• 1773 Citations
  • 26 h-Index
1981 …2019
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Research Output 1981 2019

  • 1773 Citations
  • 26 h-Index
  • 145 Article
2019

Antiviral effect of sinefungin on in vitro growth of feline herpesvirus type 1

Kuroda, Y., Yamagata, H., Nemoto, M., Inagaki, K., Tamura, T. & Maeda, K., Dec 1 2019, In : Journal of Antibiotics. 72, 12, p. 981-985 5 p.

Research output: Contribution to journalArticle

sinefungin
Herpesviridae
Felidae
Antiviral Agents
Growth

Application of L-methionine γ-lyase in chiral amino acid analysis

Kato, S., Inagaki, K. & Oikawa, T., Sep 1 2019, In : Analytical Biochemistry. 580, p. 56-61 6 p.

Research output: Contribution to journalArticle

Lyases
Methionine
Amino Acids
Tryptophan
o-Phthalaldehyde

Development of Recombinant Methioninase for Cancer Treatment

Hoffman, R. M., Tan, Y., Li, S., Han, Q., Yagi, S., Takakura, T., Takimoto, A., Inagaki, K. & Kudou, D., Jan 1 2019, In : Methods in molecular biology (Clifton, N.J.). 1866, p. 107-131 25 p.

Research output: Contribution to journalArticle

Methionine
Neoplasms
Half-Life
Holoenzymes
Enzymes

Integrated transcriptomic and proteomic analyses of a molecular mechanism of radular teeth biomineralization in Cryptochiton stelleri

Nemoto, M., Ren, D., Herrera, S., Pan, S., Tamura, T., Inagaki, K. & Kisailus, D., Jan 29 2019, In : Scientific Reports. 9, 1, p. 856 856.

Research output: Contribution to journalArticle

Proteomics
Tooth
Polyplacophora
Proteins
Ferrosoferric Oxide
2017
1 Citation (Scopus)

Gene cloning, recombinant expression, purification and characterization of l-methionine decarboxylase from Streptomyces sp. 590

Hayashi, M., Okada, A., Yamamoto, K., Okugochi, T., Kusaka, C., Kudou, D., Nemoto, M., Inagaki, J., Hirose, Y., Okajima, T., Tamura, T., Soda, K. & Inagaki, K., Apr 1 2017, In : Journal of Biochemistry. 161, 4, p. 389-398 10 p.

Research output: Contribution to journalArticle

Cloning
Streptomyces
Purification
Organism Cloning
Genes

Structural and mechanistic insights into homocysteine degradation by a mutant of methionine γ-lyase based on substrate-assisted catalysis

Sato, D., Shiba, T., Yunoto, S., Furutani, K., Fukumoto, M., Kudou, D., Tamura, T., Inagaki, K. & Harada, S., Jun 1 2017, In : Protein Science. 26, 6, p. 1224-1230 7 p.

Research output: Contribution to journalArticle

Lyases
Homocysteine
Catalysis
Methionine
Degradation

The hyperthermophilic cystathionine c-synthase from the aerobic crenarchaeon Sulfolobus tokodaii: Expression, purification, crystallization and structural insights

Sato, D., Shiba, T., Mizuno, S., Kawamura, A., Hanada, S., Yamada, T., Shinozaki, M., Yanagitani, M., Tamura, T., Inagaki, K. & Harada, S., 2017, In : Acta Crystallographica Section:F Structural Biology Communications. 73, p. 152-158 7 p.

Research output: Contribution to journalArticle

Sulfolobus
Cystathionine
Pyridoxal Phosphate
Crystallization
purification
2016

A non-radioactive assay for selenophosphate synthetase activity using recombinant pyruvate pyrophosphate dikinase from thermus thermophilus HB8

Kamada, S., Okugochi, T., Asano, K., Tobe, R., Mihara, H., Nemoto, M., Inagaki, K. & Tamura, T., 2016, In : Bioscience, Biotechnology and Biochemistry. 80, 10, p. 1970-1972 3 p.

Research output: Contribution to journalArticle

Thermus thermophilus
Adenosine Monophosphate
Pyruvic Acid
Assays
Selenocysteine
2 Citations (Scopus)

Epistasis effects of multiple ancestral-consensus amino acid substitutions on the thermal stability of glycerol kinase from Cellulomonas sp. NT3060

Fukuda, Y., Abe, A., Tamura, T., Kishimoto, T., Sogabe, A., Akanuma, S., Yokobori, S. I., Yamagishi, A., Imada, K. & Inagaki, K., May 1 2016, In : Journal of Bioscience and Bioengineering. 121, 5, p. 497-502 6 p.

Research output: Contribution to journalArticle

Cellulomonas
Glycerol Kinase
Amino Acid Substitution
Glycerol
Amino acids
2 Citations (Scopus)

Identification and characterization of the zosA gene involved in copper uptake in Bacillus subtilis 168

Fukuhara, T., Kobayashi, K., Kanayama, Y., Enomoto, S. I., Kondo, T., Tsunekawa, N., Nemoto, M., Ogasawara, N., Inagaki, K. & Tamura, T., 2016, In : Bioscience, Biotechnology and Biochemistry. 80, 3, p. 600-609 10 p.

Research output: Contribution to journalArticle

Penicillamine
Bacilli
Bacillus subtilis
Copper
Genes
1 Citation (Scopus)

Molecular evolution of gas cavity in [NiFeSe] hydrogenases resurrected in silico

Tamura, T., Tsunekawa, N., Nemoto, M., Inagaki, K., Hirano, T. & Sato, F., Jan 28 2016, In : Scientific Reports. 6, 19742.

Research output: Contribution to journalArticle

Molecular Evolution
Computer Simulation
Gases
Selenocysteine
Oxygen
2015
1 Citation (Scopus)
1 Citation (Scopus)

Molecular cloning and characterization of l-methionine γ-lyase from Streptomyces avermitilis

Kudou, D., Yasuda, E., Hirai, Y., Tamura, T. & Inagaki, K., Oct 1 2015, In : Journal of Bioscience and Bioengineering. 120, 4, p. 380-383 4 p.

Research output: Contribution to journalArticle

Lyases
Cloning
Streptomyces
Molecular Cloning
Methionine
1 Citation (Scopus)

Reactivity of sorbose dehydrogenase from Sinorhizobium sp. 97507 for 1,5-anhydro-D-glucitol

Araki, T., Nakatsuka, T., Kobayashi, F., Watanabe-Ishimaru, E., Sanada, H., Tamura, T. & Inagaki, K., 2015, In : Bioscience, Biotechnology and Biochemistry. 79, 7, p. 1130-1132 3 p.

Research output: Contribution to journalArticle

Sinorhizobium
Sorbose
Sugar Alcohols
Sugars
Kinetics
8 Citations (Scopus)

Recombinant expression, molecular characterization and crystal structure of antitumor enzyme, L-lysine a-oxidase from Trichoderma viride

Amano, M., Mizuguchi, H., Sano, T., Kondo, H., Shinyashiki, K., Inagaki, J., Tamura, T., Kawaguchi, T., Kusakabe, H., Imada, K. & Inagaki, K., 2015, In : Journal of Biochemistry. 157, 6, p. 549-559 11 p.

Research output: Contribution to journalArticle

L-lysine oxidase
Trichoderma
Lysine
Oxidoreductases
Crystal structure
2014
1 Citation (Scopus)

Glycerol kinase from Cellulomonas sp. NT3060 which has high resistance against preservatives

Sogabe, A., Kitabayashi, M., Morishima, K., Furukawa, M., Hatta, T., Fukuda, Y., Nishise, H., Oka, M., Tamura, T. & Inagaki, K., 2014, In : Seibutsu-kogaku Kaishi. 92, 8, p. 402-409 8 p.

Research output: Contribution to journalArticle

glycerol kinase
Cellulomonas
Glycerol Kinase
preservatives
triacylglycerols

セルロモナスNT3060株の防腐剤耐性グリセロールキナーゼの遺伝子クローニングと特性解析

Translated title of the contribution: Glycerol kinase from Cellulomonas sp. NT3060 which has high resistance against preservatives曽我部敦, 北林雅夫, 森島賢一, 古川美代子, 八田貴, 福田靖久, 西瀬弘, 岡正則, Tamura, T. & Inagaki, K., Aug 25 2014, In : Seibutsu-kogaku Kaishi. 92, 8, p. 402-409 8 p.

Research output: Contribution to journalArticle

glycerol kinase
Cellulomonas
Glycerol Kinase
preservatives
triacylglycerols
2013
19 Citations (Scopus)

X-Ray crystallographic evidence for the presence of the cysteine tryptophylquinone cofactor in L-lysine ε-oxidase from Marinomonas mediterranea

Okazaki, S., Nakano, S., Matsui, D., Akaji, S., Inagaki, K. & Asano, Y., Sep 2013, In : Journal of Biochemistry. 154, 3, p. 233-236 4 p.

Research output: Contribution to journalArticle

L-lysine oxidase
Marinomonas
Lysine
X-Rays
X rays
2012
4 Citations (Scopus)

Arg305 of streptomyces l-glutamate oxidase plays a crucial role for substrate recognition

Utsumi, T., Arima, J., Sakaguchi, C., Tamura, T., Sasaki, C., Kusakabe, H., Sugio, S. & Inagaki, K., Jan 20 2012, In : Biochemical and Biophysical Research Communications. 417, 3, p. 951-955 5 p.

Research output: Contribution to journalArticle

Streptomyces
Glutamic Acid
Oxidoreductases
Substrates
Substrate Specificity
13 Citations (Scopus)

The role of amino acid residues in the active site of L-methionine γ-lyase from Pseudomonas putida

Ukumoto, M. F., Udou, D. K., Urano, S. M., Hiba, T. S., Sato, D., Tamura, T., Harada, S. & Inagaki, K., 2012, In : Bioscience, Biotechnology and Biochemistry. 76, 7, p. 1275-1284 10 p.

Research output: Contribution to journalArticle

Pseudomonas putida
Lyases
Methionine
Catalytic Domain
Substrate Specificity
2011
2 Citations (Scopus)
Selenocysteine
Thioredoxin-Disulfide Reductase
Orbital calculations
Molecular orbitals
Drosophila
9 Citations (Scopus)

Selenite reduction by the thioredoxin system: Kinetics and identification of protein-bound selenide

Tamura, T., Sato, K., Komori, K., Imai, T., Kuwahara, M., Okugochi, T., Mihara, H., Esaki, N. & Inagaki, K., 2011, In : Bioscience, Biotechnology and Biochemistry. 75, 6, p. 1184-1187 4 p.

Research output: Contribution to journalArticle

Selenious Acid
Thioredoxins
Thioredoxin-Disulfide Reductase
Selenium
Kinetics
13 Citations (Scopus)
sinefungin
Streptomyces
Nucleosides
Mutation
Rifampin
2009
31 Citations (Scopus)

Structural characterization of L-glutamate oxidase from Streptomyces sp. X-119-6.

Arima, J., Sasaki, C., Sakaguchi, C., Mizuno, H., Tamura, T., Kashima, A., Kusakabe, H., Sugio, S. & Inagaki, K., Jul 2009, In : FEBS Journal. 276, 14, p. 3894-3903 10 p.

Research output: Contribution to journalArticle

L-glutamate oxidase
Streptomyces
L-Amino Acid Oxidase
Catalytic Domain
Glutamic Acid
2008
19 Citations (Scopus)

Selenite assimilation into formate dehydrogenase H depends on thioredoxin reductase in Escherichia coli

Takahata, M., Tamura, T., Abe, K., Mihara, H., Kurokawa, S., Yamamoto, Y., Nakano, R., Esaki, N. & Inagaki, K., Apr 2008, In : Journal of Biochemistry. 143, 4, p. 467-473 7 p.

Research output: Contribution to journalArticle

formic acid
Thioredoxin-Disulfide Reductase
Selenious Acid
Escherichia coli
Glutathione Reductase
16 Citations (Scopus)

Structure and quantum chemical analysis of NAD+-dependent isocitrate dehydrogenase: Hydride transfer and co-factor specificity

Imada, K., Tamura, T., Takenaka, R., Kobayashi, I., Namba, K. & Inagaki, K., Jan 2008, In : Proteins: Structure, Function and Genetics. 70, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

Transfer Factor
Isocitrate Dehydrogenase
Hydrides
NAD
Chemical analysis
26 Citations (Scopus)

The role of cysteine 116 in the active site of the antitumor enzyme L-methionine γ-lyase from Pseudomonas putida

Kudou, D., Misaki, S., Yamashita, M., Tamura, T., Esaki, N. & Inagaki, K., 2008, In : Bioscience, Biotechnology and Biochemistry. 72, 7, p. 1722-1730 9 p.

Research output: Contribution to journalArticle

Pseudomonas putida
Lyases
lyases
active sites
Methionine

Structural and functional analysis of the antitumor enzyme L- methionine γ-lyase

Kudou, D. & Inagaki, K., 2007, In : Seikagaku. The Journal of Japanese Biochemical Society. 79, 7, p. 682-686 5 p.

Research output: Contribution to journalArticle

Carbon-Sulfur Lyases
Protein Conformation
Pseudomonas putida
Molecular Evolution
Drug Design
52 Citations (Scopus)

Structure of the antitumour enzyme L-methionine γ-lyase from Pseudomonas putida at 1.8 Å resolution

Kudou, D., Misaki, S., Yamashita, M., Tamura, T., Takakura, T., Yoshioka, T., Yagi, S., Hoffman, R. M., Takimoto, A., Esaki, N. & Inagaki, K., Apr 2007, In : Journal of Biochemistry. 141, 4, p. 535-544 10 p.

Research output: Contribution to journalArticle

Pseudomonas putida
Lyases
Pyridoxal Phosphate
Methionine
R388
2006
27 Citations (Scopus)

Characterization of monofunctional catalase KatA from radioresistant bacterium Deinococcus radiodurans

Kobayashi, I., Tamura, T., Sghaier, H., Narumi, I., Yamaguchi, S., Umeda, K. & Inagaki, K., Apr 2006, In : Journal of Bioscience and Bioengineering. 101, 4, p. 315-321 7 p.

Research output: Contribution to journalArticle

Deinococcus
Catalase
Bacteria
Sodium
Cloning
51 Citations (Scopus)

Effects of the principal nutrients on lovastatin production by Monascus pilosus

Miyake, T., Uchitomi, K., Zhang, M. Y., Kono, I., Nozaki, N., Sammoto, H. & Inagaki, K., 2006, In : Bioscience, Biotechnology and Biochemistry. 70, 5, p. 1154-1159 6 p.

Research output: Contribution to journalArticle

Monascus pilosus
Monascus
lovastatin
Lovastatin
Nutrients
42 Citations (Scopus)

High-level expression and bulk crystallization of recombinant L-methionine γ-lyase, an anticancer agent

Takakura, T., Ito, T., Yagi, S., Notsu, Y., Itakura, T., Nakamura, T., Inagaki, K., Esaki, N., Hoffman, R. M. & Takimoto, A., Mar 2006, In : Applied Microbiology and Biotechnology. 70, 2, p. 183-192 10 p.

Research output: Contribution to journalArticle

Lyases
Crystallization
Methionine
Antineoplastic Agents
Enzymes
15 Citations (Scopus)

Performance characterization of recombinant l-glutamate oxidase in a micro GOT/GPT sensing system

Upadhyay, S., Ohgami, N., Kusakabe, H., Mizuno, H., Arima, J., Tamura, T., Inagaki, K. & Suzuki, H., Dec 7 2006, In : Sensors and Actuators, B: Chemical. 119, 2, p. 570-576 7 p.

Research output: Contribution to journalArticle

glutamates
oxidase
Aspartate Aminotransferases
Alanine Transaminase
Glutamic Acid
24 Citations (Scopus)

Physicochemical and pharmacokinetic characterization of highly potent recombinant L-methionine γ-lyase conjugated with polyethylene glycol as an antitumor agent

Takakura, T., Takimoto, A., Notsu, Y., Yoshida, H., Ito, T., Nagatome, H., Ohno, M., Kobayashi, Y., Yoshioka, T., Inagaki, K., Yagi, S., Hoffman, R. M. & Esaki, N., Mar 1 2006, In : Cancer Research. 66, 5, p. 2807-2814 8 p.

Research output: Contribution to journalArticle

Lyases
Methionine
Antineoplastic Agents
Pyridoxal Phosphate
Pharmacokinetics
1 Citation (Scopus)

The crystal structure of hypothetical methyltransferase from Thermus thermophilus HB8

Sasaki, C., Sugiura, I., Ebihara, A., Tamura, T., Sugio, S. & Inagaki, K., Aug 1 2006, In : Proteins: Structure, Function and Genetics. 64, 2, p. 552-557 6 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Thermus thermophilus
Secondary Protein Structure
Protein Conformation
Molecular Models

染料脱色微生物による染料脱色機構の解析

Inagaki, K., 2006, In : 岡山大学農学部学術報告. 95, p. 1-5 5 p.

Research output: Contribution to journalArticle

2005

ヒト肺がん細胞のセレノリン酸合成酵素Sps1, Sps2の機能解析

Inagaki, K., 2005, In : Trace Nutrients Res.. 22, p. 147-152 6 p.

Research output: Contribution to journalArticle

2004
31 Citations (Scopus)

Assay method for antitumor L-methionine γ-lyase: Comprehensive kinetic analysis of the complex reaction with L-methionine

Takakura, T., Mitsushima, K., Yagi, S., Inagaki, K., Tanaka, H., Esaki, N., Soda, K. & Takimoto, A., Apr 15 2004, In : Analytical Biochemistry. 327, 2, p. 233-240 8 p.

Research output: Contribution to journalArticle

Lyases
Methionine
Assays
Enzyme kinetics
Pyridoxal Phosphate
65 Citations (Scopus)

Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation

Tamura, T., Yamamoto, S., Takahata, M., Sakaguchi, H., Tanaka, H., Stadtman, T. C. & Inagaki, K., Nov 16 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 46, p. 16162-16167 6 p.

Research output: Contribution to journalArticle

Selenocysteine
Selenious Acid
Recycling
Selenium
selenocysteine lyase