. & Demircan, K., Jul 1 2015, In : Molecular Medicine Reports. 12, 1, p. 595-600 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2014

ADAMTS1 inhibits lymphangiogenesis by attenuating phosphorylation of the lymphatic endothelial cell-specific VEGF receptor

Inagaki, J., Takahashi, K., Ogawa, H., Asano, K., Faruk Hatipoglu, O., Zeynel Cilek, M., Obika, M., Ohtsuki, T., Hofmann, M., Kusachi, S., Ninomiya, Y. & Hirohata, S., May 1 2014, In : Experimental Cell Research. 323, 2, p. 263-275 13 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury

Demircan, K., Topcu, V., Takigawa, T., Akyol, S., Yonezawa, T., Ozturk, G., Ugurcu, V., Hasgul, R., Yigitoglu, M. R., Akyol, O., McCulloch, D. R. & Hirohata, S., 2014, In : BioMed research international. 2014, 693746.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Early eicosapentaenoic acid treatment after percutaneous coronary intervention reduces acute inflammatory responses and ventricular arrhythmias in patients with acute myocardial infarction: A randomized, controlled study

Doi, M., Nosaka, K., Miyoshi, T., Iwamoto, M., Kajiya, M., Okawa, K., Nakayama, R., Takagi, W., Takeda, K., Hirohata, S. & Ito, H., Oct 20 2014, In : International Journal of Cardiology. 176, 3, p. 577-582 6 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Low serum level of secreted frizzled-related protein 5, an anti-inflammatory adipokine, is associated with coronary artery disease

Miyoshi, T., Doi, M., Usui, S., Iwamoto, M., Kajiya, M., Takeda, K., Nosaka, K., Nakayama, R., Okawa, K., Takagi, W., Nakamura, K., Hirohata, S. & Ito, H., Apr 2014, In : Atherosclerosis. 233, 2, p. 454-459 6 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2013

ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse

Demircan, K., Yonezawa, T., Takigawa, T., Topcu, V., Erdogan, S., Ucar, F., Armutcu, F., Yigitoglu, M. R., Ninomiya, Y. & Hirohata, S., Jun 7 2013, In : Neuroscience Letters. 544, p. 25-30 6 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Adaptive-servo ventilation combined with deep sedation is an effective strategy during pulmonary vein isolation

Murakami, T., Yamaji, H., Numa, K., Kawamura, H., Murakami, M., Higashiya, S., Kamikawa, S., Hina, K., Hirohata, S. & Kusachi, S., Jul 1 2013, In : Europace. 15, 7, p. 951-956 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

A potential association between the number of CA repeats in the promoter region of the ADAMTS9 gene with lymphatic metastasis of breast cancer

Bozer, M., Aşik, F., Acar, M., Haltaş, H., Yenidünya, S., Canbal, M., Topçu, V., Yiǧitoǧlu, M. R., Gündüz, M., Gündüz, E., Hirohata, S. & Demircan, K., Aug 30 2013, In : Turkish Journal of Medical Sciences. 43, 5, p. 671-677 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Augmentation of ADAMTS9 gene expression by IL-1β is reversed by NFκB and MAPK inhibitors, but not PI3 kinase inhibitors

Uysal, S., Ünal, Z. N., Erdoǧan, S., Akyol, S., Ramazan Yiǧitoǧlu, M., Hirohata, S., Işik, B. & Demircan, K., Oct 1 2013, In : Cell biochemistry and function. 31, 7, p. 539-544 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Eosinophil cationic protein enhances stabilization of β-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells

Jin, G., Mizutani, A., Fukuda, T., Otani, T., Yan, T., Prieto Vila, M., Murakami, H., Kudoh, T., Hirohata, S., Kasai, T., Salomon, D. S. & Seno, M., Apr 1 2013, In : Molecular Biology Reports. 40, 4, p. 3165-3171 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Reduced diurnal variation of heart rate is associated with increased plasma B-type natriuretic peptide level in patients with atrial fibrillation

Kamikawa, S., Miyoshi, T., Doi, M., Orita, N., Sangawa, M., Nakatsu, T., Noguchi, Y., Hirohata, S., Kusachi, S., Nakamura, K. & Ito, H., Jul 1 2013, In : Clinical Cardiology. 36, 7, p. 394-400 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Serum adipocyte fatty acid-binding protein is independently associated with complex coronary lesions in patients with stable coronary artery disease

Kajiya, M., Miyoshi, T., Doi, M., Usui, S., Iwamoto, M., Takeda, K., Nosaka, K., Nakayama, R., Hirohata, S., Kusachi, S., Nakamura, K. & Ito, H., Nov 1 2013, In : Heart and Vessels. 28, 6, p. 696-703 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Usefulness of dabigatran etexilate as periprocedural anticoagulation therapy for atrial fibrillation ablation

Yamaji, H., Murakami, T., Hina, K., Higashiya, S., Kawamura, H., Murakami, M., Kamikawa, S., Hirohata, S. & Kusachi, S., Jun 1 2013, In : Clinical Drug Investigation. 33, 6, p. 409-418 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Vascular endothelial growth factor C-induced lymphangiogenesis decreases tumor interstitial fluid pressure and tumor

Hofmann, M., Pflanzer, R., Zöller, N. N., Bernd, A., Kaufmann, R., Thaci, D., Bereiter-Hahn, J., Hirohata, S. & Kippenberger, S., Aug 2013, In : Translational Oncology. 6, 4, p. 398-404 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2012

Elevated serum adipocyte fatty acid-binding protein concentrations are independently associated with renal dysfunction in patients with stable angina pectoris

Iwamoto, M., Miyoshi, T., Doi, M., Takeda, K., Kajiya, M., Nosaka, K., Nakayama, R., Hirohata, S., Usui, S., Kusachi, S., Sakane, K., Nakamura, K. & Ito, H., Mar 21 2012, In : Cardiovascular Diabetology. 11, 26.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Eosinophil cationic protein enhances cardiomyocyte differentiation of P19CL6 embryonal carcinoma cells by stimulating the FGF receptor signaling pathway

Jin, G., Mizutani, A., Fukuda, T., Chen, L., Nakanishi, K., Yan, T., Kudoh, T., Hirohata, S., Kasai, T., Murakami, H., Salomon, D. S. & Seno, M., Oct 1 2012, In : Growth Factors. 30, 5, p. 344-355 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Four-year clinical outcomes of the OLIVUS-Ex (impact of Olmesartan on progression of coronary atherosclerosis: Evaluation by intravascular ultrasound) extension trial

Hirohata, A., Yamamoto, K., Miyoshi, T., Hatanaka, K., Hirohata, S., Yamawaki, H., Komatsubara, I., Hirose, E., Kobayashi, Y., Ohkawa, K., Ohara, M., Takafuji, H., Sano, F., Toyama, Y., Kusachi, S., Ohe, T. & Ito, H., Jan 1 2012, In : Atherosclerosis. 220, 1, p. 134-138 5 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Sufficient pulmonary vein image quality of non-enhanced multi-detector row computed tomography for pulmonary vein isolation by catheter ablation

Yamaji, H., Hina, K., Kawamura, H., Murakami, T., Murakami, M., Hirohata, S., Ohmaru, N. & Kusachi, S., Jan 1 2012, In : Europace. 14, 1, p. 52-59 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Tumor growth inhibitory effect of ADAMTS1 is accompanied by the inhibition of tumor angiogenesis

Obika, M., Ogawa, H., Takahashi, K., Li, J., Hatipoglu, O. F., Cilek, M. Z., Miyoshi, T., Inagaki, J., Ohtsuki, T., Kusachi, S., Ninomiya, Y. & Hirohata, S., Oct 1 2012, In : Cancer Science. 103, 10, p. 1889-1897 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2011

AHR, a novel acute hypoxia-response sequence, drives reporter gene expression under hypoxia in vitro and in vivo

Cilek, M. Z., Hirohata, S., Hatipoglu, O. F., Ogawa, H., Miyoshi, T., Inagaki, J., Ohtsuki, T., Harada, H., Kamikawa, S., Kusachi, S. & Ninomiya, Y., Jan 1 2011, In : Cell Biology International. 35, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Association of increased plasma adipocyte fatty acid-binding protein with coronary artery disease in non-elderly men

Doi, M., Miyoshi, T., Hirohata, S., Nakamura, K., Usui, S., Takeda, K., Iwamoto, M., Kusachi, S., Kusano, K. & Ito, H., May 23 2011, In : Cardiovascular Diabetology. 10, 44.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Association of serum levels of arachidonic acid and eicosapentaenoic acid with prevalence of major adverse cardiac events after acute myocardial infarction

Ueeda, M., Doumei, T., Takaya, Y., Ohnishi, N., Takaishi, A., Hirohata, S., Miyoshi, T., Shinohata, R., Usui, S. & Kusachi, S., Mar 1 2011, In : Heart and Vessels. 26, 2, p. 145-152 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Distribution pattern of urine albumin creatinine ratio and the prevalence of high-normal levels in untreated asymptomatic non-diabetic hypertensive patients

Ohmaru, N., Nakatsu, T., Izumi, R., Mashima, K., Toki, M., Kobayashi, A., Ogawa, H., Hirohata, S., Ikeda, S. & Kusachi, S., Aug 24 2011, In : Internal Medicine. 50, 16, p. 1621-1629 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Olmesartan reduces arterial stiffness and serum adipocyte fatty acid-binding protein in hypertensive patients

Miyoshi, T., Doi, M., Hirohata, S., Kamikawa, S., Usui, S., Ogawa, H., Sakane, K., Izumi, R., Ninomiya, Y. & Kusachi, S., Jul 1 2011, In : Heart and Vessels. 26, 4, p. 408-413 6 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)
76 Citations (Scopus)

Serum hepatitis B virus DNA before liver transplantation correlates with HBV reinfection rate even under successful low-dose hepatitis B immunoglobulin prophylaxis

Yasunaka, T., Takaki, A., Yagi, T., Iwasaki, Y., Sadamori, H., Koike, K., Hirohata, S., Tatsukawa, M., Kawai, D., Shiraha, H., Miyake, Y., Ikeda, F., Kobashi, H., Matsuda, H., Shinoura, S., Yoshida, R., Satoh, D., Utsumi, M., Onishi, T. & Yamamoto, K., Dec 1 2011, In : Hepatology International. 5, 4, p. 918-926 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2010

Cardio-ankle vascular index is independently associated with the severity of coronary atherosclerosis and left ventricular function in patients with Ischemic heart disease

Miyoshi, T., Doi, M., Hirohata, S., Sakane, K., Kamikawa, S., Kitawaki, T., Kaji, Y., Kusano, K. F., Ninomiya, Y. & Kusachi, S., Jan 1 2010, In : Journal of atherosclerosis and thrombosis. 17, 3, p. 249-258 10 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)