• 1796 Citations
  • 25 h-Index
1991 …2019
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Research Output 1991 2019

  • 1796 Citations
  • 25 h-Index
  • 66 Article
2019

ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration

Hirose, T., Cabrera-Socorro, A., Chitayat, D., Lemonnier, T., Féraud, O., Cifuentes-Diaz, C., Gervasi, N., Mombereau, C., Ghosh, T., Stoica, L., d’Arc Al Bacha, J., Yamada, H., Lauterbach, M. A., Guillon, M., Kaneko, K., Norris, J. W., Siriwardena, K., Blasér, S., Teillon, J., Mendoza-Londono, R. & 12 others, Russeau, M., Hadoux, J., Ito, S., Corvol, P., Matheus, M. G., Holden, K. R., Takei, K., Emiliani, V., Bennaceur-Griscelli, A., Schwartz, C. E., Nguyen, G. & Groszer, M., May 1 2019, In : Journal of Clinical Investigation. 129, 5, p. 2145-2162 18 p.

Research output: Contribution to journalArticle

Open Access
Proteolysis
Adenosine Triphosphatases
Brain
Neural Stem Cells
Carcinogenesis

Phosphorylation of cortactin by cyclin-dependent kinase 5 modulates actin bundling by the dynamin 1-cortactin ring-like complex and formation of filopodia and lamellipodia in NG108-15 glioma-derived cells

Abe, T., La, T. M., Miyagaki, Y., Oya, E., Wei, F. Y., Sumida, K., Fujise, K., Takeda, T., Tomizawa, K., Takei, K. & Yamada, H., Feb 1 2019, In : International Journal of Oncology. 54, 2, p. 550-558 9 p.

Research output: Contribution to journalArticle

Dynamin I
Cortactin
Cyclin-Dependent Kinase 5
Pseudopodia
Glioma
2018
9 Citations (Scopus)

Dynamic clustering of dynamin-amphiphysin helices regulates membrane constriction and fission coupled with GTP hydrolysis

Takeda, T., Kozai, T., Yang, H., Ishikuro, D., Seyama, K., Kumagai, Y., Abe, T., Yamada, H., Uchihashi, T., Ando, T. & Takei, K., Jan 23 2018, In : eLife. 7, e30246.

Research output: Contribution to journalArticle

Dynamins
Guanosine Triphosphate
Constriction
Cluster Analysis
Hydrolysis
2016
5 Citations (Scopus)

Dynamin2 GTPase contributes to invadopodia formation in invasive bladder cancer cells

Zhang, Y., Nolan, M., Yamada, H., Watanabe, M., Nasu, Y., Takei, K. & Takeda, T., Nov 18 2016, In : Biochemical and Biophysical Research Communications. 480, 3, p. 409-414 6 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Urinary Bladder Neoplasms
Dynamins
Cells
Actins
1 Citation (Scopus)

Expression of a dynamin 2 mutant associated with Charcot-Marie-Tooth disease leads to aberrant actin dynamics and lamellipodia formation

Yamada, H., Kobayashi, K., Zhang, Y., Takeda, T. & Takei, K., Aug 15 2016, In : Neuroscience Letters. 628, p. 179-185 7 p.

Research output: Contribution to journalArticle

Dynamin II
Charcot-Marie-Tooth Disease
Pseudopodia
Dynamins
Actins
16 Citations (Scopus)

Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization

Hayashi, K., Michiue, H., Yamada, H., Takata, K., Nakayama, H., Wei, F. Y., Fujimura, A., Tazawa, H., Asai, A., Ogo, N., Miyachi, H., Nishiki, T., Tomizawa, K., Takei, K. & Matsui, H., Mar 18 2016, In : Scientific Reports. 6, 23372.

Research output: Contribution to journalArticle

Fluvoxamine
Glioblastoma
Polymerization
Actins
Brain Neoplasms
20 Citations (Scopus)

Inhibition of SGLT2 alleviates diabetic nephropathy by suppressing high glucose-induced oxidative stress in type 1 diabetic mice

Hatanaka, T., Ogawa, D., Tachibana, H., Eguchi, J., Inoue, T., Yamada, H., Takei, K., Makino, H. & Wada, J., Aug 1 2016, In : Pharmacology Research and Perspectives. 4, 4, e00239.

Research output: Contribution to journalArticle

Sodium-Glucose Transport Proteins
Diabetic Nephropathies
Oxidative Stress
Glucose
Hyperglycemia
2015
2 Citations (Scopus)

Possible role of cortactin phosphorylation by protein kinase Cα in actin-bundle formation at growth cone

Yamada, H., Kikuchi, T., Masumoto, T., Wei, F. Y., Abe, T., Takeda, T., Nishiki, T., Tomizawa, K., Watanabe, M., Matsui, H. & Takei, K., Sep 1 2015, In : Biology of the Cell. 107, 9, p. 319-330 12 p.

Research output: Contribution to journalArticle

Cortactin
Growth Cones
Protein Kinase C
Actins
Phosphorylation
2014
119 Citations (Scopus)

Long-term treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db/db mice

Terami, N., Ogawa, D., Tachibana, H., Hatanaka, T., Wada, J., Nakatsuka, A., Eguchi, J., Sato Horiguchi, C., Nishii, N., Yamada, H., Takei, K. & Makino, H., Jun 24 2014, In : PLoS One. 9, 6, e100777.

Research output: Contribution to journalArticle

Sodium-Glucose Transport Proteins
diabetic nephropathy
Diabetic Nephropathies
homeostasis
Homeostasis
14 Citations (Scopus)

Metallothionein deficiency exacerbates diabetic nephropathy in streptozotocin-induced diabetic mice

Tachibana, H., Ogawa, D., Sogawa, N., Asanuma, M., Miyazaki, I., Terami, N., Hatanaka, T., Horiguchi, C. S., Nakatsuka, A., Eguchi, J., Wada, J., Yamada, H., Takei, K. & Makino, H., Jan 1 2014, In : American Journal of Physiology - Renal Physiology. 306, 1

Research output: Contribution to journalArticle

Metallothionein
Diabetic Nephropathies
Streptozocin
Inflammation
Reactive Oxygen Species
10 Citations (Scopus)
Dynamins
GTP Phosphohydrolases
Polymerization
Cell Movement
Actins
31 Citations (Scopus)

Stabilization of actin bundles by a Dynamin 1/cortactin ring complex is necessary for growth cone filopodia

Yamada, H., Abe, T., Satoh, A., Okazaki, N., Tago, S., Kobayashi, K., Yoshida, Y., Oda, Y., Watanabe, M., Tomizawa, K., Matsui, H. & Takei, K., Mar 6 2013, In : Journal of Neuroscience. 33, 10, p. 4514-4526 13 p.

Research output: Contribution to journalArticle

Dynamin I
Cortactin
Growth Cones
Pseudopodia
Actins
2012
6 Citations (Scopus)

A novel gene expression system for detecting viable bladder cancer cells

Ueki, H., Watanabe, M., Kaku, H., Huang, P., Li, S. A., Ochiai, K., Hirata, T., Noguchi, H., Yamada, H., Takei, K., Nasu, Y., Kashiwakura, Y. & Kumon, H., Jul 2012, In : International Journal of Oncology. 41, 1, p. 135-140 6 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Green Fluorescent Proteins
Gene Expression
Neoplasm Genes
Plasmids
13 Citations (Scopus)

REIC/Dkk-3-encoding adenoviral vector as a potentially effective therapeutic agent for bladder cancer

Hirata, T., Watanabe, M., Kaku, H., Kobayashi, Y., Yamada, H., Sakaguchi, M., Takei, K., Huh, N. H., Nasu, Y. & Kumon, H., Aug 2012, In : International Journal of Oncology. 41, 2, p. 559-564 6 p.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Neoplasms
Doxorubicin
Intravesical Administration
Therapeutics
2010
29 Citations (Scopus)

Expression pattern of REIC/Dkk-3 in various cell types and the implications of the soluble form in prostatic acinar development

Zhang, K., Watanabe, M., Kashiwakura, Y., Li, S. A., Edamura, K., Huang, P., Yamaguchi, K., Nasu, Y., Kobayashi, Y., Sakaguchi, M., Ochiai, K., Yamada, H., Takei, K., Ueki, H., Huh, N. H., Li, M., Kaku, H., Na, Y. & Kumon, H., Dec 2010, In : International Journal of Oncology. 37, 6, p. 1495-1501 7 p.

Research output: Contribution to journalArticle

Proteins
Prostate
Down-Regulation
Neoplasms
Acinar Cells
1 Citation (Scopus)

Use of liposomes to study vesicular transport.

Takei, K., Yamada, H. & Abe, T., 2010, In : Methods in Molecular Biology. 606, p. 531-542 12 p.

Research output: Contribution to journalArticle

Clathrin
Liposomes
Unilamellar Liposomes
Styrene
Cell-Free System
2009
44 Citations (Scopus)

Dynamic interaction of amphiphysin with N-WASP regulates actin assembly

Yamada, H., Padilla-Parra, S., Park, S. J., Itoh, T., Chaineau, M., Monaldi, I., Cremona, O., Benfenati, F., De Camilli, P., Coppey-Moisan, M., Tramier, M., Galli, T. & Takei, K., Dec 4 2009, In : Journal of Biological Chemistry. 284, 49, p. 34244-34256 13 p.

Research output: Contribution to journalArticle

Actins
Liposomes
Polymerization
Association reactions
Dynamins
24 Citations (Scopus)

Dynamin 2 is required for actin assembly in phagocytosis in Sertoli cells

Otsuka, A., Abe, T., Watanabe, M., Yagisawa, H., Takei, K. & Yamada, H., Jan 16 2009, In : Biochemical and Biophysical Research Communications. 378, 3, p. 478-482 5 p.

Research output: Contribution to journalArticle

Dynamin II
Sertoli Cells
Phagocytosis
Actins
Dynamins
42 Citations (Scopus)

Dynasore, a dynamin inhibitor, suppresses lamellipodia formation and cancer cell invasion by destabilizing actin filaments

Yamada, H., Abe, T., Li, S. A., Masuoka, Y., Isoda, M., Watanabe, M., Nasu, Y., Kumon, H., Asai, A. & Takei, K., Dec 25 2009, In : Biochemical and Biophysical Research Communications. 390, 4, p. 1142-1148 7 p.

Research output: Contribution to journalArticle

Dynamins
Pseudopodia
Actin Cytoskeleton
Actins
Cells
2008
4 Citations (Scopus)

Dynamin 2 cooperates with amphiphysin 1 in phagocytosis in Sertoli cells

Nakanishi, A., Abe, T., Watanabe, M., Takei, K. & Yamada, H., Dec 2008, In : Acta Medica Okayama. 62, 6, 5.

Research output: Contribution to journalArticle

Dynamin II
Sertoli Cells
Phagocytosis
Phosphatidylserines
Dynamins
2007
30 Citations (Scopus)

Amphiphysin 1 is important for actin polymerization during phagocytosis

Yamada, H., Ohashi, E., Abe, T., Kusumi, N., Li, S. A., Yoshida, Y., Watanabe, M., Tomizawa, K., Kashiwakura, Y., Kumon, H., Matsui, H. & Takei, K., Nov 2007, In : Molecular Biology of the Cell. 18, 11, p. 4669-4680 12 p.

Research output: Contribution to journalArticle

Phagocytosis
Polymerization
Actins
Sertoli Cells
Cytosol

Amphiphysin 1 participates in phagocytosis by stimulating actin polymerization.(共著)

Yamada, H., 2007, In : Molecular Biology of the Cell. 18, 11, p. 4669-4680 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Identification of Vanabin-interacting protein 1 (VIP1) from blood cells of the vanadium-rich ascidian Ascidia sydneiensis samea

Ueki, T., Shintaku, K., Yonekawa, Y., Takatsu, N., Yamada, H., Hamada, T., Hirota, H. & Michibata, H., Jun 2007, In : Biochimica et Biophysica Acta - General Subjects. 1770, 6, p. 951-957 7 p.

Research output: Contribution to journalArticle

Urochordata
Vanadium
Blood Cells
Blood
Cells
29 Citations (Scopus)

Implication of amphiphysin 1 and dynamin 2 in tubulobulbar complex formation and spermatid release

Kusumi, N., Watanabe, M., Yamada, H., Li, S. A., Kashiwakura, Y., Matsukawa, T., Nagai, A., Nasu, Y., Kumon, H. & Takei, K., 2007, In : Cell Structure and Function. 32, 2, p. 101-113 13 p.

Research output: Contribution to journalArticle

Dynamin II
Spermatids
Seminiferous Tubules
Sertoli Cells
Vinculin
16 Citations (Scopus)

Major Cdk5-dependent phosphorylation sites of amphiphysin 1 are implicated in the regulation of the membrane binding and endocytosis

Liang, S., Wei, F. Y., Wu, Y. M., Tanabe, K., Abe, T., Oda, Y., Yoshida, Y., Yamada, H., Matsui, H., Tomizawa, K. & Takei, K., Sep 2007, In : Journal of Neurochemistry. 102, 5, p. 1466-1476 11 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 5
Phosphorylation
Endocytosis
Membranes
Membrane Lipids
2006
15 Citations (Scopus)

Localization of Vanabins, vanadium-binding proteins, in the blood cells of the vanadium-rich ascidian, Ascidia sydneiensis samea

Yamaguchi, N., Amakawa, Y., Yamada, H., Ueki, T. & Michibata, H., Oct 2006, In : Zoological Science. 23, 10, p. 909-915 7 p.

Research output: Contribution to journalArticle

Samea
vanadium
Ascidiacea
blood cells
binding proteins
2005
61 Citations (Scopus)

Regulatory mechanisms of dynamin-dependent endocytosis

Takei, K., Yoshida, Y. & Yamada, H., Mar 2005, In : Journal of Biochemistry. 137, 3, p. 243-247 5 p.

Research output: Contribution to journalArticle

Dynamins
Endocytosis
Dynamin I
Phosphatidylinositols
Molecules
2004
20 Citations (Scopus)

Dynamin-2 regulates oxidized low-density lipoprotein-induced apoptosis of vascular smooth muscle cell

Kashiwakura, Y., Watanabe, M., Kusumi, N., Sumiyoshi, K., Nasu, Y., Yamada, H., Sawamura, T., Kumon, H., Takei, K. & Daida, H., Nov 23 2004, In : Circulation. 110, 21, p. 3329-3334 6 p.

Research output: Contribution to journalArticle

Dynamin II
Vascular Smooth Muscle
Smooth Muscle Myocytes
Apoptosis
Endocytosis
226 Citations (Scopus)

Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice

Li, S. A., Watanabe, M., Yamada, H., Nagai, A., Kinuta, M. & Takei, K., Dec 2004, In : Cell Structure and Function. 29, 4, p. 91-99 9 p.

Research output: Contribution to journalArticle

Kidney
Brain
Phenotype
Germ Cells
Distal Kidney Tubule
2003
2 Citations (Scopus)

Formation of S-[2-carboxy-1-(1H-imidazol-4-yl) ethyl]glutathione, a new metabolite of L-histidine, from cis-urocanic acid and glutathione by the action of glutathione S-transferase

Kinuta, M., Kinuta, K., Yamada, H., Abe, T., Yoshida, Y., Araki, K., Li, S. A., Otsuka, A., Nakanishi, A., Moriyama, Y. & Takei, K., Sep 2003, In : Electrophoresis. 24, 18, p. 3212-3218 7 p.

Research output: Contribution to journalArticle

NSC 153174
Urocanic Acid
Metabolites
Glutathione Transferase
Histidine
103 Citations (Scopus)

Secretory granule-mediated co-secretion of L-glutamate and glucagon triggers glutamatergic signal transmission in islets of Langerhans

Hayashi, M., Yamada, H., Uehara, S., Morimoto, R., Muroyama, A., Yatsushiro, S., Takeda, J., Yamamoto, A. & Moriyama, Y., Jan 17 2003, In : Journal of Biological Chemistry. 278, 3, p. 1966-1974 9 p.

Research output: Contribution to journalArticle

Secretory Vesicles
Glucagon
Islets of Langerhans
Glutamic Acid
Vesicular Glutamate Transport Protein 2
2002
33 Citations (Scopus)

Distribution of dynamins in testis and their possible relation to spermatogenesis

Kamitani, A., Yamada, H., Kinuta, M., Watanabe, M., Li, S. A., Matsukawa, T., McNiven, M., Kumon, H. & Takei, K., 2002, In : Biochemical and Biophysical Research Communications. 294, 2, p. 261-267 7 p.

Research output: Contribution to journalArticle

Dynamin III
Dynamin II
Dynamins
Spermatogenesis
Testis
6 Citations (Scopus)

Norepinephrine triggers Ca2+-dependent exocytosis of 5-hydroxytryptamine from rat pinealocytes in culture

Yamada, H., Hayashi, M., Uehara, S., Kinoshita, M., Muroyama, A., Watanabe, M., Takei, K. & Moriyama, Y., 2002, In : Journal of Neurochemistry. 81, 3, p. 533-540 8 p.

Research output: Contribution to journalArticle

Exocytosis
Rats
Serotonin
Norepinephrine
Phenylephrine
24 Citations (Scopus)

Phosphatidylinositol 4,5-bisphosphate stimulates vesicle formation from liposomes by brain cytosol

Kinuta, M., Yamada, H., Abe, T., Watanabe, M., Li, S. A., Kamitani, A., Yasuda, T., Matsukawa, T., Kumon, H. & Takei, K., Mar 5 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 5, p. 2842-2847 6 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Liposomes
Cytosol
Brain
Guanosine Triphosphate
2001
33 Citations (Scopus)

Ca2+-dependent exocytosis of L-glutamate by αTC6, clonal mouse pancreatic α-cells

Yamada, H., Otsuka, M., Hayashi, M., Nakatsuka, S., Hamaguchi, K., Yamamoto, A. & Moriyama, Y., 2001, In : Diabetes. 50, 5, p. 1012-1020 9 p.

Research output: Contribution to journalArticle

Exocytosis
Glutamic Acid
Synaptophysin
Islets of Langerhans
Glucose
43 Citations (Scopus)

D-Aspartate is Stored in Secretory Granules and Released through a Ca 2+-dependent Pathway in a Subset of Rat Pheochromocytoma PC12 Cells

Nakatsuka, S., Hayashi, M., Muroyama, A., Otsuka, M., Kozaki, S., Yamada, H. & Moriyama, Y., Jul 13 2001, In : Journal of Biological Chemistry. 276, 28, p. 26589-26596 8 p.

Research output: Contribution to journalArticle

D-Aspartic Acid
PC12 Cells
Secretory Vesicles
Pheochromocytoma
Rats
2 Citations (Scopus)

Determination of S-[2-carboxy-1-(1H-imidazol-4-yl)ethyl]glutathione, a novel metabolite of L-histidine, in tissue extracts from sunlight-irradiated rat by capillary electrophoresis

Kinuta, M., Ohta, J., Yamada, H., Kinuta, K., Abe, T., Li, S. A., Otsuka, A., Nakanishi, A. & Takei, K., 2001, In : Electrophoresis. 22, 16, p. 3365-3370 6 p.

Research output: Contribution to journalArticle

Capillary electrophoresis
Tissue Extracts
Sunlight
Capillary Electrophoresis
Metabolites
51 Citations (Scopus)

Identification and Characterization of a Synaptojanin 2 Splice Isoform Predominantly Expressed in Nerve Terminals

Nemoto, Y., Wenk, M. R., Watanabe, M., Daniell, L., Murakami, T., Ringstad, N., Yamada, H., Takei, K. & De Camilli, P., Nov 2 2001, In : Journal of Biological Chemistry. 276, 44, p. 41133-41142 10 p.

Research output: Contribution to journalArticle

Protein Isoforms
synaptojanin
Brain
Spermatids
Phosphatidylinositols
2000

AMPA triggers glutamate exocytosis via ionotropic glutamate receptors expressed in rat pinealocytes.

Yamada, H., 2000, In : J. Neurochem.. 75, p. 288-297 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Ionotropic glutamate receptors expressed in human retinoblastoma Y79 cells

Takeda, M., Haga, M., Yamada, H., Kinoshita, M., Otsuka, M., Tsuboi, S. & Moriyama, Y., Nov 17 2000, In : Neuroscience Letters. 294, 2, p. 97-100 4 p.

Research output: Contribution to journalArticle

Ionotropic Glutamate Receptors
Retinoblastoma
Glutamate Receptors
Messenger RNA
Glutamic Acid
21 Citations (Scopus)

Ionotropic glutamate receptors trigger microvesicle-mediated exocytosis of L-glutamate in rat pinealocytes

Yatsushiro, S., Yamada, H., Hayashi, M., Yamamoto, A. & Moriyama, Y., 2000, In : Journal of Neurochemistry. 75, 1, p. 288-297 10 p.

Research output: Contribution to journalArticle

Ionotropic Glutamate Receptors
Exocytosis
Rats
Glutamic Acid
Melatonin
45 Citations (Scopus)

Synaptic-like microvesicles, synaptic vesicle counterparts in endocrine cells, are involved in a novel regulatory mechanism for the synthesis and secretion of hormones

Moriyama, Y., Hayashi, M., Yamada, H., Yatsushiro, S., Ishio, S. & Yamamoto, A., Jan 2000, In : Journal of Experimental Biology. 203, 1, p. 117-125 9 p.

Research output: Contribution to journalArticle

Endocrine Cells
Synaptic Vesicles
hormone secretion
melatonin
Melatonin
81 Citations (Scopus)

Vacuolar H+-ATPase localized in plasma membranes of malaria parasite cells, Plasmodium falciparum, is involved in regional acidification of parasitized erythrocytes

Hayashi, M., Yamada, H., Mitamura, T., Horii, T., Yamamoto, A. & Moriyama, Y., Nov 3 2000, In : Journal of Biological Chemistry. 275, 44, p. 34353-34358 6 p.

Research output: Contribution to journalArticle

Vacuolar Proton-Translocating ATPases
Acidification
Cell membranes
Plasmodium falciparum
Malaria
1999
12 Citations (Scopus)

Functional expression of metabotropic glutamate receptor type 5 in rat pinealocytes

Yatsushiro, S., Yamada, H., Hayashi, M., Tsuboi, S. & Moriyama, Y., May 14 1999, In : NeuroReport. 10, 7, p. 1599-1603 5 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate 5 Receptor
Metabotropic Glutamate Receptors
Melatonin
Quisqualic Acid
Pineal Gland
13 Citations (Scopus)

Hydroxyindole-O-methyltransferase is another target for L-glutamate-evoked inhibition of melatonin synthesis in rat pinealocytes

Ishio, S., Yamada, H., Craft, C. M. & Moriyama, Y., Dec 11 1999, In : Brain Research. 850, 1-2, p. 73-78 6 p.

Research output: Contribution to journalArticle

Acetylserotonin O-Methyltransferase
Melatonin
Glutamic Acid
Acetyltransferases
Arylalkylamine N-Acetyltransferase
2 Citations (Scopus)

Intrinsic glutaminergic system negatively regulates melatonin synthesis in mammalian pineal gland

Moriyama, Y., Yamada, H., Hayashi, M. & Yatsushiro, S., 1999, In : Advances in Experimental Medicine and Biology. 460, p. 83-90 8 p.

Research output: Contribution to journalArticle

Biological Models
Signal transduction
Mammals
Pineal Gland
Melatonin