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2019

Acidic Pre-Conditioning Enhances the Stem Cell Phenotype of Human Bone Marrow Stem/Progenitor Cells

Hazehara-Kunitomo, Y., Hara, E., Ono, M., Aung, K. T., Komi, K., Pham, H. T., Akiyama, K., Okada, M., Oohashi, T., Matsumoto, T. & Kuboki, T., Mar 4 2019, In : International journal of molecular sciences. 20, 5

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Ammonium tetrathiomolybdate enhances the antitumor effect of cisplatin via the suppression of ATPase copper transporting beta in head and neck squamous cell carcinoma

Ryumon, S., Okui, T., Kunisada, Y., Kishimoto, K., Shimo, T., Hasegawa, K., Ibaragi, S., Akiyama, K., Ha, N. T. T., Hassan, N. M. M. & Sasaki, A., Jan 1 2019, In : Oncology reports. 42, 6, p. 2611-2621 11 p.

Research output: Contribution to journalArticle

Bone Marrow Cells Inhibit BMP-2-Induced Osteoblast Activity in the Marrow Environment

Nguyen, H. T., Ono, M., Oida, Y., Hara, E. S., Komori, T., Akiyama, K., Nguyen, H. T. T., Aung, K. T., Pham, H. T., Tosa, I., Takarada, T., Matsuo, K., Mizoguchi, T., Oohashi, T. & Kuboki, T., Feb 1 2019, In : Journal of Bone and Mineral Research. 34, 2, p. 327-332 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2018

Impact of commensal flora on periodontal immune response to lipopolysaccharide

Fukuhara, D., Irie, K., Uchida, Y., Kataoka, K., Akiyama, K., Ekuni, D., Tomofuji, T. & Morita, M., Jan 1 2018, In : Journal of periodontology. 89, 10, p. 1213-1220 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2015

mTOR inhibition rescues osteopenia in mice with systemic sclerosis

Chen, C., Akiyama, K., Wang, D., Xu, X., Li, B., Moshaverinia, A., Brombacher, F., Sun, L. & Shi, S., Jan 12 2015, In : Journal of Experimental Medicine. 212, 1, p. 73-91 19 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)
2014

Bone regeneration potential of stem cells derived from periodontal ligament or gingival tissue sources encapsulated in RGD-modified alginate scaffold

Moshaverinia, A., Chen, C., Xu, X., Akiyama, K., Ansari, S., Zadeh, H. H. & Shi, S., Feb 1 2014, In : Tissue Engineering - Part A. 20, 3-4, p. 611-621 11 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Efficient bone formation in a swine socket lift model using escherichia coli-derived recombinant human bone morphogenetic protein-2 adsorbed in β-tricalcium phosphate

Ono, M., Sonoyama, W., Yamamoto, K., Oida, Y., Akiyama, K., Shinkawa, S., Nakajima, R., Pham, H. T., Hara, E. S. & Kuboki, T., Feb 24 2014, In : Cells Tissues Organs. 199, 4, p. 249-255 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
8 Citations (Scopus)

Mesenchymal stem/progenitor cell isolation from tooth extraction sockets

Nakajima, R., Ono, M., Hara, E. S., Oida, Y., Shinkawa, S., Pham, H. T., Akiyama, K., Sonoyama, W., Maekawa, K. & Kuboki, T., Nov 11 2014, In : Journal of dental research. 93, 11, p. 1133-1140 8 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Telomerase governs immunomodulatory properties of mesenchymal stem cells by regulating FAS ligand expression

Chen, C., Akiyama, K., Yamaza, T., You, Y. O., Xu, X., Li, B., Zhao, Y. & Shi, S., Mar 2014, In : EMBO Molecular Medicine. 6, 3, p. 322-334 13 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2013

A subset of IL-17 + mesenchymal stem cells possesses anti-Candida albicans effect

Yang, R., Liu, Y., Kelk, P., Qu, C., Akiyama, K., Chen, C., Atsuta, I., Chen, W., Zhou, Y. & Shi, S., Jan 1 2013, In : Cell Research. 23, 1, p. 107-121 15 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Co-encapsulation of anti-BMP2 monoclonal antibody and mesenchymal stem cells in alginate microspheres for bone tissue engineering

Moshaverinia, A., Ansari, S., Chen, C., Xu, X., Akiyama, K., Snead, M. L., Zadeh, H. H. & Shi, S., Sep 1 2013, In : Biomaterials. 34, 28, p. 6572-6579 8 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Dental mesenchymal stem cells encapsulated in an alginate hydrogel co-delivery microencapsulation system for cartilage regeneration

Moshaverinia, A., Xu, X., Chen, C., Akiyama, K., Snead, M. L. & Shi, S., Dec 1 2013, In : Acta Biomaterialia. 9, 12, p. 9343-9350 8 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Encapsulated dental-derived mesenchymal stem cells in an injectable and biodegradable scaffold for applications in bone tissue engineering

Moshaverinia, A., Chen, C., Akiyama, K., Xu, X., Chee, W. W. L., Schricker, S. R. & Shi, S., Nov 1 2013, In : Journal of Biomedical Materials Research - Part A. 101, 11, p. 3285-3294 10 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Gingivae contain neural-crest- and mesoderm-derived mesenchymal stem cells

Xu, X., Chen, C., Akiyama, K., Chai, Y., Le, A. D., Wang, Z. & Shi, S., Sep 1 2013, In : Journal of dental research. 92, 9, p. 825-832 8 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)

IFN-γ and TNF-α synergistically induce mesenchymal stem cell impairment and tumorigenesis via NFκB signaling

Wang, L., Zhao, Y., Liu, Y., Akiyama, K., Chen, C., Qu, C., Jin, Y. & Shi, S., Jul 1 2013, In : Stem Cells. 31, 7, p. 1383-1395 13 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Immune therapeutic potential of stem cells from human supernumerary teeth

Makino, Y., Yamaza, H., Akiyama, K., Ma, L., Hoshino, Y., Nonaka, K., Terada, Y., Kukita, T., Shi, S. & Yamaza, T., Jul 1 2013, In : Journal of dental research. 92, 7, p. 609-615 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Mesenchymal progenitors residing close to the bone surface are functionally distinct from those in the central bone marrow.

Siclari, V. A., Zhu, J., Akiyama, K., Liu, F., Zhang, X., Chandra, A., Nah, H. D., Shi, S. & Qin, L., Apr 2013, In : Bone. 53, 2, p. 575-586 12 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Mesenchymal stem cells inhibit multiple myeloma cells via the Fas/Fas ligand pathway

Atsuta, I., Liu, S., Miura, Y., Akiyama, K., Chen, C., An, Y., Shi, S. & Chen, F. M., Sep 13 2013, In : Stem Cell Research and Therapy. 4, 5, 111.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Ossifying fibroma tumor stem cells are maintained by epigenetic regulation of a TSP1/TGF-β/SMAD3 autocrine loop.

Qin, H., Qu, C., Yamaza, T., Yang, R., Lin, X., Duan, X. Y., Akiyama, K., Liu, Y., Zhang, Q., Chen, C., Chen, Y., Qi, H. H., Feng, X. H., Le, A. D. & Shi, S., Nov 7 2013, In : Cell stem cell. 13, 5, p. 577-589 13 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2012

Alginate hydrogel as a promising scaffold for dental-derived stem cells: An in vitro study

Moshaverinia, A., Chen, C., Akiyama, K., Ansari, S., Xu, X., Chee, W. W., Schricker, S. R. & Shi, S., Dec 1 2012, In : Journal of Materials Science: Materials in Medicine. 23, 12, p. 3041-3051 11 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Basic fibroblast growth factor inhibits osteogenic differentiation of stem cells from human exfoliated deciduous teeth through ERK signaling

Li, B., Qu, C., Chen, C., Liu, Y., Akiyama, K., Yang, R., Chen, F., Zhao, Y. & Shi, S., Apr 1 2012, In : Oral Diseases. 18, 3, p. 285-292 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Characterization of bone marrow derived mesenchymal stem cells in suspension

Akiyama, K., You, Y. O., Yamaza, T., Chen, C., Tang, L., Jin, Y., Chen, X. D., Gronthos, S. & Shi, S., Dec 24 2012, In : Stem Cell Research and Therapy. 3, 5, 40.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Cryopreserved Dental Pulp Tissues of Exfoliated Deciduous Teeth Is a Feasible Stem Cell Resource for Regenerative Medicine

Ma, L., Makino, Y., Yamaza, H., Akiyama, K., Hoshino, Y., Song, G., Kukita, T., Nonaka, K., Shi, S. & Yamaza, T., Dec 14 2012, In : PloS one. 7, 12, e51777.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Double allogenic mesenchymal stem cells transplantations could not enhance therapeutic effect compared with single transplantation in systemic lupus erythematosus

Wang, D., Akiyama, K., Zhang, H., Yamaza, T., Li, X., Feng, X., Wang, H., Hua, B., Liu, B., Xu, H., Chen, W., Shi, S. & Sun, L., Aug 17 2012, In : Clinical and Developmental Immunology. 2012, 273291.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis

Akiyama, K., Chen, C., Wang, D., Xu, X., Qu, C., Yamaza, T., Cai, T., Chen, W., Sun, L. & Shi, S., May 4 2012, In : Cell stem cell. 10, 5, p. 544-555 12 p.

Research output: Contribution to journalArticle

353 Citations (Scopus)

Technetium-99 conjugated with methylene diphosphonate ameliorates ovariectomy-induced osteoporotic phenotype without causing osteonecrosis in the jaw

Zhao, Y., Wang, L., Liu, Y., Akiyama, K., Chen, C., Atsuta, I., Zhou, T., Duan, X., Jin, Y. & Shi, S., Dec 1 2012, In : Calcified Tissue International. 91, 6, p. 400-408 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2011

Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α

Liu, Y., Wang, L., Kikuiri, T., Akiyama, K., Chen, C., Xu, X., Yang, R., Chen, W. J., Wang, S. & Shi, S., Dec 1 2011, In : Nature Medicine. 17, 12, p. 1594-1601 8 p.

Research output: Contribution to journalArticle

352 Citations (Scopus)

Mouse mandible contains distinctive mesenchymal stem cells

Yamaza, T., Ren, G., Akiyama, K., Chen, C., Shi, Y. & Shi, S., Mar 1 2011, In : Journal of dental research. 90, 3, p. 317-324 8 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)
2010

Cell-based immunotherapy with mesenchymal stem cells cures bisphosphonate-related osteonecrosis of the jaw-like disease in mice

Kikuiri, T., Kim, I., Yamaza, T., Akiyama, K., Zhang, Q., Li, Y., Chen, C., Chen, W. J., Wang, S., Le, A. D. & Shi, S., Jul 1 2010, In : Journal of Bone and Mineral Research. 25, 7, p. 1668-1679 12 p.

Research output: Contribution to journalArticle

119 Citations (Scopus)

Immunomodulatory properties of stem cells from human exfoliated deciduous teeth

Yamaza, T., Kentaro, A., Chen, C., Liu, Y., Shi, Y., Gronthos, S., Wang, S. & Shi, S., Dec 1 2010, In : Stem Cell Research and Therapy. 1, 1, 5.

Research output: Contribution to journalArticle

171 Citations (Scopus)

Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors

Parsa, S., Kuremoto, K. I., Seidel, K., Tabatabai, R., MacKenzie, B. A., Yamaza, T., Akiyama, K., Branch, J., Koh, C. J., Al Alam, D., Klein, O. D. & Bellusci, S., Nov 15 2010, In : Development. 137, 22, p. 3743-3752 10 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Transplantation of umbilical cord mesenchymal stem cells alleviates lupus nephritis in MRL/lpr mice

Gu, Z., Akiyama, K., Ma, X., Zhang, H., Feng, X., Yao, G., Hou, Y., Lu, L., Gilkeson, G. S., Silver, R. M., Zeng, X., Shi, S. & Sun, L., Nov 1 2010, In : Lupus. 19, 13, p. 1502-1514 13 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)

Utility of PDL progenitors for in vivo tissue regeneration: A report of 3 cases

Feng, F., Akiyama, K., Liu, Y., Yamaza, T., Wang, T. M., Chen, J. H., Wang, B. B., Huang, G. T. J., Wang, S. & Shi, S., Jan 1 2010, In : Oral Diseases. 16, 1, p. 20-28 9 p.

Research output: Contribution to journalArticle

176 Citations (Scopus)
2009

Mesenchymal stem cell-mediated ectopic hematopoiesis alleviates aging-related phenotype in immunocompromised mice

Yamaza, T., Miura, Y., Akiyama, K., Bi, Y., Sonoyama, W., Gronthos, S., Chen, W., Le, A. & Shi, S., Mar 12 2009, In : Blood. 113, 11, p. 2595-2604 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans

Sun, L., Akiyama, K., Zhang, H., Yamaza, T., Hou, Y., Zhao, S., Xu, T., Le, A. & Shi, S., Jun 1 2009, In : Stem Cells. 27, 6, p. 1421-1432 12 p.

Research output: Contribution to journalArticle

392 Citations (Scopus)

Simvastatin Induces the Odontogenic Differentiation of Human Dental Pulp Stem Cells In Vitro and In Vivo

Okamoto, Y., Sonoyama, W., Ono, M., Akiyama, K., Fujisawa, T., Oshima, M., Tsuchimoto, Y., Matsuka, Y., Yasuda, T., Shi, S. & Kuboki, T., Mar 1 2009, In : Journal of Endodontics. 35, 3, p. 367-372 6 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)
2008

Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents

Yamaza, T., Miura, Y., Bi, Y., Liu, Y., Akiyama, K., Sonoyama, W., Patel, V., Gutkind, S., Young, M., Gronthos, S., Le, A., Wang, C. Y., Chen, W. J. & Shi, S., Jul 9 2008, In : PloS one. 3, 7, e2615.

Research output: Contribution to journalArticle

120 Citations (Scopus)

Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN2

Ono, M., Kubota, S., Fujisawa, T., Sonoyama, W., Kawaki, H., Akiyama, K., Shimono, K., Oshima, M., Nishida, T., Yoshida, Y., Suzuki, K., Takigawa, M. & Kuboki, T., Jan 1 2008, In : Cell Transplantation. 17, 1-2, p. 231-240 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

SHED repair critical-size calvarial defects in mice

Seo, B. M., Sonoyama, W., Yamaza, T., Coppe, C., Kikuiri, T., Akiyama, K., Lee, J. S. & Shi, S., Jul 1 2008, In : Oral Diseases. 14, 5, p. 428-434 7 p.

Research output: Contribution to journalArticle

157 Citations (Scopus)
2007

Promotion of attachment of human bone marrow stromal cells by CCN2

Ono, M., Kubota, S., Fujisawa, T., Sonoyama, W., Kawaki, H., Akiyama, K., Oshima, M., Nishida, T., Yoshida, Y., Suzuki, K., Takigawa, M. & Kuboki, T., May 25 2007, In : Biochemical and Biophysical Research Communications. 357, 1, p. 20-25 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2003

Cbfa1/Runx2 gene expression in articular chondrocytes of the mice temporomandibular and knee joints in vivo

Kuboki, T., Kanyama, M., Nakanishi, T., Akiyama, K., Nawachi, K., Yatani, H., Yamashita, K., Takano-Yamamoto, T. & Takigawa, M., Jul 1 2003, In : Archives of Oral Biology. 48, 7, p. 519-525 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Connective tissue growth factor expressed in rat alveolar bone regeneration sites after tooth extraction

Kanyama, M., Kuboki, T., Akiyama, K., Nawachi, K., Miyauchi, F. M., Yatani, H., Kubota, S., Nakanishi, T. & Takigawa, M., Oct 1 2003, In : Archives of Oral Biology. 48, 10, p. 723-730 8 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)