• 2314 Citations
  • 27 h-Index
1986 …2019
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Research Output 1986 2019

  • 2314 Citations
  • 27 h-Index
  • 96 Article
  • 2 Chapter
2019
1 Citation (Scopus)

Acceleration of bone regeneration of horizontal bone defect in rats using collagen-binding basic fibroblast growth factor combined with collagen scaffolds

Nakamura, S., Ito, T., Okamoto, K., Mima, T., Uchida, K., Siddiqui, Y. D., Ito, M., Tai, M., Okubo, K., Yamashiro, K., Omori, K., Yamamoto, T., Matsushita, O. & Takashiba, S., Sep 1 2019, In : Journal of periodontology. 90, 9, p. 1043-1052 10 p.

Research output: Contribution to journalArticle

Open Access
Bone Regeneration
Fibroblast Growth Factor 2
Collagen
Bone and Bones
Powders
2 Citations (Scopus)

Association of host immunity with Helicobacter pylori infection in recurrent gastric cancer

Sato, M., Miura, K., Kageyama, C., Sakae, H., Obayashi, Y., Kawahara, Y., Matsushita, O., Yokota, K. & Okada, H., Feb 11 2019, In : Infectious Agents and Cancer. 14, 1, 4.

Research output: Contribution to journalArticle

Open Access
Helicobacter Infections
Helicobacter pylori
Stomach Neoplasms
Immunity
Single Nucleotide Polymorphism
1 Citation (Scopus)

Increase in antibiotic resistant Helicobacter pylori in a University Hospital in Japan

Kageyama, C., Sato, M., Sakae, H., Obayashi, Y., Kawahara, Y., Mima, T., Matsushita, O., Yokota, K., Mizuno, M. & Okada, H., Jan 1 2019, In : Infection and Drug Resistance. 12, p. 597-602 6 p.

Research output: Contribution to journalArticle

Open Access
Amoxicillin
Helicobacter pylori
Clarithromycin
Microbial Sensitivity Tests
Japan

Polyglycolic acid-collagen tube combined with collagen-binding basic fibroblast growth factor accelerates gait recovery in a rat sciatic nerve critical-size defect model

Fujimaki, H., Uchida, K., Inoue, G., Matsushita, O., Nemoto, N., Miyagi, M., Inage, K., Takano, S., Orita, S., Ohtori, S., Tanaka, K., Sekiguchi, H. & Takaso, M., Jan 1 2019, In : Journal of Biomedical Materials Research - Part B Applied Biomaterials.

Research output: Contribution to journalArticle

Polyglycolic Acid
Fibroblast Growth Factor 2
Fibroblasts
Collagen
Rats
2018
2 Citations (Scopus)

Basic Fibroblast Growth Factor Fused with Tandem Collagen-Binding Domains from Clostridium histolyticum Collagenase ColG Increases Bone Formation

Sekiguchi, H., Uchida, K., Matsushita, O., Inoue, G., Nishi, N., Masuda, R., Hamamoto, N., Koide, T., Shoji, S. & Takaso, M., Jan 1 2018, In : BioMed Research International. 2018, 8393194.

Research output: Contribution to journalArticle

Microbial Collagenase
Collagenases
Fibroblast Growth Factor 2
Osteogenesis
Bone

Ca2+-induced orientation of tandem collagen binding domains from clostridial collagenase ColG permits two opposing functions of collagen fibril formation and retardation

Caviness, P., Bauer, R., Tanaka, K., Janowska, K., Roeser, J. R., Harter, D., Sanders, J., Ruth, C., Matsushita, O. & Sakon, J., Sep 1 2018, In : FEBS Journal. 285, 17, p. 3254-3269 16 p.

Research output: Contribution to journalArticle

Collagenases
Collagen
Tropocollagen
Clostridium
X ray scattering

DEC205 mediates local and systemic immune responses to Helicobacter pylori infection in humans

Kita, M., Yokota, K., Kageyama, C., Take, S., Goto, K., Kawahara, Y., Matsushita, O. & Okada, H., Jan 1 2018, In : Oncotarget. 9, 22, p. 15828-15835 8 p.

Research output: Contribution to journalArticle

Helicobacter Infections
Helicobacter pylori
Gastric Mucosa
Macrophages
Phagocytosis

Vibrio alginolyticus VepA induces lysosomal membrane permeability and cathepsin-independent cell death

Darwinata, A. E., Goto, K., Mima, T., Yamamoto, Y., Yokota, K. & Matsushita, O., Jan 1 2018, In : Acta Medica Okayama. 72, 3, p. 231-239 9 p.

Research output: Contribution to journalArticle

Vibrio alginolyticus
Cathepsins
Cell death
Cytotoxicity
Permeability
2017

Basic Fibroblast Growth Factor-Anchored Multilayered Mesenchymal Cell Sheets Accelerate Periosteal Bone Formation

Uchida, K., Inoue, G., Matsushita, O., Horikawa, K., Sekiguchi, H., Saito, W., Takano, S., Fujimaki, H., Miyagi, M. & Takaso, M., 2017, In : BioMed Research International. 2017, 4371460.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Osteogenesis
Bone
Polycystic Kidney Diseases
Collagen
2 Citations (Scopus)

Effect of Freeze-Dried Allograft Bone with Human Basic Fibroblast Growth Factor Containing a Collagen-Binding Domain from Clostridium Histolyticum Collagenase on Bone Formation after Lumbar Posterolateral Fusion Surgery in Rats

Inoue, G., Uchida, K., Matsushita, O., Fujimaki, H., Saito, W., Miyagi, M., Sekiguchi, H., Nishi, N., Ohtori, S., Yogoro, M. & Takaso, M., Jan 16 2017, (Accepted/In press) In : Spine.

Research output: Contribution to journalArticle

Microbial Collagenase
Polycystic Kidney Diseases
Fibroblast Growth Factor 2
Osteogenesis
Allografts
2 Citations (Scopus)

Expression of Collagenase is Regulated by the VarS/VarA Two-Component Regulatory System in Vibrio alginolyticus

Mima, T., Goto, K., Yamamoto, Y., Maeda, K., Shirakawa, T., Matsui, S., Murata, Y., Koide, T., Tokumitsu, H. & Matsushita, O., Oct 9 2017, (Accepted/In press) In : Journal of Membrane Biology. p. 1-13 13 p.

Research output: Contribution to journalArticle

Vibrio alginolyticus
Colicins
Collagenases
Phosphorylation
Virulence Factors
15 Citations (Scopus)

Oriented collagen tubes combined with basic fibroblast growth factor promote peripheral nerve regeneration in a 15 mm sciatic nerve defect rat model

Fujimaki, H., Uchida, K., Inoue, G., Miyagi, M., Nemoto, N., Saku, T., Isobe, Y., Inage, K., Matsushita, O., Yagishita, S., Sato, J., Takano, S., Sakuma, Y., Ohtori, S., Takahashi, K. & Takaso, M., Jan 1 2017, In : Journal of Biomedical Materials Research - Part A. 105, 1, p. 8-14 7 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Fibroblasts
Collagen
Rats
Defects
2016
6 Citations (Scopus)

Acceleration of bone formation during fracture healing by poly(pro-hyp-gly)10 and basic fibroblast growth factor containing polycystic kidney disease and collagen-binding domains from Clostridium histolyticum collagenase

Sekiguchi, H., Uchida, K., Inoue, G., Matsushita, O., Saito, W., Aikawa, J., Tanaka, K., Fujimaki, H., Miyagi, M. & Takaso, M., 2016, (Accepted/In press) In : Journal of Biomedical Materials Research - Part A.

Research output: Contribution to journalArticle

Microbial Collagenase
Clostridium
Fibroblast Growth Factor 2
Fibroblasts
Collagen
2015
9 Citations (Scopus)
Fracture Healing
Bony Callus
Kidney Diseases
Fibroblast Growth Factor 2
Powders
1 Citation (Scopus)
Helicobacter Infections
Serologic Tests
Helicobacter pylori
Stomach Neoplasms
Immunoglobulin G
5 Citations (Scopus)

Cross-excitation in peripheral sensory ganglia associated with pain transmission

Omoto, K., Maruhama, K., Terayama, R., Yamamoto, Y., Matsushita, O., Sugimoto, T., Oguma, K. & Matsuka, Y., Aug 4 2015, In : Toxins. 7, 8, p. 2906-2917 12 p.

Research output: Contribution to journalArticle

Sensory Ganglia
Nerve Compression Syndromes
Spinal Ganglia
Sciatic Nerve
Pain
5 Citations (Scopus)
Microbial Collagenase
Polycystic Kidney Diseases
Clostridium
Fibroblast Growth Factor 2
Fibroblasts
10 Citations (Scopus)

Structures of three polycystic kidney disease-like domains from Clostridium histolyticum collagenases ColG and ColH

Bauer, R., Janowska, K., Taylor, K., Jordan, B., Gann, S., Janowski, T., Latimer, E. C., Matsushita, O. & Sakon, J., Mar 1 2015, In : Acta Crystallographica Section D: Biological Crystallography. 71, p. 565-577 13 p.

Research output: Contribution to journalArticle

Microbial Collagenase
Polycystic Kidney Diseases
Collagenases
Collagen
Surface Properties
2014
18 Citations (Scopus)

Acceleration of bone formation during fracture healing by injectable collagen powder and human basic fibroblast growth factor containing a collagen-binding domain from Clostridium histolyticum collagenase

Saito, W., Uchida, K., Ueno, M., Matsushita, O., Inoue, G., Nishi, N., Ogura, T., Hattori, S., Fujimaki, H., Tanaka, K. & Takaso, M., 2014, In : Journal of Biomedical Materials Research - Part A. 102, 9, p. 3049-3055 7 p.

Research output: Contribution to journalArticle

Microbial Collagenase
Clostridium
Fracture Healing
Fibroblast Growth Factor 2
Fibroblasts
11 Citations (Scopus)

Acceleration of bone union after structural bone grafts with a collagen-binding basic fibroblast growth factor anchored-collagen sheet for critical-size bone defects

Ueno, M., Uchida, K., Saito, W., Matsushita, O., Yogoro, M., Nishi, N., Ogura, T., Hattori, S., Inoue, G., Tanaka, K., Takahira, N. & Takaso, M., 2014, In : Biomedical Materials (Bristol). 9, 3, 035014.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Fibroblasts
Collagen
Grafts
Bone
18 Citations (Scopus)

Acceleration of periosteal bone formation by human basic fibroblast growth factor containing a collagen-binding domain from Clostridium histolyticum collagenase

Uchida, K., Matsushita, O., Naruse, K., Mima, T., Nishi, N., Hattori, S., Ogura, T., Inoue, G., Tanaka, K. & Takaso, M., 2014, In : Journal of Biomedical Materials Research - Part A. 102, 6, p. 1737-1743 7 p.

Research output: Contribution to journalArticle

Microbial Collagenase
Clostridium
Fibroblast Growth Factor 2
Fibroblasts
Collagen
9 Citations (Scopus)

Cellular responses to Staphylococcus aureus alpha-toxin in chronic rhinosinusitis with nasal polyps

Okano, M., Fujiwara, T., Kariya, S., Higaki, T., Haruna, T., Matsushita, O., Noda, Y., Makihara, S., Kanai, K., Noyama, Y., Taniguchi, M. & Nishizaki, K., 2014, In : Allergology International. 63, 4, p. 563-573 11 p.

Research output: Contribution to journalArticle

Nasal Polyps
Interleukin-10
Interleukin-13
Interleukin-17
Interleukin-5
5 Citations (Scopus)

Direct cytocidal effect of galectin-9 localized on collagen matrices on human immune cell lines

Fukata, Y., Itoh, A., Nonaka, Y., Ogawa, T., Nakamura, T., Matsushita, O. & Nishi, N., 2014, In : Biochimica et Biophysica Acta - General Subjects. 1840, 6, p. 1892-1901 10 p.

Research output: Contribution to journalArticle

Galectins
Collagen
Cells
Cell Line
Jurkat Cells
17 Citations (Scopus)

Treatment and prevention of chemotherapy-induced alopecia with PTH-CBD, a collagen-targeted parathyroid hormone analog, in a non-depilated mouse model

Katikaneni, R., Ponnapakkam, T., Matsushita, O., Sakon, J. & Gensure, R., Jan 2014, In : Anti-Cancer Drugs. 25, 1, p. 30-38 9 p.

Research output: Contribution to journalArticle

Alopecia
Parathyroid Hormone
Collagen
Drug Therapy
Therapeutics
2013
2 Citations (Scopus)

[New Helicobacters other than H. pylori].

Yokota, K., Kita, M., Okada, H., Matsushita, O. & Oguma, K., Aug 2013, In : Nihon rinsho. Japanese journal of clinical medicine. 71, 8, p. 1374-1379 6 p.

Research output: Contribution to journalArticle

Helicobacter
Pylorus
Helicobacter pylori
Stomach
Zoonoses
12 Citations (Scopus)

Effects of CB-VEGF-A injection in rat flap models for improved survival

Akimoto, M., Takeda, A., Matsushita, O., Inoue, J., Sakamoto, K., Hattori, M., Kounoike, N. & Uchinuma, E., Apr 2013, In : Plastic and Reconstructive Surgery. 131, 4, p. 717-725 9 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Collagen
Injections
Skin
Necrosis

Lambda Toxin (Clostridium perfringens)

Okabe, A. & Matsushita, O., 2013, Handbook of Proteolytic Enzymes. Elsevier Ltd, Vol. 1. p. 561-563 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

caseinase
9 Citations (Scopus)

Phospholipase C produced by clostridium botulinum types C and D: Comparison of gene, enzymatic, and biological activities with those of Clostridium perfringens alpha-toxin

Fatmawati, N. N. D., Sakaguchi, Y., Suzuki, T., Oda, M., Shimizu, K., Yamamoto, Y., Sakurai, J., Matsushita, O. & Oguma, K., 2013, In : Acta Medica Okayama. 67, 1, p. 9-18 10 p.

Research output: Contribution to journalArticle

Clostridium botulinum type D
Clostridium botulinum type C
Clostridium
Type C Phospholipases
Programmable logic controllers
19 Citations (Scopus)

Structural comparison of ColH and ColG collagen-binding domains from Clostridium histolyticum

Bauer, R., Wilson, J. J., Philominathan, S. T. L., Davis, D., Matsushita, O. & Sakona, J., Jan 2013, In : Journal of Bacteriology. 195, 2, p. 318-327 10 p.

Research output: Contribution to journalArticle

Clostridium histolyticum
Collagen
Microbial Collagenase
Binding Sites
X-Rays
2 Citations (Scopus)

The genetic diversity of Helicobacter pylori virulence genes is not associated with gastric atrophy progression

Kita, M., Yokota, K., Okada, H., Take, S., Takenaka, R., Kawahara, Y., Oguma, K., Matsushita, O. & Yamamoto, K., 2013, In : Acta Medica Okayama. 67, 2, p. 93-98 6 p.

Research output: Contribution to journalArticle

Helicobacter pylori
Atrophy
Virulence
Stomach
Genes
2012
13 Citations (Scopus)

A single injection of the anabolic bone agent, parathyroid hormone-collagen binding domain (PTH-CBD), results in sustained increases in bone mineral density for up to 12 months in normal female mice

Ponnapakkam, T., Katikaneni, R., Suda, H., Miyata, S., Matsushita, O., Sakon, J. & Gensure, R. C., Sep 2012, In : Calcified Tissue International. 91, 3, p. 196-203 8 p.

Research output: Contribution to journalArticle

Anabolic Agents
Parathyroid Hormone
Bone Density
Collagen
Bone and Bones
16 Citations (Scopus)

Bacterial collagen-binding domain targets undertwisted regions of collagen

Philominathan, S. T. L., Koide, T., Matsushita, O. & Sakon, J., Oct 2012, In : Protein Science. 21, 10, p. 1554-1565 12 p.

Research output: Contribution to journalArticle

Collagen
Titration
Microbial Collagenase
Substitution reactions
Magnetic Resonance Spectroscopy
12 Citations (Scopus)

Probing the 3-D structure, dynamics, and stability of bacterial collagenase collagen binding domain (apo- versus holo-) by limited proteolysis MALDI-TOF MS

Sides, C. R., Liyanage, R., Lay, J. O., Philominathan, S. T. L., Matsushita, O. & Sakon, J., Mar 2012, In : Journal of the American Society for Mass Spectrometry. 23, 3, p. 505-519 15 p.

Research output: Contribution to journalArticle

Proteolysis
Collagenases
Ionization
Mass spectrometry
Desorption
20 Citations (Scopus)

Treatment for chemotherapy-induced alopecia in mice using parathyroid hormone agonists and antagonists linked to a collagen binding domain

Katikaneni, R., Ponnapakkam, T., Suda, H., Miyata, S., Sakon, J., Matsushita, O. & Gensure, R. C., Sep 1 2012, In : International Journal of Cancer. 131, 5

Research output: Contribution to journalArticle

Hormone Antagonists
Alopecia
Parathyroid Hormone
Collagen
Drug Therapy
2011
6 Citations (Scopus)

Identification of a novel virulence factor in Clostridium Difficile that modulates toxin sensitivity of cultured epithelial cells

Miura, M., Kato, H. & Matsushita, O., Sep 2011, In : Infection and Immunity. 79, 9, p. 3810-3820 11 p.

Research output: Contribution to journalArticle

Clostridium difficile
Virulence Factors
Actins
Cultured Cells
Epithelial Cells
18 Citations (Scopus)

Monthly administration of a novel PTH-collagen binding domain fusion protein is anabolic in mice

Ponnapakkam, T., Katikaneni, R., Miller, E., Ponnapakkam, A., Hirofumi, S., Miyata, S., Suva, L. J., Sakon, J., Matsushita, O. & Gensure, R. C., Jun 2011, In : Calcified Tissue International. 88, 6, p. 511-520 10 p.

Research output: Contribution to journalArticle

Parathyroid Hormone
Collagen
Bone and Bones
Bone Density
Protein Domains
19 Citations (Scopus)

Prevention of chemotherapy-induced osteoporosis by cyclophosphamide with a long-acting form of parathyroid hormone.

Ponnapakkam, T., Katikaneni, R., Nichols, T., Tobin, G., Sakon, J., Matsushita, O. & Gensure, R. C., Dec 2011, In : Journal of Endocrinological Investigation. 34, 11

Research output: Contribution to journalArticle

Parathyroid Hormone
Cyclophosphamide
Osteoporosis
Drug Therapy
Bone Density
2009
15 Citations (Scopus)

Ca2+-induced linker transformation leads to a compact and rigid collagen-binding domain of Clostridium histolyticum collagenase

Philominathan, S. T. L., Matsushita, O., Gensure, R. & Sakon, J., Jul 2009, In : FEBS Journal. 276, 13, p. 3589-3601 13 p.

Research output: Contribution to journalArticle

Microbial Collagenase
Collagen
Denaturation
Ions
Calcium
11 Citations (Scopus)

Development of a high-throughput screening system for the compounds that inhibit collagen-protein interactions

Okano-Kosugi, H., Matsushita, O., Asada, S., Herr, A. B., Kitagawa, K. & Koide, T., Nov 1 2009, In : Analytical Biochemistry. 394, 1, p. 125-131 7 p.

Research output: Contribution to journalArticle

Screening
Collagen
Throughput
Carrier Proteins
Proteins
22 Citations (Scopus)

Unidirectional binding of clostridial collagenase to triple helical substrates

Philominathan, S. T. L., Koide, T., Hamada, K., Yasui, H., Seifert, S., Matsushita, O. & Sakon, J., Apr 17 2009, In : Journal of Biological Chemistry. 284, 16, p. 10868-10876 9 p.

Research output: Contribution to journalArticle

Collagenases
Collagen
Tropocollagen
Substrates
Titration
2008
8 Citations (Scopus)

1H, 13C, and 15N resonance assignments of Ca 2+ bound collagen-binding domain derived from a clostridial collagenase

Philominathan, S. T. L., Matsushita, O., Jordan, J. B. & Sakon, J., Dec 2008, In : Biomolecular NMR Assignments. 2, 2, p. 127-129 3 p.

Research output: Contribution to journalArticle

Collagenases
Clostridium histolyticum
Collagen
Clostridium
Drug Design

Behavioral approach to facilitate appropriate use of antibiotics

Matsushita, O., Higuchi, K., Ishii, N., Negayama, K. & Taminato, T., Nov 2008, In : Rinsho byori. The Japanese journal of clinical pathology. 56, 11, p. 994-1006 13 p.

Research output: Contribution to journalArticle

Infection Control
Cross Infection
Anti-Infective Agents
Prescriptions
Anti-Bacterial Agents
12 Citations (Scopus)

High-level expression of his-tagged clostridial collagenase in Clostridium perfringens

Tamai, E., Miyata, S., Tanaka, H., Nariya, H., Suzuki, M., Matsushita, O., Hatano, N. & Okabe, A., Sep 2008, In : Applied Microbiology and Biotechnology. 80, 4, p. 627-635 9 p.

Research output: Contribution to journalArticle

Clostridium
Microbial Collagenase
Clostridium perfringens
Collagenases
Affinity chromatography
2006

Optimum preparation of levocarnitine chloride solution in the hospital pharmacy

Tanaka, H., Asakura, M., Doi, C., Fukuoka, N., Tamai, E., Miyata, S., Matsushita, O., Okabe, A., Negayama, K. & Houchi, H., 2006, In : Yakugaku Zasshi. 126, 9, p. 805-809 5 p.

Research output: Contribution to journalArticle

Carnitine
Chlorides
Tablets
Deglutition
Water
2005
27 Citations (Scopus)

Changes in ganglioside content affect the binding of Clostridium perfringens epsilon-toxin to detergent-resistant membranes of Madin-Darby canine kidney cells

Shimamoto, S., Tamai, E., Matsushita, O., Minami, J., Okabe, A. & Miyata, S., 2005, In : Microbiology and Immunology. 49, 3, p. 245-253 9 p.

Research output: Contribution to journalArticle

Madin Darby Canine Kidney Cells
Gangliosides
Detergents
Sphingolipids
Membranes
2004
10 Citations (Scopus)

High-level expression of clostridial sialidase using a ferredoxin gene promoter-based plasmid

Takamizawa, A., Miyata, S., Matsushita, O., Kaji, M., Taniguchi, Y., Tamai, E., Shimamoto, S. & Okabe, A., Jul 2004, In : Protein Expression and Purification. 36, 1, p. 70-75 6 p.

Research output: Contribution to journalArticle

Ferredoxins
Neuraminidase
Plasmids
Genes
Clostridium perfringens

Lambda toxin (Clostridium perfringens)

Okabe, A. & Matsushita, O., Jun 30 2004, Aspartic and Metallo Peptidases. Elsevier Inc., Vol. 1. p. 387-389 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

caseinase
2003
86 Citations (Scopus)

A bacterial collagen-binding domain with novel calcium-binding motif controls domain orientation

Wilson, J. J., Matsushita, O., Okabe, A. & Sakon, J., Apr 15 2003, In : EMBO Journal. 22, 8, p. 1743-1752 10 p.

Research output: Contribution to journalArticle

Crystal orientation
Collagen
Calcium
Clostridium histolyticum
Clostridium
40 Citations (Scopus)

Accumulation of Clostridium perfringens epsilon-toxin in the mouse kidney and its possible biological significance

Tamai, E., Ishida, T., Miyata, S., Matsushita, O., Suda, H., Kobayashi, S., Sonobe, H. & Okabe, A., Sep 1 2003, In : Infection and Immunity. 71, 9, p. 5371-5375 5 p.

Research output: Contribution to journalArticle

Kidney
Nephrectomy
Epithelial Cells
Wounds and Injuries
Clostridium perfringens epsilon-toxin
13 Citations (Scopus)

A novel type of DNA curvature present in a Clostridium perfringens ferredoxin gene: Characterization and role in gene expression

Kaji, M., Matsushita, O., Tamai, E., Miyata, S., Taniguchi, Y., Shimamoto, S., Katayama, S., Morita, S. & Okabe, A., Nov 2003, In : Microbiology. 149, 11, p. 3083-3091 9 p.

Research output: Contribution to journalArticle

Ferredoxins
Clostridium perfringens
Gene Expression
DNA
Genes