• 11048 Citations
  • 53 h-Index
1979 …2020

Research output per year

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Research Output

  • 11048 Citations
  • 53 h-Index
  • 219 Article
  • 19 Review article
  • 1 Short survey
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Article
2020

Study of multiple genetic variations caused by persistent hepatitis C virus replication in long-term cell culture

Kato, N., Ueda, Y., Sejima, H., Gu, W., Satoh, S., Dansako, H., Ikeda, M. & Shimotohno, K., Feb 2020, In : Archives of Virology. 165, 2, p. 331-343 13 p.

Research output: Contribution to journalArticle

2019

Acidic polysaccharides isolated from marine algae inhibit the early step of viral infection

Ueno, M., Nogawa, M., Siddiqui, R., Watashi, K., Wakita, T., Kato, N., Ikeda, M., Okimura, T., Isaka, S., Oda, T. & Ariumi, Y., Mar 1 2019, In : International Journal of Biological Macromolecules. 124, p. 282-290 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

A new hepatoma cell line exhibiting high susceptibility to hepatitis B virus infection

Ueda, Y., Gu, W., Dansako, H., Nishitsuji, H., Satoh, S., Shimotohno, K. & Kato, N., Jul 12 2019, In : Biochemical and Biophysical Research Communications. 515, 1, p. 156-162 7 p.

Research output: Contribution to journalArticle

Ribavirin-induced down-regulation of CCAAT/ enhancer-binding protein α leads to suppression of lipogenesis

Satoh, S., Onomura, D., Ueda, Y., Dansako, H., Honda, M., Kaneko, S. & Kato, N., Jan 15 2019, In : Biochemical Journal. 476, 1, p. 137-149 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2018
2 Citations (Scopus)

Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells

Murakami, Y., Sugiyama, K., Ebinuma, H., Nakamoto, N., Ojiro, K., Chu, P. S., Taniki, N., Saito, Y., Teratani, T., Koda, Y., Suzuki, T., Saito, K., Fukasawa, M., Ikeda, M., Kato, N., Kanai, T. & Saito, H., Jun 25 2018, In : BMC cancer. 18, 1, 680.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Multiple antiviral activities of the antimalarial and anti-hepatitis C drug candidates N-89 and N-251

Ueda, Y., Gu, W., Dansako, H., Kim, H. S., Yoshizaki, S., Okumura, N., Ishikawa, T., Nishitsuji, H., Kato, F., Hishiki, T., Satoh, S., Ishii, K., Masuda, M., Shimotohno, K., Ikeda, M. & Kato, N., Sep 2018, In : Biochemistry and Biophysics Reports. 15, p. 1-6 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Regulation of interferon signaling and HCV-RNA replication by extracellular matrix

Kuwashiro, T., Iwane, S., Jinghe, X., Matsuhashi, S., Eguchi, Y., Anzai, K., Fujimoto, K., Mizuta, T., Sakamoto, N., Ikeda, M., Kato, N. & Ozaki, I., 2018, In : International journal of molecular medicine. 42, 2, p. 957-965 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
4 Citations (Scopus)
2017
5 Citations (Scopus)

Suppression of Oncolytic Adenovirus-Mediated Hepatotoxicity by Liver-Specific Inhibition of NF-κB

Machitani, M., Sakurai, F., Wakabayashi, K., Nakatani, K., Tachibana, M., Kato, N., Fujiwara, T. & Mizuguchi, H., Dec 15 2017, In : Molecular Therapy - Oncolytics. 7, p. 76-85 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2016

Effects of resistance-associated NS5A mutations in hepatitis C virus on viral production and susceptibility to antiviral reagents

Nitta, S., Asahina, Y., Matsuda, M., Yamada, N., Sugiyama, R., Masaki, T., Suzuki, R., Kato, N., Watanabe, M., Wakita, T. & Kato, T., Oct 5 2016, In : Scientific reports. 6, 34652.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Molecular mechanism underlying the suppression of CPB2 expression caused by persistent hepatitis C virus RNA replication

Sejima, H., Satoh, S., Dansako, H., Honda, M., Kaneko, S., Ikeda, M. & Kato, N., 2016, In : Acta Medica Okayama. 70, 2, p. 75-88 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Rab13 is involved in the entry step of hepatitis C virus infection

Takeda, M., Ikeda, M., Satoh, S., Dansako, H., Wakita, T. & Kato, N., 2016, In : Acta Medica Okayama. 70, 2, p. 111-118 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Synthesis and in vitro activity of pyrrolo[3,4-d]pyrimidine-2,5-diones as potential non-nucleoside HCV inhibitors

Mostafa, A. S., El Bialy, S. A., Bayoumi, W. A., Ueda, Y., Ikeda, M., Kato, N. & Abdelal, A. M., Aug 1 2016, In : Current Enzyme Inhibition. 12, 2, p. 170-176 7 p.

Research output: Contribution to journalArticle

The cyclic GMP-AMP synthetase-STING signaling pathway is required for both the innate immune response against HBV and the suppression of HBV assembly

Dansako, H., Ueda, Y., Okumura, N., Satoh, S., Sugiyama, M., Mizokami, M., Ikeda, M. & Kato, N., Jan 1 2016, In : FEBS Journal. 283, 1, p. 144-156 13 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
2015

Annexin A1 negatively regulates viral RNA replication of hepatitis C virus

Hiramoto, H., Dansako, H., Takeda, M., Satoh, S., Wakita, T., Ikeda, M. & Kato, N., 2015, In : Acta medica Okayama. 69, 2, p. 71-78 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Control of HCV replication with iMIRs, a novel anti-RNAi agent

Itami, S., Eguchi, Y., Mizutani, T., Aoki, E., Ohgi, T., Kuroda, M., Ochiya, T., Kato, N., Suzuki, H. I., Kawada, N. & Murakami, Y., Jan 1 2015, In : Molecular Therapy - Nucleic Acids. 4, 1, e219.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Establishment of Hepatitis C Virus RNA-Replicating cell lines possessing ribavirin-resistant phenotype

Satoh, S., Mori, K., Ueda, Y., Sejima, H., Dansako, H., Ikeda, M. & Kato, N., Feb 20 2015, In : PLoS One. 10, 2, e0118313.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Involvement of FKBP6 in hepatitis C virus replication

Kasai, H., Kawakami, K., Yokoe, H., Yoshimura, K., Matsuda, M., Yasumoto, J., Maekawa, S., Yamashita, A., Tanaka, T., Ikeda, M., Kato, N., Okamoto, T., Matsuura, Y., Sakamoto, N., Enomoto, N., Takeda, S., Fujii, H., Tsubuki, M., Kusunoki, M. & Moriishi, K., Nov 16 2015, In : Scientific reports. 5, 16699.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Negative regulation of hepatitis B virus replication by forkhead box protein A in human hepatoma cells

Okumura, N., Ikeda, M., Satoh, S., Dansako, H., Sugiyama, M., Mizokami, M. & Kato, N., Apr 28 2015, In : FEBS Letters. 589, 10, p. 1112-1118 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The mechanism of hepatitis C virus replication

Satoh, S. & Kato, N., Dec 1 2015, In : Nihon rinsho. Japanese journal of clinical medicine. 73, p. 116-120 5 p.

Research output: Contribution to journalArticle

2014

Alternative endocytosis pathway for productive entry of hepatitis C virus

Matsuda, M., Suzuki, R., Kataoka, C., Watashi, K., Aizaki, H., Kato, N., Matsuura, Y., Suzuki, T. & Wakita, T., Dec 1 2014, In : Journal of General Virology. 95, p. 2658-2667 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Anti-HCV activity of the Chinese medicinal fungus Cordyceps militaris

Ueda, Y., Mori, K., Satoh, S., Dansako, H., Ikeda, M. & Kato, N., May 2 2014, In : Biochemical and Biophysical Research Communications. 447, 2, p. 341-345 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Genetic characterization of hepatitis C virus in long-term RNA replication using Li23 cell culture systems

Kato, N., Sejima, H., Ueda, Y., Mori, K., Satoh, S., Dansako, H. & Ikeda, M., Mar 13 2014, In : PloS one. 9, 3, e91156.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization

Hara, Y., Yanatori, I., Ikeda, M., Kiyokage, E., Nishina, S., Tomiyama, Y., Toida, K., Kishi, F., Kato, N., Imamura, M., Chayama, K. & Hino, K., Nov 1 2014, In : American Journal of Pathology. 184, 11, p. 3026-3039 14 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

IPS-1 is essential for type III IFN production by Hepatocytes and Dendritic cells in response to Hepatitis C virus infection

Okamoto, M., Oshiumi, H., Azuma, M., Kato, N., Matsumoto, M. & Seya, T., Mar 15 2014, In : Journal of Immunology. 192, 6, p. 2770-2777 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Rab18 is required for viral assembly of hepatitis C virus through trafficking of the core protein to lipid droplets

Dansako, H., Hiramoto, H., Ikeda, M., Wakita, T. & Kato, N., Aug 2014, In : Virology. 462-463, 1, p. 166-174 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Synthesis and inhibitory activity on hepatitis C virus RNA replication of 4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propyl)aniline analogs

Matsuno, K., Ueda, Y., Fukuda, M., Onoda, K., Waki, M., Ikeda, M., Kato, N. & Miyachi, H., Sep 1 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 17, p. 4276-4280 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Synthesis of 3′,4′-difluoro-3′-deoxyribonucleosides and its evaluation of the biological activities: Discovery of a novel type of anti-HCV agent 3′,4′-difluorocordycepin

Shimada, H., Haraguchi, K., Hotta, K., Miyaike, T., Kitagawa, Y., Tanaka, H., Kaneda, R., Abe, H., Shuto, S., Mori, K., Ueda, Y., Kato, N., Snoeck, R., Andrei, G. & Balzarini, J., Nov 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 21, p. 6174-6182 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2013

Adenosine kinase is a key determinant for the anti-HCV activity of ribavirin

Mori, K., Hiraoka, O., Ikeda, M., Ariumi, Y., Hiramoto, A., Wataya, Y. & Kato, N., Oct 2013, In : Hepatology. 58, 4, p. 1236-1244 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Ca2+/S100 proteins regulate HCV virus NS5A-FKBP8/FKBP38 interaction and HCV virus RNA replication

Tani, J., Shimamoto, S., Mori, K., Kato, N., Moriishi, K., Matsuura, Y., Tokumitsu, H., Tsuchiya, M., Fujimoto, T., Kato, K., Miyoshi, H., Masaki, T. & Kobayashi, R., Aug 2013, In : Liver International. 33, 7, p. 1008-1018 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Class A Scavenger Receptor 1 (MSR1) Restricts Hepatitis C Virus Replication by Mediating Toll-like Receptor 3 Recognition of Viral RNAs Produced in Neighboring Cells

Dansako, H., Yamane, D., Welsch, C., McGivern, D. R., Hu, F., Kato, N. & Lemon, S. M., May 2013, In : PLoS Pathogens. 9, 5, e1003345.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Direct targeting of proteins to lipid droplets demonstrated by time-lapse live cell imaging

Tanaka, T., Kuroda, K., Ikeda, M., Kato, N., Shimizu, K. & Makishima, M., Nov 2013, In : Journal of Bioscience and Bioengineering. 116, 5, p. 620-623 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Hepatic triglyceride lipase plays an essential role in changing the lipid metabolism in genotype 1b hepatitis C virus replicon cells and hepatitis C patients

Shinohara, Y., Imajo, K., Yoneda, M., Tomeno, W., Ogawa, Y., Fujita, K., Kirikoshi, H., Takahashi, J., Funakoshi, K., Ikeda, M., Kato, N., Nakajima, A. & Saito, S., Nov 2013, In : Hepatology Research. 43, 11, p. 1190-1198 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity

Ding, Q., Cao, X., Lu, J., Huang, B., Liu, Y. J., Kato, N., Shu, H. B. & Zhong, J., Jul 2013, In : Journal of Hepatology. 59, 1, p. 52-58 7 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Hepatitis C virus NS4B targets lipid droplets through hydrophobic residues in the amphipathic helices

Tanaka, T., Kuroda, K., Ikeda, M., Wakita, T., Kato, N. & Makishima, M., Apr 2013, In : Journal of Lipid Research. 54, 4, p. 881-892 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Inhibitory effects of caffeic acid phenethyl ester derivatives on replication of hepatitis C virus

Shen, H., Yamashita, A., Nakakoshi, M., Yokoe, H., Sudo, M., Kasai, H., Tanaka, T., Fujimoto, Y., Ikeda, M., Kato, N., Sakamoto, N., Shindo, H., Maekawa, S., Enomoto, N., Tsubuki, M. & Moriishi, K., Dec 17 2013, In : PloS one. 8, 12, e82299.

Research output: Contribution to journalArticle

16 Citations (Scopus)

New Preclinical Antimalarial Drugs Potently Inhibit Hepatitis C Virus Genotype 1b RNA Replication

Ueda, Y., Takeda, M., Mori, K., Dansako, H., Wakita, T., Kim, H. S., Sato, A., Wataya, Y., Ikeda, M. & Kato, N., Aug 30 2013, In : PloS one. 8, 8, e72519.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Peroxisome proliferator-activated receptor delta antagonists inhibit hepatitis C virus RNA replication

Ban, S., Ueda, Y., Ohashi, M., Matsuno, K., Ikeda, M., Kato, N. & Miyachi, H., Sep 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 17, p. 4774-4778 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

PML tumor suppressor protein is required for HCV production

Kuroki, M., Ariumi, Y., Hijikata, M., Ikeda, M., Dansako, H., Wakita, T., Shimotohno, K. & Kato, N., Jan 11 2013, In : Biochemical and Biophysical Research Communications. 430, 2, p. 592-597 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Suppressive effect of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) on hepatitis C virus replication

Sato, A., Saito, Y., Sugiyama, K., Sakasegawa, N., Muramatsu, T., Fukuda, S., Yoneya, M., Kimura, M., Ebinuma, H., Hibi, T., Ikeda, M., Kato, N. & Saito, H., 2013, In : Journal of Cellular Biochemistry. 114, 9, p. 1987-1996 10 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Unfolded protein response pathways regulate Hepatitis C virus replication via modulation of autophagy

Shinohara, Y., Imajo, K., Yoneda, M., Tomeno, W., Ogawa, Y., Kirikoshi, H., Funakoshi, K., Ikeda, M., Kato, N., Nakajima, A. & Saito, S., Mar 8 2013, In : Biochemical and Biophysical Research Communications. 432, 2, p. 326-332 7 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2012

Development of a drug assay system with hepatitis C virus genome derived from a patient with acute hepatitis C

Mori, K., Ueda, Y., Ariumi, Y., Dansako, H., Ikeda, M. & Kato, N., Jun 2012, In : Virus Genes. 44, 3, p. 374-381 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Development of hepatitis C virus production reporter-assay systems using two different hepatoma cell lines

Takeda, M., Ikeda, M., Ariumi, Y., Wakita, T. & Kato, N., Jul 2012, In : Journal of General Virology. 93, PART 7, p. 1422-1431 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

ENT1, a ribavirin transporter, plays a pivotal role in antiviral efficacy of ribavirin in a hepatitis C virus replication cell system

Iikura, M., Furihata, T., Mizuguchi, M., Nagai, M., Ikeda, M., Kato, N., Tsubota, A. & Chiba, K., Mar 2012, In : Antimicrobial Agents and Chemotherapy. 56, 3, p. 1407-1413 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Eradication of hepatitis c virus subgenomic replicon by interferon results in aberrant retinol-related protein expression

Koike, K., Takaki, A., Kato, N., Ouchida, M., Kanzaki, H., Yasunaka, T., Shiraha, H., Miyake, Y. & Yamamoto, K., 2012, In : Acta medica Okayama. 66, 6, p. 461-468 8 p.

Research output: Contribution to journalArticle

Geranylgeranylacetone has anti-hepatitis C virus activity via activation of mTOR in human hepatoma cells

Takeshita, S., Ichikawa, T., Taura, N., Miyaaki, H., Matsuzaki, T., Otani, M., Muraoka, T., Akiyama, M., Miuma, S., Ozawa, E., Ikeda, M., Kato, N., Isomoto, H., Takeshima, F. & Nakao, K., Feb 2012, In : Journal of Gastroenterology. 47, 2, p. 195-202 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Identification of host genes showing differential expression profiles with cell-based long-term replication of hepatitis C virus RNA

Sejima, H., Mori, K., Ariumi, Y., Ikeda, M. & Kato, N., Jul 2012, In : Virus research. 167, 1, p. 74-85 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)