• 3419 Citations
  • 28 h-Index
20032019

Research output per year

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Research Output

2019

Acidic Pre-Conditioning Enhances the Stem Cell Phenotype of Human Bone Marrow Stem/Progenitor Cells

Hazehara-Kunitomo, Y., Hara, E., Ono, M., Aung, K. T., Komi, K., Pham, H. T., Akiyama, K., Okada, M., Oohashi, T., Matsumoto, T. & Kuboki, T., Mar 4 2019, In : International journal of molecular sciences. 20, 5

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Ammonium tetrathiomolybdate enhances the antitumor effect of cisplatin via the suppression of ATPase copper transporting beta in head and neck squamous cell carcinoma

Ryumon, S., Okui, T., Kunisada, Y., Kishimoto, K., Shimo, T., Hasegawa, K., Ibaragi, S., Akiyama, K., Ha, N. T. T., Hassan, N. M. M. & Sasaki, A., Jan 1 2019, In : Oncology reports. 42, 6, p. 2611-2621 11 p.

Research output: Contribution to journalArticle

2018

Bone Marrow Cells Inhibit BMP-2-Induced Osteoblast Activity in the Marrow Environment

Nguyen, H. T., Ono, M., Oida, Y., Hara, E., Komori, T., Akiyama, K., Nguyen, H. T. T., Aung, K. T., Pham, H. T., Tosa, I., Takarada, T., Matsuo, K., Mizoguchi, T., Oohashi, T. & Kuboki, T., Jan 1 2018, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Impact of commensal flora on periodontal immune response to lipopolysaccharide

Fukuhara, D., Irie, K., Uchida, Y., Kataoka, K., Akiyama, K., Ekuni, D., Tomofuji, T. & Morita, M., Jan 1 2018, In : Journal of periodontology. 89, 10, p. 1213-1220 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2015

Cell-based bone regeneration for alveolar ridge augmentation - Cell source, endogenous cell recruitment and immunomodulatory function

Kaku, M., Akiba, Y., Akiyama, K., Akita, D. & Nishimura, M., Apr 1 2015, In : Journal of Prosthodontic Research. 59, 2, p. 96-112 17 p.

Research output: Contribution to journalReview article

20 Citations (Scopus)

Erratum: Retraction Notice to: Ossifying Fibroma Tumor Stem Cells Are Maintained by Epigenetic Regulation of a TSP1/TGF-β/SMAD3 Autocrine Loop (Cell Stem Cell (2013) 13 (577-589))

Qin, H., Qu, C., Yamaza, T., Yang, R., Lin, X., Duan, X. Y., Akiyama, K., Liu, Y., Zhang, Q., Chen, C., Chen, Y., Qi, H. H., Feng, X. H., Le, A. D. & Shi, S., May 7 2015, In : Cell stem cell. 16, 5, 1 p.

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Immunotherapy in Transplantation

Akiyama, K., Hara Satoshi, E. & Kuboki, T., Jan 1 2015, Stem Cell Biology and Tissue Engineering in Dental Sciences. Elsevier Inc., p. 831-839 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

mTOR inhibition rescues osteopenia in mice with systemic sclerosis

Chen, C., Akiyama, K., Wang, D., Xu, X., Li, B., Moshaverinia, A., Brombacher, F., Sun, L. & Shi, S., Jan 1 2015, In : Journal of Experimental Medicine. 212, 1, p. 73-91 19 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
2014

Bone regeneration potential of stem cells derived from periodontal ligament or gingival tissue sources encapsulated in RGD-modified alginate scaffold

Moshaverinia, A., Chen, C., Xu, X., Akiyama, K., Ansari, S., Zadeh, H. H. & Shi, S., Feb 1 2014, In : Tissue Engineering - Part A. 20, 3-4, p. 611-621 11 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

Efficient bone formation in a swine socket lift model using escherichia coli-derived recombinant human bone morphogenetic protein-2 adsorbed in β-tricalcium phosphate

Ono, M., Sonoyama, W., Yamamoto, K., Oida, Y., Akiyama, K., Shinkawa, S., Nakajima, R., Pham, H. T., Hara, E. S. & Kuboki, T., Feb 24 2014, In : Cells Tissues Organs. 199, 4, p. 249-255 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
8 Citations (Scopus)

Mesenchymal stem/progenitor cell isolation from tooth extraction sockets

Nakajima, R., Ono, M., Hara, E. S., Oida, Y., Shinkawa, S., Pham, H. T., Akiyama, K., Sonoyama, W., Maekawa, K. & Kuboki, T., Nov 11 2014, In : Journal of dental research. 93, 11, p. 1133-1140 8 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Telomerase governs immunomodulatory properties of mesenchymal stem cells by regulating FAS ligand expression

Chen, C., Akiyama, K., Yamaza, T., You, Y. O., Xu, X., Li, B., Zhao, Y. & Shi, S., Mar 2014, In : EMBO Molecular Medicine. 6, 3, p. 322-334 13 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2013

A subset of IL-17 + mesenchymal stem cells possesses anti-Candida albicans effect

Yang, R., Liu, Y., Kelk, P., Qu, C., Akiyama, K., Chen, C., Atsuta, I., Chen, W., Zhou, Y. & Shi, S., Jan 1 2013, In : Cell Research. 23, 1, p. 107-121 15 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Co-encapsulation of anti-BMP2 monoclonal antibody and mesenchymal stem cells in alginate microspheres for bone tissue engineering

Moshaverinia, A., Ansari, S., Chen, C., Xu, X., Akiyama, K., Snead, M. L., Zadeh, H. H. & Shi, S., Sep 1 2013, In : Biomaterials. 34, 28, p. 6572-6579 8 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Dental mesenchymal stem cells encapsulated in an alginate hydrogel co-delivery microencapsulation system for cartilage regeneration

Moshaverinia, A., Xu, X., Chen, C., Akiyama, K., Snead, M. L. & Shi, S., Dec 1 2013, In : Acta Biomaterialia. 9, 12, p. 9343-9350 8 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Encapsulated dental-derived mesenchymal stem cells in an injectable and biodegradable scaffold for applications in bone tissue engineering

Moshaverinia, A., Chen, C., Akiyama, K., Xu, X., Chee, W. W. L., Schricker, S. R. & Shi, S., Nov 1 2013, In : Journal of Biomedical Materials Research - Part A. 101, 11, p. 3285-3294 10 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Gingivae contain neural-crest- and mesoderm-derived mesenchymal stem cells

Xu, X., Chen, C., Akiyama, K., Chai, Y., Le, A. D., Wang, Z. & Shi, S., Sep 1 2013, In : Journal of dental research. 92, 9, p. 825-832 8 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

IFN-γ and TNF-α synergistically induce mesenchymal stem cell impairment and tumorigenesis via NFκB signaling

Wang, L., Zhao, Y., Liu, Y., Akiyama, K., Chen, C., Qu, C., Jin, Y. & Shi, S., Jul 1 2013, In : Stem Cells. 31, 7, p. 1383-1395 13 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Immune therapeutic potential of stem cells from human supernumerary teeth

Makino, Y., Yamaza, H., Akiyama, K., Ma, L., Hoshino, Y., Nonaka, K., Terada, Y., Kukita, T., Shi, S. & Yamaza, T., Jul 1 2013, In : Journal of dental research. 92, 7, p. 609-615 7 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Mesenchymal progenitors residing close to the bone surface are functionally distinct from those in the central bone marrow.

Siclari, V. A., Zhu, J., Akiyama, K., Liu, F., Zhang, X., Chandra, A., Nah, H. D., Shi, S. & Qin, L., Apr 2013, In : Bone. 53, 2, p. 575-586 12 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Mesenchymal stem cells inhibit multiple myeloma cells via the Fas/Fas ligand pathway

Atsuta, I., Liu, S., Miura, Y., Akiyama, K., Chen, C., An, Y., Shi, S. & Chen, F. M., Sep 13 2013, In : Stem Cell Research and Therapy. 4, 5, 111.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Ossifying fibroma tumor stem cells are maintained by epigenetic regulation of a TSP1/TGF-β/SMAD3 autocrine loop.

Qin, H., Qu, C., Yamaza, T., Yang, R., Lin, X., Duan, X. Y., Akiyama, K., Liu, Y., Zhang, Q., Chen, C., Chen, Y., Qi, H. H., Feng, X. H., Le, A. D. & Shi, S., Nov 7 2013, In : Cell stem cell. 13, 5, p. 577-589 13 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Stem Cell Biology in the Craniofacial Apparatus

Parada, C., Akiyama, K., Chai, Y. & Shi, S., Apr 5 2013, Mineralized Tissues in Oral and Craniofacial Science: Biological Principles and Clinical Correlates. John Wiley and Sons, p. 79-92 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2012

Alginate hydrogel as a promising scaffold for dental-derived stem cells: An in vitro study

Moshaverinia, A., Chen, C., Akiyama, K., Ansari, S., Xu, X., Chee, W. W., Schricker, S. R. & Shi, S., Dec 1 2012, In : Journal of Materials Science: Materials in Medicine. 23, 12, p. 3041-3051 11 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Basic fibroblast growth factor inhibits osteogenic differentiation of stem cells from human exfoliated deciduous teeth through ERK signaling

Li, B., Qu, C., Chen, C., Liu, Y., Akiyama, K., Yang, R., Chen, F., Zhao, Y. & Shi, S., Apr 1 2012, In : Oral Diseases. 18, 3, p. 285-292 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Characterization of bone marrow derived mesenchymal stem cells in suspension

Akiyama, K., You, Y. O., Yamaza, T., Chen, C., Tang, L., Jin, Y., Chen, X. D., Gronthos, S. & Shi, S., Dec 24 2012, In : Stem Cell Research and Therapy. 3, 5, 40.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Cryopreserved Dental Pulp Tissues of Exfoliated Deciduous Teeth Is a Feasible Stem Cell Resource for Regenerative Medicine

Ma, L., Makino, Y., Yamaza, H., Akiyama, K., Hoshino, Y., Song, G., Kukita, T., Nonaka, K., Shi, S. & Yamaza, T., Dec 14 2012, In : PloS one. 7, 12, e51777.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Double allogenic mesenchymal stem cells transplantations could not enhance therapeutic effect compared with single transplantation in systemic lupus erythematosus

Wang, D., Akiyama, K., Zhang, H., Yamaza, T., Li, X., Feng, X., Wang, H., Hua, B., Liu, B., Xu, H., Chen, W., Shi, S. & Sun, L., Aug 17 2012, In : Clinical and Developmental Immunology. 2012, 273291.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Lineage differentiation of mesenchymal stem cells from dental pulp, Apical Papilla, and periodontal ligament

Akiyama, K., Chen, C., Gronthos, S. & Shi, S., Jan 1 2012, Odontogenesis: Methods and Protocols. Humana Press Inc., p. 111-121 11 p. (Methods in Molecular Biology; vol. 887).

Research output: Chapter in Book/Report/Conference proceedingChapter

24 Citations (Scopus)

Mesenchymal-stem-cell-induced immunoregulation involves FAS-ligand-/FAS-mediated T cell apoptosis

Akiyama, K., Chen, C., Wang, D., Xu, X., Qu, C., Yamaza, T., Cai, T., Chen, W., Sun, L. & Shi, S., May 4 2012, In : Cell stem cell. 10, 5, p. 544-555 12 p.

Research output: Contribution to journalArticle

347 Citations (Scopus)

Stem cells in dentistry - Part I: Stem cell sources

Egusa, H., Sonoyama, W., Nishimura, M., Atsuta, I. & Akiyama, K., Jul 1 2012, In : Journal of Prosthodontic Research. 56, 3, p. 151-165 15 p.

Research output: Contribution to journalReview article

160 Citations (Scopus)

Stem cells in dentistry - Part II: Clinical applications

Egusa, H., Sonoyama, W., Nishimura, M., Atsuta, I. & Akiyama, K., Oct 1 2012, In : Journal of Prosthodontic Research. 56, 4, p. 229-248 20 p.

Research output: Contribution to journalReview article

93 Citations (Scopus)

Technetium-99 conjugated with methylene diphosphonate ameliorates ovariectomy-induced osteoporotic phenotype without causing osteonecrosis in the jaw

Zhao, Y., Wang, L., Liu, Y., Akiyama, K., Chen, C., Atsuta, I., Zhou, T., Duan, X., Jin, Y. & Shi, S., Dec 1 2012, In : Calcified Tissue International. 91, 6, p. 400-408 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2011

Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α

Liu, Y., Wang, L., Kikuiri, T., Akiyama, K., Chen, C., Xu, X., Yang, R., Chen, W. J., Wang, S. & Shi, S., Dec 1 2011, In : Nature Medicine. 17, 12, p. 1594-1601 8 p.

Research output: Contribution to journalArticle

348 Citations (Scopus)

Mouse mandible contains distinctive mesenchymal stem cells

Yamaza, T., Ren, G., Akiyama, K., Chen, C., Shi, Y. & Shi, S., Mar 1 2011, In : Journal of dental research. 90, 3, p. 317-324 8 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)
2010

Cell-based immunotherapy with mesenchymal stem cells cures bisphosphonate-related osteonecrosis of the jaw-like disease in mice

Kikuiri, T., Kim, I., Yamaza, T., Akiyama, K., Zhang, Q., Li, Y., Chen, C., Chen, W. J., Wang, S., Le, A. D. & Shi, S., Jul 1 2010, In : Journal of Bone and Mineral Research. 25, 7, p. 1668-1679 12 p.

Research output: Contribution to journalArticle

119 Citations (Scopus)

Immunomodulatory properties of stem cells from human exfoliated deciduous teeth

Yamaza, T., Kentaro, A., Chen, C., Liu, Y., Shi, Y., Gronthos, S., Wang, S. & Shi, S., Dec 1 2010, In : Stem Cell Research and Therapy. 1, 1, 5.

Research output: Contribution to journalArticle

170 Citations (Scopus)

Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors

Parsa, S., Kuremoto, K. I., Seidel, K., Tabatabai, R., MacKenzie, B. A., Yamaza, T., Akiyama, K., Branch, J., Koh, C. J., Al Alam, D., Klein, O. D. & Bellusci, S., Nov 15 2010, In : Development. 137, 22, p. 3743-3752 10 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Transplantation of umbilical cord mesenchymal stem cells alleviates lupus nephritis in MRL/lpr mice

Gu, Z., Akiyama, K., Ma, X., Zhang, H., Feng, X., Yao, G., Hou, Y., Lu, L., Gilkeson, G. S., Silver, R. M., Zeng, X., Shi, S. & Sun, L., Nov 1 2010, In : Lupus. 19, 13, p. 1502-1514 13 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Utility of PDL progenitors for in vivo tissue regeneration: A report of 3 cases

Feng, F., Akiyama, K., Liu, Y., Yamaza, T., Wang, T. M., Chen, J. H., Wang, B. B., Huang, G. T. J., Wang, S. & Shi, S., Jan 1 2010, In : Oral Diseases. 16, 1, p. 20-28 9 p.

Research output: Contribution to journalArticle

174 Citations (Scopus)
2009

Erratum: SHED repair critical-size calvarial defects in mice. (Oral Dis (2008) 14:(428-434))

Seo, B. M., Sonoyama, W., Yamaza, T., Coppe, C., Kikuiri, T., Akiyama, K., Lee, J. S. & Shi, S., May 1 2009, In : Oral Diseases. 15, 4, 1 p.

Research output: Contribution to journalComment/debate

Mesenchymal stem cell-mediated ectopic hematopoiesis alleviates aging-related phenotype in immunocompromised mice

Yamaza, T., Miura, Y., Akiyama, K., Bi, Y., Sonoyama, W., Gronthos, S., Chen, W., Le, A. & Shi, S., Mar 12 2009, In : Blood. 113, 11, p. 2595-2604 10 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans

Sun, L., Akiyama, K., Zhang, H., Yamaza, T., Hou, Y., Zhao, S., Xu, T., Le, A. & Shi, S., Jun 1 2009, In : Stem Cells. 27, 6, p. 1421-1432 12 p.

Research output: Contribution to journalArticle

388 Citations (Scopus)

Simvastatin Induces the Odontogenic Differentiation of Human Dental Pulp Stem Cells In Vitro and In Vivo

Okamoto, Y., Sonoyama, W., Ono, M., Akiyama, K., Fujisawa, T., Oshima, M., Tsuchimoto, Y., Matsuka, Y., Yasuda, T., Shi, S. & Kuboki, T., Mar 1 2009, In : Journal of Endodontics. 35, 3, p. 367-372 6 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)
2008

Is aspirin treatment an appropriate intervention for osteoporosis?

Yamaza, T., Akiyama, K. & Shi, S., Dec 1 2008, In : Future Rheumatology. 3, 6, p. 499-502 4 p.

Research output: Contribution to journalEditorial

11 Citations (Scopus)

Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents

Yamaza, T., Miura, Y., Bi, Y., Liu, Y., Akiyama, K., Sonoyama, W., Patel, V., Gutkind, S., Young, M., Gronthos, S., Le, A., Wang, C. Y., Chen, W. J. & Shi, S., Jul 9 2008, In : PloS one. 3, 7, e2615.

Research output: Contribution to journalArticle

119 Citations (Scopus)

Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN2

Ono, M., Kubota, S., Fujisawa, T., Sonoyama, W., Kawaki, H., Akiyama, K., Shimono, K., Oshima, M., Nishida, T., Yoshida, Y., Suzuki, K., Takigawa, M. & Kuboki, T., Jan 1 2008, In : Cell Transplantation. 17, 1-2, p. 231-240 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

SHED repair critical-size calvarial defects in mice

Seo, B. M., Sonoyama, W., Yamaza, T., Coppe, C., Kikuiri, T., Akiyama, K., Lee, J. S. & Shi, S., Jul 1 2008, In : Oral Diseases. 14, 5, p. 428-434 7 p.

Research output: Contribution to journalArticle

155 Citations (Scopus)