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Research Output 1998 2019

  • 825 Citations
  • 18 h-Index
  • 56 Article
  • 2 Review article
  • 1 Comment/debate
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Article
2019

3H-Imidazo[4,5-b]pyridine-6-carboxylic acid derivatives as rexinoids with reduced teratogenicity

Takamura, Y., Takahashi, M., Nishii, M., Shibahara, O., Watanabe, M., Fujihara, M. & Kakuta, H., Jan 1 2019, In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Retinoid X Receptors
Carboxylic Acids
Derivatives
Zebrafish
Transcription
1 Citation (Scopus)

A partial agonist for retinoid X receptor mitigates experimental colitis

Masayoshi, O., Masaki, W., Narumi, I., Koichiro, S., Kei, T., Masato, H., Takahiro, Y., Aiko, E., Osamu, S., Midori, N., Michiko, F., Makoto, M., Daisuke, T., Yukihiro, F., Kakuta, H. & Koji, H., Feb 19 2019, In : International Immunology. 31, 4, p. 251-262 12 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Colitis
Cytoplasmic and Nuclear Receptors
Ulcerative Colitis
Peroxisome Proliferator-Activated Receptors

A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation

Morichika, D., Miyahara, N., Fujii, U., Taniguchi, A., Oda, N., Senoo, S., Kataoka, M., Tanimoto, M., Kakuta, H., Kiura, K., Maeda, Y. & Kanehiro, A., Jan 3 2019, In : Respiratory Research. 20, 1, 2.

Research output: Contribution to journalArticle

Retinoid X Receptors
Pulmonary Emphysema
Emphysema
Inflammation
Pancreatic Elastase

Fluorine-18 (18F)-labeled retinoid x receptor (RXR) partial agonist whose tissue transferability is affected by other RXR ligands

Takamura, Y., Shibahara, O., Watanabe, M., Fujihara, M., Yamada, S., Akehi, M., Sasaki, T., Hirano, H. & Kakuta, H., Jan 1 2019, In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

Positron emission tomography
Fluorine
Positron-Emission Tomography
Tissue
Ligands
Open Access
Industry
Intellectual Property
Drug Industry
Drug Discovery
Pharmaceutical Preparations
1 Citation (Scopus)

Reversal of established liver fibrosis by IC-2-engineered mesenchymal stem cell sheets

Itaba, N., Kono, Y., Watanabe, K., Yokobata, T., Oka, H., Osaki, M., Kakuta, H., Morimoto, M. & Shiota, G., Dec 1 2019, In : Scientific reports. 9, 1, 6841.

Research output: Contribution to journalArticle

Open Access
Mesenchymal Stromal Cells
Liver Cirrhosis
Matrix Metalloproteinase 14
Hepatic Stellate Cells
Alcoholic Intoxication
Open Access
Health Care Quality Assurance
Health Knowledge, Attitudes, Practice
Preclinical Drug Evaluations
Drug Industry
Drug Discovery
2018
1 Citation (Scopus)

Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor α (RXRα)

Miyashita, Y., Numoto, N., Arulmozhiraja, S., Nakano, S., Matsuo, N., Shimizu, K., Shibahara, O., Fujihara, M., Kakuta, H., Ito, S., Ikura, T., Ito, N. & Tokiwa, H., Jan 1 2018, (Accepted/In press) In : FEBS Letters.

Research output: Contribution to journalArticle

Retinoid X Receptors
Conformations
Ligands
Furylfuramide
Central Nervous System Diseases

Strategy for tumor-selective disruption of androgen receptor function in the spectrum of prostate cancer

Rosati, R., Polin, L., Ducker, C., Li, J., Bao, X., Selvakumar, D., Kim, S., Xhabija, B., Larsen, M., McFall, T., Huang, Y., Kidder, B. L., Fribley, A., Saxton, J., Kakuta, H., Shaw, P. & Ratnam, M., Dec 15 2018, In : Clinical Cancer Research. 24, 24, p. 6509-6522 14 p.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
Neoplasms
Growth
flavone
2017
5 Citations (Scopus)

Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma

Fujii, U., Miyahara, N., Taniguchi, A., Oda, N., Morichika, D., Murakami, E., Nakayama, H., Waseda, K., Kataoka, M., Kakuta, H., Tanimoto, M. & Kanehiro, A., Jan 23 2017, In : Respiratory Research. 18, 1, 23.

Research output: Contribution to journalArticle

Retinoid X Receptors
Asthma
Inflammation
Ovalbumin
Cytoplasmic and Nuclear Receptors
5 Citations (Scopus)
Retinoid X Receptors
Carbon Cycle
Carboxylic Acids
Carbon Dioxide
Positron-Emission Tomography
2016
5 Citations (Scopus)

iPSC-derived cancer stem cells provide a model of tumor vasculature

Prieto-Vila, M., Yan, T., Calle, A. S., Nair, N., Hurley, L., Kasai, T., Kakuta, H., Masuda, J., Murakami, H., Mizutani, A. & Seno, M., 2016, In : American Journal of Cancer Research. 6, 9, p. 1906-1921 16 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Neoplasms
Chorioallantoic Membrane
Induced Pluripotent Stem Cells
Angiogenesis Inducing Agents
2015
12 Citations (Scopus)

Positron emission tomography to elucidate pharmacokinetic differences of regioisomeric retinoid x receptor agonists

Kobayashi, T., Furusawa, Y., Yamada, S., Akehi, M., Takenaka, F., Sasaki, T., Akahoshi, A., Hanada, T., Matsuura, E., Hirano, H., Tai, A. & Kakuta, H., Mar 12 2015, In : ACS Medicinal Chemistry Letters. 6, 3, p. 334-338 5 p.

Research output: Contribution to journalArticle

Positron emission tomography
Pharmacokinetics
Retinoids
Positron-Emission Tomography
Blood
20 Citations (Scopus)

RXR partial agonist produced by side chain repositioning of alkoxy RXR full agonist retains antitype 2 diabetes activity without the adverse effects

Kawata, K., Morishita, K. I., Nakayama, M., Yamada, S., Kobayashi, T., Furusawa, Y., Arimoto, S., Oohashi, T., Makishima, M., Naitou, H., Ishitsubo, E., Tokiwa, H., Tai, A. & Kakuta, H., Jan 22 2015, In : Journal of Medicinal Chemistry. 58, 2, p. 912-926 15 p.

Research output: Contribution to journalArticle

Carboxylic Acids
Glucose
Peroxisome Proliferator-Activated Receptors
Oral Administration
pyridine
2014
2 Citations (Scopus)
Retinoid X Receptors
Niacin
Liver Microsomes
Metabolism
Skeleton
18 Citations (Scopus)

In vitro anti-proliferative and anti-angiogenic activities of thalidomide dithiocarbamate analogs

El-Aarag, B. Y. A., Kasai, T., Zahran, M. A. H., Zakhary, N. I., Shigehiro, T., Sekhar, S. C., Agwa, H. S., Mizutani, A., Murakami, H., Kakuta, H. & Seno, M., 2014, In : International Immunopharmacology. 21, 2, p. 283-292 10 p.

Research output: Contribution to journalArticle

Thalidomide
Human Umbilical Vein Endothelial Cells
Matrix Metalloproteinases
Interleukin-8
Wound Healing
7 Citations (Scopus)
Peroxisome Proliferator-Activated Receptors
Glucocorticoid Receptors
Retinoid X Receptors
Anti-Inflammatory Agents
pioglitazone
24 Citations (Scopus)

Retinoid X receptor ligands: A patent review (2007-2013)

Yamada, S. & Kakuta, H., 2014, In : Expert Opinion on Therapeutic Patents. 24, 4, p. 443-452 10 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Ligands
Cytoplasmic and Nuclear Receptors
Type 2 Diabetes Mellitus
Cutaneous T-Cell Lymphoma
2013
26 Citations (Scopus)

Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5- carboxylic acid and structural development to increase potency

Ohsawa, F., Yamada, S., Yakushiji, N., Shinozaki, R., Nakayama, M., Kawata, K., Hagaya, M., Kobayashi, T., Kohara, K., Furusawa, Y., Fujiwara, C., Ohta, Y., Makishima, M., Naitou, H., Tai, A., Yoshikawa, Y., Yasui, H. & Kakuta, H., Mar 14 2013, In : Journal of Medicinal Chemistry. 56, 5, p. 1865-1877 13 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Static Electricity
1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid
Type 2 Diabetes Mellitus
Oxygen
2012
12 Citations (Scopus)

Feasibility of structural modification of retinoid X receptor agonists to separate blood glucose-lowering action from adverse effects: Studies in KKA y type 2 diabetes model mice

Kakuta, H., Ohsawa, F., Yamada, S., Makishima, M., Tai, A., Yasui, H. & Yoshikawa, Y., Apr 2012, In : Biological and Pharmaceutical Bulletin. 35, 4, p. 629-633 5 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Type 2 Diabetes Mellitus
Blood Glucose
Triglycerides
Peroxisome Proliferator-Activated Receptors

Relevance of nuclear receptor expression in a Tchreg cell line, HOZOT: RXRα and PPARγ negatively regulate IFN-γ production

Suzukiamo, M., Takeuchi, M., Tsuji-Takayama, K., Harashima, A., Otani, T., Toraya, T., Kakuta, H., Yamasaki, F., Nakamura, S. & Kibata, M., 2012, In : Results in Immunology. 2, p. 158-165 8 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Cytoplasmic and Nuclear Receptors
Cell Line
T-Lymphocyte Subsets
Regulatory T-Lymphocytes
32 Citations (Scopus)

RXR partial agonist CBt-PMN exerts therapeutic effects on type 2 diabetes without the side effects of RXR full agonists

Kakuta, H., Yakushiji, N., Shinozaki, R., Ohsawa, F., Yamada, S., Ohta, Y., Kawata, K., Nakayama, M., Hagaya, M., Fujiwara, C., Makishima, M., Uno, S., Tai, A., Maehara, A., Nakayama, M., Oohashi, T., Yasui, H. & Yoshikawa, Y., May 10 2012, In : ACS Medicinal Chemistry Letters. 3, 5, p. 427-432 6 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Therapeutic Uses
Medical problems
Type 2 Diabetes Mellitus
Insulin
2011
4 Citations (Scopus)

An arylidene-thiazolidinedione derivative, GPU-4, without PPARγ activation, reduces retinal neovascularization

Nakamura, S., Hayashi, K., Takizawa, H., Murase, T., Tsuruma, K., Shimazawa, M., Kakuta, H., Nagasawa, H. & Hara, H., Feb 2011, In : Current Neurovascular Research. 8, 1, p. 25-34 10 p.

Research output: Contribution to journalArticle

Retinal Neovascularization
Peroxisome Proliferator-Activated Receptors
Vascular Endothelial Growth Factor A
Retinopathy of Prematurity
Endothelial Cells
2 Citations (Scopus)
Retinoid X Receptors
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Peroxisome Proliferator-Activated Receptors
Thiazolidinediones
7 Citations (Scopus)

Design and Synthesis of Novel Cyclooxygenase-1 Inhibitors as Analgesics: 5-Amino-2-ethoxy-N-(substituted-phenyl)benzamides

Fukai, R., Zheng, X., Motoshima, K., Tai, A., Yazama, F. & Kakuta, H., Mar 7 2011, In : ChemMedChem. 6, 3, p. 550-560 11 p.

Research output: Contribution to journalArticle

Benzamides
Cyclooxygenase 1
Cyclooxygenase Inhibitors
Analgesics
Indomethacin
11 Citations (Scopus)

Discovery of a potent retinoid X receptor antagonist structurally closely related to RXR agonist NEt-3IB

Nakayama, M., Yamada, S., Ohsawa, F., Ohta, Y., Kawata, K., Makishima, M. & Kakuta, H., Dec 8 2011, In : ACS Medicinal Chemistry Letters. 2, 12, p. 896-900 5 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Niacin
Iodine
Atoms
Palladium
9 Citations (Scopus)
Retinoid X Receptors
Peroxisome Proliferator-Activated Receptors
Anti-Inflammatory Agents
Ligands
pioglitazone
2 Citations (Scopus)

Pharmacokinetic properties of newly synthesized retinoid X receptor agonists possessing a 6-[N-ethyl-N-(3-alkoxy-4-isopropylphenyl)amino]nicotinic acid skeleton in rats

Ogasawara, A., Murakami, Y., Yakushiji, N., Ohsawa, F., Kusaba, J. I., Aiba, T., Kurosaki, Y. & Kakuta, H., Sep 2011, In : Drug Development and Industrial Pharmacy. 37, 9, p. 1060-1067 8 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Pharmacokinetics
Niacin
Skeleton
Rats
6 Citations (Scopus)

Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity

Okitsu, T., Sato, K., Iwatsuka, K., Sawada, N., Nakagawa, K., Okano, T., Yamada, S., Kakuta, H. & Wada, A., May 1 2011, In : Bioorganic and Medicinal Chemistry. 19, 9, p. 2939-2949 11 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Terpenes
Retinoic Acid Receptors
Skeleton
alitretinoin
4 Citations (Scopus)

Significance and creation of novel cyclooxygenase-1 (COX-1) selective inhibitors

Fukai, R., Zheng, X., Motoshima, K. & Kakuta, H., Mar 2011, In : Yakugaku Zasshi. 131, 3, p. 347-351 5 p.

Research output: Contribution to journalArticle

Cyclooxygenase 1
Stomach
Analgesics
Indomethacin
Anti-Inflammatory Agents
2010
10 Citations (Scopus)

Cyclic-tri(N-methyl-meta-benzamide)s: Substituent effects on the bowl-shaped conformation in the crystal and solution states

Kakuta, H., Azumaya, I., Masu, H., Matsumura, M., Yamaguchi, K., Kagechika, H. & Tanatani, A., Oct 16 2010, In : Tetrahedron. 66, 42, p. 8254-8260 7 p.

Research output: Contribution to journalArticle

Conformations
Crystals
Benzoic Acid
Energy barriers
Amides
2 Citations (Scopus)

Effect of 5-aminosalicylate on allergic rhinitis model in mice

Kuyama, S., Yamamoto, A., Sugiyama, M., Kakuta, H. & Sugimoto, Y., Jun 2010, In : International Immunopharmacology. 10, 6, p. 713-716 4 p.

Research output: Contribution to journalArticle

Mesalamine
Nose
Ovalbumin
Peroxisome Proliferator-Activated Receptors
Interleukin-4
7 Citations (Scopus)

Fluorescent retinoid X receptor ligands for fluorescence polarization assay

Yamada, S., Ohsawa, F., Fujii, S., Shinozaki, R., Makishima, M., Naitou, H., Enomoto, S., Tai, A. & Kakuta, H., Sep 1 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 17, p. 5143-5146 4 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Fluorescence Polarization
Assays
Fluorescence
Polarization
8 Citations (Scopus)

Identification of urine metabolites of TFAP, a cyclooxygenase-1 inhibitor

Kakuta, H., Fukai, R., Xiaoxia, Z., Ohsawa, F., Bamba, T., Hirata, K. & Tai, A., Mar 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 6, p. 1840-1843 4 p.

Research output: Contribution to journalArticle

Cyclooxygenase 1
Cyclooxygenase Inhibitors
Metabolites
Urine
Analgesics
27 Citations (Scopus)

Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation

Fujii, S., Ohsawa, F., Yamada, S., Shinozaki, R., Fukai, R., Makishima, M., Enomoto, S., Tai, A. & Kakuta, H., Sep 1 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 17, p. 5139-5142 4 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Chemical activation
Peroxisome Proliferator-Activated Receptors
Liver
Hydroxamic Acids
29 Citations (Scopus)

Modification at the lipophilic domain of RXR agonists differentially influences activation of RXR heterodimers

Ohsawa, F., Morishita, K. I., Yamada, S., Makishima, M. & Kakuta, H., Dec 9 2010, In : ACS Medicinal Chemistry Letters. 1, 9, p. 521-525 5 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Chemical activation
Niacin
Medical problems
Hyperlipidemias
2009
25 Citations (Scopus)

Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity

Morishita, K. I., Yakushiji, N., Ohsawa, F., Takamatsu, K., Matsuura, N., Makishima, M., Kawahata, M., Yamaguchi, K., Tai, A., Sasaki, K. & Kakuta, H., Feb 1 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 3, p. 1001-1003 3 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Sulfonamides
Switches
Ligands
Allergies
2008
62 Citations (Scopus)
Cyclooxygenase 1
Analgesics
Stomach
Bioactivity
In Vitro Techniques
22 Citations (Scopus)

Design and synthesis of benzenesulfonanilides active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus

Namba, K., Zheng, X., Motoshima, K., Kobayashi, H., Tai, A., Takahashi, E., Sasaki, K., Okamoto, K. & Kakuta, H., Jun 1 2008, In : Bioorganic and Medicinal Chemistry. 16, 11, p. 6131-6144 14 p.

Research output: Contribution to journalArticle

Methicillin
Vancomycin
Methicillin-Resistant Staphylococcus aureus
Dihydropteroate Synthase
Folic Acid
2 Citations (Scopus)

Effect of the oral absorption of benzenesulfonanilide-type cyclooxygenase-1 inhibitors on analgesic action and gastric ulcer formation

Zheng, X., Oda, H., Harada, S., Sugimoto, Y., Tai, A., Sasaki, K. & Kakuta, H., Dec 2008, In : Journal of Pharmaceutical Sciences. 97, 12, p. 5446-5452 7 p.

Research output: Contribution to journalArticle

Cyclooxygenase 1
Cyclooxygenase Inhibitors
Stomach Ulcer
Analgesics
Inhibitory Concentration 50
1 Citation (Scopus)
Cyclin D1
Patents and inventions
Nanoparticles
Small Interfering RNA
Leukocytes
13 Citations (Scopus)

Pyridinium cationic-dimer antimalarials, unlike chloroquine, act selectively between the schizont stage and the ring stage of Plasmodium falciparum

Yoshikawa, M., Motoshima, K., Fujimoto, K., Tai, A., Kakuta, H. & Sasaki, K., Jun 1 2008, In : Bioorganic and Medicinal Chemistry. 16, 11, p. 6027-6033 7 p.

Research output: Contribution to journalArticle

Schizonts
Chloroquine
Antimalarials
Plasmodium falciparum
Dimers
19 Citations (Scopus)

Reduction of lipophilicity at the lipophilic domain of RXR agonists enables production of subtype preference: RXRα-preferential agonist possessing a sulfonamide moiety

Takamatsu, K., Takano, A., Yakushiji, N., Morishita, K. I., Matsuura, N., Makishima, M., Ali, H. I., Akaho, E., Tai, A., Sasaki, K. & Kakuta, H., Mar 14 2008, In : ChemMedChem. 3, 3, p. 454-460 7 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Benzoic Acid
Sulfonamides
Tamoxifen
Paclitaxel
42 Citations (Scopus)

The first potent subtype-selective retinoid X receptor (RXR) agonist possessing a 3-isopropoxy-4-isopropylphenylamino moiety, NEt-3IP (RXRα/β-dual agonist)

Takamatsu, K., Takano, A., Yakushiji, N., Morohashi, K., Morishita, K., Matsuura, N., Makishima, M., Tai, A., Sasaki, K. & Kakuta, H., May 19 2008, In : ChemMedChem. 3, 5, p. 780-787 8 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Niacin
Benzoic Acid
Metabolic Diseases
Tamoxifen
2007
23 Citations (Scopus)

Analgesic agents without gastric damage: Design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors

Zheng, X., Oda, H., Takamatsu, K., Sugimoto, Y., Tai, A., Akaho, E., Ali, H. I., Oshiki, T., Kakuta, H. & Sasaki, K., Jan 15 2007, In : Bioorganic and Medicinal Chemistry. 15, 2, p. 1014-1021 8 p.

Research output: Contribution to journalArticle

Cyclooxygenase 1
Cyclooxygenase Inhibitors
Analgesics
Stomach
Aspirin
22 Citations (Scopus)

Antimalarial cation-dimers synthesized in two steps from an inexpensive starting material, isonicotinic acid

Motoshima, K., Hiwasa, Y., Yoshikawa, M., Fujimoto, K., Tai, A., Kakuta, H. & Sasaki, K., Oct 8 2007, In : ChemMedChem. 2, 10, p. 1527-1532 6 p.

Research output: Contribution to journalArticle

Isonicotinic Acids
Antimalarials
Dimers
Cations
Bromides
2 Citations (Scopus)
Cyclooxygenase 1
Analgesics
Stomach
corrigendum
2006
31 Citations (Scopus)

Antimalarial effect of bis-pyridinium salts, N,N′-hexamethylenebis(4-carbamoyl-1-alkylpyridinium bromide)

Fujimoto, K., Morisaki, D., Yoshida, M., Namba, T., Kim, H-S., Wataya, Y., Kourai, H., Kakuta, H. & Sasaki, K., May 15 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 10, p. 2758-2760 3 p.

Research output: Contribution to journalArticle

Antimalarials
Bromides
Salts
Chain length
Chloroquine
2004
79 Citations (Scopus)

Membrane permeabilization by non-steroidal anti-inflammatory drugs

Tomisato, W., Tanaka, K. I., Katsu, T., Kakuta, H., Sasaki, K., Tsutsumi, S., Hoshino, T., Aburaya, M., Li, D., Tsuchiya, T., Suzuki, K., Yokomizo, K. & Mizushima, T., Oct 22 2004, In : Biochemical and Biophysical Research Communications. 323, 3, p. 1032-1039 8 p.

Research output: Contribution to journalArticle

Anti-Inflammatory Agents
Membranes
Pharmaceutical Preparations
Cytotoxicity
Cell death
2003
14 Citations (Scopus)

Cyclooxygenase inhibitors derived from thalidomide

Suizu, M., Muroya, Y., Kakuta, H., Kagechika, H., Tanatani, A., Nagasawa, K. & Hashimoto, Y., Sep 2003, In : Chemical and Pharmaceutical Bulletin. 51, 9, p. 1098-1102 5 p.

Research output: Contribution to journalArticle

Thalidomide
Cyclooxygenase Inhibitors
Prostaglandin-Endoperoxide Synthases
Aspirin