Eiki Ichihara

  • 2486 Citations
  • 22 h-Index
20072020

Research output per year

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Research Output

  • 2486 Citations
  • 22 h-Index
  • 76 Article
  • 5 Letter
  • 4 Review article
  • 1 Comment/debate
2020

Association between Histological Types and Enhancement of Dynamic CT for Primary Lung Cancer

Fukuma, S., Shinya, T., Sou, J., Fukuhara, R., Ogawa, N., Higaki, F., Tanaka, T., Ichihara, E., Hiraki, T., Toyooka, S. & Kanazawa, S., Apr 1 2020, In : Acta medica Okayama. 74, 2, p. 129-135 7 p.

Research output: Contribution to journalArticle

Managing lung cancer with comorbid interstitial pneumonia

Ichihara, E., Miyahara, N., Maeda, Y. & Kiura, K., Jan 15 2020, In : Internal Medicine. 59, 2, p. 163-167 5 p.

Research output: Contribution to journalReview article

Open Access
Open Access

The impact of body mass index on the efficacy of anti-PD-1/PD-L1 antibodies in patients with non-small cell lung cancer

Ichihara, E., Harada, D., Inoue, K., Sato, K., Hosokawa, S., Kishino, D., Watanabe, K., Ochi, N., Oda, N., Hara, N., Hotta, K., Maeda, Y. & Kiura, K., Jan 2020, In : Lung Cancer. 139, p. 140-145 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2019

A Prospective Cohort Study to Define the Clinical Features and Outcome of Lung Cancers Harboring HER2 Aberration in Japan (HER2-CS STUDY)

Ninomiya, K., Hata, T., Yoshioka, H., Ohashi, K., Bessho, A., Hosokawa, S., Ishikawa, N., Yamasaki, M., Shibayama, T., Aoe, K., Kozuki, T., Harita, S., Ueda, Y., Murakami, T., Fujimoto, N., Yanai, H., Toyooka, S., Takata, M., Hotta, K., Kiura, K. & 108 others, Gemba, K., Ikeda, G., Yasugi, M., Kurimoto, E., Nakano, K., Moritaka, T., Inoue, K., Miyoshi, S., Hamaguchi, N., Ito, R., Sano, Y., Takata, I., Mitani, A., Nishisaka, T., Shoda, H., Nishida, A., Tamamoto, S., Fujitaka, K., Masuda, T., Miyamoto, S., Hattori, N., Sugimoto, K., Fujii, S., Ueda, Y., Sakugawa, M., Fukamatsu, N., Ogata, Y., Bandoh, S., Kanaji, N., Takigawa, N., Yamane, H., Ochi, N., Honda, Y., Oka, M., Kittaka, M., Kubota, T., Yokoyama, A., Yokoyama, T., Sato, E., Shiota, Y., Horita, N., Kanematsu, T., Awaya, Y., Nakamasu, A., Murakami, I., Kuyama, S., Kudo, K., Tamura, T., Umeno, T., Morichika, D., Fujiwara, K., Sato, K., Harada, D., Nogami, N., Nishii, K., Fuchimoto, Y., Kishimoto, T., Kawai, H., Watanabe, K., Tokumo, K., Isobe, T., Tsubata, Y., Inoue, M., Ichikawa, H., Nishioka, Y., Hanibuchi, M., Goto, H., Sumikawa, T., Kodani, M., Suyama, H., Makino, H., Kinosita, N., Shimizu, E., Obata, H., Ikegami, H., Chikamori, K., Maeda, T., Kishino, T., Kamei, H., Ueoka, H., Kunihiro, Y., Kobayashi, T., Ueda, K., Hayashi, M., Kamiya, M., Murakami, J., Sato, A., Ichihara, E., Kubo, T., Ninomiya, T., Hirata, T., Minami, D., Kato, Y., Higo, H., Makimoto, G., Toyota, Y., Oda, N., Nakanishi, M., Kayatani, H., Senoo, S., Kano, H., Watanabe, H., Ando, T., Nakasuka, T., Hara, N., Itano, J., Nakashima, H. & Tabata, M., Aug 2019, In : Chest. 156, 2, p. 357-366 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Chemoradiotherapy for locally advanced lung cancer patients with interstitial lung abnormalities

Higo, H., Kubo, T., Makimoto, S., Makimoto, G., Ihara, H., Masaoka, Y., Ninomiya, T., Ichihara, E., Ohashi, K., Sato, A., Hotta, K., Tabata, M., Takigawa, N., Maeda, Y. & Kiura, K., Jan 1 2019, In : Japanese journal of clinical oncology. 49, 5, p. 458-464 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Efficacy of afatinib treatment for lung adenocarcinoma harboring exon 18 delE709_T710insD mutation

Iwamoto, Y., Ichihara, E., Hara, N., Nakasuka, T., Ando, C., Umeno, T., Hirabae, A., Maeda, Y. & Kiura, K., Aug 1 2019, In : Japanese journal of clinical oncology. 49, 8, p. 786-788 3 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Granulation tissue-induced pseudo-relapse during nivolumab treatment in advanced non-small cell lung cancer

Ando, C., Ichihara, E., Kano, H., Iwamoto, Y., Hirabae, A., Nakasuka, T., Maeda, Y. & Kiura, K., Jan 1 2019, In : In Vivo. 33, 6, p. 2113-2115 3 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Patients’ preferences and perceptions of lung cancer treatment decision making: results from Okayama lung cancer study group trial 1406

Makimoto, G., Hotta, K., Oze, I., Ninomiya, K., Nakanishi, M., Hara, N., Kano, H., Watanabe, H., Hata, Y., Nishii, K., Nakasuka, T., Itano, J., Ninomiya, T., Kubo, T., Ohashi, K., Ichihara, E., Minami, D., Sato, A., Tabata, M., Maeda, Y. & 1 others, Kiura, K., Jan 1 2019, (Accepted/In press) In : Acta Oncologica.

Research output: Contribution to journalLetter

Primary Resistance to Alectinib Was Lost after Bevacizumab Combined Chemotherapy in ALK-Rearranged Lung Adenocarcinoma

Nakasuka, T., Ichihara, E., Makimoto, G., Maeda, Y. & Kiura, K., Aug 1 2019, In : Journal of Thoracic Oncology. 14, 8, p. e168-e169

Research output: Contribution to journalLetter

1 Citation (Scopus)

Rapid Acquisition of Alectinib Resistance in ALK-Positive Lung Cancer With High Tumor Mutation Burden

Makimoto, G., Ohashi, K., Tomida, S., Nishii, K., Matsubara, T., Kayatani, H., Higo, H., Ninomiya, K., Sato, A., Watanabe, H., Kano, H., Ninomiya, T., Kubo, T., Rai, K., Ichihara, E., Hotta, K., Tabata, M., Toyooka, S., Takata, M., Maeda, Y. & 1 others, Kiura, K., Jan 1 2019, (Accepted/In press) In : Journal of Thoracic Oncology.

Research output: Contribution to journalArticle

2 Citations (Scopus)
4 Citations (Scopus)

Summary of the Japanese Respiratory Society statement for the treatment of lung cancer with comorbid interstitial pneumonia

DLD/TO Assemblies of JRS, Nov 2019, In : Respiratory Investigation. 57, 6, p. 512-533 22 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)

The effect and safety of immune checkpoint inhibitor rechallenge in non-small cell lung cancer

Watanabe, H., Kubo, T., Ninomiya, K., Kudo, K., Minami, D., Murakami, E., Ochi, N., Ninomiya, T., Harada, D., Yasugi, M., Ichihara, E., Ohashi, K., Fujiwara, K., Hotta, K., Tabata, M., Maeda, Y. & Kiura, K., Aug 1 2019, In : Japanese journal of clinical oncology. 49, 8, p. 762-765 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2018

A phase II trial of EGFR-TKI readministration with afatinib in advanced non-small-cell lung cancer harboring a sensitive non-T790M EGFR mutation: Okayama Lung Cancer Study Group trial 1403

Oda, N., Hotta, K., Ninomiya, K., Minami, D., Ichihara, E., Murakami, T., Yokoyama, T., Ichikawa, H., Chikamori, K., Takigawa, N., Ochi, N., Harita, S., Maeda, Y. & Kiura, K., Jan 1 2018, (Accepted/In press) In : Cancer Chemotherapy and Pharmacology.

Research output: Contribution to journalArticle

5 Citations (Scopus)
6 Citations (Scopus)

Combined effect of cabozantinib and gefitinib in crizotinib-resistant lung tumors harboring ROS1 fusions

Kato, Y., Ninomiya, K., Ohashi, K., Tomida, S., Makimoto, G., Watanabe, H., Kudo, K., Matsumoto, S., Umemura, S., Goto, K., Ichihara, E., Ninomiya, T., Kubo, T., Sato, A., Hotta, K., Tabata, M., Toyooka, S., Maeda, Y. & Kiura, K., Oct 2018, In : Cancer Science. 109, 10, p. 3149-3158 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Immune checkpoint inhibitor efficacy and safety in elderly non-small cell lung cancer patients

Kubo, T., Watanabe, H., Ninomiya, K., Kudo, K., Minami, D., Murakami, E., Ochi, N., Ninomiya, T., Harada, D., Yasugi, M., Ichihara, E., Ohashi, K., Fujiwara, K., Hotta, K., Tabata, M., Maeda, Y. & Kiura, K., Oct 1 2018, In : Annals of oncology : official journal of the European Society for Medical Oncology. 29, p. viii533-viii534

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
15 Citations (Scopus)
11 Citations (Scopus)
2017

A Phase II Study of Trastuzumab Emtansine in HER2-Positive Non-Small Cell Lung Cancer

Hotta, K., Aoe, K., Kozuki, T., Oohashi, K., Ninomiya, K., Ichihara, E., Kubo, T., Ninomiya, T., Chikamori, K., Harada, D., Nogami, N., Hirata, T., Hinotsu, S., Toyooka, S. & Kiura, K., Jan 1 2017, (Accepted/In press) In : Journal of Thoracic Oncology.

Research output: Contribution to journalArticle

27 Citations (Scopus)

A phase II trial of carboplatin plus S-1 for elderly patients with advanced non-small-cell lung cancer with wild-type epidermal growth factor receptor: The Okayama Lung Cancer Study Group Trial 1202

Kuyama, S., Ochi, N., Bessho, A., Hotta, K., Ikeda, G., Kishino, D., Kubo, T., Harada, D., Fujimoto, N., Nakanishi, M., Umeno, T., Okada, T., Chikamori, K., Yamagishi, T., Ohashi, K., Ichihara, E., Takigawa, N., Tanimoto, M. & Kiura, K., Oct 2017, In : Lung Cancer. 112, p. 188-194 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
3 Citations (Scopus)

Congestive heart failure during osimertinib treatment for epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC)

Watanabe, H., Ichihara, E., Kano, H., Ninomiya, K., Tanimoto, M. & Kiura, K., Jan 1 2017, In : Internal Medicine. 56, 16, p. 2195-2197 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Discomfort during bronchoscopy performed after endobronchial intubation with fentanyl and midazolam: A prospective study

Minami, D., Takigawa, N., Kano, H., Ninomiya, T., Kubo, T., Ichihara, E., Ohashi, K., Sato, A., Hotta, K., Tabata, M., Tanimoto, M. & Kiura, K., May 1 2017, In : Japanese journal of clinical oncology. 47, 5, p. 434-437 4 p., hyx022.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Effects of (-)-epigallocatechin-3-gallate on egfr- or fusion gene-driven lung cancer cells

Honda, Y., Takigawa, N., Ichihara, E., Ninomiya, T., Kubo, T., Ochi, N., Yasugi, M., Murakami, T., Yamane, H., Tanimoto, M. & Kiura, K., Jan 1 2017, In : Acta medica Okayama. 71, 6, p. 505-512 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Phase II Study of the EGFR-TKI Rechallenge With Afatinib in Patients With Advanced NSCLC Harboring Sensitive EGFR Mutation Without T790M: Okayama Lung Cancer Study Group Trial OLCSG 1403

Oda, N., Ichihara, E., Hotta, K., Ninomiya, K., Ninomiya, T., Kubo, T., Minami, D., Murakami, T., Yokoyama, T., Harada, D., Kuyama, S., Ichikawa, H., Inoue, K., Kishino, D., Inoue, M., Takigawa, N., Shibayama, T., Harita, S., Tanimoto, M. & Kiura, K., Mar 1 2017, In : Clinical Lung Cancer. 18, 2, p. 241-244 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Protective effects of bisoprolol against acute exacerbation in moderate-to-severe chronic obstructive pulmonary disease

Taniguchi, A., Miyahara, N., Oda, N., Morichika, D., Ichihara, E., Ozed, I., Tanimoto, Y., Ichikawa, H., Fujii, U., Tanimoto, M., Kanehiro, A. & Kiura, K., Jan 1 2017, In : Acta medica Okayama. 71, 5, p. 453-457 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

SFK/FAK signaling attenuates osimertinib efficacy in both drug-sensitive and drug-resistant models of EGFR-mutant lung cancer

Ichihara, E., Westover, D., Meador, C. B., Yan, Y., Bauer, J. A., Lu, P., Ye, F., Kulick, A., De Stanchina, E., McEwen, R., Ladanyi, M., Cross, D., Pao, W. & Lovly, C. M., Jun 1 2017, In : Cancer Research. 77, 11, p. 2990-3000 11 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Three-Arm Randomized Trial of Sodium Alginate for Preventing Radiation-Induced Esophagitis in Locally Advanced Non–Small Cell Lung Cancer Receiving Concurrent Chemoradiotherapy: The OLCSG1401 Study Protocol

Ninomiya, K., Ichihara, E., Hotta, K., Sone, N., Murakami, T., Harada, D., Oze, I., Kubo, T., Tanaka, H., Kuyama, S., Kishino, D., Bessho, A., Harita, S., Katsui, K., Tanimoto, M. & Kiura, K., Mar 1 2017, In : Clinical Lung Cancer. 18, 2, p. 245-249 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Treatment Rationale and Design for J-SONIC: A Randomized Study of Carboplatin Plus Nab-paclitaxel With or Without Nintedanib for Advanced Non-Small-cell Lung Cancer With Idiopathic Pulmonary Fibrosis

Otsubo, K., Kishimoto, J., Kenmotsu, H., Minegishi, Y., Ichihara, E., Shiraki, A., Kato, T., Atagi, S., Horinouchi, H., Ando, M., Kondoh, Y., Kusumoto, M., Ichikado, K., Yamamoto, N., Nakanishi, Y. & Okamoto, I., 2017, (Accepted/In press) In : Clinical Lung Cancer.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Triplet therapy with afatinib, cetuximab, and bevacizumab induces deep remission in lung cancer cells harboring EGFR T790M in vivo

Kudo, K., Ohashi, K., Makimoto, G., Higo, H., Kato, Y., Kayatani, H., Kurata, Y., Takami, Y., Minami, D., Ninomiya, T., Kubo, T., Ichihara, E., Sato, A., Hotta, K., Yoshino, T., Tanimoto, M. & Kiura, K., Jan 1 2017, In : Molecular Oncology. 11, 6, p. 670-681 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2016

Effect of vandetanib on lung tumorigenesis in transgenic mice carrying an activating Egfr gene mutation

Osawa, M., Oohashi, K., Kubo, T., Ichihara, E., Takata, S., Takigawa, N., Takata, M., Tanimoto, M. & Kiura, K., 2016, In : Acta Medica Okayama. 70, 4, p. 243-254 12 p.

Research output: Contribution to journalArticle

EGFR fusions as novel therapeutic targets in lung cancer

Konduri, K., Gallant, J. N., Chae, Y. K., Giles, F. J., Gitlitz, B. J., Gowen, K., Ichihara, E., Owonikoko, T. K., Peddareddigari, V., Ramalingam, S. S., Reddy, S. K., Eaby-Sandy, B., Vavalà, T., Whiteley, A., Chen, H., Yan, Y., Sheehan, J. H., Meiler, J., Morosini, D., Ross, J. S. & 4 others, Stephens, P. J., Miller, V. A., Ali, S. M. & Lovly, C. M., Jun 2016, In : Cancer discovery. 6, 6, p. 601-611 11 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Non-small cell lung cancer cells acquire resistance to the ALK inhibitor alectinib by activating alternative receptor tyrosine kinases

Isozaki, H., Ichihara, E., Takigawa, N., Oohashi, K., Ochi, N., Yasugi, M., Ninomiya, T., Yamane, H., Hotta, K., Sakai, K., Matsumoto, K., Hosokawa, S., Bessho, A., Sendo, T., Tanimoto, M. & Kiura, K., Mar 15 2016, In : Cancer Research. 76, 6, p. 1506-1516 11 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)
3 Citations (Scopus)

Protocol Design for the Bench to Bed Trial in Alectinib-Refractory Non–Small-Cell Lung Cancer Patients Harboring the EML4-ALK Fusion Gene (ALRIGHT/OLCSG1405)

Isozaki, H., Hotta, K., Ichihara, E., Takigawa, N., Oohashi, K., Kubo, T., Ninomiya, T., Ninomiya, K., Oda, N., Yoshioka, H., Ichikawa, H., Inoue, M., Takata, I., Shibayama, T., Kuyama, S., Sugimoto, K., Harada, D., Harita, S., Sendo, T., Tanimoto, M. & 1 others, Kiura, K., Nov 1 2016, In : Clinical Lung Cancer. 17, 6, p. 602-605 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Short-term low-volume hydration in cisplatin-based chemotherapy for patients with lung cancer: the second prospective feasibility study in the Okayama Lung Cancer Study Group Trial 1201

Ninomiya, K., Hotta, K., Hisamoto-Sato, A., Ichihara, E., Gotoda, H., Morichika, D., Tamura, T., Kayatani, H., Minami, D., Kubo, T., Tabata, M., Tanimoto, M. & Kiura, K., Feb 1 2016, In : International Journal of Clinical Oncology. 21, 1, p. 81-87 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2015

Acquired resistance to the mutant-selective EGFR inhibitor AZD9291 is associated with increased dependence on RAS signaling in preclinical models

Eberlein, C. A., Stetson, D., Markovets, A. A., Al-Kadhimi, K. J., Lai, Z., Fisher, P. R., Meador, C. B., Spitzler, P., Ichihara, E., Ross, S. J., Ahdesmaki, M. J., Ahmed, A., Ratcliffe, L. E., O'Brien, E. L. C., Barnes, C. H., Brown, H., Smith, P. D., Dry, J. R., Beran, G., Thress, K. S. & 3 others, Dougherty, B., Pao, W. & Cross, D. A. E., Jun 15 2015, In : Cancer Research. 75, 12, p. 2489-2500 12 p.

Research output: Contribution to journalArticle

154 Citations (Scopus)

Impact of body surface area on survival in EGFR-mutant non-small cell lung cancer patients treated with gefitinib monotherapy: observational study of the Okayama Lung Cancer Study Group 0703

Kudo, K., Hotta, K., Ichihara, E., Yoshioka, H., Kunimasa, K., Tsubouchi, K., Iwasaku, M., Kato, Y., Oze, I., Takigawa, N., Tanimoto, M. & Kiura, K., Aug 27 2015, In : Cancer Chemotherapy and Pharmacology. 76, 2, p. 251-256 6 p., 2789.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Phase II trial of gefitinib in combination with bevacizumab as first-line therapy for advanced non-small cell lung cancer with activating EGFR gene mutations: The okayama lung cancer study group trial 1001

Ichihara, E., Hotta, K., Nogami, N., Kuyama, S., Kishino, D., Fujii, M., Kozuki, T., Tabata, M., Harada, D., Chikamori, K., Aoe, K., Ueoka, H., Hosokawa, S., Bessho, A., Hisamoto-Sato, A., Kubo, T., Oze, I., Takigawa, N., Tanimoto, M. & Kiura, K., Mar 30 2015, In : Journal of Thoracic Oncology. 10, 3, p. 486-491 6 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer

Hrustanovic, G., Olivas, V., Pazarentzos, E., Tulpule, A., Asthana, S., Blakely, C. M., Okimoto, R. A., Lin, L., Neel, D. S., Sabnis, A., Flanagan, J., Chan, E., Varella-Garcia, M., Aisner, D. L., Vaishnavi, A., Ou, S. H. I., Collisson, E. A., Ichihara, E., Mack, P. C., Lovly, C. M. & 5 others, Karachaliou, N., Rosell, R., Riess, J. W., Doebele, R. C. & Bivona, T. G., Sep 8 2015, In : Nature Medicine. 21, 9, p. 1038-1047 10 p.

Research output: Contribution to journalArticle

121 Citations (Scopus)

Shades of T790M: Intratumor Heterogeneity in EGFR-Mutant Lung Cancer

Ichihara, E. & Lovly, C. M., Jul 1 2015, In : Cancer discovery. 5, 7, p. 694-696 3 p.

Research output: Contribution to journalComment/debate

11 Citations (Scopus)
2014

A new human lung adenocarcinoma cell line harboring the EML4-ALK fusion gene

Isozaki, H., Yasugi, M., Takigawa, N., Hotta, K., Ichihara, E., Taniguchi, A., Toyooka, S., Hashida, S., Sendo, T., Tanimoto, M. & Kiura, K., Oct 1 2014, In : Japanese journal of clinical oncology. 44, 10, p. 963-968 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)