• 2393 Citations
  • 28 h-Index
1986 …2020

Research output per year

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Research Output

  • 2393 Citations
  • 28 h-Index
  • 93 Article
  • 2 Chapter
  • 2 Review article
  • 1 Short survey
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Article
2020

Polyglycolic acid-collagen tube combined with collagen-binding basic fibroblast growth factor accelerates gait recovery in a rat sciatic nerve critical-size defect model

Fujimaki, H., Uchida, K., Inoue, G., Matsushita, O., Nemoto, N., Miyagi, M., Inage, K., Takano, S., Orita, S., Ohtori, S., Tanaka, K., Sekiguchi, H. & Takaso, M., Feb 1 2020, In : Journal of Biomedical Materials Research - Part B Applied Biomaterials. 108, 2, p. 326-332 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2019

Acceleration of bone regeneration of horizontal bone defect in rats using collagen-binding basic fibroblast growth factor combined with collagen scaffolds

Nakamura, S., Ito, T., Okamoto, K., Mima, T., Uchida, K., Siddiqui, Y. D., Ito, M., Tai, M., Okubo, K., Yamashiro, K., Omori, K., Yamamoto, T., Matsushita, O. & Takashiba, S., Sep 1 2019, In : Journal of periodontology. 90, 9, p. 1043-1052 10 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Association of host immunity with Helicobacter pylori infection in recurrent gastric cancer

Sato, M., Miura, K., Kageyama, C., Sakae, H., Obayashi, Y., Kawahara, Y., Matsushita, O., Yokota, K. & Okada, H., Feb 11 2019, In : Infectious Agents and Cancer. 14, 1, 4.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Increase in antibiotic resistant Helicobacter pylori in a University Hospital in Japan

Kageyama, C., Sato, M., Sakae, H., Obayashi, Y., Kawahara, Y., Mima, T., Matsushita, O., Yokota, K., Mizuno, M. & Okada, H., 2019, In : Infection and Drug Resistance. 12, p. 597-602 6 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
2018

Basic Fibroblast Growth Factor Fused with Tandem Collagen-Binding Domains from Clostridium histolyticum Collagenase ColG Increases Bone Formation

Sekiguchi, H., Uchida, K., Matsushita, O., Inoue, G., Nishi, N., Masuda, R., Hamamoto, N., Koide, T., Shoji, S. & Takaso, M., 2018, In : BioMed research international. 2018, 8393194.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Ca2+-induced orientation of tandem collagen binding domains from clostridial collagenase ColG permits two opposing functions of collagen fibril formation and retardation

Caviness, P., Bauer, R., Tanaka, K., Janowska, K., Roeser, J. R., Harter, D., Sanders, J., Ruth, C., Matsushita, O. & Sakon, J., Sep 2018, In : FEBS Journal. 285, 17, p. 3254-3269 16 p.

Research output: Contribution to journalArticle

DEC205 mediates local and systemic immune responses to Helicobacter pylori infection in humans

Kita, M., Yokota, K., Kageyama, C., Take, S., Goto, K., Kawahara, Y., Matsushita, O. & Okada, H., 2018, In : Oncotarget. 9, 22, p. 15828-15835 8 p.

Research output: Contribution to journalArticle

Expression of Collagenase is Regulated by the VarS/VarA Two-Component Regulatory System in Vibrio alginolyticus

Mima, T., Gotoh, K., Yamamoto, Y., Maeda, K., Shirakawa, T., Matsui, S., Murata, Y., Koide, T., Tokumitsu, H. & Matsushita, O., Feb 1 2018, In : Journal of Membrane Biology. 251, 1, p. 51-63 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

Basic Fibroblast Growth Factor-Anchored Multilayered Mesenchymal Cell Sheets Accelerate Periosteal Bone Formation

Uchida, K., Inoue, G., Matsushita, O., Horikawa, K., Sekiguchi, H., Saito, W., Takano, S., Fujimaki, H., Miyagi, M. & Takaso, M., 2017, In : BioMed research international. 2017, 4371460.

Research output: Contribution to journalArticle

Effect of Freeze-Dried Allograft Bone with Human Basic Fibroblast Growth Factor Containing a Collagen-Binding Domain from Clostridium histolyticum Collagenase on Bone Formation after Lumbar Posterolateral Fusion Surgery in Rats

Inoue, G., Uchida, K., Matsushita, O., Fujimaki, H., Saito, W., Miyagi, M., Sekiguchi, H., Nishi, N., Ohtori, S., Yogoro, M. & Takaso, M., Sep 1 2017, In : Spine. 42, 17, p. E995-E1001

Research output: Contribution to journalArticle

4 Citations (Scopus)
6 Citations (Scopus)

Oriented collagen tubes combined with basic fibroblast growth factor promote peripheral nerve regeneration in a 15 mm sciatic nerve defect rat model

Fujimaki, H., Uchida, K., Inoue, G., Miyagi, M., Nemoto, N., Saku, T., Isobe, Y., Inage, K., Matsushita, O., Yagishita, S., Sato, J., Takano, S., Sakuma, Y., Ohtori, S., Takahashi, K. & Takaso, M., Jan 1 2017, In : Journal of Biomedical Materials Research - Part A. 105, 1, p. 8-14 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2016

Acceleration of bone formation during fracture healing by poly(pro-hyp-gly)10 and basic fibroblast growth factor containing polycystic kidney disease and collagen-binding domains from Clostridium histolyticum collagenase

Sekiguchi, H., Uchida, K., Inoue, G., Matsushita, O., Saito, W., Aikawa, J., Tanaka, K., Fujimaki, H., Miyagi, M. & Takaso, M., Jun 1 2016, In : Journal of Biomedical Materials Research - Part A. 104, 6, p. 1372-1378 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2015
12 Citations (Scopus)
1 Citation (Scopus)

Cross-excitation in peripheral sensory ganglia associated with pain transmission

Omoto, K., Maruhama, K., Terayama, R., Yamamoto, Y., Matsushita, O., Sugimoto, T., Oguma, K. & Matsuka, Y., Aug 4 2015, In : Toxins. 7, 8, p. 2906-2917 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Structures of three polycystic kidney disease-like domains from Clostridium histolyticum collagenases ColG and ColH

Bauer, R., Janowska, K., Taylor, K., Jordan, B., Gann, S., Janowski, T., Latimer, E. C., Matsushita, O. & Sakon, J., Mar 1 2015, In : Acta Crystallographica Section D: Biological Crystallography. 71, p. 565-577 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2014

Acceleration of bone formation during fracture healing by injectable collagen powder and human basic fibroblast growth factor containing a collagen-binding domain from Clostridium histolyticum collagenase

Saito, W., Uchida, K., Ueno, M., Matsushita, O., Inoue, G., Nishi, N., Ogura, T., Hattori, S., Fujimaki, H., Tanaka, K. & Takaso, M., Sep 2014, In : Journal of Biomedical Materials Research - Part A. 102, 9, p. 3049-3055 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Acceleration of bone union after structural bone grafts with a collagen-binding basic fibroblast growth factor anchored-collagen sheet for critical-size bone defects

Ueno, M., Uchida, K., Saito, W., Matsushita, O., Yogoro, M., Nishi, N., Ogura, T., Hattori, S., Inoue, G., Tanaka, K., Takahira, N. & Takaso, M., Jun 2014, In : Biomedical Materials (Bristol). 9, 3, 035014.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Acceleration of periosteal bone formation by human basic fibroblast growth factor containing a collagen-binding domain from Clostridium histolyticum collagenase

Uchida, K., Matsushita, O., Naruse, K., Mima, T., Nishi, N., Hattori, S., Ogura, T., Inoue, G., Tanaka, K. & Takaso, M., Jun 2014, In : Journal of Biomedical Materials Research - Part A. 102, 6, p. 1737-1743 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Cellular responses to Staphylococcus aureus alpha-toxin in chronic rhinosinusitis with nasal polyps

Okano, M., Fujiwara, T., Kariya, S., Higaki, T., Haruna, T., Matsushita, O., Noda, Y., Makihara, S., Kanai, K., Noyama, Y., Taniguchi, M. & Nishizaki, K., 2014, In : Allergology International. 63, 4, p. 563-573 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Direct cytocidal effect of galectin-9 localized on collagen matrices on human immune cell lines

Fukata, Y., Itoh, A., Nonaka, Y., Ogawa, T., Nakamura, T., Matsushita, O. & Nishi, N., Jun 2014, In : Biochimica et Biophysica Acta - General Subjects. 1840, 6, p. 1892-1901 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Treatment and prevention of chemotherapy-induced alopecia with PTH-CBD, a collagen-targeted parathyroid hormone analog, in a non-depilated mouse model

Katikaneni, R., Ponnapakkam, T., Matsushita, O., Sakon, J. & Gensure, R., Jan 2014, In : Anti-Cancer Drugs. 25, 1, p. 30-38 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2013

Effects of CB-VEGF-A injection in rat flap models for improved survival

Akimoto, M., Takeda, A., Matsushita, O., Inoue, J., Sakamoto, K., Hattori, M., Kounoike, N. & Uchinuma, E., Apr 1 2013, In : Plastic and reconstructive surgery. 131, 4, p. 717-725 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Phospholipase C produced by clostridium botulinum types C and D: Comparison of gene, enzymatic, and biological activities with those of Clostridium perfringens alpha-toxin

Fatmawati, N. N. D., Sakaguchi, Y., Suzuki, T., Oda, M., Shimizu, K., Yamamoto, Y., Sakurai, J., Matsushita, O. & Oguma, K., 2013, In : Acta medica Okayama. 67, 1, p. 9-18 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Structural comparison of ColH and ColG collagen-binding domains from Clostridium histolyticum

Bauer, R., Wilson, J. J., Philominathan, S. T. L., Davis, D., Matsushita, O. & Sakona, J., Jan 1 2013, In : Journal of bacteriology. 195, 2, p. 318-327 10 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

The genetic diversity of Helicobacter pylori virulence genes is not associated with gastric atrophy progression

Kita, M., Yokota, K., Okada, H., Take, S., Takenaka, R., Kawahara, Y., Oguma, K., Matsushita, O. & Yamamoto, K., 2013, In : Acta medica Okayama. 67, 2, p. 93-98 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2012

A single injection of the anabolic bone agent, parathyroid hormone-collagen binding domain (PTH-CBD), results in sustained increases in bone mineral density for up to 12 months in normal female mice

Ponnapakkam, T., Katikaneni, R., Suda, H., Miyata, S., Matsushita, O., Sakon, J. & Gensure, R. C., Sep 1 2012, In : Calcified Tissue International. 91, 3, p. 196-203 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Bacterial collagen-binding domain targets undertwisted regions of collagen

Philominathan, S. T. L., Koide, T., Matsushita, O. & Sakon, J., Oct 1 2012, In : Protein Science. 21, 10, p. 1554-1565 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Probing the 3-D structure, dynamics, and stability of bacterial collagenase collagen binding domain (apo- versus holo-) by limited proteolysis MALDI-TOF MS

Sides, C. R., Liyanage, R., Lay, J. O., Philominathan, S. T. L., Matsushita, O. & Sakon, J., Mar 1 2012, In : Journal of the American Society for Mass Spectrometry. 23, 3, p. 505-519 15 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Treatment for chemotherapy-induced alopecia in mice using parathyroid hormone agonists and antagonists linked to a collagen binding domain

Katikaneni, R., Ponnapakkam, T., Suda, H., Miyata, S., Sakon, J., Matsushita, O. & Gensure, R. C., Sep 1 2012, In : International Journal of Cancer. 131, 5, p. E813-E821

Research output: Contribution to journalArticle

20 Citations (Scopus)
2011

Identification of a novel virulence factor in Clostridium Difficile that modulates toxin sensitivity of cultured epithelial cells

Miura, M., Kato, H. & Matsushita, O., Sep 1 2011, In : Infection and Immunity. 79, 9, p. 3810-3820 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Monthly administration of a novel PTH-collagen binding domain fusion protein is anabolic in mice

Ponnapakkam, T., Katikaneni, R., Miller, E., Ponnapakkam, A., Hirofumi, S., Miyata, S., Suva, L. J., Sakon, J., Matsushita, O. & Gensure, R. C., Jun 1 2011, In : Calcified Tissue International. 88, 6, p. 511-520 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Prevention of chemotherapy-induced osteoporosis by cyclophosphamide with a long-acting form of parathyroid hormone.

Ponnapakkam, T., Katikaneni, R., Nichols, T., Tobin, G., Sakon, J., Matsushita, O. & Gensure, R. C., Dec 2011, In : Journal of endocrinological investigation. 34, 11, p. e392-e397

Research output: Contribution to journalArticle

20 Citations (Scopus)
2009

Ca2+-induced linker transformation leads to a compact and rigid collagen-binding domain of Clostridium histolyticum collagenase

Philominathan, S. T. L., Matsushita, O., Gensure, R. & Sakon, J., Jul 1 2009, In : FEBS Journal. 276, 13, p. 3589-3601 13 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Development of a high-throughput screening system for the compounds that inhibit collagen-protein interactions

Okano-Kosugi, H., Matsushita, O., Asada, S., Herr, A. B., Kitagawa, K. & Koide, T., Nov 1 2009, In : Analytical Biochemistry. 394, 1, p. 125-131 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Unidirectional binding of clostridial collagenase to triple helical substrates

Philominathan, S. T. L., Koide, T., Hamada, K., Yasui, H., Seifert, S., Matsushita, O. & Sakon, J., Apr 17 2009, In : Journal of Biological Chemistry. 284, 16, p. 10868-10876 9 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2008

1H, 13C, and 15N resonance assignments of Ca 2+ bound collagen-binding domain derived from a clostridial collagenase

Philominathan, S. T. L., Matsushita, O., Jordan, J. B. & Sakon, J., Dec 1 2008, In : Biomolecular NMR Assignments. 2, 2, p. 127-129 3 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Behavioral approach to facilitate appropriate use of antibiotics

Matsushita, O., Higuchi, K., Ishii, N., Negayama, K. & Taminato, T., Nov 2008, In : Rinsho byori. The Japanese journal of clinical pathology. 56, 11, p. 994-1006 13 p.

Research output: Contribution to journalArticle

High-level expression of his-tagged clostridial collagenase in Clostridium perfringens

Tamai, E., Miyata, S., Tanaka, H., Nariya, H., Suzuki, M., Matsushita, O., Hatano, N. & Okabe, A., Sep 1 2008, In : Applied Microbiology and Biotechnology. 80, 4, p. 627-635 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2006

Optimum preparation of levocarnitine chloride solution in the hospital pharmacy

Tanaka, H., Asakura, M., Doi, C., Fukuoka, N., Tamai, E., Miyata, S., Matsushita, O., Okabe, A., Negayama, K. & Houchi, H., Sep 15 2006, In : Yakugaku Zasshi. 126, 9, p. 805-809 5 p.

Research output: Contribution to journalArticle

2005

Changes in ganglioside content affect the binding of Clostridium perfringens epsilon-toxin to detergent-resistant membranes of Madin-Darby canine kidney cells

Shimamoto, S., Tamai, E., Matsushita, O., Minami, J., Okabe, A. & Miyata, S., Jan 1 2005, In : MICROBIOLOGY and IMMUNOLOGY. 49, 3, p. 245-253 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2004

High-level expression of clostridial sialidase using a ferredoxin gene promoter-based plasmid

Takamizawa, A., Miyata, S., Matsushita, O., Kaji, M., Taniguchi, Y., Tamai, E., Shimamoto, S. & Okabe, A., Jul 1 2004, In : Protein Expression and Purification. 36, 1, p. 70-75 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2003

A bacterial collagen-binding domain with novel calcium-binding motif controls domain orientation

Wilson, J. J., Matsushita, O., Okabe, A. & Sakon, J., Apr 15 2003, In : EMBO Journal. 22, 8, p. 1743-1752 10 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)

Accumulation of Clostridium perfringens epsilon-toxin in the mouse kidney and its possible biological significance

Tamai, E., Ishida, T., Miyata, S., Matsushita, O., Suda, H., Kobayashi, S., Sonobe, H. & Okabe, A., Sep 1 2003, In : Infection and Immunity. 71, 9, p. 5371-5375 5 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

A novel type of DNA curvature present in a Clostridium perfringens ferredoxin gene: Characterization and role in gene expression

Kaji, M., Matsushita, O., Tamai, E., Miyata, S., Taniguchi, Y., Shimamoto, S., Katayama, S., Morita, S. & Okabe, A., Nov 2003, In : Microbiology. 149, 11, p. 3083-3091 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Dual-site recognition of different extracellular matrix components by anti-angiogenic/neurotrophic serpin, PEDF

Yasui, N., Mori, T., Morito, D., Matsushita, O., Kourai, H., Nagata, K. & Koide, T., Mar 25 2003, In : Biochemistry. 42, 11, p. 3160-3167 8 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)
2002

Clostridium perfringens ε-toxin forms a heptameric pore within the detergent-insoluble microdomains of Madin-Darby canine kidney cells and rat synaptosomes

Miyata, S., Minami, J., Tamai, E., Matsushita, O., Shimamoto, S. & Okabe, A., Oct 18 2002, In : Journal of Biological Chemistry. 277, 42, p. 39463-39468 6 p.

Research output: Contribution to journalArticle

111 Citations (Scopus)
2001

Cleavage of a C-terminal Peptide Is Essential for Heptamerization of Clostridium perfringens ε-Toxin in the Synaptosomal Membrane

Miyata, S., Matsushita, O., Minami, J., Katayama, S., Shimamoto, S. & Okabe, A., Apr 27 2001, In : Journal of Biological Chemistry. 276, 17, p. 13778-13783 6 p.

Research output: Contribution to journalArticle

Open Access
91 Citations (Scopus)