• 484 Citations
  • 13 h-Index
20032020
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Research Output 2003 2020

2020

Chemotherapy improved pulmonary arterial hypertension in a patient with chronic-active epstein-barr virus infection

Akagi, S., Miki, T., Sando, Y., Fujii, N., Sarashina, T., Nakamura, K. & Ito, H., Jan 1 2020, In : International heart journal. 61, 1, p. 191-194 4 p.

Research output: Contribution to journalArticle

Open Access
Epstein-Barr Virus Infections
Pulmonary Hypertension
Drug Therapy
Ventricular Pressure
Cardiac Catheterization
2019
Open Access
hypertension
Epoprostenol
Drug Delivery Systems
Pulmonary Hypertension
Nanoparticles
2 Citations (Scopus)
Open Access
Neprilysin
Angiotensin Receptors
Cardiomegaly
Isoproterenol
Valsartan
Pulmonary Hypertension
Aneurysm
Pulmonary Artery
Lung
Dissection

Inhibitory Effects of Tofogliflozin on Cardiac Hypertrophy in Dahl Salt-Sensitive and Salt-Resistant Rats Fed a High-Fat Diet

Kimura, T., Nakamura, K., Miyoshi, T., Yoshida, M., Akazawa, K., Saito, Y., Akagi, S., Ohno, Y., Kondo, M., Miura, D., Wada, J. & Itoh, H., May 30 2019, In : International heart journal. 60, 3, p. 728-735 8 p.

Research output: Contribution to journalArticle

Open Access
Inbred Dahl Rats
Cardiomegaly
High Fat Diet
Salts
Sodium-Glucose Transport Proteins

Liver transplantation in a patient with hereditary haemorrhagic telangiectasia and pulmonary hypertension

Ejiri, K., Akagi, S., Nakamura, K., Amioka, N., Ichikawa, K., Yagi, T. & Ito, H., Jan 1 2019, In : Pulmonary Circulation. 9, 4

Research output: Contribution to journalArticle

Open Access
Hereditary Hemorrhagic Telangiectasia
Pulmonary Hypertension
Arteriovenous Malformations
Liver Transplantation
Atrial Pressure
1 Citation (Scopus)
Phosphodiesterase 5 Inhibitors
Pulmonary Hypertension
Cohort Studies
Headache
Hemodynamics
2018
3 Citations (Scopus)

Crucial role of RAGE in inappropriate increase of smooth muscle cells from patients with pulmonary arterial hypertension

Nakamura, K., Sakaguchi, M., Matsubara, H., Akagi, S., Sarashina, T., Ejiri, K., Akazawa, K., Kondo, M., Nakagawa, K., Yoshida, M., Miyoshi, T., Ogo, T., Oto, T., Toyooka, S., Higashimoto, Y., Fukami, K. & Itoh, H., Sep 1 2018, In : PLoS One. 13, 9, e0203046.

Research output: Contribution to journalArticle

pulmonary artery
Pulmonary Hypertension
smooth muscle
myocytes
Pulmonary Artery
9 Citations (Scopus)

Modern treatment to reduce pulmonary arterial pressure in pulmonary arterial hypertension

Akagi, S., Matsubara, H., Nakamura, K. & Itoh, H., Jan 1 2018, (Accepted/In press) In : Journal of Cardiology.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Arterial Pressure
Lung
Therapeutics
Connective Tissue Diseases

Right ventricular pseudoaneurysm

Sakaguchi, T., Akagi, S., Totsugawa, T., Tamura, K. & Hiraoka, A., Jul 1 2018, In : European Heart Journal Cardiovascular Imaging. 19, 7, 1 p.

Research output: Contribution to journalComment/debate

False Aneurysm
1 Citation (Scopus)
Open Access
Ventricular Heart Septal Defects
Pulmonary Hypertension
Therapeutics
Vascular Resistance
Pulmonary Artery
2017

Effects of reduction of pressure overload on right ventricular function in patients with Eisenmenger syndrome

Nakamura, K., Sarashina, T., Ejiri, K. & Akagi, S., May 1 2017, In : Journal of Cardiology. 69, 5, p. 739-740 2 p.

Research output: Contribution to journalEditorial

Eisenmenger Complex
Right Ventricular Function
Pulmonary Hypertension
Pressure
4 Citations (Scopus)

Enhanced EP4 Expression in a Pulmonary Artery Aneurysm with Dissection in a Patient with Pulmonary Arterial Hypertension

Akagi, S., Nakamura, K., Yokoyama, U., Kasahara, S., Sarashina, T., Ejiri, K. & Itoh, H., Feb 1 2017, In : Circulation: Cardiovascular Imaging. 10, 2, e005839.

Research output: Contribution to journalShort survey

Pulmonary Hypertension
Pulmonary Artery
Aneurysm
Dissection
3 Citations (Scopus)
Lung Transplantation
Epoprostenol
Pulmonary Hypertension
Hemorrhage
Hematoma
Balloon Angioplasty
Lung Injury
Pulmonary Hypertension
Lung
3 Citations (Scopus)
Pulmonary Hypertension
Pulmonary Artery
Aneurysm
Dilatation
Pressure
10 Citations (Scopus)
Ventricular Remodeling
Lung Transplantation
Pulmonary Hypertension
Pharmaceutical Preparations
Therapeutics
4 Citations (Scopus)

Suppression of Wnt signaling and osteogenic changes in vascular smooth muscle cells by eicosapentaenoic acid

Saito, Y., Nakamura, K., Miura, D., Yunoki, K., Miyoshi, T., Yoshida, M., Kawakita, N., Kimura, T., Kondo, M., Sarashina, T., Akagi, S., Watanabe, A., Nishii, N., Morita, H. & Itoh, H., Aug 10 2017, In : Nutrients. 9, 8, 858.

Research output: Contribution to journalArticle

Eicosapentaenoic Acid
eicosapentaenoic acid
Vascular Smooth Muscle
blood vessels
smooth muscle
2016
2 Citations (Scopus)
Atrial Heart Septal Defects
Clinical Protocols
Pulmonary Hypertension
Repair
Defects
10 Citations (Scopus)
beraprost
Monocrotaline
Epoprostenol
Pulmonary Hypertension
Nanoparticles

Translational research on pulmonary hypertension

Nakamura, K. & Akagi, S., Jun 1 2016, In : Respiration and Circulation. 64, 6, p. 582-587 6 p.

Research output: Contribution to journalArticle

Translational Medical Research
Pulmonary Hypertension
2015

Are beta-blockers effective or contraindicated in pulmonary arterial hypertension?

Nakamura, K., Fujio, H., Akagi, S., Miura, A., Sarashina, T. & Ito, N. N. H., Apr 1 2015, Recent Developments in Beta-Blockers Research. Nova Science Publishers, Inc., p. 101-108 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pulmonary Hypertension
Adrenergic beta-Antagonists
Receptors, Adrenergic, beta
Adrenergic Antagonists
Vascular Resistance
14 Citations (Scopus)

Delivery of Imatinib-Incorporated Nanoparticles into Lungs Suppresses the Development of Monocrotaline-Induced Ulmonary Arterial Hypertension

Akagi, S., Nakamura, K., Miura, D., Saito, Y., Matsubara, H., Ogawa, A., Matoba, T., Egashira, K. & Itoh, H., Apr 27 2015, In : International Heart Journal. 56, 3, p. 354-359 6 p.

Research output: Contribution to journalArticle

Monocrotaline
Nanoparticles
Hypertension
Lung
Pulmonary Hypertension
17 Citations (Scopus)

Epoprostenol sodium for treatment of pulmonary arterial hypertension

Saito, Y., Nakamura, K., Akagi, S., Sarashina, T., Ejiri, K., Miura, A., Ogawa, A., Matsubara, H. & Itoh, H., May 14 2015, In : Vascular Health and Risk Management. 11, p. 265-270 6 p.

Research output: Contribution to journalArticle

Epoprostenol
Pulmonary Hypertension
Therapeutics
Hemodynamics
Catheter-Related Infections
8 Citations (Scopus)

Epoprostenol therapy for pulmonary arterial hypertension

Akagi, S., Nakamura, K., Matsubara, H., Ogawa, A., Sarashina, T., Ejiri, K. & Itoh, H., 2015, In : Acta Medica Okayama. 69, 3, p. 129-136 8 p.

Research output: Contribution to journalArticle

Epoprostenol
Pulmonary Hypertension
Pulmonary Artery
Therapeutics
Pulmonary Veno-Occlusive Disease
10 Citations (Scopus)

Treat and repair strategy in patients with atrial septal defect and significant pulmonary arterial hypertension

Kijima, Y., Akagi, T., Takaya, Y., Akagi, S., Nakagawa, K., Kusano, K., Sano, S. & Itoh, H., Dec 25 2015, In : Circulation Journal. 80, 1, p. 227-234 8 p.

Research output: Contribution to journalArticle

Atrial Heart Septal Defects
Pulmonary Hypertension
Vascular Resistance
Pulmonary Artery
Pressure
2014
5 Citations (Scopus)

Catecholamine support at the initiation of epoprostenol therapy in pulmonary arterial hypertension

Akagi, S., Ogawa, A., Miyaji, K., Kusano, K., Itoh, H. & Matsubaral, H., 2014, In : Annals of the American Thoracic Society. 11, 5, p. 719-727 9 p.

Research output: Contribution to journalArticle

Epoprostenol
Pulmonary Hypertension
Catecholamines
Dobutamine
Dopamine
44 Citations (Scopus)
Dipeptidyl-Peptidase IV Inhibitors
Cardiomegaly
Adrenergic Agents
Left Ventricular Hypertrophy
Isoproterenol
6 Citations (Scopus)

Reverse remodeling of pulmonary arteries by high-dose prostaglandin I2 therapy: A case report

Akagi, S., Nakamura, K., Matsubara, H., Ohta-Ogo, K., Yutani, C., Miyaji, K., Ogawa, A., Kusano, K., Oto, T., Ishibashi-Ueda, H. & Itoh, H., 2014, In : Journal of Cardiology Cases. 9, 5, p. 173-176 4 p.

Research output: Contribution to journalArticle

Epoprostenol
Pulmonary Artery
Lung
Therapeutics
Familial Primary Pulmonary Hypertension
2 Citations (Scopus)

Treatment with imatinib for refractory PAH

Nakamura, K., Akagi, S., Sarashina, T., Ogawa, A., Matsubara, H. & Itoh, H., 2014, In : Folia Pharmacologica Japonica. 143, 4, p. 173-177 5 p.

Research output: Contribution to journalArticle

Pulmonary Veno-Occlusive Disease
Piperazines
Benzamides
Molecular Targeted Therapy
Proto-Oncogene Proteins c-sis
2013
26 Citations (Scopus)

Different sizes of centrilobular ground-glass opacities in chest high-resolution computed tomography of patients with pulmonary veno-occlusive disease and patients with pulmonary capillary hemangiomatosis

Miura, A., Akagi, S., Nakamura, K., Ohta-Ogo, K., Hashimoto, K., Nagase, S., Kohno, K., Kusano, K., Ogawa, A., Matsubara, H., Toyooka, S., Oto, T., Ohtsuka, A., Ohe, T. & Itoh, H., Jul 2013, In : Cardiovascular Pathology. 22, 4, p. 287-293 7 p.

Research output: Contribution to journalArticle

Pulmonary Veno-Occlusive Disease
Glass
Thorax
Tomography
Lung

Prostaglandin I2-encapsulated nano particle improves pulmonary hypertension in rats

Akagi, S., 2013, In : Therapeutic Research. 34, 9, p. 1202 1 p.

Research output: Contribution to journalArticle

Epoprostenol
Pulmonary Hypertension
19 Citations (Scopus)

Prostaglandin I2 induces apoptosis via upregulation of Fas ligand in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension

Akagi, S., Nakamura, K., Matsubara, H., Fukushima Kusano, K., Kataoka, N., Oto, T., Miyaji, K., Miura, A., Ogawa, A., Yoshida, M., Ueda-Ishibashi, H., Yutani, C. & Itoh, H., 2013, In : International Journal of Cardiology. 165, 3, p. 499-505 7 p.

Research output: Contribution to journalArticle

Fas Ligand Protein
Epoprostenol
Pulmonary Artery
Smooth Muscle Myocytes
Up-Regulation
2012
5 Citations (Scopus)

Acute vasoreactivity testing with nicardipine in patients with pulmonary arterial hypertension

Saito, Y., Nakamura, K., Miyaji, K., Akagi, S., Mizoguchi, H., Ogawa, A., Fuke, S., Fujio, H., Kiyooka, T., Nagase, S., Kohno, K., Morita, H., Kusano, K. F., Matsubara, H., Ohe, T. & Itoh, H., 2012, In : Journal of Pharmacological Sciences. 120, 3, p. 206-212 7 p.

Research output: Contribution to journalArticle

Nicardipine
Pulmonary Hypertension
Calcium Channel Blockers
Hemodynamics
Cardiac Catheters
36 Citations (Scopus)

Pro-apoptotic effects of imatinib on PDGF-stimulated pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension

Nakamura, K., Akagi, S., Ogawa, A., Kusano, K. F., Matsubara, H., Miura, D., Fuke, S., Nishii, N., Nagase, S., Kohno, K., Morita, H., Oto, T., Yamanaka, R., Otsuka, F., Miura, A., Yutani, C., Ohe, T. & Itoh, H., Aug 23 2012, In : International Journal of Cardiology. 159, 2, p. 100-106 7 p.

Research output: Contribution to journalArticle

Platelet-Derived Growth Factor
Pulmonary Artery
Smooth Muscle Myocytes
Phosphorylation
Imatinib Mesylate
6 Citations (Scopus)
Takotsubo Cardiomyopathy
Chemoradiotherapy
Non-Small Cell Lung Carcinoma
Lung
Left Ventricular Dysfunction

Treatment with imatinib for refractory IPAH

Nakamura, K. & Akagi, S., Jan 15 2012, In : Respiration and Circulation. 60, 1, p. 27-31 5 p.

Research output: Contribution to journalArticle

Imatinib Mesylate
2011
3 Citations (Scopus)

Circulating KCNH2 current-activating factor in patients with heart failure and ventricular tachyarrhythmia

Sugiyama, H., Nakamura, K., Morita, H., Akagi, S., Tani, Y., Katayama, Y., Nishii, N., Miyoshi, T., Nagase, S., Kohno, K., Kusano, K. F., Ohe, T., Kurokawa, J., Furukawa, T. & Itoh, H., 2011, In : PLoS One. 6, 5, e19897.

Research output: Contribution to journalArticle

heart failure
Tachycardia
Heart Failure
Clamping devices
arrhythmia
34 Citations (Scopus)

Intermittent arm ischemia induces vasodilatation of the contralateral upper limb

Enko, K., Nakamura, K., Yunoki, K., Miyoshi, T., Akagi, S., Yoshida, M., Toh, N., Sangawa, M., Nishii, N., Nagase, S., Kohno, K., Morita, H., Kusano, K. F. & Itoh, H., Nov 2011, In : Journal of Physiological Sciences. 61, 6, p. 507-513 7 p.

Research output: Contribution to journalArticle

Vasodilation
Upper Extremity
Arm
Ischemia
Autonomic Pathways
1 Citation (Scopus)
Tricuspid Valve Insufficiency
Hypertension
Lung
Cardiac Catheterization
Epoprostenol
2010

A case of portopulmonary hypertension treated with sildenafil

Akagi, S., Oct 20 2010, In : Therapeutic Research. 31, 10, p. 1396-1397 2 p.

Research output: Contribution to journalArticle

Hypertension
Sildenafil Citrate
22 Citations (Scopus)

Inhibitory effects of simvastatin on platelet-derived growth factor signaling in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension

Ikeda, T., Nakamura, K., Akagi, S., Kusano, K. F., Matsubara, H., Fujio, H., Ogawa, A., Miura, A., Miura, D., Oto, T., Yamanaka, R., Otsuka, F., Date, H., Ohe, T. & Itoh, H., Jan 2010, In : Journal of Cardiovascular Pharmacology. 55, 1, p. 39-48 10 p.

Research output: Contribution to journalArticle

Simvastatin
Platelet-Derived Growth Factor
Pulmonary Artery
Smooth Muscle Myocytes
Familial Primary Pulmonary Hypertension
45 Citations (Scopus)

Marked hemodynamic improvements by high-dose epoprostenol therapy in patients with idiopathic pulmonary arterial hypertension

Akagi, S., Nakamura, K., Miyaji, K., Ogawa, A., Kusano, K. F., Itoh, H. & Matsubara, H., 2010, In : Circulation Journal. 74, 10, p. 2200-2205 6 p.

Research output: Contribution to journalArticle

Epoprostenol
Hemodynamics
Pulmonary Artery
Therapeutics
Pressure
19 Citations (Scopus)

Three-Dimensional structure of pulmonary capillary vessels in patients with pulmonary hypertension

Miura, A., Nakamura, K., Kusano, K. F., Matsubara, H., Ogawa, A., Akagi, S., Oto, T., Murakami, T., Ohtsuka, A., Yutani, C., Ohe, T. & Itoh, H., May 18 2010, In : Circulation. 121, 19, p. 2151-2153 3 p.

Research output: Contribution to journalArticle

Pulmonary Alveoli
Capillary Hemangioma
Three-Dimensional Imaging
Lung Transplantation
Bronchogenic Carcinoma
2009
34 Citations (Scopus)

Intravenous administration of nicorandil immediately before percutaneous coronary intervention can prevent slow coronary flow phenomenon

Kawai, Y., Hisamatsu, K., Matsubara, H., Dan, K., Akagi, S., Miyaji, K., Munemasa, M., Fujimoto, Y., Kusano, K. F. & Ohe, T., Apr 2009, In : European Heart Journal. 30, 7, p. 765-772 8 p.

Research output: Contribution to journalArticle

No-Reflow Phenomenon
Nicorandil
Percutaneous Coronary Intervention
Intravenous Administration
Acute Coronary Syndrome
2008
34 Citations (Scopus)

Additional effects of bosentan in patients with idiopathic pulmonary arterial hypertension already treated with high-dose epoprostenol

Akagi, S., Matsubara, H., Miyaji, K., Ikeda, E., Dan, K., Tokunaga, N., Hisamatsu, K., Munemasa, M., Fujimoto, Y. & Ohe, T., 2008, In : Circulation Journal. 72, 7, p. 1142-1146 5 p.

Research output: Contribution to journalArticle

Epoprostenol
Hemodynamics
Oxygen
Familial Primary Pulmonary Hypertension
bosentan
2 Citations (Scopus)

Anticoagulation therapy in pulmonary arterial hypertension

Akagi, S. & Kusano, K. F., Nov 2008, In : Nihon rinsho. Japanese journal of clinical medicine. 66, 11, p. 2174-2178 5 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Warfarin
Therapeutics
Manuscripts
Epoprostenol
9 Citations (Scopus)

Epoprostenol infusion therapy changes angiographic findings of pulmonary arteries in patients with idiopathic pulmonary arterial hypertension

Sakuma, M., Demachi, J., Nawata, J., Suzuki, J., Takahashi, T., Matsubara, H., Akagi, S. & Shirato, K., 2008, In : Circulation Journal. 72, 7, p. 1147-1151 5 p.

Research output: Contribution to journalArticle

Epoprostenol
Pulmonary Artery
Lung
Angiography
Therapeutics
2007
27 Citations (Scopus)

Prevention of catheter-related infections using a closed hub system in patients with pulmonary arterial hypertension

Akagi, S., Matsubara, H., Ogawa, A., Kawai, Y., Hisamatsu, K., Miyaji, K., Munemasa, M., Fujimoto, Y., Kusano, K. F. & Ohe, T., 2007, In : Circulation Journal. 71, 4, p. 559-564 6 p.

Research output: Contribution to journalArticle

Catheter-Related Infections
Pulmonary Hypertension
Catheters
Kaplan-Meier Estimate
Epoprostenol