• 712 Citations
  • 16 h-Index
19982019
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Research Output 1998 2019

  • 712 Citations
  • 16 h-Index
  • 54 Article
2019
1 Citation (Scopus)

Catalytic enantioselective Hosomi-Sakurai reaction of α-ketoesters promoted by chiral copper(ii) complexes

Niwa, Y., Miyake, M., Hayakawa, I. & Sakakura, A., Jan 1 2019, In : Chemical Communications. 55, 27, p. 3923-3926 4 p.

Research output: Contribution to journalArticle

Bearings (structural)
Silanes
Enantioselectivity
Copper
Catalyst activity

Structure-activity relationship study of gatastatin based on the TOPLISS tree approach

Hayakawa, I., Shioda, S., Chinen, T., Usui, T. & Kigoshi, H., Jan 1 2019, In : Heterocycles. p. 238-247 10 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Tubulin
Cytotoxicity
Tubulin Modulators
Derivatives

Toward the Synthesis of SB-203207: Construction of Four Contiguous Nitrogen-Containing Stereogenic Centers

Hayakawa, I., Nagayasu, A. & Sakakura, A., Jan 1 2019, (Accepted/In press) In : Journal of Organic Chemistry.

Research output: Contribution to journalArticle

Isoleucine-tRNA Ligase
Nitrogen
Carbon
Cyclopentanes
Alkylation
2 Citations (Scopus)

Toward the Synthesis of Yuzurimine-Type Alkaloids: Stereoselective Construction of the Heterocyclic Portions of Deoxyyuzurimine and Macrodaphnine

Hayakawa, I., Nagatani, R., Ikeda, M., Yoo, D. E., Saito, K., Kigoshi, H. & Sakakura, A., Aug 16 2019, In : Organic Letters. 21, 16, p. 6337-6341 5 p.

Research output: Contribution to journalArticle

alkaloids
Alkaloids
Oxidation
synthesis
hydroboration
2018
1 Citation (Scopus)

Development of a novel inducer of protein-protein interactions based on aplyronine A

Ohyoshi, T., Takano, A., Namiki, M., Ogura, T., Miyazaki, Y., Ebihara, Y., Takeno, K., Hayakawa, I. & Kigoshi, H., Jan 1 2018, In : Chemical Communications. 54, 68, p. 9537-9540 4 p.

Research output: Contribution to journalArticle

Proteins
Actins
Cytotoxicity
Bioactivity
Tubulin
2017

Regioselective dmad-insertion reaction of silyl dienol ether of γ-pyrone under catalyst- and heating-free conditions

Hayakawa, I., Yamanaka, Y., Mitsudo, K., Ota, H. & Sakakura, A., Jan 1 2017, In : Heterocycles. 94, 12, p. 2299-2306 8 p.

Research output: Contribution to journalArticle

Pyrones
Ether
Heating
Catalysts
Cycloaddition
3 Citations (Scopus)
Pyrones
Cyclization
Biomimetics
Esters
Transesterification
4 Citations (Scopus)

Second-generation total synthesis of aplyronine A featuring Ni/Cr-mediated coupling reactions

Hayakawa, I., Saito, K., Matsumoto, S., Kobayashi, S., Taniguchi, A., Kobayashi, K., Fujii, Y., Kaneko, T. & Kigoshi, H., 2017, In : Organic and Biomolecular Chemistry. 15, 1, p. 124-131 8 p.

Research output: Contribution to journalArticle

synthesis
Stereoselectivity
Macrolides
aplyronine A

Stimulation of microtubule-based transport by nucleation of microtubules on pigment granules

Semenova, I., Gupta, D., Usui, T., Hayakawa, I., Cowan, A. & Rodionov, V., Jun 1 2017, In : Molecular Biology of the Cell. 28, 11, p. 1418-1425 8 p.

Research output: Contribution to journalArticle

Microtubules
Centrosome
Tubulin Modulators
Melanophores
Tubulin
3 Citations (Scopus)

Total Synthesis of Biselide A, A Cytotoxic Macrolide of Marine Origin

Hayakawa, I., Okamura, M., Suzuki, K., Shimanuki, M., Kimura, K., Yamada, T., Ohyoshi, T. & Kigoshi, H., Jul 3 2017, In : Synthesis (Germany). 49, 13, p. 2958-2970 13 p.

Research output: Contribution to journalArticle

Macrolides
Functional groups
Oxygen
Enzymatic hydrolysis
3-hydroxybutanal
2 Citations (Scopus)

Total Synthesis of Biselide E, a Marine Polyketide

Hayakawa, I., Suzuki, K., Okamura, M., Funakubo, S., Onozaki, Y., Kawamura, D., Ohyoshi, T. & Kigoshi, H., Oct 20 2017, In : Organic Letters. 19, 20, p. 5713-5716 4 p.

Research output: Contribution to journalArticle

Polyketides
Urochordata
Lactones
synthesis
elimination
2016
4 Citations (Scopus)

Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization

Hayakawa, I., Shioda, S., Chinen, T., Hatanaka, T., Ebisu, H., Sakakura, A., Usui, T. & Kigoshi, H., 2016, In : Bioorganic and Medicinal Chemistry. 24, 21, p. 5639-5645 7 p.

Research output: Contribution to journalArticle

Tubulin Modulators
Colchicine
Tubulin
Microtubules
Polymerization
2 Citations (Scopus)

Total synthesis of natural derivatives and artificial analogs of 13-oxyingenol and their biological evaluation

Ohyoshi, T., Tamura, Y., Hayakawa, I., Hirai, G., Miyazawa, Y., Funakubo, S., Sodeoka, M. & Kigoshi, H., 2016, In : Organic and Biomolecular Chemistry. 14, 48, p. 11426-11437 12 p.

Research output: Contribution to journalArticle

Protein Kinase C
analogs
Derivatives
proteins
evaluation
2015
14 Citations (Scopus)

Construction of the [6-7-5-5] tetracyclic core of all the carbocyclic frameworks of yuzurimine-type alkaloids

Hayakawa, I., Niida, K. & Kigoshi, H., Jul 25 2015, In : Chemical Communications. 51, 58, p. 11568-11571 4 p.

Research output: Contribution to journalArticle

Alkaloids
Cyclization
4 Citations (Scopus)

Recent progress in the synthetic study of an antitumor marine macrolide aplyronine A and related molecules

Hayakawa, I. & Kigoshi, H. K., 2015, In : Heterocycles. 91, 6, p. 1137-1155 19 p.

Research output: Contribution to journalArticle

Macrolides
Molecules
Bioactivity
Molecular Structure
Molecular structure
2 Citations (Scopus)

Synthesis and structure-activity relationships for cytotoxicity and apoptosis-inducing activity of (+)-halichonine B

Hayakawa, I., Nakamura, T., Ohno, O., Suenaga, K. & Kigoshi, H., Aug 11 2015, In : Organic and Biomolecular Chemistry. 13, 39, p. 9969-9976 8 p.

Research output: Contribution to journalArticle

apoptosis
Structure-Activity Relationship
Cytotoxicity
Cells
analogs
23 Citations (Scopus)

The γ-tubulin-specific inhibitor gatastatin reveals temporal requirements of microtubule nucleation during the cell cycle

Chinen, T., Liu, P., Shioda, S., Pagel, J., Cerikan, B., Lin, T. C., Gruss, O., Hayashi, Y., Takeno, H., Shima, T., Okada, Y., Hayakawa, I., Hayashi, Y., Kigoshi, H., Usui, T. & Schiebel, E., Oct 27 2015, In : Nature Communications. 6, 8722.

Research output: Contribution to journalArticle

Tubulin Modulators
spindles
Tubulin
Microtubules
inhibitors
2014
1 Citation (Scopus)
Biological Products
Lead compounds
Molecules
Alkenes
Bioactivity
3 Citations (Scopus)

Practical synthesis of glaziovianin A, a cytotoxic isoflavone, and its O7-propargyl analogue

Hayakawa, I., Shioda, S., Ikedo, A. & Kigoshi, H., 2014, In : Bulletin of the Chemical Society of Japan. 87, 4, p. 544-549 6 p.

Research output: Contribution to journalArticle

Isoflavones
Cells
glaziovianin A

生物活性天然物の全合成を起点とした生体機能分子創製への展開

Hayakawa, I., 2014, In : 有機合成化学協会誌. 72, 2, p. 126-136 11 p.

Research output: Contribution to journalArticle

2013
12 Citations (Scopus)

Glaziovianin a prevents endosome maturation via inhibiting microtubule dynamics

Chinen, T., Kazami, S., Nagumo, Y., Hayakawa, I., Ikedo, A., Takagi, M., Yokosuka, A., Imamoto, N., Mimaki, Y., Kigoshi, H., Osada, H. & Usui, T., May 17 2013, In : ACS Chemical Biology. 8, 5, p. 884-889 6 p.

Research output: Contribution to journalArticle

Endosomes
Microtubules
Chemical activation
Tubulin
Epidermal Growth Factor
2012
16 Citations (Scopus)

Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone

Hayakawa, I., Ikedo, A., Chinen, T., Usui, T. & Kigoshi, H., Oct 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 19, p. 5745-5756 12 p.

Research output: Contribution to journalArticle

Isoflavones
HeLa Cells
Molecular Probes
Cytotoxicity
Bioactivity
22 Citations (Scopus)

Design, synthesis, and biological evaluations of aplyronine A-mycalolide B hybrid compound

Kobayashi, K., Fujii, Y., Hirayama, Y., Kobayashi, S., Hayakawa, I. & Kigoshi, H., Mar 2 2012, In : Organic Letters. 14, 5, p. 1290-1293 4 p.

Research output: Contribution to journalArticle

Cytotoxicity
evaluation
Actins
synthesis
activity (biology)
4 Citations (Scopus)

Synthetic studies toward biselides. Part 1: Synthesis of the core carbon framework of biselides A, B, and e using Stille coupling

Satoh, Y., Kawamura, D., Yamaura, M., Ikeda, Y., Ochiai, Y., Hayakawa, I. & Kigoshi, H., Mar 14 2012, In : Tetrahedron Letters. 53, 11, p. 1390-1392 3 p.

Research output: Contribution to journalArticle

Oxidative Coupling
Polyketides
Lactones
Carbon
C 15
5 Citations (Scopus)

Synthetic studies toward biselides. Part 2: Synthesis of the macrolactone part of biselides A and B using allylic oxidation

Satoh, Y., Yamada, T., Onozaki, Y., Kawamura, D., Hayakawa, I. & Kigoshi, H., Mar 14 2012, In : Tetrahedron Letters. 53, 11, p. 1393-1396 4 p.

Research output: Contribution to journalArticle

Polyketides
Oxidation
4 Citations (Scopus)

Total synthesis and biological evaluation of auripyrones A and B

Hayakawa, I., Takemura, T., Fukasawa, E., Ebihara, Y., Sato, N., Nakamura, T., Suenaga, K. & Kigoshi, H., 2012, In : Bulletin of the Chemical Society of Japan. 85, 10, p. 1077-1092 16 p.

Research output: Contribution to journalArticle

Cytotoxicity
Pyrones
Cell proliferation
Cells
auripyrone A
30 Citations (Scopus)

Total synthesis of (-)-13-oxyingenol and its natural derivative

Ohyoshi, T., Funakubo, S., Miyazawa, Y., Niida, K., Hayakawa, I. & Kigoshi, H., May 14 2012, In : Angewandte Chemie - International Edition. 51, 20, p. 4972-4975 4 p.

Research output: Contribution to journalArticle

Derivatives
Diterpenes
Alkenes
Olefins
13-oxyingenol
5 Citations (Scopus)

Toward the synthesis of γ-pyrone-containing natural products: Diastereoselective aldol-type reaction of a γ-pyrone

Takemura, T., Hayakawa, I., Fukasawa, E., Sengoku, T. & Kigoshi, H., Aug 12 2012, In : Tetrahedron. 68, 32, p. 6477-6484 8 p.

Research output: Contribution to journalArticle

Pyrones
Biological Products
Ether
Anions
Sodium
2011
14 Citations (Scopus)

Synthetic studies toward 13-Oxyingenol: Construction of the fully substituted tetracyclic compound

Ohyoshi, T., Miyazawa, Y., Aoki, K., Ohmura, S., Asuma, Y., Hayakawa, I. & Kigoshi, H., May 6 2011, In : Organic Letters. 13, 9, p. 2160-2163 4 p.

Research output: Contribution to journalArticle

human immunodeficiency virus
metathesis
closing
musculoskeletal system
alkenes
7 Citations (Scopus)

Synthetic studies towards optically active 13-oxyingenol via asymmetric cyclopropanation

Hayakawa, I., Miyazawa, Y., Ohyoshi, T., Asuma, Y., Aoki, K. & Kigoshi, H., 2011, In : Synthesis. 5, p. 769-777 9 p.

Research output: Contribution to journalArticle

13-oxyingenol
20 Citations (Scopus)

Toward the second generation synthesis of aplyronine A: Stereocontrolled assembly of the C1-C19 segment by using an asymmetric Nozaki-Hiyama-Kishi coupling

Kobayashi, K., Fujii, Y., Hayakawa, I. & Kigoshi, H., Mar 4 2011, In : Organic Letters. 13, 5, p. 900-903 4 p.

Research output: Contribution to journalArticle

assembly
synthesis
aplyronine A
2010
15 Citations (Scopus)

Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells

Ikedo, A., Hayakawa, I., Usui, T., Kazami, S., Osada, H. & Kigoshi, H., Sep 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 18, p. 5402-5404 3 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
HeLa Cells
Cell Cycle
Cells
Derivatives
4 Citations (Scopus)
Cytotoxicity
Macrolides
Stereochemistry
Esters
Animals
18 Citations (Scopus)

Total synthesis of auripyrones A and B and determination of the absolute configuration of auripyrone B

Hayakawa, I., Takemura, T., Fukasawa, E., Ebihara, Y., Sato, N., Nakamura, T., Suenaga, K. & Kigoshi, H., Mar 22 2010, In : Angewandte Chemie - International Edition. 49, 13, p. 2401-2405 5 p.

Research output: Contribution to journalArticle

Pyrones
auripyrone A
3-hydroxybutanal
auripyrone B
2009
13 Citations (Scopus)

Aldol-type reaction of a 4-pyrone: a straightforward approach to 4-pyrone-containing natural products

Sengoku, T., Takemura, T., Fukasawa, E., Hayakawa, I. & Kigoshi, H., Jan 21 2009, In : Tetrahedron Letters. 50, 3, p. 325-328 4 p.

Research output: Contribution to journalArticle

Pyrones
Biological Products
Aldehydes
Cations
3-hydroxybutanal
3 Citations (Scopus)

Practical syntheses of enantiomerically pure key intermediates of opioid receptor-like 1 (ORL1) antagonists

Yoshizumi, T., Ohno, A., Tsujita, T., Takahashi, H., Okamoto, O., Hayakawa, I. & Kigoshi, H., Apr 2009, In : Synthesis. 7, p. 1153-1162 10 p., F22608SS.

Research output: Contribution to journalArticle

Opioid Receptors
Tin
Poisons
26 Citations (Scopus)

Total synthesis and cytotoxicity of haterumalides NA and B and their artificial analogues

Ueda, M., Yamaura, M., Ikeda, Y., Suzuki, Y., Yoshizato, K., Hayakawa, I. & Kigoshi, H., May 1 2009, In : Journal of Organic Chemistry. 74, 9, p. 3370-3377 8 p.

Research output: Contribution to journalArticle

Cytotoxicity
Macrolides
Stereochemistry
Esters
2008
24 Citations (Scopus)

Second-generation total synthesis of haterumalide NA using B-alkyl Suzuki-Miyaura coupling

Hayakawa, I., Ueda, M., Yamaura, M., Ikeda, Y., Suzuki, Y., Yoshizato, K. & Kigoshi, H., May 1 2008, In : Organic Letters. 10, 9, p. 1859-1862 4 p.

Research output: Contribution to journalArticle

Macrolides
synthesis
haterumalide NA
6 Citations (Scopus)

Structure of zamamistatin-a correction

Kita, M., Tsunematsu, Y., Hayakawa, I. & Kigoshi, H., Sep 8 2008, In : Tetrahedron Letters. 49, 37, p. 5383-5384 2 p.

Research output: Contribution to journalArticle

Derivatives
Acids
Dimers
aeroplysinin I
11 Citations (Scopus)

Synthesis of ustalic acid, an inhibitor of Na+,K+-ATPase

Hayakawa, I., Watanabe, H. & Kigoshi, H., Jun 16 2008, In : Tetrahedron. 64, 25, p. 5873-5877 5 p.

Research output: Contribution to journalArticle

Acetals
Agaricales
Oxidation
Acids
ATPase inhibitory protein
2007

Development of practical synthesis of halichondrins

Hayakawa, I., Dec 2007, In : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 65, 12, p. 1225-1226 2 p.

Research output: Contribution to journalArticle

Polyethers
Macrolides
Cell growth
Cytotoxicity
Biological Products
21 Citations (Scopus)

Marine cytotoxic macrolides haterumalides and biselides, and related natural products

Kigoshi, H. & Hayakawa, I., 2007, In : Chemical Record. 7, 4, p. 254-264 11 p.

Research output: Contribution to journalArticle

Macrolides
Biological Products
Animals
Cytotoxicity
Bioactivity
16 Citations (Scopus)

Synthesis of glaziovianin A: A potent antitumor isoflavone

Hayakawa, I., Ikedo, A. & Kigoshi, H., Nov 5 2007, In : Chemistry Letters. 36, 11, p. 1382-1383 2 p.

Research output: Contribution to journalArticle

Isoflavones
Tubulin Modulators
glaziovianin A
9 Citations (Scopus)

Synthetic studies on mycalolide B: Synthesis of the C7-C35 fragment

Kimura, T., Kuribayashi, S., Sengoku, T., Matsui, K., Ueda, S., Hayakawa, I., Suenaga, K. & Kigoshi, H., Dec 5 2007, In : Chemistry Letters. 36, 12, p. 1490-1491 2 p.

Research output: Contribution to journalArticle

Macrolides
Alkenes
Actins
mycalolide B
15 Citations (Scopus)

Synthetic study on 13-oxyingenol: construction of the full carbon framework

Hayakawa, I., Asuma, Y., Ohyoshi, T., Aoki, K. & Kigoshi, H., Aug 27 2007, In : Tetrahedron Letters. 48, 35, p. 6221-6224 4 p.

Research output: Contribution to journalArticle

Carbon
Euphorbia
Diterpenes
Alkenes
HIV
2006
22 Citations (Scopus)

Enantioselective synthesis of aurisides A and B, cytotoxic macrolide glycosides of marine origin

Suenaga, K., Hoshino, H., Yoshii, T., Mori, K., Sone, H., Bessho, Y., Sakakura, A., Hayakawa, I., Yamada, K. & Kigoshi, H., Aug 14 2006, In : Tetrahedron. 62, 33, p. 7687-7698 12 p.

Research output: Contribution to journalArticle

Macrolides
Glycosides
Glycosylation
Bromine
Lactones
18 Citations (Scopus)

Revised structure of zamamistatin

Hayakawa, I., Teruya, T. & Kigoshi, H., Jan 9 2006, In : Tetrahedron Letters. 47, 2, p. 155-158 4 p.

Research output: Contribution to journalArticle

Porifera
Nuclear magnetic resonance
Derivatives
bromotyrosine
Carbon-13 Magnetic Resonance Spectroscopy
2004
21 Citations (Scopus)

Synthesis of the tricyclic core of halichlorine

Hayakawa, I., Arimoto, H. & Uemura, D., May 21 2004, In : Chemical Communications. 10, 10, p. 1222-1223 2 p.

Research output: Contribution to journalArticle

Vascular Cell Adhesion Molecule-1
Cyclization
halichlorine