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Research Output 1990 2019

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Article
2019

A randomized controlled, open-label early phase II trial comparing incidence of FOLFIRI.3-induced diarrhoea between Hangeshashinto and oral alkalization in Japanese patients with colorectal cancer

Yamazaki, K., Ariyoshi, N., Miyauchi, H., Ohira, G., Kaneya, N., Yamamoto, K., Arai, K., Yamazaki, S., Matsubara, H., Suzuki, T. & Ishii, I., Jan 1 2019, (Accepted/In press) In : Journal of Clinical Pharmacy and Therapeutics.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Diarrhea
Incidence
Ursodeoxycholic Acid
Sodium Bicarbonate

Effect of CYP3A5*3 genetic variant on the metabolism of direct-acting antivirals in vitro: a different effect on asunaprevir versus daclatasvir and beclabuvir

Matsumoto, J., San, S. N., Fujiyoshi, M., Kawauchi, A., Chiba, N., Tagai, R., Sanbe, R., Yanaka, S., Sakaue, H., Kato, Y., Nakamura, H., Yamada, H. & Ariyoshi, N., Jan 1 2019, (Accepted/In press) In : Journal of Human Genetics.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Antiviral Agents
8-cyclohexyl-N-((dimethylamino)sulfonyl)-1,1a,2,12b-tetrahydro-11-methoxy-1a-((3-methyl-3,8-diazabicyclo(3.2.1)oct-8-yl)carbonyl)cycloprop(d)indolo(2,1-a)(2)benzazepine-5-carboxamide
In Vitro Techniques
BMS-790052
2018
2 Citations (Scopus)

Efficacy of 2.5-mg prasugrel in elderly or low-body-weight patients

Wakabayashi, S., Ariyoshi, N., Kitahara, H., Fujii, K., Fujimoto, Y. & Kobayashi, Y., Jan 1 2018, In : Circulation Journal. 82, 9, p. 2326-2331 6 p.

Research output: Contribution to journalArticle

clopidogrel
Body Weight
Blood Platelets
Percutaneous Coronary Intervention
Prasugrel Hydrochloride

High residual platelet reactivity after switching from clopidogrel to low-dose prasugrel in Japanese patients with end-stage renal disease on hemodialysis

Ohno, Y., Kitahara, H., Fujii, K., Kohno, Y., Ariyoshi, N., Nishi, T., Fujimoto, Y. & Kobayashi, Y., Jan 1 2018, (Accepted/In press) In : Journal of Cardiology.

Research output: Contribution to journalArticle

clopidogrel
Chronic Kidney Failure
Renal Dialysis
Blood Platelets
Therapeutics
1 Citation (Scopus)

Minor contribution of CYP3A5 to the metabolism of hepatitis C protease inhibitor paritaprevir in vitro

San, S. N., Matsumoto, J., Saito, Y., Koike, M., Sakaue, H., Kato, Y., Fujiyoshi, M., Ariyoshi, N. & Yamada, H., Jan 1 2018, (Accepted/In press) In : Xenobiotica.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Hepatitis C
Protease Inhibitors
Metabolism
Liver Microsomes
2 Citations (Scopus)

Platelet inhibition after loading dose of prasugrel in patients with ST-elevation and non-ST-elevation acute coronary syndrome

Wakabayashi, S., Kitahara, H., Nishi, T., Sugimoto, K., Nakayama, T., Fujimoto, Y., Ariyoshi, N. & Kobayashi, Y., Jul 1 2018, In : Cardiovascular Intervention and Therapeutics. 33, 3, p. 239-246 8 p.

Research output: Contribution to journalArticle

Acute Coronary Syndrome
Blood Platelets
Prasugrel Hydrochloride
ST Elevation Myocardial Infarction
Therapeutics
2017
1 Citation (Scopus)

An extremely high bioavailability of orally administered vancomycin in a patient with severe colitis and renal insufficiency

Yamazaki, S., Suzuki, T., Suzuki, T., Takatsuka, H., Ishikawa, M., Hattori, N., Fujishiro, T., Miyauchi, H., Oami, T., Ariyoshi, N., Oda, S., Matsubara, H. & Ishii, I., 2017, (Accepted/In press) In : Journal of Infection and Chemotherapy.

Research output: Contribution to journalArticle

Colitis
Vancomycin
Biological Availability
Renal Insufficiency
Renal Replacement Therapy
4 Citations (Scopus)

Impact of chronic kidney disease on platelet inhibition of clopidogrel and prasugrel in Japanese patients

Nishi, T., Ariyoshi, N., Nakayama, T., Fujimoto, Y., Sugimoto, K., Wakabayashi, S., Hanaoka, H. & Kobayashi, Y., May 1 2017, In : Journal of Cardiology. 69, 5, p. 752-755 4 p.

Research output: Contribution to journalArticle

clopidogrel
Chronic Renal Insufficiency
Blood Platelets
Kidney Diseases
Glomerular Filtration Rate
2016
1 Citation (Scopus)

Beta-migrating very low-density lipoprotein conjugates with acrolein in high-cholesterol diet-fed rabbits and localizes to atherosclerotic lesions with macrophages

Kanogawa, Y., Fujiyoshi, M., Nakazato, Y., Watanabe, K., Kurihara, M., Takezawa, A., Uchida, M., Igarashi, K., Suzuki, T., Ariyoshi, N. & Ishii, I., 2016, In : International Journal of Clinical and Experimental Pathology. 9, 11, p. 11149-11158 10 p.

Research output: Contribution to journalArticle

IDL Lipoproteins
Acrolein
Macrophages
Cholesterol
VLDL Lipoproteins
2015
10 Citations (Scopus)

Increased platelet inhibition after switching from maintenance clopidogrel to prasugrel in japanese patients with stable coronary artery disease

Nishi, T., Ariyoshi, N., Nakayama, T., Fujimoto, Y., Sugimoto, K., Takahara, M., Wakabayashi, S., Koshizaka, M., Hanaoka, H. & Kobayashi, Y., Oct 23 2015, In : Circulation Journal. 79, 11, p. 2439-2444 6 p.

Research output: Contribution to journalArticle

clopidogrel
Coronary Artery Disease
Blood Platelets
Maintenance
Prasugrel Hydrochloride
8 Citations (Scopus)

Organic anion transporting polypeptide 2B1 expression correlates with uptake of estrone-3-sulfate and cell proliferation in estrogen receptor-positive breast cancer cells

Matsumoto, J., Ariyoshi, N., Sakakibara, M., Nakanishi, T., Okubo, Y., Shiina, N., Fujisaki, K., Nagashima, T., Nakatani, Y., Tamai, I., Yamada, H., Takeda, H. & Ishii, I., Jan 4 2015, In : Drug Metabolism and Pharmacokinetics. 30, 2, p. 133-141 9 p., 13.

Research output: Contribution to journalArticle

MCF-7 Cells
Estrogen Receptors
Anions
Cell Proliferation
Breast Neoplasms
2014

Decrease in the amount of lactose as a diluent for the powder dispensing and its evaluation

Tsukiji, M., Masuda, K., Suzuki, T., Ariyoshi, N. & Ishii, I., 2014, In : Chiba Medical Journal. 90, 6, p. 205-210 6 p.

Research output: Contribution to journalArticle

Lactose
Powders
Medicine
Weights and Measures
Product Packaging
3 Citations (Scopus)

Genetic and non-genetic factors responsible for antiplatelet effects of clopidogrel in Japanese patients undergoing coronary stent implantation: An algorithm to predict on-clopidogrel platelet reactivity

Miura, G., Ariyoshi, N., Sato, Y., Yamaguchi, H., Iwata, Y., Fujimoto, Y., Kobayashi, Y. & Ishii, I., Oct 1 2014, In : Thrombosis Research. 134, 4, p. 877-883 7 p.

Research output: Contribution to journalArticle

clopidogrel
Stents
Blood Platelets
Genetic Polymorphisms
Dyslipidemias
2013
3 Citations (Scopus)
Steryl-Sulfatase
Single Nucleotide Polymorphism
Dehydroepiandrosterone Sulfate
Population
Genes
2012
3 Citations (Scopus)

Correlation between antizyme 1 and differentiation of vascular smooth muscle cells cultured in honeycomb-like type-I collagen matrix

Ishii, I., Suzuki, T., Kaneko, H., Uchida, M., Suzuki, Y., Higashi, K., Yagi, S., Ariyoshi, N., Igarashi, K. & Kitada, M., Feb 2012, In : Amino Acids. 42, 2-3, p. 565-575 11 p.

Research output: Contribution to journalArticle

Collagen Type I
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
Ornithine Decarboxylase

Drug therapy and pharmacogenetics

Ariyoshi, N., 2012, In : Japanese Journal of Allergology. 61, 7, p. 941-947 7 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Genetic Polymorphisms
Hypersensitivity
Drug Therapy
2011
5 Citations (Scopus)

Degradation of filamin induces contraction of vascular smooth muscle cells in type-I collagen matrix honeycombs

Uchida, M., Ishii, I., Hirata, K., Yamamoto, F., Tashiro, K., Suzuki, T., Nakayama, Y., Ariyoshi, N. & Kitada, M., 2011, In : Cellular Physiology and Biochemistry. 27, 6, p. 669-680 12 p.

Research output: Contribution to journalArticle

Filamins
Collagen Type I
Vascular Smooth Muscle
Smooth Muscle Myocytes
Actin Cytoskeleton
27 Citations (Scopus)

Q172H replacement overcomes effects on the metabolism of cyclophosphamide and efavirenz caused by CYP2B6 variant with Arg262

Ariyoshi, N., Ohara, M., Kaneko, M., Afuso, S., Kumamoto, T., Nakamura, H., Ishii, I., Ishikawa, T. & Kitada, M., Nov 2011, In : Drug Metabolism and Disposition. 39, 11, p. 2045-2048 4 p.

Research output: Contribution to journalArticle

efavirenz
Cyclophosphamide
Single Nucleotide Polymorphism
Pharmaceutical Preparations
Enzymes
2010
32 Citations (Scopus)

Enhanced susceptibility of HLA-mediated ticlopidine-induced idiosyncratic hepatotoxicity by CYP2B6 polymorphism in Japanese

Ariyoshi, N., Iga, Y., Hirata, K., Sato, Y., Miura, G., Ishii, I., Nagamori, S. & Kitada, M., 2010, In : Drug Metabolism and Pharmacokinetics. 25, 3, p. 298-306 9 p.

Research output: Contribution to journalArticle

Ticlopidine
HLA Antigens
Haplotypes
Drug-Related Side Effects and Adverse Reactions
Reporter Genes
29 Citations (Scopus)

Kefiran reduces atherosclerosis in rabbits fed a high cholesterol diet

Uchida, M., Ishii, I., Inoue, C., Akisato, Y., Watanabe, K., Hosoyama, S., Toida, T., Ariyoshi, N. & Kitada, M., 2010, In : Journal of Atherosclerosis and Thrombosis. 17, 9, p. 980-988 9 p.

Research output: Contribution to journalArticle

Nutrition
Atherosclerosis
Cholesterol
Diet
Rabbits
3 Citations (Scopus)

Six novel single nucleotide polymorphisms of the steroid sulfatase gene in a Japanese population

Matsumoto, J., Ariyoshi, N., Ishii, I. & Kitada, M., 2010, In : Drug Metabolism and Pharmacokinetics. 25, 4, p. 403-407 5 p.

Research output: Contribution to journalArticle

Steryl-Sulfatase
Single Nucleotide Polymorphism
Exons
Population
Genes
7 Citations (Scopus)

Super-acute onset of tumor lysis syndrome accompanied by hypercytokinemia during treatment of Hodgkin's lymphoma with ABVD chemotherapy

Suzuki, T., Takeuchi, M., Saeki, H., Yamazaki, S., Koga, H., Abe, D., Nishimura, M., Nakaseko, C., Nakasa, H., Nakamura, H., Ariyoshi, N. & Kitada, M., Mar 2010, In : Clinical Therapeutics. 32, 3, p. 527-531 5 p.

Research output: Contribution to journalArticle

Tumor Lysis Syndrome
Dacarbazine
Vinblastine
Bleomycin
Hodgkin Disease
2009
5 Citations (Scopus)

Growth inhibition and differentiation of cultured smooth muscle cells depend on cellular crossbridges across the tubular lumen of type I collagen matrix honeycombs

Suzuki, T., Ishii, I., Kotani, A., Masuda, M., Hirata, K., Ueda, M., Ogata, T., Sakai, T., Ariyoshi, N. & Kitada, M., Mar 2009, In : Microvascular Research. 77, 2, p. 143-149 7 p.

Research output: Contribution to journalArticle

Collagen Type I
Smooth Muscle Myocytes
Muscle
Cells
Growth
10 Citations (Scopus)

Unexpected serum level of vancomycin after oral administration in a patient with severe colitis and renal insufficiency

Yamazaki, S., Nakamura, H., Yamagata, S., Miura, G., Hattori, N., Shinozaki, K., Sadahiro, T., Toyoda, A., Nakasa, H., Ariyoshi, N., Oda, S., Harigaya, K. & Kitada, M., 2009, In : International Journal of Clinical Pharmacology and Therapeutics. 47, 11, p. 701-706 6 p.

Research output: Contribution to journalArticle

Colitis
Vancomycin
Renal Insufficiency
Oral Administration
Serum
2008
2 Citations (Scopus)

Appropriate use of the anti-methicillin-resistant Staphylococcus aureus agents in retrospective study

Nakamura, Y., Yokoyama, I., Hashimoto, N., Hasegawa, A., Nakasa, H., Nakamura, H., Watanabe, M., Nomura, F., Watanabe, A., Igari, H., Sato, T., Nakazawa, K., Ariyoshi, N. & Kitada, M., Jul 2008, In : Yakugaku Zasshi. 128, 7, p. 1073-1079 7 p.

Research output: Contribution to journalArticle

Methicillin-Resistant Staphylococcus aureus
Retrospective Studies
Drug Monitoring
Body Temperature
Leukocyte Count
15 Citations (Scopus)

Population pharmacokinetics of oral busulfan in young Japanese children before hematopoietic stem cell transplantation

Nakamura, H., Sato, T., Okada, K., Miura, G., Ariyoshi, N., Nakazawa, K. & Kitada, M., Feb 2008, In : Therapeutic Drug Monitoring. 30, 1, p. 75-83 9 p.

Research output: Contribution to journalArticle

Busulfan
Pharmacokinetics
Hematopoietic Stem Cell Transplantation
Stem cells
Population
4 Citations (Scopus)

Probable interaction between warfarin and antitumor agents used in R-ESHAP chemotherapy

Suzuki, T., Koga, H., Yamazaki, S., Saeki, H., Tanaka, H., Nishimura, M., Nakaseko, C., Nakasa, H., Nakamura, H., Ariyoshi, N. & Kitada, M., Jun 2008, In : Clinical Therapeutics. 30, 6, p. 1155-1159 5 p.

Research output: Contribution to journalArticle

Warfarin
Antineoplastic Agents
International Normalized Ratio
Drug Therapy
Reference Values
2007
14 Citations (Scopus)

Helices F-G are important for the substrate specificities of CYP3A7

Torimoto, N., Ishii, I., Toyama, K. I., Hata, M., Tanaka, K., Shimomura, H., Nakamura, H., Ariyoshi, N., Ohmori, S. & Kitada, M., Mar 2007, In : Drug Metabolism and Disposition. 35, 3, p. 484-492 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Substrate Specificity
Dehydroepiandrosterone
Substrates
Hydroxylation
6 Citations (Scopus)

Identification and partial characterization of a novel CYP2C9 splicing variant encoding a protein lacking eight amino acid residues.

Ariyoshi, N., Shimizu, Y., Kobayashi, Y., Nakamura, H., Nakasa, H., Nakazawa, K., Ishii, I. & Kitada, M., Jun 2007, In : Drug Metabolism and Pharmacokinetics. 22, 3, p. 187-194 8 p.

Research output: Contribution to journalArticle

Amino Acids
Proteins
Protein Splicing
Tolbutamide
Messenger RNA
13 Citations (Scopus)

Relationship between Kaposi's varicelliform eruption in Japanese patients with atopic dermatitis treated with tacrolimus ointment and genetic polymorphisms in the IL-18 gene promoter region

Osawa, K., Etoh, T., Ariyoshi, N., Ishii, I., Ohtani, M., Kariya, S., Uchino, K. & Kitada, M., Aug 2007, In : Journal of Dermatology. 34, 8, p. 531-536 6 p.

Research output: Contribution to journalArticle

Kaposi Varicelliform Eruption
Interleukin-18
Tacrolimus
Genetic Polymorphisms
Atopic Dermatitis
3 Citations (Scopus)

Theoretical calculation of triazolam hydroxylation and endogenous steroid inhibition in the active site of CYP3A4

Torimoto, N., Ishii, I., Hata, M., Kobayashi, Y., Nakamura, H., Ariyoshi, N. & Kitada, M., Feb 2007, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1774, 2, p. 223-232 10 p.

Research output: Contribution to journalArticle

Triazolam
Cytochrome P-450 CYP3A
Hydroxylation
Catalytic Domain
Steroids
2005
23 Citations (Scopus)

Inhibitory effects of nicardipine to cytochrome P450 (CYP) in human liver microsomes

Nakamura, K., Ariyoshi, N., Iwatsubo, T., Fukunaga, Y., Higuchi, S., Itoh, K., Shimada, N., Nagashima, K., Yokoi, T., Yamamoto, K., Horiuchi, R. & Kamataki, T., May 2005, In : Biological and Pharmaceutical Bulletin. 28, 5, p. 882-885 4 p.

Research output: Contribution to journalArticle

Nicardipine
Liver Microsomes
Cytochrome P-450 Enzyme System
Cytochrome P-450 CYP3A
Cytochrome P-450 CYP2D6
2004
57 Citations (Scopus)

Effects of continuous ingestion of green tea or grape seed extracts on the pharmacokinetics of midazolam.

Nishikawa, M., Ariyoshi, N., Kotani, A., Ishii, I., Nakamura, H., Nakasa, H., Ida, M., Nakamura, H., Kimura, N., Kimura, M., Hasegawa, A., Kusu, F., Ohmori, S., Nakazawa, K. & Kitada, M., 2004, In : Drug Metabolism and Pharmacokinetics. 19, 4, p. 280-289 10 p.

Research output: Contribution to journalArticle

Grape Seed Extract
Cytochrome P-450 CYP3A
Midazolam
Tea
Pharmacokinetics
15 Citations (Scopus)

Identification of deletion-junction site of CYP2A6*4B allele lacking entire coding region of CYP2A6 in Japanese

Ariyoshi, N., Sekine, H., Nakayama, K., Saito, K., Miyamoto, A. & Kamataki, T., Oct 2004, In : Pharmacogenetics. 14, 10, p. 701-705 5 p.

Research output: Contribution to journalArticle

2003
38 Citations (Scopus)

Association of CYP2A6 gene deletion with cigarette smoking status in Japanese adults

Ando, M., Hamajima, N., Ariyoshi, N., Kamataki, T., Matsuo, K. & Ohno, Y., 2003, In : Journal of Epidemiology. 13, 3, p. 176-181 6 p.

Research output: Contribution to journalArticle

Gene Deletion
Smoking
Tobacco Smoke Pollution
Alleles
Genotype
33 Citations (Scopus)

CYP3A4 and CYP3A7-mediated carbamazepine 10,11-epoxidation are activated by differential endogenous steroids

Nakamura, H., Torimoto, N., Ishii, I., Ariyoshi, N., Nakasa, H., Ohmori, S. & Kitada, M., Apr 1 2003, In : Drug Metabolism and Disposition. 31, 4, p. 432-438 7 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Epoxidation
Carbamazepine
Steroids
Dehydroepiandrosterone
38 Citations (Scopus)

Direct Interaction between Substrates and Endogenous Steroids in the Active Site May Change the Activity of Cytochrome P450 3A4

Torimoto, N., Ishii, I., Hata, M., Nakamura, H., Imada, H., Ariyoshi, N., Ohmori, S., Igarashi, T. & Kitada, M., Dec 30 2003, In : Biochemistry. 42, 51, p. 15068-15077 10 p.

Research output: Contribution to journalArticle

Nevirapine
Cytochrome P-450 CYP3A
Catalytic Domain
Carbamazepine
Steroids

The interchange between hospital pharmacists and pharmacists: Evaluation of practical classes "chozaigijutsu-konwakai"' from the participants

Nakamura, Y., Nakasa, H., Hasegawa, A., Matsushima, T., Kimura, M., Shibata, M., Miura, G., Inano, Y., Ohtsuka, T., Akashi, R., Tanno, K., Ariyoshi, N., Nakazawa, K., Nakamura, H., Ohmori, S. & Kitada, M., Jun 2003, In : Yakugaku Zasshi. 123, 6, p. 463-468 6 p.

Research output: Contribution to journalArticle

Pharmacists
Prescriptions
Exercise
Referral and Consultation
Communication
2002
20 Citations (Scopus)

Activation of microsomal epoxide hydrolase by interaction with cytochromes p450: Kinetic analysis of the association and substrate-specific activation of epoxide hydrolase function

Taura, K. I., Yamada, H., Naito, E., Ariyoshi, N., Mori, M. A. & Oguri, K., Jun 15 2002, In : Archives of Biochemistry and Biophysics. 402, 2, p. 275-280 6 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Cytochrome P-450 Enzyme System
styrene oxide
Chemical activation
Association reactions
110 Citations (Scopus)

A novel mutant allele of the CYP2A6 gene (CYP2A6* 11) found in a cancer patient who showed poor metabolic phenotype towards tegafur

Daigo, S., Takahashi, Y., Fujieda, M., Ariyoshi, N., Yamazaki, H., Koizumi, W., Tanabe, S., Saigenji, K., Nagayama, S., Ikeda, K., Nishioka, Y. & Kamataki, T., 2002, In : Pharmacogenetics. 12, 4, p. 299-306 8 p.

Research output: Contribution to journalArticle

Tegafur
Cytochrome P-450 Enzyme System
Alleles
Phenotype
Genes
19 Citations (Scopus)

Characterization of a genotype previously designated as CYP2A6 D-type: CYP2A6*4B, another entire gene deletion allele of the CYP2A6 gene in Japanese

Ariyoshi, N., Sekine, H., Saito, K. & Kamataki, T., Aug 2002, In : Pharmacogenetics. 12, 6, p. 501-504 4 p.

Research output: Contribution to journalArticle

Gene Deletion
Alleles
Genotype
Genes
Tegafur
33 Citations (Scopus)

CYP2D6.10 present in human liver microsomes shows low catalytic activity and thermal stability

Nakamura, K., Ariyoshi, N., Yokoi, T., Ohgiya, S., Chida, M., Nagashima, K., Inoue, K., Kodama, T., Shimada, N. & Kamataki, T., 2002, In : Biochemical and Biophysical Research Communications. 293, 3, p. 969-973 5 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Liver Microsomes
Liver
Catalyst activity
Thermodynamic stability
53 Citations (Scopus)

Effects of endogenous steroids on CYP3A4-mediated drug metabolism by human liver microsomes

Nakamura, H., Nakasa, H., Ishii, I., Ariyoshi, N., Igarashi, T., Ohmori, S. & Kitada, M., 2002, In : Drug Metabolism and Disposition. 30, 5, p. 534-540 7 p.

Research output: Contribution to journalArticle

zonisamide
Cytochrome P-450 CYP3A
Hydroxylation
Androstenedione
Carbamazepine
132 Citations (Scopus)

Genetic polymorphism of CYP2A6 gene and tobacco-induced lung cancer risk in male smokers

Ariyoshi, N., Miyamoto, M., Umetsu, Y., Kunitoh, H., Dosaka-Akita, H., Sawamura, Y. I., Yokota, J., Nemoto, N., Sato, K. & Kamataki, T., 2002, In : Cancer Epidemiology Biomarkers and Prevention. 11, 9, p. 890-894 5 p.

Research output: Contribution to journalArticle

Genetic Polymorphisms
Cytochrome P-450 Enzyme System
Tobacco
Lung Neoplasms
Genotype
21 Citations (Scopus)

New allelic arrangement CYP2D6*36 x 2 found in a Japanese poor metabolizer of debrisoquine

Chida, M., Ariyoshi, N., Yokoi, T., Nemoto, N., Inaba, M., Kinoshita, M. & Kamataki, T., Nov 2002, In : Pharmacogenetics. 12, 8, p. 659-662 4 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Variation in coumarin 7-hydroxylase activity associated with genetic polymorphism of cytochrome P450 2A6 and the body status of iron stores in adult Thai males and females

Ujjin, P., Satarug, S., Vanavanitkun, Y., Daigo, S., Ariyoshi, N., Yamazaki, H., Reilly, P. E. B., Moore, M. R. & Kamataki, T., 2002, In : Pharmacogenetics. 12, 3, p. 241-249 9 p.

Research output: Contribution to journalArticle

Genetic Polymorphisms
Cytochrome P-450 Enzyme System
Iron
Hydroxylation
Genes
2001
6 Citations (Scopus)

Accumulation of the 1-methyl-4-phenylpyridinium ion in suncus (Suncus murinus) brain: Implication for flavin-containing monooxygenase activity in brain microvessels

Mushiroda, T., Ariyoshi, N., Yokoi, T., Takahara, E., Nagata, O., Kato, H. & Kamataki, T., 2001, In : Chemical Research in Toxicology. 14, 2, p. 228-232 5 p.

Research output: Contribution to journalArticle

dimethylaniline monooxygenase (N-oxide forming)
1-Methyl-4-phenylpyridinium
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Microvessels
Brain
87 Citations (Scopus)

A novel single nucleotide polymorphism altering stability and activity of CYP2A6

Ariyoshi, N., Sawamura, Y. I. & Kamataki, T., 2001, In : Biochemical and Biophysical Research Communications. 281, 3, p. 810-814 5 p.

Research output: Contribution to journalArticle

Polymorphism
Nicotine
Single Nucleotide Polymorphism
Nucleotides
Alleles
117 Citations (Scopus)

A single nucleotide polymorphism of CYP2B6 found in japanese enhances catalytic activity by autoactivation

Ariyoshi, N., Miyazaki, M., Toide, K., Sawamura, Y. I. & Kamataki, T., 2001, In : Biochemical and Biophysical Research Communications. 281, 5, p. 1256-1260 5 p.

Research output: Contribution to journalArticle

Polymorphism
Single Nucleotide Polymorphism
Catalyst activity
Nucleotides
Substitution reactions

Comparison of the levels of enzymes involved in drug metabolism between transgenic or gene-knockout and the parental mice

Ariyoshi, N., Imaoka, S., Nakayama, K., Takahashi, Y., Fujita, K., Funae, Y. & Kamataki, T., Nov 13 2001, In : Toxicologic Pathology. 29, SUPPL., p. 161-172 12 p.

Research output: Contribution to journalArticle

Xeroderma Pigmentosum Group A Protein
RNA-Binding Proteins
DNA-Binding Proteins
Metabolism
Carcinogens