Eiki Ichihara

  • 2181 Citations
  • 20 h-Index
20072019
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Research Output 2007 2019

  • 2181 Citations
  • 20 h-Index
  • 75 Article
  • 2 Letter
  • 1 Comment/debate
  • 1 Review article
2019

A Prospective Cohort Study to Define the Clinical Features and Outcome of Lung Cacers Harboring HER2 Aberration in Japan (HER2-CS STUDY)

Ninomiya, K., Hata, T., Yoshioka, H., Ohashi, K., Bessho, A., Hosokawa, S., Ishikawa, N., Yamasaki, M., Shibayama, T., Aoe, K., Kozuki, T., Harita, S., Ueda, Y., Murakami, T., Fujimoto, N., Yanai, H., Toyooka, S., Takata, M., Hotta, K., Kiura, K. & 108 others, Gemba, K., Ikeda, G., Yasugi, M., Kurimoto, E., Nakano, K., Moritaka, T., Inoue, K., Miyoshi, S., Hamaguchi, N., Ito, R., Sano, Y., Takata, I., Mitani, A., Nishisaka, T., Shoda, H., Nishida, A., Tamamoto, S., Fujitaka, K., Masuda, T., Miyamoto, S., Hattori, N., Sugimoto, K., Fujii, S., Ueda, Y., Sakugawa, Y., Fukamatsu, N., Ogata, K., Bandoh, S., Kanaji, N., Takigawa, N., Yamane, H., Ochi, N., Honda, Y., Oka, M., Kittaka, M., Kubota, T., Yokoyama, A., Yokoyama, T., Sato, E., Shiota, Y., Horita, N., Kanematsu, T., Awaya, Y., Nakamasu, A., Murakami, I., Kuyama, S., Kudo, K., Tamura, T., Umeno, T., Morichika, D., Fujiwara, K., Sato, K., Harada, D., Nogami, N., Nishii, K., Fuchimoto, Y., Kishimoto, T., Kawai, H., Watanabe, K., Tokumo, K., Isobe, T., Tsubata, Y., Inoue, M., Ichikawa, H., Nishioka, Y., Hanibuchi, M., Goto, H., Sumikawa, T., Kodani, M., Suyama, H., Makino, H., Kinosita, N., Shimizu, E., Obata, H., Ikegami, H., Chikamori, K., Maeda, T., Kishino, T., Kamei, H., Ueoka, H., Kunihiro, Y., Kobayashi, T., Ueda, K., Hayashi, M., Kamiya, M., Murakami, J., Sato, A., Ichihara, E., Kubo, T., Ninomiya, T., Hirata, T., Minami, D., Kato, Y., Higo, H., Makimoto, G., Toyota, Y., Oda, N., Nakanishi, M., Kayatani, H., Senoo, S., Kano, H., Watanabe, H., Ando, T., Nakasuka, T., Hara, N., Itano, J., Nakashima, H. & Tabata, M., Jan 1 2019, In : Chest.

Research output: Contribution to journalArticle

Epidermal Growth Factor
Japan
Cohort Studies
Prospective Studies
Lung

Chemoradiotherapy for locally advanced lung cancer patients with interstitial lung abnormalities

Higo, H., Kubo, T., Makimoto, S., Makimoto, G., Ihara, H., Masaoka, Y., Ninomiya, T., Ichihara, E., Oohashi, K., Sato, A., Hotta, K., Tabata, M., Takigawa, N., Maeda, Y. & Kiura, K., Jan 1 2019, In : Japanese journal of clinical oncology. 49, 5, p. 458-464 7 p.

Research output: Contribution to journalArticle

Chemoradiotherapy
Lung Neoplasms
Lung
Radiation Pneumonitis
Tomography

Efficacy of afatinib treatment for lung adenocarcinoma harboring exon 18 delE709_T710insD mutation

Iwamoto, Y., Ichihara, E., Hara, N., Nakasuka, T., Ando, C., Umeno, T., Hirabae, A., Maeda, Y. & Kiura, K., Aug 1 2019, In : Japanese journal of clinical oncology. 49, 8, p. 786-788 3 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Exons
Mutation
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases

Granulation tissue-induced pseudo-relapse during nivolumab treatment in advanced non-small cell lung cancer

Ando, C., Ichihara, E., Kano, H., Iwamoto, Y., Hirabae, A., Nakasuka, T., Maeda, Y. & Kiura, K., Jan 1 2019, In : In Vivo. 33, 6, p. 2113-2115 3 p.

Research output: Contribution to journalArticle

Open Access
Granulation
Granulation Tissue
Non-Small Cell Lung Carcinoma
Cells
Tissue

Patients’ preferences and perceptions of lung cancer treatment decision making: results from Okayama lung cancer study group trial 1406

Makimoto, G., Hotta, K., Oze, I., Ninomiya, K., Nakanishi, M., Hara, N., Kano, H., Watanabe, H., Hata, Y., Nishii, K., Nakasuka, T., Itano, J., Ninomiya, T., Kubo, T., Ohashi, K., Ichihara, E., Minami, D., Sato, A., Tabata, M., Maeda, Y. & 1 others, Kiura, K., Jan 1 2019, (Accepted/In press) In : Acta Oncologica.

Research output: Contribution to journalLetter

Patient Preference
Lung Neoplasms
Decision Making

Primary Resistance to Alectinib Was Lost after Bevacizumab Combined Chemotherapy in ALK-Rearranged Lung Adenocarcinoma

Nakasuka, T., Ichihara, E., Makimoto, G., Maeda, Y. & Kiura, K., Aug 1 2019, In : Journal of Thoracic Oncology. 14, 8, p. e168-e169

Research output: Contribution to journalLetter

Drug Therapy
CH5424802
Adenocarcinoma of lung
Bevacizumab

Rapid Acquisition of Alectinib Resistance in ALK-Positive Lung Cancer With High Tumor Mutation Burden

Makimoto, G., Oohashi, K., Tomida, S., Nishii, K., Matsubara, T., Kayatani, H., Higo, H., Ninomiya, K., Sato, A., Watanabe, H., Kano, H., Ninomiya, T., Kubo, T., Rai, K., Ichihara, E., Hotta, K., Tabata, M., Toyooka, S., Takata, M., Maeda, Y. & 1 others, Kiura, K., Jan 1 2019, (Accepted/In press) In : Journal of Thoracic Oncology.

Research output: Contribution to journalArticle

Tumor Burden
Lung Neoplasms
Mutation
Neoplasms
Heterografts
1 Citation (Scopus)
Non-Small Cell Lung Carcinoma
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
osimertinib
Meningeal Carcinomatosis

Summary of the Japanese Respiratory Society statement for the treatment of lung cancer with comorbid interstitial pneumonia

DLD/TO Assemblies of JRS, Jan 1 2019, (Accepted/In press) In : Respiratory Investigation.

Research output: Contribution to journalReview article

Interstitial Lung Diseases
Lung Neoplasms
Therapeutics
Clinical Trials
Lung Injury

The effect and safety of immune checkpoint inhibitor rechallenge in non-small cell lung cancer

Watanabe, H., Kubo, T., Ninomiya, K., Kudo, K., Minami, D., Murakami, E., Ochi, N., Ninomiya, T., Harada, D., Yasugi, M., Ichihara, E., Ohashi, K., Fujiwara, K., Hotta, K., Tabata, M., Maeda, Y. & Kiura, K., Aug 1 2019, In : Japanese journal of clinical oncology. 49, 8, p. 762-765 4 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Safety
Confidence Intervals
Survival
Disease-Free Survival
2018
4 Citations (Scopus)

A phase II trial of EGFR-TKI readministration with afatinib in advanced non-small-cell lung cancer harboring a sensitive non-T790M EGFR mutation: Okayama Lung Cancer Study Group trial 1403

Oda, N., Hotta, K., Ninomiya, K., Minami, D., Ichihara, E., Murakami, T., Yokoyama, T., Ichikawa, H., Chikamori, K., Takigawa, N., Ochi, N., Harita, S., Maeda, Y. & Kiura, K., Jan 1 2018, (Accepted/In press) In : Cancer Chemotherapy and Pharmacology.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Lung Neoplasms
Cells
5 Citations (Scopus)
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Mutation
Essential Drugs
Protein-Tyrosine Kinases
2 Citations (Scopus)

Combined effect of cabozantinib and gefitinib in crizotinib-resistant lung tumors harboring ROS1 fusions

Kato, Y., Ninomiya, K., Ohashi, K., Tomida, S., Makimoto, G., Watanabe, H., Kudo, K., Matsumoto, S., Umemura, S., Goto, K., Ichihara, E., Ninomiya, T., Kubo, T., Sato, A., Hotta, K., Tabata, M., Toyooka, S., Maeda, Y. & Kiura, K., Jan 1 2018, (Accepted/In press) In : Cancer Science.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Lung
Protein-Tyrosine Kinases
Gene Fusion
Neoplasms
14 Citations (Scopus)
Epidermal Growth Factor Receptor
Mitogen-Activated Protein Kinase Kinases
Protein-Tyrosine Kinases
Therapeutics
osimertinib
Oncogenes
Non-Small Cell Lung Carcinoma
Biopsy
Molecular Biology
Neoplasms
2017
14 Citations (Scopus)

A Phase II Study of Trastuzumab Emtansine in HER2-Positive Non-Small Cell Lung Cancer

Hotta, K., Aoe, K., Kozuki, T., Oohashi, K., Ninomiya, K., Ichihara, E., Kubo, T., Ninomiya, T., Chikamori, K., Harada, D., Nogami, N., Hirata, T., Hinotsu, S., Toyooka, S. & Kiura, K., Jan 1 2017, (Accepted/In press) In : Journal of Thoracic Oncology.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Immunohistochemistry
Fluorescence In Situ Hybridization
Exons
TYK2 Kinase
2 Citations (Scopus)

A phase II trial of carboplatin plus S-1 for elderly patients with advanced non-small-cell lung cancer with wild-type epidermal growth factor receptor: The Okayama Lung Cancer Study Group Trial 1202

Kuyama, S., Ochi, N., Bessho, A., Hotta, K., Ikeda, G., Kishino, D., Kubo, T., Harada, D., Fujimoto, N., Nakanishi, M., Umeno, T., Okada, T., Chikamori, K., Yamagishi, T., Oohashi, K., Ichihara, E., Takigawa, N., Tanimoto, M. & Kiura, K., Oct 1 2017, In : Lung Cancer. 112, p. 188-194 7 p.

Research output: Contribution to journalArticle

Carboplatin
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Confidence Intervals
2 Citations (Scopus)
Waiting Lists
Interstitial Lung Diseases
Transplants
Lung
Transplantation

Congestive heart failure during osimertinib treatment for epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC)

Watanabe, H., Ichihara, E., Kano, H., Ninomiya, K., Tanimoto, M. & Kiura, K., 2017, In : Internal Medicine. 56, 16, p. 2195-2197 3 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Heart Failure
Therapeutics
Dyspnea
2 Citations (Scopus)

Discomfort during bronchoscopy performed after endobronchial intubation with fentanyl and midazolam: A prospective study

Minami, D., Takigawa, N., Kano, H., Ninomiya, T., Kubo, T., Ichihara, E., Oohashi, K., Sato, A., Hotta, K., Tabata, M., Tanimoto, M. & Kiura, K., May 1 2017, In : Japanese Journal of Clinical Oncology. 47, 5, p. 434-437 4 p., hyx022.

Research output: Contribution to journalArticle

Midazolam
Bronchoscopy
Fentanyl
Intubation
Prospective Studies
1 Citation (Scopus)

Effects of (-)-epigallocatechin-3-gallate on egfr- or fusion gene-driven lung cancer cells

Honda, Y., Takigawa, N., Ichihara, E., Ninomiya, T., Kubo, T., Ochi, N., Yasugi, M., Murakami, T., Yamane, H., Tanimoto, M. & Kiura, K., Jan 1 2017, In : Acta Medica Okayama. 71, 6, p. 505-512 8 p.

Research output: Contribution to journalArticle

Gene Fusion
Lung Neoplasms
Fusion reactions
Genes
Cells
4 Citations (Scopus)

Phase II Study of the EGFR-TKI Rechallenge With Afatinib in Patients With Advanced NSCLC Harboring Sensitive EGFR Mutation Without T790M: Okayama Lung Cancer Study Group Trial OLCSG 1403

Oda, N., Ichihara, E., Hotta, K., Ninomiya, K., Ninomiya, T., Kubo, T., Minami, D., Murakami, T., Yokoyama, T., Harada, D., Kuyama, S., Ichikawa, H., Inoue, K., Kishino, D., Inoue, M., Takigawa, N., Shibayama, T., Harita, S., Tanimoto, M. & Kiura, K., Mar 1 2017, In : Clinical Lung Cancer. 18, 2, p. 241-244 4 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Lung Neoplasms
Mutation
8 Citations (Scopus)
Therapeutic Uses
Non-Small Cell Lung Carcinoma
Interleukin-6
Cells
Epidermal Growth Factor Receptor
2 Citations (Scopus)

Protective effects of bisoprolol against acute exacerbation in moderate-to-severe chronic obstructive pulmonary disease

Taniguchi, A., Miyahara, N., Oda, N., Morichika, D., Ichihara, E., Ozed, I., Tanimoto, Y., Ichikawa, H., Fujii, U., Tanimoto, M., Kanehiro, A. & Kiura, K., 2017, In : Acta Medica Okayama. 71, 5, p. 453-457 5 p.

Research output: Contribution to journalArticle

Bisoprolol
Pulmonary diseases
Chronic Obstructive Pulmonary Disease
Heart Failure
Disease Progression
34 Citations (Scopus)

SFK/FAK signaling attenuates osimertinib efficacy in both drug-sensitive and drug-resistant models of EGFR-mutant lung cancer

Ichihara, E., Westover, D., Meador, C. B., Yan, Y., Bauer, J. A., Lu, P., Ye, F., Kulick, A., De Stanchina, E., McEwen, R., Ladanyi, M., Cross, D., Pao, W. & Lovly, C. M., Jun 1 2017, In : Cancer Research. 77, 11, p. 2990-3000 11 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
src-Family Kinases
Lung Neoplasms
Pharmaceutical Preparations
Protein-Tyrosine Kinases
1 Citation (Scopus)

Three-Arm Randomized Trial of Sodium Alginate for Preventing Radiation-Induced Esophagitis in Locally Advanced Non–Small Cell Lung Cancer Receiving Concurrent Chemoradiotherapy: The OLCSG1401 Study Protocol

Ninomiya, K., Ichihara, E., Hotta, K., Sone, N., Murakami, T., Harada, D., Oze, I., Kubo, T., Tanaka, H., Kuyama, S., Kishino, D., Bessho, A., Harita, S., Katsui, K., Tanimoto, M. & Kiura, K., Mar 1 2017, In : Clinical Lung Cancer. 18, 2, p. 245-249 5 p.

Research output: Contribution to journalArticle

Esophagitis
Chemoradiotherapy
Non-Small Cell Lung Carcinoma
Radiation
Quality of Life
14 Citations (Scopus)

Treatment Rationale and Design for J-SONIC: A Randomized Study of Carboplatin Plus Nab-paclitaxel With or Without Nintedanib for Advanced Non-Small-cell Lung Cancer With Idiopathic Pulmonary Fibrosis

Otsubo, K., Kishimoto, J., Kenmotsu, H., Minegishi, Y., Ichihara, E., Shiraki, A., Kato, T., Atagi, S., Horinouchi, H., Ando, M., Kondoh, Y., Kusumoto, M., Ichikado, K., Yamamoto, N., Nakanishi, Y. & Okamoto, I., 2017, (Accepted/In press) In : Clinical Lung Cancer.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Carboplatin
Non-Small Cell Lung Carcinoma
Nanoparticles
Therapeutics
5 Citations (Scopus)

Triplet therapy with afatinib, cetuximab, and bevacizumab induces deep remission in lung cancer cells harboring EGFR T790M in vivo

Kudo, K., Ohashi, K., Makimoto, G., Higo, H., Kato, Y., Kayatani, H., Kurata, Y., Takami, Y., Minami, D., Ninomiya, T., Kubo, T., Ichihara, E., Sato, A., Hotta, K., Yoshino, T., Tanimoto, M. & Kiura, K., 2017, In : Molecular Oncology. 11, 6, p. 670-681 12 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Lung Neoplasms
Neoplasms
Therapeutics
Heterografts
2016

Effect of vandetanib on lung tumorigenesis in transgenic mice carrying an activating Egfr gene mutation

Osawa, M., Oohashi, K., Kubo, T., Ichihara, E., Takata, S., Takigawa, N., Takata, M., Tanimoto, M. & Kiura, K., 2016, In : Acta Medica Okayama. 70, 4, p. 243-254 12 p.

Research output: Contribution to journalArticle

Transgenic Mice
Carcinogenesis
Genes
Epidermal Growth Factor Receptor
Lung
32 Citations (Scopus)

EGFR fusions as novel therapeutic targets in lung cancer

Konduri, K., Gallant, J. N., Chae, Y. K., Giles, F. J., Gitlitz, B. J., Gowen, K., Ichihara, E., Owonikoko, T. K., Peddareddigari, V., Ramalingam, S. S., Reddy, S. K., Eaby-Sandy, B., Vavalà, T., Whiteley, A., Chen, H., Yan, Y., Sheehan, J. H., Meiler, J., Morosini, D., Ross, J. S. & 4 others, Stephens, P. J., Miller, V. A., Ali, S. M. & Lovly, C. M., Jun 1 2016, In : Cancer Discovery. 6, 6, p. 601-611 11 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Lung Neoplasms
Therapeutics
Neoplasms
erbB-1 Genes
65 Citations (Scopus)

Non-small cell lung cancer cells acquire resistance to the ALK inhibitor alectinib by activating alternative receptor tyrosine kinases

Isozaki, H., Ichihara, E., Takigawa, N., Oohashi, K., Ochi, N., Yasugi, M., Ninomiya, T., Yamane, H., Hotta, K., Sakai, K., Matsumoto, K., Hosokawa, S., Bessho, A., Sendo, T., Tanimoto, M. & Kiura, K., Mar 15 2016, In : Cancer Research. 76, 6, p. 1506-1516 11 p.

Research output: Contribution to journalArticle

Receptor Protein-Tyrosine Kinases
Non-Small Cell Lung Carcinoma
Epidermal Growth Factor Receptor
Somatomedin Receptors
Cell Line
3 Citations (Scopus)
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Cells
Liver
7 Citations (Scopus)

Protocol Design for the Bench to Bed Trial in Alectinib-Refractory Non–Small-Cell Lung Cancer Patients Harboring the EML4-ALK Fusion Gene (ALRIGHT/OLCSG1405)

Isozaki, H., Hotta, K., Ichihara, E., Takigawa, N., Oohashi, K., Kubo, T., Ninomiya, T., Ninomiya, K., Oda, N., Yoshioka, H., Ichikawa, H., Inoue, M., Takata, I., Shibayama, T., Kuyama, S., Sugimoto, K., Harada, D., Harita, S., Sendo, T., Tanimoto, M. & 1 others, Kiura, K., Nov 1 2016, In : Clinical Lung Cancer. 17, 6, p. 602-605 4 p.

Research output: Contribution to journalArticle

Gene Fusion
Non-Small Cell Lung Carcinoma
Hepatocyte Growth Factor
Disease Progression
MAP4
12 Citations (Scopus)

Short-term low-volume hydration in cisplatin-based chemotherapy for patients with lung cancer: the second prospective feasibility study in the Okayama Lung Cancer Study Group Trial 1201

Ninomiya, K., Hotta, K., Hisamoto-Sato, A., Ichihara, E., Gotoda, H., Morichika, D., Tamura, T., Kayatani, H., Minami, D., Kubo, T., Tabata, M., Tanimoto, M. & Kiura, K., Feb 1 2016, In : International Journal of Clinical Oncology. 21, 1, p. 81-87 7 p.

Research output: Contribution to journalArticle

Feasibility Studies
Cisplatin
Lung Neoplasms
Prospective Studies
Drug Therapy
2015
137 Citations (Scopus)

Acquired resistance to the mutant-selective EGFR inhibitor AZD9291 is associated with increased dependence on RAS signaling in preclinical models

Eberlein, C. A., Stetson, D., Markovets, A. A., Al-Kadhimi, K. J., Lai, Z., Fisher, P. R., Meador, C. B., Spitzler, P., Ichihara, E., Ross, S. J., Ahdesmaki, M. J., Ahmed, A., Ratcliffe, L. E., O'Brien, E. L. C., Barnes, C. H., Brown, H., Smith, P. D., Dry, J. R., Beran, G., Thress, K. S. & 3 others, Dougherty, B., Pao, W. & Cross, D. A. E., Jun 15 2015, In : Cancer Research. 75, 12, p. 2489-2500 12 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Population
Neoplasms
Mutation
Protein-Tyrosine Kinases
Antineoplastic Combined Chemotherapy Protocols
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Adenocarcinoma
6 Citations (Scopus)

Impact of body surface area on survival in EGFR-mutant non-small cell lung cancer patients treated with gefitinib monotherapy: observational study of the Okayama Lung Cancer Study Group 0703

Kudo, K., Hotta, K., Ichihara, E., Yoshioka, H., Kunimasa, K., Tsubouchi, K., Iwasaku, M., Kato, Y., Oze, I., Takigawa, N., Tanimoto, M. & Kiura, K., Jun 3 2015, In : Cancer Chemotherapy and Pharmacology. 76, 2, p. 251-256 6 p., 2789.

Research output: Contribution to journalArticle

Body Surface Area
Non-Small Cell Lung Carcinoma
Observational Studies
Lung Neoplasms
Cells
57 Citations (Scopus)

Phase II trial of gefitinib in combination with bevacizumab as first-line therapy for advanced non-small cell lung cancer with activating EGFR gene mutations: The okayama lung cancer study group trial 1001

Ichihara, E., Hotta, K., Nogami, N., Kuyama, S., Kishino, D., Fujii, M., Kozuki, T., Tabata, M., Harada, D., Chikamori, K., Aoe, K., Ueoka, H., Hosokawa, S., Bessho, A., Hisamoto-Sato, A., Kubo, T., Oze, I., Takigawa, N., Tanimoto, M. & Kiura, K., Mar 30 2015, In : Journal of Thoracic Oncology. 10, 3, p. 486-491 6 p.

Research output: Contribution to journalArticle

erbB-1 Genes
Non-Small Cell Lung Carcinoma
Disease-Free Survival
Lung Neoplasms
Epidermal Growth Factor Receptor
107 Citations (Scopus)

RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer

Hrustanovic, G., Olivas, V., Pazarentzos, E., Tulpule, A., Asthana, S., Blakely, C. M., Okimoto, R. A., Lin, L., Neel, D. S., Sabnis, A., Flanagan, J., Chan, E., Varella-Garcia, M., Aisner, D. L., Vaishnavi, A., Ou, S. H. I., Collisson, E. A., Ichihara, E., Mack, P. C., Lovly, C. M. & 5 others, Karachaliou, N., Rosell, R., Riess, J. W., Doebele, R. C. & Bivona, T. G., Sep 8 2015, In : Nature Medicine. 21, 9, p. 1038-1047 10 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinases
Lung Neoplasms
Tumors
Mitogen-Activated Protein Kinase Phosphatases
Cells
10 Citations (Scopus)

Shades of T790M: Intratumor Heterogeneity in EGFR-Mutant Lung Cancer

Ichihara, E. & Lovly, C. M., Jul 1 2015, In : Cancer Discovery. 5, 7, p. 694-696 3 p.

Research output: Contribution to journalComment/debate

Drug Resistance
Lung Neoplasms
Mutation Rate
Gene Frequency
DNA
2014
7 Citations (Scopus)

A new human lung adenocarcinoma cell line harboring the EML4-ALK fusion gene

Isozaki, H., Yasugi, M., Takigawa, N., Hotta, K., Ichihara, E., Taniguchi, A., Toyooka, S., Hashida, S., Sendo, T., Tanimoto, M. & Kiura, K., Oct 1 2014, In : Japanese Journal of Clinical Oncology. 44, 10, p. 963-968 6 p.

Research output: Contribution to journalArticle

Gene Fusion
Cell Line
Fluorescence In Situ Hybridization
Lung Neoplasms
Malignant Pleural Effusion
801 Citations (Scopus)

AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer

Cross, D. A. E., Ashton, S. E., Ghiorghiu, S., Eberlein, C., Nebhan, C. A., Spitzler, P. J., Orme, J. P., Finlay, M. R. V., Ward, R. A., Mellor, M. J., Hughes, G., Rahi, A., Jacobs, V. N., Brewer, M. R., Ichihara, E., Sun, J., Jin, H., Ballard, P., Al-Kadhimi, K., Rowlinson, R. & 6 others, Klinowska, T., Richmond, G. H. P., Cantarini, M., Kim, D. W., Ranson, M. R. & Pao, W., 2014, In : Cancer Discovery. 4, 9, p. 1046-1061 16 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Lung Neoplasms
Non-Small Cell Lung Carcinoma
Heterografts
Disease Progression
18 Citations (Scopus)

Effect of AZD1480 in an epidermal growth factor receptor-driven lung cancer model

Murakami, T., Takigawa, N., Ninomiya, T., Ochi, N., Yasugi, M., Honda, Y., Kubo, T., Ichihara, E., Hotta, K., Tanimoto, M. & Kiura, K., Jan 2014, In : Lung Cancer. 83, 1, p. 30-36 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Lung Neoplasms
Transgenic Mice
Heterografts
Janus Kinases
3 Citations (Scopus)

Everolimus prolonged survival in transgenic mice with EGFR-driven lung tumors

Yasugi, M., Takigawa, N., Ochi, N., Oohashi, K., Harada, D., Ninomiya, T., Murakami, T., Honda, Y., Ichihara, E., Tanimoto, M. & Kiura, K., Aug 15 2014, In : Experimental Cell Research. 326, 2, p. 201-209 9 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Transgenic Mice
Lung
Neoplasms
Cell Line
7 Citations (Scopus)

Factor associated with failure to administer subsequent treatment after progression in the first-line chemotherapy in EGFR-mutant non-small cell lung cancer: Okayama Lung Cancer Study Group experience

Kato, Y., Hotta, K., Takigawa, N., Nogami, N., Kozuki, T., Sato, A., Ichihara, E., Kudo, K., Oze, I., Tabata, M., Shinkai, T., Tanimoto, M. & Kiura, K., 2014, In : Cancer Chemotherapy and Pharmacology. 73, 5, p. 943-950 8 p.

Research output: Contribution to journalArticle

Chemotherapy
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Lung Neoplasms
27 Citations (Scopus)

Src mediates ERK reactivation in gefitinib resistance in non-small cell lung cancer

Ochi, N., Takigawa, N., Harada, D., Yasugi, M., Ichihara, E., Hotta, K., Tabata, M., Tanimoto, M. & Kiura, K., Mar 10 2014, In : Experimental Cell Research. 322, 1, p. 168-177 10 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cell Line
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
MAP Kinase Signaling System
gefitinib
2013
163 Citations (Scopus)

Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells

Shien, K., Toyooka, S., Yamamoto, H., Sou, J., Jida, M., Thu, K. L., Hashida, S., Maki, Y., Ichihara, E., Asano, H., Tsukuda, K., Takigawa, N., Kiura, K., Gazdar, A. F., Lam, W. L. & Miyosh, S., May 15 2013, In : Cancer Research. 73, 10, p. 3051-3061 11 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Stem Cells
Protein-Tyrosine Kinases
Epithelial-Mesenchymal Transition
Neoplasms
2 Citations (Scopus)

A definite case of l-carbocisteine-induced pneumonia with CATCH22 syndrome

Kudo, K., Ichihara, E., Hisamoto, A., Hotta, K., Miyahara, N., Tanimoto, Y., Akagi, S., Kato, K., Tanimoto, M. & Kiura, K., 2013, In : Internal Medicine. 52, 1, p. 97-100 4 p.

Research output: Contribution to journalArticle

Pneumonia
Pharmaceutical Preparations
Viral Pneumonia
Bacterial Pneumonia
Bronchitis