• 4845 Citations
  • 39 h-Index
1983 …2020

Research output per year

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Research Output

2020

A novel model of liver cancer stem cells developed from induced pluripotent stem cells

Afify, S. M., Sanchez Calle, A., Hassan, G., Kumon, K., Nawara, H. M., Zahra, M. H., Mansour, H. M., Khayrani, A. C., Alam, M. J., Du, J., Seno, A., Iwasaki, Y. & Seno, M., Apr 28 2020, In : British Journal of Cancer. 122, 9, p. 1378-1390 13 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Blood and Cancer: Cancer Stem Cells as Origin of Hematopoietic Cells in Solid Tumor Microenvironments

Hassan, G. & Seno, M., May 22 2020, In : Cells. 9, 5

Research output: Contribution to journalReview article

Open Access

Cancer stem cell generation by silenced MAPK enhancing PI3K/AKT signaling

Hassan, G., Du, J., Afify, S. M., Seno, A. & Seno, M., Aug 2020, In : Medical Hypotheses. 141, 109742.

Research output: Contribution to journalArticle

Hematopoietic cells derived from cancer stem cells generated from mouse induced pluripotent stem cells

Hassan, G., Afify, S. M., Nair, N., Kumon, K., Osman, A., Du, J., Mansour, H., Quora, H. A. A., Nawara, H. M., Satoh, A., Zahra, M. H., Okada, N., Seno, A. & Seno, M., Jan 2020, In : Cancers. 12, 1, 82.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Paclitaxel and sorafenib: The effective combination of suppressing the self-renewal of cancer stem cells

Nawara, H. M., Afify, S. M., Hassan, G., Zahra, M. H., Atallah, M. N., Mansour, H., Abu Quora, H. A., Alam, M. J., Osman, A., Kakuta, H., Hamada, H., Seno, A. & Seno, M., Jun 2020, In : Cancers. 12, 6, 1360.

Research output: Contribution to journalArticle

Open Access

Revisiting cancer stem cells as the origin of cancer-associated cells in the tumor microenvironment: A hypothetical view from the potential of iPSCs

Osman, A., Afify, S. M., Hassan, G., Fu, X., Seno, A. & Seno, M., Apr 2020, In : Cancers. 12, 4, 879.

Research output: Contribution to journalReview article

Open Access
2 Citations (Scopus)

Signaling Inhibitors Accelerate the Conversion of mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment

Du, J., Xu, Y., Sasada, S., Oo, A. K. K., Hassan, G., Mahmud, H., Khayrani, A. C., Alam, M. J., Kumon, K., Uesaki, R., Afify, S. M., Mansour, H. M., Nair, N., Zahra, M. H., Seno, A., Okada, N., Chen, L., Yan, T. & Seno, M., Dec 1 2020, In : Scientific reports. 10, 1, 9955.

Research output: Contribution to journalArticle

Open Access
2019

A novel combination cancer therapy with iron chelator targeting cancer stem cells via suppressing stemness

Katsura, Y., Ohara, T., Noma, K., Ninomiya, T., Kashima, H., Kato, T., Sato, H., Komoto, S., Narusaka, T., Tomono, Y., Xing, B., Chen, Y., Tazawa, H., Kagawa, S., Shirakawa, Y., Kasai, T., Seno, M., Matsukawa, A. & Fujiwara, T., Feb 2019, In : Cancers. 11, 2, 177.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Cancer stem cell induction from mouse embryonic stem cells

Seno, A., Murakami, C., El-Aarag, B., Iwasaki, Y., Ohara, T. & Seno, M., Sep 2019, In : Oncology Letters. 18, 3, p. 2756-2762 7 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Conversion of stem cells to cancer stem cells: Undercurrent of cancer initiation

Afify, S. M. & Seno, M., Mar 2019, In : Cancers. 11, 3, 345.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Metastasis of cancer stem cells developed in the microenvironment of hepatocellular carcinoma

Afify, S. M., Hassan, G., Osman, A., Calle, A. S., Nawara, H. M., Zahra, M. H., El-Ghlban, S., Mansour, H., Alam, M. J., Abu Quora, H. A., Du, J., Seno, A., Iwasaki, Y. & Seno, M., Sep 2019, In : Bioengineering. 6, 3, 73.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Targeting ovarian cancer cells overexpressing cd44 with immunoliposomes encapsulating glycosylated paclitaxel

Khayrani, A. C., Mahmud, H., Ko Oo, A. K., Zahra, M. H., Oze, M., Du, J., Alam, M. J., Afify, S. M., Abu Quora, H. A., Shigehiro, T., Calle, A. S., Okada, N., Seno, A., Fujita, K., Hamada, H., Seno, Y., Mandai, T. & Seno, M., Mar 1 2019, In : International journal of molecular sciences. 20, 5, 1042.

Research output: Contribution to journalArticle

Open Access

Use of DNA-generated gold nanoparticles to radiosensitize and eradicate radioresistant glioma stem cells

Kunoh, T., Shimura, T., Kasai, T., Matsumoto, S., Mahmud, H., Khayrani, A. C., Seno, M., Kunoh, H. & Takada, J., Feb 1 2019, In : Nanotechnology. 30, 5, 055101.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2018

Cytokine expression and macrophage localization in xenograft and allograft tumor models stimulated with lipopolysaccharide

Masuda, J., Shigehiro, T., Matsumoto, T., Satoh, A., Mizutani, A., Umemura, C., Saito, S., Kijihira, M., Takayama, E., Seno, A., Murakami, H. & Seno, M., Apr 23 2018, In : International journal of molecular sciences. 19, 4, 1261.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Exogenous cripto-1 suppresses self-renewal of cancer stem cell model

Alam, M. J., Takahashi, R., Afify, S. M., Oo, A. K. K., Kumon, K., Nawara, H. M., Khayrani, A. C., Du, J., Zahra, M. H., Seno, A., Salomon, D. S. & Seno, M., Nov 2018, In : International journal of molecular sciences. 19, 11, 3345.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Five fibrosis biomarkers together with serum ferritin level to diagnose liver fibrosis and cirrhosis

Afify, S. M., Tabll, A., Nawara, H. M., El Kassas, M., Elfert, A., Seno, M. & El-Kousy, S., Jan 1 2018, In : Clinical Laboratory. 64, 10, p. 1685-1693 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

HSP-enriched properties of extracellular vesicles involve survival of metastatic oral cancer cells

Ono, K., Eguchi, T., Sogawa, C., Calderwood, S. K., Futagawa, J., Kasai, T., Seno, M., Okamoto, K., Sasaki, A. & Kozaki, K. I., Sep 2018, In : Journal of Cellular Biochemistry. 119, 9, p. 7350-7362 13 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Suppression effect on IFN-γ of adipose tissue-derived mesenchymal stem cells isolated from β2-microglobulin-deficient mice

Masuda, J., Takayama, E., Ichinohe, T., Strober, W., Mizuno-Kamiya, M., Ikawa, T., Kitani, A., Kawaki, H., Fuss, I., Kawamoto, H., Seno, A., Vaidyanath, A., Umemura, N., Mizutani, A., Kasai, T., Honjo, Y., Satoh, A., Murakami, H., Katsura, Y., Kondoh, N. & 1 others, Seno, M., Nov 2018, In : Experimental and Therapeutic Medicine. 16, 5, p. 4277-4282 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Targeting glioblastoma cells expressing CD44 with liposomes encapsulating doxorubicin and displaying chlorotoxin-IgG Fc fusion protein

Mahmud, H., Kasai, T., Khayrani, A. C., Asakura, M., Oo, A. K. K., Du, J., Vaidyanath, A., El-Ghlban, S., Mizutani, A., Seno, A., Murakami, H., Masuda, J. & Seno, M., Mar 2018, In : International journal of molecular sciences. 19, 3, 659.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Up-Regulation of PI 3-Kinases and the Activation of PI3K-Akt Signaling Pathway in Cancer Stem-Like Cells Through DNA Hypomethylation Mediated by the Cancer Microenvironment

Oo, A. K. K., Calle, A. S., Nair, N., Mahmud, H., Vaidyanath, A., Yamauchi, J., Khayrani, A. C., Du, J., Alam, M. J., Seno, A., Mizutani, A., Murakami, H., Iwasaki, Y., Chen, L., Kasai, T. & Seno, M., Jun 1 2018, In : Translational Oncology. 11, 3, p. 653-663 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2017

A cancer stem cell model as the point of origin of cancer-associated fibroblasts in tumor microenvironment

Nair, N., Calle, A. S., Zahra, M. H., Prieto-Vila, M., Oo, A. K. K., Hurley, L., Vaidyanath, A., Seno, A., Masuda, J., Iwasaki, Y., Tanaka, H., Kasai, T. & Seno, M., Dec 1 2017, In : Scientific Reports. 7, 1, 6838.

Research output: Contribution to journalArticle

38 Citations (Scopus)

A novel model of meibomian gland dysfunction induced with complete freund’s adjuvant in rabbits

Miyake, H., Oda, T., Katsuta, O., Seno, M. & Nakamura, M., Mar 2017, In : Vision (Switzerland). 1, 1, 10.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
5 Citations (Scopus)

Iron depletion is a novel therapeutic strategy to target cancer stem cells

Ninomiya, T., Ohara, T., Noma, K., Katsura, Y., Katsube, R., Kashima, H., Kato, T., Tomono, Y., Tazawa, H., Kagawa, S., Shirakawa, Y., Kimura, F., Chen, L., Kasai, T., Seno, M., Matsukawa, A. & Fujiwara, T., 2017, In : Oncotarget. 8, 58, p. 98405-98416 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Practical liposomal formulation for taxanes with polyethoxylated castor oil and ethanol with complete encapsulation efficiency and high loading efficiency

Shigehiro, T., Masuda, J., Saito, S., Khayrani, A. C., Jinno, K., Seno, A., Vaidyanath, A., Mizutani, A., Kasai, T., Murakami, H., Satoh, A., Ito, T., Hamada, H., Seno, Y., Mandai, T. & Seno, M., Oct 2017, In : Nanomaterials. 7, 10, 290.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Synthesis and assembly of Hepatitis B virus envelope protein-derived particles in Escherichia coli

Li, H., Onbe, K., Liu, Q., Iijima, M., Tatematsu, K., Seno, M., Tada, H. & Kuroda, S. I., Aug 19 2017, In : Biochemical and Biophysical Research Communications. 490, 2, p. 155-160 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Tumor growth limited to subcutaneous site vs tumor growth in pulmonary site exhibit differential effects on systemic immunities

Masuda, J., Takayama, E., Strober, W., Satoh, A., Morimoto, Y., Honjo, Y., Ichinohe, T., Tokuno, S. I., Ishizuka, T., Nakata, T., Mizutani, A., Umemura, N., Kitani, A., Fuss, I. J., Shigehiro, T., Kawaki, H., Mizuno-Kamiya, M., Kondoh, N. & Seno, M., 2017, In : Oncology reports. 38, 1, p. 449-455 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2016

A new PDAC mouse model originated from iPSCs-converted pancreatic cancer stem cells (CSCcm)

Calle, A. S., Nair, N., Oo, A. K. K., Prieto-Vila, M., Koga, M., Khayrani, A. C., Hussein, M., Hurley, L., Vaidyanath, A., Seno, A., Iwasaki, Y., Calle, M., Kasai, T. & Seno, M., 2016, In : American Journal of Cancer Research. 6, 12, p. 2799-2815 17 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Characterization of gene expression patterns among artificially developed cancer stem cells using spherical self-organizing map

Seno, A., Kasai, T., Ikeda, M., Vaidyanath, A., Masuda, J., Mizutani, A., Murakami, H., Ishikawa, T. & Seno, M., Aug 16 2016, In : Cancer Informatics. 15, p. 163-178 16 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Evaluation of glycosylated docetaxel-encapsulated liposomes prepared by remote loading under solubility gradient

Shigehiro, T., Zhai, W., Vaidyanath, A., Masuda, J., Mizutani, A., Kasai, T., Murakami, H., Hamada, H., Salomon, D. S., Mikuni, K., Seno, Y., Mandai, T. & Seno, M., Feb 15 2016, (Accepted/In press) In : Journal of Microencapsulation. p. 1-11 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

iPSC-derived cancer stem cells provide a model of tumor vasculature

Prieto-Vila, M., Yan, T., Calle, A. S., Nair, N., Hurley, L., Kasai, T., Kakuta, H., Masuda, J., Murakami, H., Mizutani, A. & Seno, M., 2016, In : American Journal of Cancer Research. 6, 9, p. 1906-1921 16 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Meibomian gland dysfunction model in hairless mice fed a special diet with limited lipid content

Miyake, H., Oda, T., Katsuta, O., Seno, M. & Nakamura, M., Jun 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 7, p. 3268-3275 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Release of siRNA from Liposomes Induced by Curcumin

Fujita, K., Hiramatsu, Y., Minematsu, H., Somiya, M., Kuroda, S., Seno, M. & Hinuma, S., 2016, In : Journal of Nanotechnology. 2016, 7051523.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Synthesis and in vitro cancer cell growth inhibition evaluation of 11-amino-modified 5-Me-indolo[2,3-b]quinolines and their COMPARE analyses

Okada, M., Mei, Z. W., Imran Hossain, M., Wang, L., Tominaga, T., Takebayashi, T., Murakami, M., Yasuda, M., Shigehiro, T., Kasai, T., Mizutani, A., Murakami, H., El Sayed, I. E. T., Dan, S., Yamori, T., Seno, M. & Inokuchi, T., May 1 2016, In : Medicinal Chemistry Research. 25, 5, p. 879-892 14 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Transient Tcf3 Gene Repression by TALE-Transcription Factor Targeting

Masuda, J., Kawamoto, H., Strober, W., Takayama, E., Mizutani, A., Murakami, H., Ikawa, T., Kitani, A., Maeno, N., Shigehiro, T., Satoh, A., Seno, A., Arun, V., Kasai, T., Fuss, I. J., Katsura, Y. & Seno, M., Jul 12 2016, (Accepted/In press) In : Applied Biochemistry and Biotechnology. p. 1-15 15 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2015

Eosinophil cationic protein shows survival effect on H9c2 cardiac myoblast cells with enhanced phosphorylation of ERK and Akt/GSK-3β under oxidative stress

Ishii, H., Kamikawa, S., Hirohata, S., Mizutani, A., Abe, K., Seno, M., Oohashi, T. & Ninomiya, Y., 2015, In : Acta medica Okayama. 69, 3, p. 145-153 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Spherical self-organizing map detects MYBL 1 as candidate gene for triple-negative breast cancer

Ikeda, M., Kumon, K., Omoto, K., Sugii, Y., Mizutani, A., Vaidyanath, A., Kudoh, T., Kasai, T., Masuda, S. & Seno, M., Dec 1 2015, In : Neuroscience and Biomedical Engineering. 3, 2, p. 94-101 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2014

A Cancer Stem Cell Model: An Insight into the Conversion of Induced Pluripotent Stem Cells to Cancer Stem-Like Cells

Mizutani, A., Chen, L., Kasai, T., Kudoh, T., Murakami, H., Fu, L. & Seno, M., Apr 14 2014, Cancer Stem Cells. Wiley Blackwell, Vol. 9781118356166. p. 79-87 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bacteria: Prospective savior in battle against cancer

Nair, N., Kasai, T. & Seno, M., Nov 1 2014, In : Anticancer research. 34, 11, p. 6289-6296 8 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)

Cancer stem cells converted from pluripotent stem cells and the cancerous niche

Kasai, T., Chen, L., Mizutani, A., Kudoh, T., Murakami, H., Fu, L. & Seno, M., 2014, In : Journal of Stem Cells and Regenerative Medicine. 10, 1, p. 2-7 6 p.

Research output: Contribution to journalReview article

16 Citations (Scopus)

Cancer stem cells maintain a hierarchy of differentiation by creating their niche

Matsuda, S., Yan, T., Mizutani, A., Sota, T., Hiramoto, Y., Prieto-Vila, M., Chen, L., Satoh, A., Kudoh, T., Kasai, T., Murakami, H., Fu, L., Salomon, D. S. & Seno, M., Jul 1 2014, In : International Journal of Cancer. 135, 1, p. 27-36 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Characterization of cancer stem-like cells derived from mouse induced pluripotent stem cells transformed by tumor-derived extracellular vesicles

Yan, T., Mizutani, A., Chen, L., Takaki, M., Hiramoto, Y., Matsuda, S., Shigehiro, T., Kasai, T., Kudoh, T., Murakami, H., Masuda, J., Hendrix, M. J. C., Strizzi, L., Salomon, D. S., Fu, L. & Seno, M., 2014, In : Journal of Cancer. 5, 7, p. 572-584 13 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Chlorotoxin-Fc fusion inhibits release of MMP-2 from pancreatic cancer cells

El-Ghlban, S., Kasai, T., Shigehiro, T., Yin, H. X., Sekhar, S., Ida, M., Sanchez, A., Mizutani, A., Kudoh, T., Murakami, H. & Seno, M., 2014, In : BioMed research international. 2014, 152659.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Development of 111in-labeled liposomes for vulnerable atherosclerotic plaque imaging

Ogawa, M., Umeda, I. O., Kosugi, M., Kawai, A., Hamaya, Y., Takashima, M., Yin, H., Kudoh, T., Seno, M. & Magata, Y., Jan 1 2014, In : Journal of Nuclear Medicine. 55, 1, p. 115-120 6 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Efficient drug delivery of paclitaxel glycoside: A novel solubility gradient encapsulation into liposomes coupled with immunoliposomes preparation

Shigehiro, T., Kasai, T., Murakami, M., Sekhar, S. C., Tominaga, Y., Okada, M., Kudoh, T., Mizutani, A., Murakami, H., Salomon, D. S., Mikuni, K., Mandai, T., Hamada, H. & Seno, M., Sep 29 2014, In : PloS one. 9, 9, e107976.

Research output: Contribution to journalArticle

24 Citations (Scopus)

In vitro anti-proliferative and anti-angiogenic activities of thalidomide dithiocarbamate analogs

El-Aarag, B. Y. A., Kasai, T., Zahran, M. A. H., Zakhary, N. I., Shigehiro, T., Sekhar, S. C., Agwa, H. S., Mizutani, A., Murakami, H., Kakuta, H. & Seno, M., Aug 2014, In : International Immunopharmacology. 21, 2, p. 283-292 10 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

The new proposal of the calculation for the significance degree by once SOM learning - Using iris, gene, and Tof-SIMS data

Oyabu, M., Tokutaka, H., Ohkita, M., Seno, M. & Ohki, M., Feb 18 2014, 2014 Joint 7th International Conference on Soft Computing and Intelligent Systems, SCIS 2014 and 15th International Symposium on Advanced Intelligent Systems, ISIS 2014. Institute of Electrical and Electronics Engineers Inc., p. 1114-1119 6 p. 7044648. (2014 Joint 7th International Conference on Soft Computing and Intelligent Systems, SCIS 2014 and 15th International Symposium on Advanced Intelligent Systems, ISIS 2014).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)
2013

Acidic amorphous silica prepared from iron oxide of bacterial origin

Hashimoto, H., Itadani, A., Kudoh, T., Kuroda, Y., Seno, M., Kusano, Y., Ikeda, Y., Nakanishi, M., Fujii, T. & Takada, J., Feb 13 2013, In : ACS Applied Materials and Interfaces. 5, 3, p. 518-523 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors

Nagaoka, T., Karasawa, H., Turbyville, T., Rangel, M. C., Castro, N. P., Gonzales, M., Baker, A., Seno, M., Lockett, S., Greer, Y. E., Rubin, J. S., Salomon, D. S. & Bianco, C., Jan 1 2013, In : Cellular Signalling. 25, 1, p. 178-189 12 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)