• 5454 Citations
  • 40 h-Index
1989 …2019
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Research Output 1989 2019

  • 5454 Citations
  • 40 h-Index
  • 259 Article
  • 1 Chapter
  • 1 Review article
2019

Attenuation of Macrophage Migration Inhibitory Factor-Stimulated Signaling via S-Nitrosylation

Nakahara, K., Fujikawa, K., Hiraoka, H., Miyazaki, I., Asanuma, M., Ito, A., Takasugi, N. & Uehara, T., Jan 1 2019, In : Biological & pharmaceutical bulletin. 42, 6, p. 1044-1047 4 p.

Research output: Contribution to journalArticle

Open Access
Macrophage Migration-Inhibitory Factors
Brain-Derived Neurotrophic Factor
p38 Mitogen-Activated Protein Kinases
Nitric Oxide Donors
Post Translational Protein Processing
Oxidative stress
Oxidopamine
neurons
Astrocytes
Oxidative Stress
2018
1 Citation (Scopus)

Application of single prolonged stress induces post-traumatic stress disorder-like characteristics in mice

Tanaka, K. I., Yagi, T., Nanba, T. & Asanuma, M., Jan 1 2018, In : Acta Medica Okayama. 72, 5, p. 479-486 8 p.

Research output: Contribution to journalArticle

Post-Traumatic Stress Disorders
Light
Dexamethasone
Pituitary-Adrenal System
Locomotion
1 Citation (Scopus)

Involvement of 5-HT2A receptor hyperfunction in the anxiety-like behavior induced by doxorubicin and cyclophosphamide combination treatment in rats

Nakamura, Y., Kitamura, Y., Sumiyoshi, Y., Naito, N., Kan, S., Ushio, S., Miyazaki, I., Asanuma, M. & Sendo, T., Jan 1 2018, (Accepted/In press) In : Journal of Pharmacological Sciences.

Research output: Contribution to journalArticle

Receptor, Serotonin, 5-HT2A
Doxorubicin
Cyclophosphamide
Anxiety
Serotonin 5-HT1 Receptor Agonists
2017
4 Citations (Scopus)

Influence of nicotine on doxorubicin and cyclophosphamide combination treatment-induced spatial cognitive impairment and anxiety-like behavior in rats

Kitamura, Y., Kanemoto, E., Sugimoto, M., Machida, A., Nakamura, Y., Naito, N., Kanzaki, H., Miyazaki, I., Asanuma, M. & Sendo, T., Apr 1 2017, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 390, 4, p. 369-378 10 p.

Research output: Contribution to journalArticle

Nicotine
Doxorubicin
Cyclophosphamide
Anxiety
Nicotinic Receptors
4 Citations (Scopus)

Therapeutic strategy of targeting astrocytes for neuroprotection in parkinson’s disease

Miyazaki, I. & Asanuma, M., Jan 1 2017, In : Current Pharmaceutical Design. 23, 33, p. 4936-4947 12 p.

Research output: Contribution to journalReview article

Astrocytes
Parkinson Disease
Therapeutics
Sensation Disorders
Hypokinesia
2016
2 Citations (Scopus)

3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of l-DOPA

Asanuma, M. & Miyazaki, I., Jul 25 2016, In : BMC Neuroscience. 17, 1, 52.

Research output: Contribution to journalArticle

Dopamine Agents
Neuroprotective Agents
Astrocytes
Dopaminergic Neurons
Corpus Striatum
42 Citations (Scopus)

Anti-high mobility group box 1 antibody exerts neuroprotection in a rat model of Parkinson's disease

Sasaki, T., Liu, K., Agari, T., Yasuhara, T., Morimoto, J., Okazaki, M., Takeuchi, H., Toyoshima, A., Sasada, S., Shinko, A., Kondo, A., Kameda, M., Miyazaki, I., Asanuma, M., Borlongan, C. V., Nishibori, M. & Date, I., Jan 1 2016, In : Experimental Neurology. 275, p. 220-231 12 p.

Research output: Contribution to journalArticle

Parkinson Disease
Monoclonal Antibodies
Antibodies
Oxidopamine
Astrocytes

Changes in metallothionein isoform expression in the bones of ovariectomized rats

Sogawa, C., Ikegame, M., Miyazaki, I., Ara, T., Imamura, Y., Okusya, Y., Ohyama, K., Asanuma, M., Sogawa, N., Yamamoto, T. & Kozaki, K. I., Jan 15 2016, In : Journal of Hard Tissue Biology. 25, 1, p. 21-26 6 p.

Research output: Contribution to journalArticle

Metallothionein
Rats
Protein Isoforms
Bone
Metabolism
1 Citation (Scopus)
apoptosis
Cell death
polymerization
Intravenous Injections
Polymerization
9 Citations (Scopus)

L-Theanine protects against excess dopamine-induced neurotoxicity in the presence of astrocytes

Takeshima, M., Miyazaki, I., Murakami, S., Kita, T. & Asanuma, M., Sep 1 2016, In : Journal of Clinical Biochemistry and Nutrition. 59, 2, p. 93-99 7 p.

Research output: Contribution to journalArticle

Astrocytes
Dopamine
Neurons
Glutathione
Corpus Striatum
2 Citations (Scopus)

Neuroprotective effect of fermented papaya preparation by activation of Nrf2 pathway in astrocytes

Murakami, S., Miyazaki, I. & Asanuma, M., Nov 10 2016, (Accepted/In press) In : Nutritional Neuroscience. p. 1-9 9 p.

Research output: Contribution to journalArticle

Carica
Neuroprotective Agents
Astrocytes
Oxidopamine
Glutathione
20 Citations (Scopus)

Neuroprotective effects of levetiracetam target xCT in astrocytes in parkinsonian mice

Miyazaki, I., Murakami, S., Torigoe, N., Kitamura, Y. & Asanuma, M., Jan 1 2016, In : Journal of Neurochemistry. 136, 1, p. 194-204 11 p.

Research output: Contribution to journalArticle

etiracetam
Neuroprotective Agents
Astrocytes
Cystine
Neurons
10 Citations (Scopus)
Receptor, Serotonin, 5-HT1A
Astrocytes
Parkinson Disease
Neurons
Neuroprotective Agents
2015
22 Citations (Scopus)

Doxorubicin and cyclophosphamide treatment produces anxiety-like behavior and spatial cognition impairment in rats: Possible involvement of hippocampal neurogenesis via brain-derived neurotrophic factor and cyclin D1 regulation

Kitamura, Y., Hattori, S., Yoneda, S., Watanabe, S., Kanemoto, E., Sugimoto, M., Kawai, T., Machida, A., Kanzaki, H., Miyazaki, I., Asanuma, M. & Sendo, T., Oct 1 2015, In : Behavioural Brain Research. 292, p. 184-193 10 p.

Research output: Contribution to journalArticle

Cyclin D1
Brain-Derived Neurotrophic Factor
Neurogenesis
Doxorubicin
Cyclophosphamide
7 Citations (Scopus)

Long-Term Systemic Exposure to Rotenone Induces Central and Peripheral Pathology of Parkinson’s Disease in Mice

Murakami, S., Miyazaki, I., Miyoshi, K. & Asanuma, M., Apr 18 2015, In : Neurochemical Research. 40, 6, p. 1165-1178 14 p.

Research output: Contribution to journalArticle

Rotenone
Pathology
Parkinson Disease
Neurology
Olfactory Bulb
7 Citations (Scopus)

Possible involvement of iron-induced oxidative insults in neurodegeneration

Asano, T., Koike, M., Sakata, S. I., Takeda, Y., Nakagawa, T., Hatano, T., Ohashi, S., Funayama, M., Yoshimi, K., Asanuma, M., Toyokuni, S., Mochizuki, H., Uchiyama, Y., Hattori, N. & Iwai, K., Feb 9 2015, In : Neuroscience Letters. 588, 1, p. 29-35 7 p.

Research output: Contribution to journalArticle

Iron Regulatory Protein 2
Iron
Transgenic Mice
Neurons
Substantia Nigra
2014
3 Citations (Scopus)
8-Hydroxy-2-(di-n-propylamino)tetralin
Cell proliferation
Adrenocorticotropic Hormone
Rats
Cell Proliferation
3 Citations (Scopus)
Bupropion
Adrenocorticotropic Hormone
Hippocampus
Cell Proliferation
Dopamine Uptake Inhibitors
16 Citations (Scopus)

Lack of dopaminergic inputs elongates the primary cilia of striatal neurons

Miyoshi, K., Kasahara, K., Murakami, S., Takeshima, M., Kumamoto, N., Sato, A., Miyazaki, I., Matsuzaki, S., Sasaoka, T., Katayama, T. & Asanuma, M., May 15 2014, In : PLoS One. 9, 5, e97918.

Research output: Contribution to journalArticle

Corpus Striatum
Cilia
Reserpine
cilia
Neurons
14 Citations (Scopus)

Metallothionein deficiency exacerbates diabetic nephropathy in streptozotocin-induced diabetic mice

Tachibana, H., Ogawa, D., Sogawa, N., Asanuma, M., Miyazaki, I., Terami, N., Hatanaka, T., Horiguchi, C. S., Nakatsuka, A., Eguchi, J., Wada, J., Yamada, H., Takei, K. & Makino, H., Jan 1 2014, In : American Journal of Physiology - Renal Physiology. 306, 1

Research output: Contribution to journalArticle

Metallothionein
Diabetic Nephropathies
Streptozocin
Inflammation
Reactive Oxygen Species
8 Citations (Scopus)

Methylphenidate improves learning impairments and hyperthermia-induced seizures caused by an Scn1a mutation

Ohmori, I., Kawakami, N., Liu, S., Wang, H., Miyazaki, I., Asanuma, M., Michiue, H., Matsui, H., Mashimo, T. & Oouchida, M., Oct 1 2014, In : Epilepsia. 55, 10, p. 1558-1567 10 p.

Research output: Contribution to journalArticle

Methylphenidate
Induced Hyperthermia
Seizures
Learning
Mutation
20 Citations (Scopus)

Neuroprotective effects of metallothionein against rotenone-induced myenteric neurodegeneration in parkinsonian mice

Murakami, S., Miyazaki, I., Sogawa, N., Miyoshi, K. & Asanuma, M., 2014, In : Neurotoxicity Research. 26, 3, p. 285-298 14 p.

Research output: Contribution to journalArticle

Rotenone
Metallothionein
Neuroprotective Agents
Neurology
Enteric Nervous System
17 Citations (Scopus)

Protective effects of phytochemical antioxidants against neurotoxin-induced degeneration of dopaminergic neurons

Kita, T., Asanuma, M., Miyazaki, I. & Takeshima, M., 2014, In : Journal of Pharmacological Sciences. 124, 3, p. 313-319 7 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Neurotoxins
Phytochemicals
Neuroglia
Antioxidants
18 Citations (Scopus)

Striatal astrocytes act as a reservoir for L-DOPA

Asanuma, M., Miyazaki, I., Murakami, S., Diaz-Corrales, F. J. & Ogawa, N., 2014, In : PLoS One. 9, 9, e106362.

Research output: Contribution to journalArticle

Corpus Striatum
astrocytes
dopamine
Astrocytes
Dopamine
11 Citations (Scopus)

Visualization of astrocytic primary cilia in the mouse brain by immunofluorescent analysis using the cilia marker Arl13b

Kasahara, K., Miyoshi, K., Murakami, S., Miyazaki, I. & Asanuma, M., 2014, In : Acta Medica Okayama. 68, 6, p. 317-322 6 p.

Research output: Contribution to journalArticle

Cilia
Brain
Visualization
Adenylyl Cyclases
Neurons
2013
9 Citations (Scopus)

Protective effect of cepharanthin on cisplatin-induced renal toxicity through metallothionein expression

Sogawa, N., Hirai, K., Sogawa, C., Ohyama, K., Miyazaki, I., Tsukamoto, G., Asanuma, M., Sasaki, A. & Kitayama, S., Apr 9 2013, In : Life Sciences. 92, 12, p. 727-732 6 p.

Research output: Contribution to journalArticle

Metallothionein
Cisplatin
Toxicity
Kidney
cepharanthine
26 Citations (Scopus)

Targeting 5-HT1A receptors in astrocytes to protect dopaminergic neurons in parkinsonian models

Miyazaki, I., Asanuma, M., Murakami, S., Takeshima, M., Torigoe, N., Kitamura, Y. & Miyoshi, K., Nov 2013, In : Neurobiology of Disease. 59, p. 244-256 13 p.

Research output: Contribution to journalArticle

Receptor, Serotonin, 5-HT1A
Dopaminergic Neurons
Astrocytes
8-Hydroxy-2-(di-n-propylamino)tetralin
Corpus Striatum
9 Citations (Scopus)

The mechanisms of electroconvulsive stimuli in BrdU-positive cells of the dentate gyrus in ACTH-treated rats

Kuwatsuka, K., Hayashi, H., Onoue, Y., Miyazaki, I., Koyama, T., Asanuma, M., Kitamura, Y. & Sendo, T., 2013, In : Journal of Pharmacological Sciences. 122, 1, p. 34-41 8 p.

Research output: Contribution to journalArticle

Dentate Gyrus
Bromodeoxyuridine
Adrenocorticotropic Hormone
Brain-Derived Neurotrophic Factor
Cell Proliferation
5 Citations (Scopus)

Transplantation of Melanocytes Obtained from the Skin Ameliorates Apomorphine-Induced Abnormal Behavior in Rodent Hemi-Parkinsonian Models

Asanuma, M., Miyazaki, I., Diaz-Corrales, F. J., Higashi, Y., Namba, M. & Ogawa, N., Jun 12 2013, In : PLoS One. 8, 6, e65983.

Research output: Contribution to journalArticle

apomorphine
abnormal behavior
melanocytes
Monophenol Monooxygenase
Apomorphine

培養アストログリア細胞における細胞保護効果.

Asanuma, M., 2013, In : 九州栄養福祉大学研究紀要. 10, p. 179-191 13 p.

Research output: Contribution to journalArticle

2012
8 Citations (Scopus)

Centrosomal aggregates and Golgi fragmentation disrupt vesicular trafficking of DAT

Diaz-Corrales, F. J., Miyazaki, I., Asanuma, M., Ruano, D. & Rios, R. M., Oct 2012, In : Neurobiology of Aging. 33, 10, p. 2462-2477 16 p.

Research output: Contribution to journalArticle

Dopamine Plasma Membrane Transport Proteins
Golgi Apparatus
Tubulin
Microtubules
Parkinson Disease
7 Citations (Scopus)

Cyclooxygenase-independent neuroprotective effects of aspirin against dopamine quinone-induced neurotoxicity

Asanuma, M., Miyazaki, I., Kikkawa, Y., Kimoto, N., Takeshima, M., Murakami, S. & Miyoshi, K., Sep 2012, In : Neurochemical Research. 37, 9, p. 1944-1951 8 p.

Research output: Contribution to journalArticle

Levodopa
Neuroprotective Agents
Prostaglandin-Endoperoxide Synthases
Aspirin
meloxicam
1 Citation (Scopus)

Dipeptidyl compounds ameliorate the serumdeprivation-induced reduction in cell viability via the neurotrophin-activating effect in SH-SY5Y cells

Tanaka, K. I., Ogo, H., Kaji, H., Miyatake, K., Tokudome, E., Sonoda, K., Ogawa, N. & Asanuma, M., Jul 2012, In : Neurological Research. 34, 6, p. 619-622 4 p.

Research output: Contribution to journalArticle

Nerve Growth Factors
Immunophilins
Cell Survival
Ligands
Glial Cell Line-Derived Neurotrophic Factor
12 Citations (Scopus)

Effluent free radicals are associated with residual renal function and predict technique failure in peritoneal dialysis patients

Morinaga, H., Sugiyama, H., Inoue, T., Takiue, K., Kikumoto, Y., Kitagawa, M., Akagi, S., Nakao, K., Maeshima, Y., Miyazaki, I., Asanuma, M., Hiramatsu, M. & Makino, H., Jul 2012, In : Peritoneal Dialysis International. 32, 4, p. 453-461 9 p.

Research output: Contribution to journalArticle

Peritoneal Dialysis
Free Radicals
Kidney
Oxidative Stress
Survival
2011
50 Citations (Scopus)

Astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity

Miyazaki, I., Asanuma, M., Kikkawa, Y., Takeshima, M., Murakami, S., Miyoshi, K., Sogawa, N. & Kita, T., Mar 2011, In : GLIA. 59, 3, p. 435-451 17 p.

Research output: Contribution to journalArticle

Metallothionein
Dopaminergic Neurons
Astrocytes
Dopamine
Methamphetamine
18 Citations (Scopus)

Chronic treatment with imipramine and lithium increases cell proliferation in the hippocampus in adrenocorticotropic hormone-treated rats

Kitamura, Y., Doi, M., Kuwatsuka, K., Onoue, Y., Miyazaki, I., Shinomiya, K., Koyama, T., Sendo, T., Kawasaki, H., Asanuma, M. & Gomita, Y., 2011, In : Biological and Pharmaceutical Bulletin. 34, 1, p. 77-81 5 p.

Research output: Contribution to journalArticle

Imipramine
Lithium
Adrenocorticotropic Hormone
Hippocampus
Cell Proliferation
35 Citations (Scopus)

Factors that influence primary cilium length

Miyoshi, K., Kasahara, K., Miyazaki, I. & Asanuma, M., 2011, In : Acta Medica Okayama. 65, 5, p. 279-285 7 p.

Research output: Contribution to journalArticle

Cilia
Cells
Glycogen Synthase Kinase 3
Fluids
Tubulin
15 Citations (Scopus)

High glucose increases metallothionein expression in renal proximal tubular epithelial cells

Ogawa, D., Asanuma, M., Miyazaki, I., Tachibana, H., Wada, J., Sogawa, N., Sugaya, T., Kitamura, S., Maeshima, Y., Shikata, K. & Makino, H., 2011, In : Experimental Diabetes Research. 2011, 534872.

Research output: Contribution to journalArticle

Metallothionein
Epithelial Cells
Kidney
Glucose
Oxidative Stress
8 Citations (Scopus)

Protective effects of baicalein against excess L-DOPA-induced dopamine quinone neurotoxicity

Takeshima, M., Murata, M., Urasoe, N., Murakami, S., Miyazaki, I., Asanuma, M. & Kita, T., Dec 2011, In : Neurological Research. 33, 10, p. 1050-1056 7 p.

Research output: Contribution to journalArticle

Levodopa
Dopamine
Neuroprotective Agents
Cell-Free System
dopamine quinone

Reply

Asanuma, M. & Miyazaki, I., Feb 2011, In : Annals of Neurology. 69, 2, p. 426-427 2 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

α7 Nicotinic acetylcholine receptors in the central amygdaloid nucleus alter naloxone-induced withdrawal following a single exposure to morphine

Ishida, S., Kawasaki, Y., Araki, H., Asanuma, M., Matsunaga, H., Sendo, T., Kawasaki, H., Gomita, Y. & Kitamura, Y., Apr 2011, In : Psychopharmacology. 214, 4, p. 923-931 9 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Naloxone
Nicotine
Morphine
Cholinergic Agonists
2010

Antioxidative and neuroprotective effects of metallothioneins on dopaminergic neurons

Miyazaki, I. & Asanuma, M., 2010, Handbook of Free Radicals: Formation, Types and Effects. Nova Science Publishers, Inc., p. 557-568 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

dopamine
neurons
quinones
cysteine
brain
29 Citations (Scopus)

Effects of bupropion on the forced swim test and release of dopamine in the nucleus accumbens in ACTH-treated rats

Kitamura, Y., Yagi, T., Kitagawa, K., Shinomiya, K., Kawasaki, H., Asanuma, M. & Gomita, Y., Aug 2010, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 382, 2, p. 151-158 8 p.

Research output: Contribution to journalArticle

Bupropion
Nucleus Accumbens
Adrenocorticotropic Hormone
Dopamine
Prefrontal Cortex
9 Citations (Scopus)

Effects of imipramine and lithium on the suppression of cell proliferation in the dentate gyrus of the hippocampus in adrenocorticotropic hormone-treated rats

Dor, M., Miyazaki, I., Nagamachi, T., Shinomiya, K., Matsunaga, H., Sendo, T., Kawasaki, H., Asanuma, M., Gomita, Y. & Kitamura, Y., Aug 2010, In : Acta Medica Okayama. 64, 4, p. 219-223 5 p.

Research output: Contribution to journalArticle

Parahippocampal Gyrus
Imipramine
Dentate Gyrus
Cell proliferation
Lithium
12 Citations (Scopus)

Induction of Parkinsonism-related proteins in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene

Morimoto, N., Nagai, M., Miyazaki, K., Ohta, Y., Kurata, T., Takehisa, Y., Ikeda, Y., Matsuura, T., Asanuma, M. & Abe, K., Jun 2010, In : Journal of Neuroscience Research. 88, 8, p. 1804-1811 8 p.

Research output: Contribution to journalArticle

Parkinsonian Disorders
Motor Neurons
Transgenic Mice
Amyotrophic Lateral Sclerosis
Genes
70 Citations (Scopus)

Neuroprotective effects of zonisamide target astrocyte

Asanuma, M., Miyazaki, I., Diaz-Corrales, F. J., Kimoto, N., Kikkawa, Y., Takeshima, M., Miyoshi, K. & Murata, M., Feb 2010, In : Annals of Neurology. 67, 2, p. 239-249 11 p.

Research output: Contribution to journalArticle

zonisamide
Neuroprotective Agents
Astrocytes
Cystine
Oxidopamine
2009
47 Citations (Scopus)

Approaches to prevent dopamine quinone-induced neurotoxicity

Miyazaki, I. & Asanuma, M., Apr 2009, In : Neurochemical Research. 34, 4, p. 698-706 9 p.

Research output: Contribution to journalArticle

Neurons
Dopaminergic Neurons
Oxidative stress
Dopamine
Neurodegenerative diseases