• 834 Citations
  • 17 h-Index
1991 …2019
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Research Output 1991 2019

  • 834 Citations
  • 17 h-Index
  • 59 Article
  • 1 Comment/debate
2019

Author Correction: Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone (Nature Communications, (2019), 10, 1, (3436), 10.1038/s41467-019-11373-9)

Vrahnas, C., Blank, M., Dite, T. A., Tatarczuch, L., Ansari, N., Crimeen-Irwin, B., Nguyen, H., Forwood, M. R., Hu, Y., Ikegame, M., Bambery, K. R., Petibois, C., Mackie, E. J., Tobin, M. J., Smyth, G. K., Oakhill, J. S., Martin, T. J. & Sims, N. A., Dec 1 2019, In : Nature communications. 10, 1, 5073.

Research output: Contribution to journalComment/debate

Open Access
Osteocytes
Physiologic Calcification
Autophagy
bones
Bone

Circadian production of melatonin in cartilage modifies rhythmic gene expression

Fu, S., Kuwahara, M., Uchida, Y., Kondo, S., Hayashi, D., Shimomura, Y., Takagaki, A., Nishida, T., Maruyama, Y., Ikegame, M., Hattori, A., Kubota, S. & Hattori, T., Jan 1 2019, In : Journal of Endocrinology. 241, 2, p. 161-173 13 p.

Research output: Contribution to journalArticle

Melatonin
Chondrocytes
Cartilage
Gene Expression
Melatonin MT1 Receptor
1 Citation (Scopus)

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone

Vrahnas, C., Blank, M., Dite, T. A., Tatarczuch, L., Ansari, N., Crimeen-Irwin, B., Nguyen, H., Forwood, M. R., Hu, Y., Ikegame, M., Bambery, K. R., Petibois, C., Mackie, E. J., Tobin, M. J., Smyth, G. K., Oakhill, J. S., Martin, T. J. & Sims, N. A., Jul 31 2019, In : Nature communications. 10, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Osteocytes
Physiologic Calcification
Autophagy
bones
Bone

Melatonin is a potential drug for the prevention of bone loss during space flight

Ikegame, M., Hattori, A., Tabata, M. J., Kitamura, K. I., Tabuchi, Y., Furusawa, Y., Maruyama, Y., Yamamoto, T., Sekiguchi, T., Matsuoka, R., Hanmoto, T., Ikari, T., Endo, M., Omori, K., Nakano, M., Yashima, S., Ejiri, S., Taya, T., Nakashima, H., Shimizu, N. & 33 others, Nakamura, M., Kondo, T., Hayakawa, K., Takasaki, I., Kaminishi, A., Akatsuka, R., Sasayama, Y., Nishiuchi, T., Nara, M., Iseki, H., Chowdhury, V. S., Wada, S., Ijiri, K., Takeuchi, T., Suzuki, T., Ando, H., Matsuda, K., Somei, M., Mishima, H., Mikuni-Takagaki, Y., Funahashi, H., Takahashi, A., Watanabe, Y., Maeda, M., Uchida, H., Hayashi, A., Kambegawa, A., Seki, A., Yano, S., Shimazu, T., Suzuki, H., Hirayama, J. & Suzuki, N., Oct 1 2019, In : Journal of Pineal Research. 67, 3, e12594.

Research output: Contribution to journalArticle

Open Access
Weightlessness
Space Flight
Calcitonin
Osteoclasts
Melatonin
2018
Cranial Sutures
Bone Matrix
Osteoblasts
Osteopontin
Integrin-Binding Sialoprotein
2017
2 Citations (Scopus)

Determination of cell fate in skeletal muscle following BMP gene transfer by in vivo electroporation

Kawai, M., Ohmori, Y. K., Nishino, M., Yoshida, M., Tabata, K., Hirota, D. S., Ryu-Mon, A., Yamamoto, H., Sonobe, J., Kataoka, Y. H., Shiotsu, N., Ikegame, M., Maruyama, H., Yamamoto, T., Bessho, K. & Ohura, K., May 5 2017, In : European Journal of Histochemistry. 61, 2, p. 65-70 6 p., 2772.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Electroporation
Skeletal Muscle
Stem Cells
Muscles
3 Citations (Scopus)

Effects of hyperglycemia on bone metabolism and bone matrix in goldfish scales

Kitamura, K. I., Andoh, T., Okesaku, W., Tazaki, Y., Ogai, K., Sugitani, K., Kobayashi, I., Suzuki, N., Chen, W., Ikegame, M. & Hattori, A., Jan 1 2017, In : Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology. 203, p. 152-158 7 p.

Research output: Contribution to journalArticle

Goldfish
Bone Matrix
Metabolism
Hyperglycemia
Bone
2 Citations (Scopus)

Effects of low-intensity pulsed ultrasound on osteoclasts: Analysis with goldfish scales as a model of bone

Hanmoto, T., Tabuchi, Y., Ikegame, M., Kondo, T., Kitamura, K. I., Endo, M., Kobayashi, I., Mishima, H., Sekiguchi, T., Urata, M., Seki, A., Yano, S., Hattori, A. & Suzuki, N., 2017, In : Biomedical Research (Japan). 38, 1, p. 71-77 7 p.

Research output: Contribution to journalArticle

Goldfish
Osteoclasts
Bone
Ultrasonics
Bone and Bones
1 Citation (Scopus)

Morphological and functional analyses of the tight junction in the palatal epithelium of mouse

Shiotsu, N., Kawamoto, T., Kawai, M., Ikegame, M., Torii, Y., Sasaki, H. & Yamamoto, T., 2017, In : Acta Histochemica et Cytochemica. 50, 4, p. 119-125 7 p.

Research output: Contribution to journalArticle

Claudin-1
Occludin
Claudin-4
Tight Junctions
Epithelium
2 Citations (Scopus)

Reduction of protein phosphatase 2A Cα promotes in vivo bone formation and adipocyte differentiation

Yoshida, K., Teramachi, J., Uchibe, K., Ikegame, M., Qiu, L., Yang, D. & Okamura, H., Jan 1 2017, (Accepted/In press) In : Molecular and Cellular Endocrinology.

Research output: Contribution to journalArticle

Protein Phosphatase 2
Phosphoprotein Phosphatases
Adipocytes
Osteogenesis
Bone
2016

Changes in metallothionein isoform expression in the bones of ovariectomized rats

Sogawa, C., Ikegame, M., Miyazaki, I., Ara, T., Imamura, Y., Okusya, Y., Ohyama, K., Asanuma, M., Sogawa, N., Yamamoto, T. & Kozaki, K. I., Jan 15 2016, In : Journal of Hard Tissue Biology. 25, 1, p. 21-26 6 p.

Research output: Contribution to journalArticle

Metallothionein
Rats
Protein Isoforms
Bone
Metabolism
7 Citations (Scopus)

Low-intensity pulsed ultrasound induces apoptosis in osteoclasts: Fish scales are a suitable model for the analysis of bone metabolism by ultrasound

Suzuki, N., Hanmoto, T., Yano, S., Furusawa, Y., Ikegame, M., Tabuchi, Y., Kondo, T., Kitamura, K. I., Endo, M., Yamamoto, T., Sekiguchi, T., Urata, M., Mikuni-Takagaki, Y. & Hattori, A., May 1 2016, In : Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 195, p. 26-31 6 p.

Research output: Contribution to journalArticle

Osteoclasts
Metabolism
Fish
Bone
Ultrasonics
2 Citations (Scopus)

Tensile stress stimulates the expression of osteogenic cytokines/growth factors and matricellular proteins in the mouse cranial suture at the site of osteoblast differentiation

Ikegame, M., Tabuchi, Y., Furusawa, Y., Kawai, M., Hattori, A., Kondo, T. & Yamamoto, T., 2016, In : Biomedical Research. 37, 2, p. 117-126 10 p.

Research output: Contribution to journalArticle

Cranial Sutures
Cysteine-Rich Protein 61
Osteoblasts
Stem cells
Mesenchymal Stromal Cells
2014
2 Citations (Scopus)

Development of oral epithelial cell line ROE2 with differentiation potential from transgenic rats harboring temperature-sensitive simian virus 40 large T-antigen gene

Tabuchi, Y., Wada, S., Ikegame, M., Kariya, A., Furusawa, Y., Hoshi, N., Yunoki, T., Suzuki, N., Takasaki, I., Kondo, T. & Suzuki, Y., 2014, In : Experimental Animals. 63, 1, p. 31-44 14 p.

Research output: Contribution to journalArticle

Simian virus 40
Transgenic Rats
Viral Tumor Antigens
Viruses
Rats
2013
8 Citations (Scopus)

Genes responsive to low-intensity pulsed ultrasound in MC3T3-E1 preosteoblast cells

Tabuchi, Y., Sugahara, Y., Ikegame, M., Suzuki, N., Kitamura, K. I. & Kondo, T., Nov 18 2013, In : International Journal of Molecular Sciences. 14, 11, p. 22721-22740 20 p.

Research output: Contribution to journalArticle

genes
Genes
Ultrasonics
gene expression
cells
8 Citations (Scopus)

Static and dynamic hypergravity responses of osteoblasts and osteoclasts in medaka scales

Yano, S., Kitamura, K. I., Satoh, Y., Nakano, M., Hattori, A., Sekiguchi, T., Ikegame, M., Nakashima, H., Omori, K., Hayakawa, K., Chiba, A., Sasayama, Y., Ejiri, S., Mikuni-Takagaki, Y., Mishima, H., Funahashi, H., Sakamoto, T. & Suzuki, N., Mar 2013, In : Zoological Science. 30, 3, p. 217-223 7 p.

Research output: Contribution to journalArticle

osteoclasts
osteoblasts
vibration
centrifugation
bone metabolism
2012
6 Citations (Scopus)

BMP-2 gene transfer under various conditions with in vivo electroporation and bone induction

Yamamoto, H., Kawai, M., Shiotsu, N., Watanabe, M., Yoshida, Y., Suzuki, K., Maruyama, H., Miyazaki, J. I., Ikegame, M., Bessho, K. & Yamamoto, T., Mar 2012, In : Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 24, 1, p. 49-53 5 p.

Research output: Contribution to journalArticle

Electroporation
Bone and Bones
Genes
Bone Regeneration
Galactosidases
2011
43 Citations (Scopus)

Parathyroid hormone 1 (1-34) acts on the scales and involves calcium metabolism in goldfish

Suzuki, N., Danks, J. A., Maruyama, Y., Ikegame, M., Sasayama, Y., Hattori, A., Nakamura, M., Tabata, M. J., Yamamoto, T., Furuya, R., Saijoh, K., Mishima, H., Srivastav, A. K., Furusawa, Y., Kondo, T., Tabuchi, Y., Takasaki, I., Chowdhury, V. S., Hayakawa, K. & Martin, T. J., May 1 2011, In : Bone. 48, 5, p. 1186-1193 8 p.

Research output: Contribution to journalArticle

Takifugu
Goldfish
Parathyroid Hormone
Calcium
Osteoclasts
2010
26 Citations (Scopus)

Endoglin is involved in BMP-2-induced osteogenic differentiation of periodontal ligament cells through a pathway independent of Smad-1/5/8 phosphorylation

Ishibashi, O., Ikegame, M., Takizawa, F., Yoshizawa, T., Moksed, M. A., Iizawa, F., Mera, H., Matsuda, A. & Kawashima, H., Feb 2010, In : Journal of Cellular Physiology. 222, 2, p. 465-473 9 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 2
Periodontal Ligament
Phosphorylation
Ligaments
Bone Morphogenetic Proteins
10 Citations (Scopus)

Osteoblast activity in the goldfish scale responds sensitively to mechanical stress

Kitamura, K. I., Suzuki, N., Sato, Y., Nemoto, T., Ikegame, M., Shimizu, N., Kondo, T., Furusawa, Y., Wada, S. & Hattori, A., Jul 2010, In : Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 156, 3, p. 357-363 7 p.

Research output: Contribution to journalArticle

Mechanical Stress
Goldfish
Osteoblasts
Alkaline Phosphatase
Acid Phosphatase
2009

岡山大学歯学部戦略的計画 -求められている今後の対応策-

Ikegame, M., 2009, In : 岡山歯学会雑誌. 28, 2, p. 123-130 8 p.

Research output: Contribution to journalArticle

2008
41 Citations (Scopus)

Estrogen deficiency and its effect on the jaw bones

Ejiri, S., Tanaka, M., Watanabe, N., Anwar, R. B., Yamashita, E., Yamada, K. & Ikegame, M., Sep 2008, In : Journal of Bone and Mineral Metabolism. 26, 5, p. 409-415 7 p.

Research output: Contribution to journalArticle

Jaw
Estrogens
Bone and Bones
Osteoporosis
Ovariectomy
10 Citations (Scopus)

Prolactin inhibits osteoclastic activity in the goldfish scale: A novel direct action of prolactin in teleosts

Takahashi, H., Suzuki, N., Takagi, C., Ikegame, M., Yamamoto, T., Takahashi, A., Moriyama, S., Hattori, A. & Sakamoto, T., Jul 2008, In : Zoological Science. 25, 7, p. 739-745 7 p.

Research output: Contribution to journalArticle

goldfish
prolactin
bone metabolism
osteoclasts
somatotropin

Scale osteoblasts and osteoclasts sensitively respond to low-gravity loading by centrifuge.

Ikegame, M., 2008, In : Biol Sci Space. 22, p. 3-7 5 p.

Research output: Contribution to journalArticle

擬似微小重力及び過重力下における骨代謝制御:培養ウロコを用いた解析

Ikegame, M., 2008, In : Space Utiliz Res. 24, p. 230-233 4 p.

Research output: Contribution to journalArticle

2007
18 Citations (Scopus)

PIASxβ is a key regulator of osterix transcriptional activity and matrix mineralization in osteoblasts

Ali, M. M., Yoshizawa, T., Ishibashi, O., Matsuda, A., Ikegame, M., Shimomura, J., Mera, H., Nakashima, K. & Kawashima, H., Aug 1 2007, In : Journal of Cell Science. 120, 15, p. 2565-2573 9 p.

Research output: Contribution to journalArticle

Osteoblasts
Sumoylation
Up-Regulation
NFATC Transcription Factors
Differentiation Antigens
23 Citations (Scopus)

Relationship between porotic changes in alveolar bone and spinal osteoporosis

Anwar, R. B., Tanaka, M., Kohno, S., Ikegame, M., Watanabe, N., Ali, M. N. & Ejiri, S., Jan 2007, In : Journal of Dental Research. 86, 1, p. 52-57 6 p.

Research output: Contribution to journalArticle

Bone Density
Osteoporosis
Haplorhini
Estrogens
Bone and Bones
35 Citations (Scopus)

Two osteoclastic markers expressed in multinucleate osteoclasts of goldfish scales

Azuma, K., Kobayashi, M., Nakamura, M., Suzuki, N., Yashima, S., Iwamuro, S., Ikegame, M., Yamamoto, T. & Hattori, A., Oct 26 2007, In : Biochemical and Biophysical Research Communications. 362, 3, p. 594-600 7 p.

Research output: Contribution to journalArticle

Cathepsin K
Goldfish
Osteoclasts
Acid Phosphatase
Messenger RNA

魚類のウロコを用いた宇宙生物学的研究

Ikegame, M., 2007, In : Space Utiliz. Res.. 23, p. 318-321 4 p.

Research output: Contribution to journalArticle

2006
46 Citations (Scopus)

Histochemical and immunocytochemical study of hard tissue formation in dental pulp during the healing process in rat molars after tooth replantation

Tsukamoto-Tanaka, H., Ikegame, M., Takagi, R., Harada, H. & Ohshima, H., Aug 2006, In : Cell and Tissue Research. 325, 2, p. 219-229 11 p.

Research output: Contribution to journalArticle

Tooth Replantation
Dental Pulp
Cathepsin K
Pulp
Rats
2005

Inhibitory effects of calcitonin on bone resorption

Ikegame, M., 2005, In : Nihon rinsho. Japanese journal of clinical medicine. 63 Suppl 10, p. 198-201 4 p.

Research output: Contribution to journalArticle

Focal Adhesion Kinase 2
Calcitonin Receptors
Phosphatidylinositol 3-Kinase
rho GTP-Binding Proteins
Calcitonin
11 Citations (Scopus)

Ultrastructural and immunohistochemical studies of medullary bone calcification, with special reference to sulphated glycosaminoglycans

Yamamoto, T., Nagaoka, N., Hirata, A., Nakamura, H., Inoue, M., Kawai, M. & Ikegame, M., 2005, In : Journal of Electron Microscopy. 54, 1, p. 29-34 6 p.

Research output: Contribution to journalArticle

A73025
Keratan Sulfate
calcification
Diamines
bones
2004
17 Citations (Scopus)

Calcitonin-induced change in serum calcium levels and its relationship to osteoclast morphology and number of calcitonin receptors

Ikegame, M., Ejiri, S. & Ozawa, H., Jul 2004, In : Bone. 35, 1, p. 27-33 7 p.

Research output: Contribution to journalArticle

Calcitonin Receptors
Calcitonin
Osteoclasts
Calcium
Serum
15 Citations (Scopus)

Expression of osteopontin in cisplatin-induced tubular injury

Iguchi, S., Nishi, S., Ikegame, M., Hoshi, K., Yoshizawa, T., Kawashima, H., Arakawa, M., Ozawa, H. & Gejyo, F., 2004, In : Nephron - Experimental Nephrology. 97, 3

Research output: Contribution to journalArticle

Osteopontin
Cisplatin
Wounds and Injuries
Regeneration
Kidney Cortex Necrosis
2003
3 Citations (Scopus)

Tensile stress induces α-adaptin C production in mouse calvariae in an organ culture: Possible involvement of endocytosis in mechanical stress-stimulated osteoblast differentiation

Shimomura, J., Ishibashi, O., Ikegame, M., Yoshizawa, T., Ejiri, S., Noda, T. & Kawashima, H., Jun 1 2003, In : Journal of Cellular Physiology. 195, 3, p. 488-496 9 p.

Research output: Contribution to journalArticle

Mechanical Stress
Organ Culture Techniques
Osteoblasts
Endocytosis
Skull
2002
104 Citations (Scopus)

A cell line with characteristics of the periodontal ligament fibroblasts is negatively regulated for mineralization and Runx2/Cbfa1/Osf2 activity, part of which can be overcome by bone morphogenetic protein-2

Saito, Y., Yoshizawa, T., Takizawa, F., Ikegame, M., Ishibashi, O., Okuda, K., Hara, K., Ishibashi, K., Obinata, M. & Kawashima, H., Nov 1 2002, In : Journal of Cell Science. 115, 21, p. 4191-4200 10 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 2
Periodontal Ligament
Fibroblasts
Cell Line
Alkaline Phosphatase
2001
74 Citations (Scopus)

Expression of osteopontin in gentamicin-induced acute tubular necrosis and its recovery process

Xie, Y., Nishi, S., Iguchi, S., Imai, N., Sakatsume, M., Saito, A., Ikegame, M., Iino, N., Shimada, H., Ueno, M., Kawashima, H., Arakawa, M. & Gejyo, F., 2001, In : Kidney International. 59, 3, p. 959-974 16 p.

Research output: Contribution to journalArticle

Osteopontin
Gentamicins
Necrosis
Nuclear Antigens
Low Density Lipoprotein Receptor-Related Protein-2
22 Citations (Scopus)

Role of stromal cells in osteoclast differentiation in bone marrow

Kondo, Y., Irie, K., Ikegame, M., Ejiri, S., Hanada, K. & Ozawa, H., 2001, In : Journal of Bone and Mineral Metabolism. 19, 6, p. 352-358 7 p.

Research output: Contribution to journalArticle

Osteoclasts
Stromal Cells
Alkaline Phosphatase
Bone Marrow
Mesenchymal Stromal Cells
91 Citations (Scopus)

Tensile stress induces bone morphogenetic protein 4 in preosteoblastic and fibroblastic cells, which later differentiate into osteoblasts leading to osteogenesis in the mouse calvariae in organ culture

Ikegame, M., Ishibashi, O., Yoshizawa, T., Shimomura, J., Komori, T., Ozawa, H. & Kawashima, H., 2001, In : Journal of Bone and Mineral Research. 16, 1, p. 24-32 9 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 4
Organ Culture Techniques
Osteoblasts
Osteogenesis
Skull
2000
5 Citations (Scopus)
Osteoblasts
Osteogenesis
Sutures
Mechanical Stress
Genes

メカニカルストレスと骨芽細胞の分化および骨形成(共著)

Ikegame, M., 2000, In : 生体の科学. 51, 6, p. 589-595 7 p.

Research output: Contribution to journalArticle

1998
21 Citations (Scopus)

Morphology of bone metastasis

Hiraga, T., Tanaka, S., Ikegame, M., Koizumi, M., Iguchi, H., Nakajima, T. & Ozawa, H., Feb 13 1998, In : European Journal of Cancer. 34, 2, p. 230-239 10 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Bone and Bones