• 735 Citations
  • 17 h-Index
19982020

Research output per year

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Research Output

  • 735 Citations
  • 17 h-Index
  • 54 Article
  • 1 Review article
2020

Structure Optimization of Gatastatin for the Development of γ-Tubulin-Specific Inhibitor

Shintani, K., Ebisu, H., Mukaiyama, M., Hatanaka, T., Chinen, T., Takao, D., Nagumo, Y., Sakakura, A., Hayakawa, I., Usui, T. & Usui, T., Jun 11 2020, In : ACS Medicinal Chemistry Letters. 11, 6, p. 1125-1129 5 p.

Research output: Contribution to journalArticle

2019

Catalytic enantioselective Hosomi-Sakurai reaction of α-ketoesters promoted by chiral copper(ii) complexes

Niwa, Y., Miyake, M., Hayakawa, I. & Sakakura, A., 2019, In : Chemical Communications. 55, 27, p. 3923-3926 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Structure-activity relationship study of gatastatin based on the TOPLISS tree approach

Hayakawa, I., Shioda, S., Chinen, T., Usui, T. & Kigoshi, H., Jan 1 2019, In : Heterocycles. p. 238-247 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Toward the Synthesis of SB-203207: Construction of Four Contiguous Nitrogen-Containing Stereogenic Centers

Hayakawa, I., Nagayasu, A. & Sakakura, A., Jan 1 2019, (Accepted/In press) In : Journal of Organic Chemistry.

Research output: Contribution to journalArticle

Toward the Synthesis of Yuzurimine-Type Alkaloids: Stereoselective Construction of the Heterocyclic Portions of Deoxyyuzurimine and Macrodaphnine

Hayakawa, I., Nagatani, R., Ikeda, M., Yoo, D. E., Saito, K., Kigoshi, H. & Sakakura, A., Aug 16 2019, In : Organic Letters. 21, 16, p. 6337-6341 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2018

Development of a novel inducer of protein-protein interactions based on aplyronine A

Ohyoshi, T., Takano, A., Namiki, M., Ogura, T., Miyazaki, Y., Ebihara, Y., Takeno, K., Hayakawa, I. & Kigoshi, H., Jan 1 2018, In : Chemical Communications. 54, 68, p. 9537-9540 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

Regioselective dmad-insertion reaction of silyl dienol ether of γ-pyrone under catalyst- and heating-free conditions

Hayakawa, I., Yamanaka, Y., Mitsudo, K., Ota, H. & Sakakura, A., Jan 1 2017, In : Heterocycles. 94, 12, p. 2299-2306 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Second-generation total synthesis of aplyronine A featuring Ni/Cr-mediated coupling reactions

Hayakawa, I., Saito, K., Matsumoto, S., Kobayashi, S., Taniguchi, A., Kobayashi, K., Fujii, Y., Kaneko, T. & Kigoshi, H., 2017, In : Organic and Biomolecular Chemistry. 15, 1, p. 124-131 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Stimulation of microtubule-based transport by nucleation of microtubules on pigment granules

Semenova, I., Gupta, D., Usui, T., Hayakawa, I., Cowan, A. & Rodionov, V., Jun 1 2017, In : Molecular Biology of the Cell. 28, 11, p. 1418-1425 8 p.

Research output: Contribution to journalArticle

Total Synthesis of Biselide A, A Cytotoxic Macrolide of Marine Origin

Hayakawa, I., Okamura, M., Suzuki, K., Shimanuki, M., Kimura, K., Yamada, T., Ohyoshi, T. & Kigoshi, H., Jul 3 2017, In : Synthesis (Germany). 49, 13, p. 2958-2970 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Total Synthesis of Biselide E, a Marine Polyketide

Hayakawa, I., Suzuki, K., Okamura, M., Funakubo, S., Onozaki, Y., Kawamura, D., Ohyoshi, T. & Kigoshi, H., Oct 20 2017, In : Organic Letters. 19, 20, p. 5713-5716 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2016

Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization

Hayakawa, I., Shioda, S., Chinen, T., Hatanaka, T., Ebisu, H., Sakakura, A., Usui, T. & Kigoshi, H., Jan 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 21, p. 5639-5645 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Total synthesis of natural derivatives and artificial analogs of 13-oxyingenol and their biological evaluation

Ohyoshi, T., Tamura, Y., Hayakawa, I., Hirai, G., Miyazawa, Y., Funakubo, S., Sodeoka, M. & Kigoshi, H., 2016, In : Organic and Biomolecular Chemistry. 14, 48, p. 11426-11437 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2015

Construction of the [6-7-5-5] tetracyclic core of all the carbocyclic frameworks of yuzurimine-type alkaloids

Hayakawa, I., Niida, K. & Kigoshi, H., Jul 25 2015, In : Chemical Communications. 51, 58, p. 11568-11571 4 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Recent progress in the synthetic study of an antitumor marine macrolide aplyronine A and related molecules

Hayakawa, I. & Kigoshi, H. K., Jan 1 2015, In : Heterocycles. 91, 6, p. 1137-1155 19 p.

Research output: Contribution to journalReview article

4 Citations (Scopus)

Synthesis and structure-activity relationships for cytotoxicity and apoptosis-inducing activity of (+)-halichonine B

Hayakawa, I., Nakamura, T., Ohno, O., Suenaga, K. & Kigoshi, H., Aug 11 2015, In : Organic and Biomolecular Chemistry. 13, 39, p. 9969-9976 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The γ-tubulin-specific inhibitor gatastatin reveals temporal requirements of microtubule nucleation during the cell cycle

Chinen, T., Liu, P., Shioda, S., Pagel, J., Cerikan, B., Lin, T. C., Gruss, O., Hayashi, Y., Takeno, H., Shima, T., Okada, Y., Hayakawa, I., Hayashi, Y., Kigoshi, H., Usui, T. & Schiebel, E., Oct 27 2015, In : Nature communications. 6, 8722.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2014
1 Citation (Scopus)

Practical synthesis of glaziovianin A, a cytotoxic isoflavone, and its O7-propargyl analogue

Hayakawa, I., Shioda, S., Ikedo, A. & Kigoshi, H., 2014, In : Bulletin of the Chemical Society of Japan. 87, 4, p. 544-549 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

生物活性天然物の全合成を起点とした生体機能分子創製への展開

Hayakawa, I., 2014, In : 有機合成化学協会誌. 72, 2, p. 126-136 11 p.

Research output: Contribution to journalArticle

2013

Glaziovianin a prevents endosome maturation via inhibiting microtubule dynamics

Chinen, T., Kazami, S., Nagumo, Y., Hayakawa, I., Ikedo, A., Takagi, M., Yokosuka, A., Imamoto, N., Mimaki, Y., Kigoshi, H., Osada, H. & Usui, T., May 17 2013, In : ACS Chemical Biology. 8, 5, p. 884-889 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2012

Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone

Hayakawa, I., Ikedo, A., Chinen, T., Usui, T. & Kigoshi, H., Oct 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 19, p. 5745-5756 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Design, synthesis, and biological evaluations of aplyronine A-mycalolide B hybrid compound

Kobayashi, K., Fujii, Y., Hirayama, Y., Kobayashi, S., Hayakawa, I. & Kigoshi, H., Mar 2 2012, In : Organic Letters. 14, 5, p. 1290-1293 4 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Synthetic studies toward biselides. Part 1: Synthesis of the core carbon framework of biselides A, B, and e using Stille coupling

Satoh, Y., Kawamura, D., Yamaura, M., Ikeda, Y., Ochiai, Y., Hayakawa, I. & Kigoshi, H., Mar 14 2012, In : Tetrahedron Letters. 53, 11, p. 1390-1392 3 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Synthetic studies toward biselides. Part 2: Synthesis of the macrolactone part of biselides A and B using allylic oxidation

Satoh, Y., Yamada, T., Onozaki, Y., Kawamura, D., Hayakawa, I. & Kigoshi, H., Mar 14 2012, In : Tetrahedron Letters. 53, 11, p. 1393-1396 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Total synthesis and biological evaluation of auripyrones A and B

Hayakawa, I., Takemura, T., Fukasawa, E., Ebihara, Y., Sato, N., Nakamura, T., Suenaga, K. & Kigoshi, H., Oct 29 2012, In : Bulletin of the Chemical Society of Japan. 85, 10, p. 1077-1092 16 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Total synthesis of (-)-13-oxyingenol and its natural derivative

Ohyoshi, T., Funakubo, S., Miyazawa, Y., Niida, K., Hayakawa, I. & Kigoshi, H., May 14 2012, In : Angewandte Chemie - International Edition. 51, 20, p. 4972-4975 4 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Toward the synthesis of γ-pyrone-containing natural products: Diastereoselective aldol-type reaction of a γ-pyrone

Takemura, T., Hayakawa, I., Fukasawa, E., Sengoku, T. & Kigoshi, H., Aug 12 2012, In : Tetrahedron. 68, 32, p. 6477-6484 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2011

Synthetic studies toward 13-Oxyingenol: Construction of the fully substituted tetracyclic compound

Ohyoshi, T., Miyazawa, Y., Aoki, K., Ohmura, S., Asuma, Y., Hayakawa, I. & Kigoshi, H., May 6 2011, In : Organic Letters. 13, 9, p. 2160-2163 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Synthetic studies towards optically active 13-oxyingenol via asymmetric cyclopropanation

Hayakawa, I., Miyazawa, Y., Ohyoshi, T., Asuma, Y., Aoki, K. & Kigoshi, H., Feb 2 2011, In : Synthesis. 5, p. 769-777 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Toward the second generation synthesis of aplyronine A: Stereocontrolled assembly of the C1-C19 segment by using an asymmetric Nozaki-Hiyama-Kishi coupling

Kobayashi, K., Fujii, Y., Hayakawa, I. & Kigoshi, H., Mar 4 2011, In : Organic Letters. 13, 5, p. 900-903 4 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2010

Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells

Ikedo, A., Hayakawa, I., Usui, T., Kazami, S., Osada, H. & Kigoshi, H., Sep 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 18, p. 5402-5404 3 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
4 Citations (Scopus)

Total synthesis of auripyrones A and B and determination of the absolute configuration of auripyrone B

Hayakawa, I., Takemura, T., Fukasawa, E., Ebihara, Y., Sato, N., Nakamura, T., Suenaga, K. & Kigoshi, H., Mar 22 2010, In : Angewandte Chemie - International Edition. 49, 13, p. 2401-2405 5 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2009

Aldol-type reaction of a 4-pyrone: a straightforward approach to 4-pyrone-containing natural products

Sengoku, T., Takemura, T., Fukasawa, E., Hayakawa, I. & Kigoshi, H., Jan 21 2009, In : Tetrahedron Letters. 50, 3, p. 325-328 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Practical syntheses of enantiomerically pure key intermediates of opioid receptor-like 1 (ORL1) antagonists

Yoshizumi, T., Ohno, A., Tsujita, T., Takahashi, H., Okamoto, O., Hayakawa, I. & Kigoshi, H., Apr 1 2009, In : Synthesis. 7, p. 1153-1162 10 p., F22608SS.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Total synthesis and cytotoxicity of haterumalides NA and B and their artificial analogues

Ueda, M., Yamaura, M., Ikeda, Y., Suzuki, Y., Yoshizato, K., Hayakawa, I. & Kigoshi, H., May 1 2009, In : Journal of Organic Chemistry. 74, 9, p. 3370-3377 8 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2008

Second-generation total synthesis of haterumalide NA using B-alkyl Suzuki-Miyaura coupling

Hayakawa, I., Ueda, M., Yamaura, M., Ikeda, Y., Suzuki, Y., Yoshizato, K. & Kigoshi, H., May 1 2008, In : Organic Letters. 10, 9, p. 1859-1862 4 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Structure of zamamistatin-a correction

Kita, M., Tsunematsu, Y., Hayakawa, I. & Kigoshi, H., Sep 8 2008, In : Tetrahedron Letters. 49, 37, p. 5383-5384 2 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Synthesis of ustalic acid, an inhibitor of Na+,K+-ATPase

Hayakawa, I., Watanabe, H. & Kigoshi, H., Jun 16 2008, In : Tetrahedron. 64, 25, p. 5873-5877 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2007

Development of practical synthesis of halichondrins

Hayakawa, I., Dec 2007, In : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 65, 12, p. 1225-1226 2 p.

Research output: Contribution to journalArticle

Open Access

Marine cytotoxic macrolides haterumalides and biselides, and related natural products

Kigoshi, H. & Hayakawa, I., Oct 4 2007, In : Chemical Record. 7, 4, p. 254-264 11 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Synthesis of glaziovianin A: A potent antitumor isoflavone

Hayakawa, I., Ikedo, A. & Kigoshi, H., Nov 5 2007, In : Chemistry Letters. 36, 11, p. 1382-1383 2 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Synthetic studies on mycalolide B: Synthesis of the C7-C35 fragment

Kimura, T., Kuribayashi, S., Sengoku, T., Matsui, K., Ueda, S., Hayakawa, I., Suenaga, K. & Kigoshi, H., Dec 5 2007, In : Chemistry Letters. 36, 12, p. 1490-1491 2 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Synthetic study on 13-oxyingenol: construction of the full carbon framework

Hayakawa, I., Asuma, Y., Ohyoshi, T., Aoki, K. & Kigoshi, H., Aug 27 2007, In : Tetrahedron Letters. 48, 35, p. 6221-6224 4 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2006

Enantioselective synthesis of aurisides A and B, cytotoxic macrolide glycosides of marine origin

Suenaga, K., Hoshino, H., Yoshii, T., Mori, K., Sone, H., Bessho, Y., Sakakura, A., Hayakawa, I., Yamada, K. & Kigoshi, H., Aug 14 2006, In : Tetrahedron. 62, 33, p. 7687-7698 12 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Revised structure of zamamistatin

Hayakawa, I., Teruya, T. & Kigoshi, H., Jan 9 2006, In : Tetrahedron Letters. 47, 2, p. 155-158 4 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)