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Research Output 1991 2018

  • 682 Citations
  • 14 h-Index
  • 44 Article
  • 1 Editorial
  • 1 Review article
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Article
2018

Administration of kampo medicine through a tube at an advanced critical care center

Niimura, T., Zamami, Y., Imai, T., Ito, T., Sagara, H., Hiroyuki, H., Esumi, S., Takechi, K., Imanishi, M., Koyama, T., Amano, M., Kurata, N., Kitamura, Y., Nakura, H., Sendo, T. & Ishizawa, K., Jan 1 2018, In : Journal of Medical Investigation. 65, 1-2, p. 32-36 5 p.

Research output: Contribution to journalArticle

Kampo Medicine
Critical Care
Suspensions
Crushing
Amlodipine

Evaluation of the benefits of de-escalation for patients with sepsis in the emergency intensive care unit

Niimura, T., Zamami, Y., Imai, T., Nagao, K., Kayano, M., Sagara, H., Goda, M., Okada, N., Chuma, M., Takechi, K., Imanishi, M., Koyama, T., Koga, T., Nakura, H., Sendo, T. & Ishizawa, K., Feb 13 2018, In : Journal of Pharmacy and Pharmaceutical Sciences. 21, 1, p. 54-59 6 p.

Research output: Contribution to journalArticle

Emergency Medical Services
Intensive Care Units
Length of Stay
Sepsis
Anti-Bacterial Agents
2017
3 Citations (Scopus)

Meta-analysis of the efficacies of amiodarone and nifekalant in shock-resistant ventricular fibrillation and pulseless ventricular tachycardia

Sato, S., Zamami, Y., Imai, T., Tanaka, S., Koyama, T., Niimura, T., Chuma, M., Koga, T., Takechi, K., Kurata, Y., Kondo, Y., Izawa-Ishizawa, Y., Sendo, T., Nakura, H. & Ishizawa, K., Dec 1 2017, In : Scientific Reports. 7, 1, 12683.

Research output: Contribution to journalArticle

Amiodarone
Ventricular Fibrillation
Ventricular Tachycardia
Meta-Analysis
Shock
2014
1 Citation (Scopus)

Role of pharmacists in disaster medicine: Required knowledge and skills

Nakura, H., 2014, In : Yakugaku Zasshi. 134, 1, p. 3-6 4 p.

Research output: Contribution to journalArticle

Disaster Medicine
Emergency Medicine
Disasters
Pharmacists
Pharmacy Education
1 Citation (Scopus)

Role of pharmacists in disaster medicine: Proposal based on relief efforts during the 2011 earthquake in East Japan

Hirokawa, S., Nakura, H. & Norose, T., 2014, In : Yakugaku Zasshi. 134, 1, p. 1-2 2 p.

Research output: Contribution to journalArticle

Disaster Medicine
Tsunamis
Professional Role
Earthquakes
Pharmacists
2012

Clinical Usefulness of the New Japanese Glomerular Filtration Rate Equation for Initial and Individualized Dosage Adjustment Concentrations of Vancomycin

Kuroda, N., Ueshima, S., Sato, T., Kobiki, E., Kawasaki, Y., Matsunaga, H., Nakura, H. & Sendo, T., 2012, In : Yakugaku Zasshi. 132, 1, p. 125-133 9 p.

Research output: Contribution to journalArticle

Vancomycin
Glomerular Filtration Rate
Methicillin-Resistant Staphylococcus aureus
Infection
Linear Models
2011
15 Citations (Scopus)

Regio- and stereoselective oxidation of propranolol enantiomers by human CYP2D6, cynomolgus monkey CYP2D17 and marmoset CYP2D19

Narimatsu, S., Nakata, T., Shimizudani, T., Nagaoka, K., Nakura, H., Masuda, K., Katsu, T., Koeda, A., Naito, S., Yamano, S., Miyata, A. & Hanioka, N., Feb 1 2011, In : Chemico-Biological Interactions. 189, 3, p. 146-152 7 p.

Research output: Contribution to journalArticle

Callithrix
Cytochrome P-450 CYP2D6
Macaca fascicularis
Enantiomers
Propranolol
2009
13 Citations (Scopus)

Separate evaluation of intestinal and hepatic metabolism of three benzodiazepines in rats with cannulated portal and jugular veins: Comparison with the profile in non-cannulated mice

Kuze, J., Mutoh, T., Takenaka, T., Morisaki, K., Nakura, H., Hanioka, N. & Narimatsu, S., Nov 2009, In : Xenobiotica. 39, 11, p. 871-880 10 p.

Research output: Contribution to journalArticle

Jugular Veins
Portal Vein
Benzodiazepines
Metabolism
Rats
9 Citations (Scopus)

The mechanism causing the difference in kinetic properties between rat CYP2D4 and human CYP2D6 in the oxidation of dextromethorphan and bufuralol

Narimatsu, S., Kazamori, D., Masuda, K., Katsu, T., Funae, Y., Naito, S., Nakura, H., Yamano, S. & Hanioka, N., Mar 1 2009, In : Biochemical Pharmacology. 77, 5, p. 920-931 12 p.

Research output: Contribution to journalArticle

Dextromethorphan
Cytochrome P-450 CYP2D6
Rats
Oxidation
Kinetics
2008
5 Citations (Scopus)

Toxin production by Aeromonas sobria in natural environments: River water vs. seawater

Khan, R., Takahashi, E., Nakura, H., Ansaruzzaman, M., Banik, S., Ramamurthy, T. & Okamoto, K., Dec 2008, In : Acta Medica Okayama. 62, 6, 2.

Research output: Contribution to journalArticle

Aeromonas
Seawater
Rivers
Water
Peptide Hydrolases
2002
30 Citations (Scopus)

Total analysis and purification of cellular proteins binding to cisplatin-damaged DNA using submicron beads

Tomohiro, T., Sawada, J. I., Sawa, C., Nakura, H., Yoshida, S., Kodaka, M., Hatakeyama, M., Kawaguchi, H., Handa, H. & Okuno, H., Apr 13 2002, In : Bioconjugate Chemistry. 13, 2, p. 163-166 4 p.

Research output: Contribution to journalArticle

DNA-Binding Proteins
Protein Binding
Cisplatin
Purification
HMGB Proteins
2001
71 Citations (Scopus)

CYP3A activity in European American and Japanese men using midazolam as an in vivo probe

Tateishi, T., Watanabe, M., Nakura, H., Asoh, M., Shirai, H., Mizorogi, Y., Kobayashi, S., Thummel, K. E. & Wilkinson, G. R., May 2001, In : Clinical Pharmacology and Therapeutics. 69, 5, p. 333-339 7 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Midazolam
Pharmaceutical Preparations
Oral Administration
Body Weight
1999
39 Citations (Scopus)

Carbamazepine induces multiple cytochrome P450 subfamilies in rats

Tateishi, T., Asoh, M., Nakura, H., Watanabe, M., Tanaka, M., Kumai, T. & Kobayashi, S., Feb 12 1999, In : Chemico-Biological Interactions. 117, 3, p. 257-268 12 p.

Research output: Contribution to journalArticle

Carbamazepine
Cytochrome P-450 Enzyme System
Rats
Cytochrome P-450 CYP2E1
Aniline Hydroxylase
10 Citations (Scopus)

Dihydropyrimidine dehydrogenase activity and fluorouracil pharmacokinetics with liver damage induced by bile duct ligation in rats

Tateishi, T., Watanabe, M., Nakura, H., Tanaka, M., Kumai, T., Sakata, S. F., Tamaki, N., Ogura, K., Nishiyama, T., Watabe, T. & Kobayashi, S., 1999, In : Drug Metabolism and Disposition. 27, 6, p. 651-654 4 p.

Research output: Contribution to journalArticle

Dihydrouracil Dehydrogenase (NADP)
Pharmacokinetics
Bile Ducts
Fluorouracil
Liver
40 Citations (Scopus)

Frequency of immediate-type food allergy in children in Japan

Iikura, Y., Imai, Y., Imai, T., Akasawa, A., Fujita, K., Hoshiyama, K., Nakura, H., Kohno, Y., Koike, K., Okudaira, H. & Iwasaki, E., 1999, In : International Archives of Allergy and Immunology. 118, 2-4, p. 251-252 2 p.

Research output: Contribution to journalArticle

Immediate Hypersensitivity
Seafood
Food Hypersensitivity
Preschool Children
Allergens
21 Citations (Scopus)

Multiple cytochrome P-450 subfamilies are co-induced with P-glycoprotein by both phenothiazine and 2-acetylaminofluorene in rats

Tateishi, T., Nakura, H., Asoh, M., Watanabe, M., Tanaka, M., Kumai, T. & Kobayashi, S., Apr 26 1999, In : Cancer Letters. 138, 1-2, p. 73-79 7 p.

Research output: Contribution to journalArticle

2-Acetylaminofluorene
P-Glycoprotein
Cytochrome P-450 Enzyme System
Cytochrome P-450 CYP1A1
Cytochrome P-450 CYP3A
7 Citations (Scopus)

Role of CYP3A in haloperidol N-dealkylation and pharmacokinetics in rats

Watanabe, M., Tateishi, T., Asoh, M., Nakura, H., Tanaka, M., Kumai, T. & Kobayashi, S., 1999, In : Fundamental and Clinical Pharmacology. 13, 3, p. 337-342 6 p.

Research output: Contribution to journalArticle

Dealkylation
Cytochrome P-450 CYP3A
Haloperidol
Pharmacokinetics
Acids
36 Citations (Scopus)

Ticlopidine decreases the in vivo activity of CYP2C19 as measured by omeprazole metabolism

Tateishi, T., Kumai, T., Watanabe, M., Nakura, H., Tanaka, M. & Kobayashi, S., 1999, In : British Journal of Clinical Pharmacology. 47, 4, p. 454-457 4 p.

Research output: Contribution to journalArticle

Ticlopidine
Omeprazole
Area Under Curve
Cytochrome P-450 CYP2C19
5-hydroxymethylomeprazole
14 Citations (Scopus)

Ursodeoxycholic acid prevents hepatic cytochrome P450 isozyme reduction in rats with deoxycholic acid-induced liver injury

Tanaka, M., Nakura, H., Tateishi, T., Watanabe, M., Nakaya, S., Kumai, T. & Kobayashi, S., Aug 1999, In : Journal of Hepatology. 31, 2, p. 263-270 8 p.

Research output: Contribution to journalArticle

Ursodeoxycholic Acid
Deoxycholic Acid
Cytochrome P-450 Enzyme System
Isoenzymes
Bile Acids and Salts
1998
5 Citations (Scopus)

A comparison of the inhibitory effects of four volatile anaesthetics on the metabolism of chlorzoxazone, a substrate for CYP2E1, in rabbits

Tateishi, T., Watanabe, M., Nakura, H., Tanaka, M., Kumai, T., Aoki, T. & Kobayashi, S., 1998, In : Acta Anaesthesiologica Scandinavica. 42, 9, p. 1028-1032 5 p.

Research output: Contribution to journalArticle

Chlorzoxazone
Cytochrome P-450 CYP2E1
Anesthetics
Rabbits
Halothane
4 Citations (Scopus)

Effect of hypoalbuminemia on the disposition of theophylline: Comparative study with Sprague-Dawley rats and a mutant Sprague-Dawley hyperlipidemic strain with hypoalbuminemia

Nakura, H., Tateishi, T., Watanabe, M., Asoh, M., Tanaka, M., Kumai, T. & Kobayashi, S., Jun 1998, In : Drug Metabolism and Disposition. 26, 6, p. 595-597 3 p.

Research output: Contribution to journalArticle

Hypoalbuminemia
Theophylline
Sprague Dawley Rats
Rats
Apoproteins
25 Citations (Scopus)

Effects of anti-androgen treatment on the catecholamine synthetic pathway in the adrenal medulla of spontaneously hypertensive rats

Kumai, T., Tanaka, M., Tateishi, T., Watanabe, M., Nakura, H., Asoh, M. & Kobayashi, S., 1998, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 357, 6, p. 620-624 5 p.

Research output: Contribution to journalArticle

Flutamide
Adrenal Medulla
Inbred SHR Rats
Androgens
Catecholamines
28 Citations (Scopus)

Effects of glucocorticoids on pharmacokinetics and pharmacodynamics of midazolam in rats

Watanabe, M., Tateishi, T., Asoh, M., Nakura, H., Tanaka, M., Kumai, T. & Kobayashi, S., Oct 2 1998, In : Life Sciences. 63, 19, p. 1685-1692 8 p.

Research output: Contribution to journalArticle

Pharmacodynamics
Pharmacokinetics
Midazolam
Dexamethasone
Glucocorticoids
20 Citations (Scopus)

Liver damage induced by bile duct ligation affects CYP isoenzymes differently in rats

Tateishi, T., Watanabe, M., Nakura, H., Tanaka, M., Kumai, T. & Kobayashi, S., 1998, In : Pharmacology and Toxicology. 82, 2, p. 89-92 4 p.

Research output: Contribution to journalArticle

Bile Ducts
Liver
Ducts
Cytochrome P-450 Enzyme System
Isoenzymes
6 Citations (Scopus)

Reduced hepatic expression of CYP7A1 and CYP2C13 in rats with spontaneous hyperlipidaemia

Brassil, P. J., Debri, K., Nakura, H., Kobayashi, S., Davies, D. S. & Edwards, R. J., Jul 15 1998, In : Biochemical Pharmacology. 56, 2, p. 253-257 5 p.

Research output: Contribution to journalArticle

Hyperlipidemias
Sprague Dawley Rats
Rats
Liver
Cholesterol 7-alpha-Hydroxylase
1997
114 Citations (Scopus)

A comparison of hepatic cytochrome P450 protein expression between infancy and postinfancy

Tateishi, T., Nakura, H., Asoh, M., Watanabe, M., Tanaka, M., Kumai, T., Takashima, S., Imaoka, S., Funae, Y., Yabusaki, Y., Kamataki, T. & Kobayashi, S., Nov 21 1997, In : Life Sciences. 61, 26, p. 2567-2574 8 p.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Liver
Cytochrome P-450 CYP1A2
Proteins
Liver Microsomes

Effects of sodium nitroprusside on the catecholamine levels in the adrenal medulla of spontaneously hypertensive rats

Kumai, T., Tanaka, M., Tateishi, T., Watanabe, M., Nakura, H., Asoh, M. & Kobayashi, S., 1997, In : Japanese Heart Journal. 38, 4, p. 574 1 p.

Research output: Contribution to journalArticle

Adrenal Medulla
Nitroprusside
Inbred SHR Rats
Catecholamines
15 Citations (Scopus)

Effects of the estrous cycle and the gender difference on hepatic drug-metabolising enzyme activities

Watanabe, M., Tanaka, M., Tateishi, T., Nakura, H., Kumai, T. & Kobayashi, S., May 1997, In : Pharmacological Research. 35, 5, p. 477-480 4 p.

Research output: Contribution to journalArticle

Estrous Cycle
Liver
Enzymes
Pharmaceutical Preparations
Glucuronosyltransferase
2 Citations (Scopus)

Enhancement of the affinity of androgen receptor in the adrenal medulla of spontaneously hypertensive rats

Kumai, T., Tanaka, M., Tateishi, T., Watanabe, M., Nakura, H. & Kobayashi, S., Nov 1997, In : Clinical and Experimental Hypertension. 19, 8, p. 1179-1191 13 p.

Research output: Contribution to journalArticle

Adrenal Medulla
Androgen Receptors
Inbred SHR Rats
Tyrosine 3-Monooxygenase
Inbred WKY Rats
3 Citations (Scopus)

Halothane inhalation inhibits the metabolism of chlorzoxazone, a substrate for CYP2E1, in rabbits

Tateishi, T., Watanabe, M., Nakura, H., Tanaka, M., Kumai, T., Aoki, T. & Kobayashi, S., 1997, In : Anesthesia and Analgesia. 85, 1, p. 199-203 5 p.

Research output: Contribution to journalArticle

Chlorzoxazone
Cytochrome P-450 CYP2E1
Halothane
Inhalation
Rabbits
2 Citations (Scopus)

Opposite effects of isoniazid and fasting on the expression of CYP2E1 protein and mRNA in house musk shrew (Suncus murinus)

Nakura, H., Itoh, S., Kusano, H., Ishizone, H. & Kamataki, T., Feb 1997, In : Biochemistry and Molecular Biology International. 41, 2, p. 293-301 9 p.

Research output: Contribution to journalArticle

Shrews
Cytochrome P-450 CYP2E1
Isoniazid
Fasting
Messenger RNA
7 Citations (Scopus)

Sex- or age-related differences were not detected in the activity of dihydropyrimidine dehydrogenase from rat liver

Tateishi, T., Watanabe, M., Nakura, H., Tanaka, M., Kumai, T. & Kobayashi, S., Feb 1997, In : Pharmacological Research. 35, 2, p. 103-106 4 p.

Research output: Contribution to journalArticle

Dihydrouracil Dehydrogenase (NADP)
Liver
Fluorouracil
Body Weight
Cytosol
6 Citations (Scopus)

The effects of streptozotocin-induced hypoinsulinemia on serum lipid levels in spontaneously hyperlipidemic rats

Nakura, H., Tanaka, M., Tateishi, T., Watanabe, M., Kumai, T. & Kobayashi, S., 1997, In : Hormone and Metabolic Research. 29, 9, p. 454-457 4 p.

Research output: Contribution to journalArticle

Streptozocin
Rats
Lipids
Serum
Sprague Dawley Rats
1996
31 Citations (Scopus)

A cardiotonic steroid bufalin-induced differentiation of THP-1 cells. Involvement of Na+, K+-ATPase inhibition in the early changes in proto-oncogene expression

Numazawa, S., Inoue, N., Nakura, H., Sugiyama, T., Fujino, E., Shinoki, M. A., Yoshida, T. & Kuroiwa, Y., Jul 26 1996, In : Biochemical Pharmacology. 52, 2, p. 321-329 9 p.

Research output: Contribution to journalArticle

Cardiac Glycosides
Proto-Oncogenes
Adenosine Triphosphatases
Ouabain
sodium-translocating ATPase
14 Citations (Scopus)

Elevated tyrosine hydroxylase nRNA levels in medulla oblongata of spontaneously hypertensive rats

Kumai, T., Tanaka, M., Watanabe, M., Nakura, H., Tateishi, T. & Kobayashi, S., Feb 1996, In : Molecular Brain Research. 36, 1, p. 197-199 3 p.

Research output: Contribution to journalArticle

Medulla Oblongata
Tyrosine 3-Monooxygenase
Inbred SHR Rats
Messenger RNA
Inbred WKY Rats
11 Citations (Scopus)

Preliminary examination of the influence of incubation time or cytosolic protein concentration on dihydropyrimidine dehydrogenase activity

Tateishi, T., Nakura, H., Watanabe, M., Tanaka, M., Kumai, T. & Kobayashi, S., Aug 15 1996, In : Clinica Chimica Acta. 252, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Dihydrouracil Dehydrogenase (NADP)
Metabolites
Fluorouracil
Sampling
Proteins
12 Citations (Scopus)

Reduced hepatic drug-metabolising enzyme activities in spontaneously hyperlipidaemic rat as an animal model of hypercholesterolaemia

Watanabe, M., Nakura, H., Tateishi, T., Tanaka, M., Kumai, T. & Kobayashi, S., 1996, In : Medical Science Research. 24, 4, p. 257-259 3 p.

Research output: Contribution to journalArticle

Enzyme activity
Hypercholesterolemia
Sprague Dawley Rats
Rats
Animals

The activity of dihydropyrimidine dehydrogenase from rat liver was not affected by any of five 5-hydroxytryptamine antagonists

Tateishi, T., Nakura, H., Watanabe, M., Tanaka, M., Kumai, T. & Kobayashi, S., Nov 12 1996, In : Cancer Letters. 108, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Dihydrouracil Dehydrogenase (NADP)
Serotonin 5-HT3 Receptor Antagonists
Serotonin Antagonists
Fluorouracil
Liver
1995
2 Citations (Scopus)

Effects of Submaxillariectomy on Ovarian Androgen and Estrogen Production in Adult Female Rats

Tanaka, M., Watanabe, M., Kumai, T., Nakura, H. & Kobayashi, S., Aug 15 1995, In : Biochemical and Biophysical Research Communications. 213, 2, p. 550-554 5 p.

Research output: Contribution to journalArticle

Submandibular Gland
Androgens
Rats
Estrogens
17-alpha-Hydroxyprogesterone
8 Citations (Scopus)

Evidence for the lack of hepatic n-acetyltransferase in suncus (Suncus murinus)

Nakura, H., Itoh, S., Kusano, H., Ishizone, H., Deguchi, T. & Kamataki, T., Oct 12 1995, In : Biochemical Pharmacology. 50, 8, p. 1165-1170 6 p.

Research output: Contribution to journalArticle

Acetyltransferases
Cytosol
Rats
Metabolites
Liver
38 Citations (Scopus)

Influence of androgen on tyrosine hydroxylase mRNA in adrenal medulla of spontaneously hypertensive rats

Kumai, T., Tanaka, M., Watanabe, M., Nakura, H. & Kobayashi, S., 1995, In : Hypertension. 26, 1, p. 208-212 5 p.

Research output: Contribution to journalArticle

Adrenal Medulla
Tyrosine 3-Monooxygenase
Inbred SHR Rats
Androgens
Messenger RNA
1994
2 Citations (Scopus)

Activities of drug-metabolizing enzymes in the liver of suncus murinus: Possible lack of n-acetyltransferase activity in liver cytosol

Nakura, H., Itoh, S., Kusano, H., Ishizone, H. & Kamataki, T., 1994, In : Pharmacology. 48, 3, p. 201-204 4 p.

Research output: Contribution to journalArticle

Acetyltransferases
Cytosol
Liver
Enzymes
dimethylaniline monooxygenase (N-oxide forming)
1992
10 Citations (Scopus)

Decrease in the content of cytochrome P450IIE by fasting in liver microsomes of house musk shrew (Suncus murinus)

Nakura, H., Itoh, S., Kusano, H., Ishizone, H., Imaoka, S., Funae, Y., Yokoi, T. & Kamataki, T., May 8 1992, In : Biochemical Pharmacology. 43, 9, p. 1907-1910 4 p.

Research output: Contribution to journalArticle

Shrews
Level control
Liver Microsomes
Liver
Rats
1991
1 Citation (Scopus)

Formation of an antibacterial metabolite from a new macrolide compound 23-O-benzyl-5-mycaminosyl-tylonolide (TMC-101), by a hepatic microsomal drug-metabolizing enzyme system

Nakura, H., Ohi, H., Miura, T., Fujiwara, T., Ishizone, H., Yokoi, T., Kitada, M. & Kamataki, T., 1991, In : Journal of Pharmacobio-Dynamics. 14, 7, p. 377-383 7 p.

Research output: Contribution to journalArticle

Macrolides
Liver Microsomes
Liver
Enzymes
Pharmaceutical Preparations