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2020

Oxidation of a cysteine-derived nucleophilic reagent by dimethyl sulfoxide in the amino acid derivative reactivity assay

Akimoto, M., Yamamoto, Y., Watanabe, S., Yamaga, H., Yoshida, K., Wakabayashi, K., Tahara, Y., Horie, N., Fujimoto, K., Kusakari, K., Kamiya, K., Kojima, K., Kawakami, T., Kojima, H., Ono, A., Kasahara, T. & Fujita, M., Jan 1 2020, (Accepted/In press) In : Journal of Applied Toxicology. 40, 6, p. 843-854 12 p.

Research output: Contribution to journalArticle

2019

Applicability of amino acid derivative reactivity assay for prediction of skin sensitization by combining multiple alternative methods to evaluate key events

Yamamoto, Y., Fujita, M., Wanibuchi, S., Sato, A., Akimoto, M., Katsuoka, Y., Ono, A. & Kasahara, T., Jan 1 2019, In : The Journal of toxicological sciences. 44, 9, p. 585-600 16 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

The within- and between-laboratory reproducibility and predictive capacity of the in chemico amino acid derivative reactivity assay: Results of validation study implemented in four participating laboratories

Fujita, M., Yamamoto, Y., Watanabe, S., Sugawara, T., Wakabayashi, K., Tahara, Y., Horie, N., Fujimoto, K., Kusakari, K., Kurokawa, Y., Kawakami, T., Kojima, K., Sozu, T., Nakayama, T., Kusao, T., Richmond, J., Nicole, K., Kim, B. H., Kojima, H., Kasahara, T. & 1 others, Ono, A., Jan 1 2019, In : Journal of Applied Toxicology.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Toxicological significance of increased serum alkaline phosphatase activity in dog studies of pesticides: Analysis of toxicological data evaluated in Japan

Yokoyama, Y., Ono, A., Yoshida, M., Matsumoto, K. & Saito, M., Dec 2019, In : Regulatory Toxicology and Pharmacology. 109, 104482.

Research output: Contribution to journalArticle

2018

Cause of and countermeasures for oxidation of the cysteine-derived reagent used in the amino acid derivative reactivity assay

Fujita, M., Yamamoto, Y., Watanabe, S., Sugawara, T., Wakabayashi, K., Tahara, Y., Horie, N., Fujimoto, K., Kusakari, K., Kurokawa, Y., Kawakami, T., Kojima, K., Kojima, H., Ono, A., Katsuoka, Y., Tanabe, H., Yokoyama, H. & Kasahara, T., Jan 1 2018, (Accepted/In press) In : Journal of Applied Toxicology.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Initial hazard assessment of 4-benzylphenol, a structural analog of bisphenol F: Genotoxicity tests in vitro and a 28-day repeated-dose toxicity study in rats

Igarashi, T., Serizawa, H., Kobayashi, K., Suzuki, H., Matsumoto, M., Iso, T., Kawamura, T., Inoue, K., Ono, A., Yamada, T. & Hirose, A., Jul 1 2018, In : Regulatory Toxicology and Pharmacology. 96, p. 64-75 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Initial hazard assessment of benzyl salicylate: In vitro genotoxicity test and combined repeated-dose and reproductive/developmental toxicity screening test in rats

Igarashi, T., Takashima, H., Takabe, M., Suzuki, H., Ushida, K., Kawamura, T., Matsumoto, M., Iso, T., Tanabe, S., Inoue, K., Ono, A., Yamada, T. & Hirose, A., Dec 1 2018, In : Regulatory Toxicology and Pharmacology. 100, p. 105-117 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2016

Risk assessment of skin lightening cosmetics containing hydroquinone

Matsumoto, M., Todo, H., Akiyama, T., Hirata-Koizumi, M., Sugibayashi, K., Ikarashi, Y., Ono, A., Hirose, A. & Yokoyama, K., Nov 1 2016, In : Regulatory Toxicology and Pharmacology. 81, p. 128-135 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Summary information of human health hazard assessment of existing chemical substances (II)

Takahashi, M., Matsumoto, M., Yamada, T., Ono, A. & Hirose, A., 2016, In : Bulletin of National Institute of Health Sciences. 2016, 134, p. 79-83 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2015

Open TG-GATEs: A large-scale toxicogenomics database

Igarashi, Y., Nakatsu, N., Yamashita, T., Ono, A., Ohno, Y., Urushidani, T. & Yamada, H., Jan 28 2015, In : Nucleic acids research. 43, D1, p. D921-D927

Research output: Contribution to journalArticle

156 Citations (Scopus)

Repeated dose and reproductive/developmental toxicity of perfluorododecanoic acid in rats

Kato, H., Fujii, S., Takahashi, M., Matsumoto, M., Hirata-Koizumi, M., Ono, A. & Hirose, A., Nov 2015, In : Environmental Toxicology. 30, 11, p. 1244-1263 20 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Summary information of human health hazard assessment of existing chemical substances(I)

Matsumoto, M., Kobayashi, K., Takahashi, M., Hirata-Koizumi, M., Ono, A. & Hirose, A., Jan 1 2015, In : Bulletin of National Institute of Health Sciences. 2015, 133, p. 42-47 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2014

Comparative gene and protein expression analyses of a panel of cytokines in acute and chronic drug-induced liver injury in rats

Hanafusa, H., Morikawa, Y., Uehara, T., Kaneto, M., Ono, A., Yamada, H., Ohno, Y. & Urushidani, T., Oct 3 2014, In : Toxicology. 324, p. 43-54 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Comprehensive analysis of DNA methylation and gene expression of rat liver in a 2-stage hepatocarcinogenesis model

Omura, K., Uehara, T., Morikawa, Y., Hayashi, H., Mitsumori, K., Minami, K., Kanki, M., Yamada, H., Ono, A. & Urushidani, T., Dec 1 2014, In : Journal of Toxicological Sciences. 39, 6, p. 837-848 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Detection of initiating potential of non-genotoxic carcinogens in a two-stage hepatocarcinogenesis study in rats

Omura, K., Uehara, T., Morikawa, Y., Hayashi, H., Mitsumori, K., Minami, K., Kanki, M., Yamada, H., Ono, A. & Urushidani, T., Jan 1 2014, In : Journal of Toxicological Sciences. 39, 5, p. 785-794 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Development of a category approach to predict the testicular toxicity of chemical substances structurally related to ethylene glycol methyl ether

Yamada, T., Tanaka, Y., Hasegawa, R., Sakuratani, Y., Yamazoe, Y., Ono, A., Hirose, A. & Hayashi, M., Dec 1 2014, In : Regulatory Toxicology and Pharmacology. 70, 3, p. 711-719 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Evaluation of in vivo mutagenicity of hydroquinone in Muta™ mice

Matsumoto, M., Masumori, S., Hirata-Koizumi, M., Ono, A., Honma, M., Yokoyama, K. & Hirose, A., Dec 1 2014, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 775-776, p. 94-98 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Historical control data on developmental toxicity studies in rodents

Ema, M., Endoh, K., Fukushima, R., Fujii, S., Hara, H., Hirata-Koizumi, M., Hirose, A., Hojo, H., Horimoto, M., Hoshino, N., Hosokawa, Y., Imai, Y., Inada, H., Inawaka, K., Itoh, K., Katsumata, Y., Izumi, H., Kato, H., Maeda, M., Matsumoto, K. & 23 others, Matsuo, S., Matsuoka, T., Matsuura, I., Mineshima, H., Miwa, Y., Nakano, N., Naya, M., Noyori, H., Ohta, T., Oku, H., Ono, A., Shimizu, T., Shimomura, K., Takakura, I., Tanaka, R., Tateishi, T., Tominaga, Y., Uesugi, T., Urakawa, C., Yabe, K., Yamashita, A., Yamauchi, T. & Yokoi, R., Aug 2014, In : Congenital Anomalies. 54, 3, p. 150-161 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Identification of metabolomic biomarkers for drug-induced acute kidney injury in rats

Uehara, T., Horinouchi, A., Morikawa, Y., Tonomura, Y., Minami, K., Ono, A., Yamate, J., Yamada, H., Ohno, Y. & Urushidani, T., Oct 2014, In : Journal of Applied Toxicology. 34, 10, p. 1087-1095 9 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

MiRNA expression atlas in male rat

Minami, K., Uehara, T., Morikawa, Y., Omura, K., Kanki, M., Horinouchi, A., Ono, A., Yamada, H., Ohno, Y. & Urushidani, T., May 27 2014, In : Scientific Data. 1, 140005.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Repeated dose and reproductive/developmental toxicity of perfluoroundecanoic acid in rats

Takahashi, M., Ishida, S., Hirata-Koizumi, M., Ono, A. & Hirose, A., Jan 15 2014, In : Journal of Toxicological Sciences. 39, 1, p. 97-108 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2013

A category approach to predicting the repeated-dose hepatotoxicity of allyl esters

Yamada, T., Tanaka, Y., Hasegawa, R., Sakuratani, Y., Yamada, J., Kamata, E., Ono, A., Hirose, A., Yamazoe, Y., Mekenyan, O. & Hayashi, M., Mar 1 2013, In : Regulatory Toxicology and Pharmacology. 65, 2, p. 189-195 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

An antioxidant, N,N'-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats: A 28-day repeated dose test and reproduction/developmental toxicity test

Matsumoto, M., Yamaguchi, M., Yoshida, Y., Senuma, M., Takashima, H., Kawamura, T., Kato, H., Takahashi, M., Hirata-Koizumi, M., Ono, A., Yokoyama, K. & Hirose, A., Jun 1 2013, In : Food and Chemical Toxicology. 56, p. 290-296 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Basic principles for setting acute reference dose, ARfD in Japan

Yoshida, M., Suzuki, D., Matsumoto, K., Shirota, M., Inoue, K., Takahashi, M., Morita, T. & Ono, A., Aug 1 2013, In : Journal of the Food Hygienic Society of Japan. 54, 4, p. 331-334 4 p.

Research output: Contribution to journalArticle

Identification of novel liver-specific mrnas in plasma for biomarkers of drug-induced liver injury and quantitative evaluation in rats treated with various hepatotoxic compounds

Okubo, S., Miyamoto, M., Takami, K., Kanki, M., Ono, A., Nakatsu, N., Yamada, H., Ohno, Y. & Urushidani, T., Mar 1 2013, In : Toxicological Sciences. 132, 1, p. 21-31 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Reproductive and developmental toxicity screening test of 3-cyanopyridine in rats

Takahashi, M., Yabe, K., Kato, H., Kawamura, T., Matsumoto, M., Hirata-Koizumi, M., Ono, A. & Hirose, A., Jan 1 2013, In : Reproductive Toxicology. 35, 1, p. 7-16 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Safety assessment of boron by application of new uncertainty factors and their subdivision

Hasegawa, R., Hirata-Koizumi, M., Dourson, M. L., Parker, A., Ono, A. & Hirose, A., Feb 1 2013, In : Regulatory Toxicology and Pharmacology. 65, 1, p. 108-114 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Simulation of acute reference dose (ARfD) settings for pesticides in Japan

Yoshida, M., Suzuki, D., Matsumoto, K., Shirota, M., Inoue, K., Takahashi, M., Morita, T. & Ono, A., Apr 3 2013, In : Journal of Toxicological Sciences. 38, 2, p. 205-214 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Toxicogenomic biomarkers for renal papillary injury in rats

Uehara, T., Kondo, C., Morikawa, Y., Hanafusa, H., Ueda, S., Minowa, Y., Nakatsu, N., Ono, A., Maruyama, T., Kato, I., Yamate, J., Yamada, H., Ohno, Y. & Urushidani, T., Jan 7 2013, In : Toxicology. 303, p. 1-8 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2012

Evaluation of DNA microarray results in the toxicogenomics project (TGP) consortium in Japan

Noriyuki, N., Igarashi, Y., Ono, A., Yamada, H., Ohno, Y. & Urushidani, T., Sep 6 2012, In : Journal of Toxicological Sciences. 37, 4, p. 791-801 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Identification of a novel set of biomarkers for evaluating phospholipidosis-inducing potential of compounds using rat liver microarray data measured 24-h after single dose administration

Yudate, H. T., Kai, T., Aoki, M., Minowa, Y., Yamada, T., Kimura, T., Ono, A., Yamada, H., Ohno, Y. & Urushidani, T., May 16 2012, In : Toxicology. 295, 1-3, p. 1-7 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

No toxicological effects on acute and repeated oral gavage doses of single-wall or multi-wall carbon nanotube in rats

Matsumoto, M., Serizawa, H., Sunaga, M., Kato, H., Takahashi, M., Hirata-Koizumi, M., Ono, A., Kamata, E. & Hirose, A., Jan 1 2012, In : Journal of Toxicological Sciences. 37, 3, p. 463-474 12 p.

Research output: Contribution to journalArticle

Open Access
19 Citations (Scopus)

Ovariectomized mouse uterotrophic assay of 36 chemicals

Ohta, R., Takagi, A., Ohmukai, H., Marumo, H., Ono, A., Matsushima, Y., Inoue, T., Ono, H. & Kanno, J., Oct 2012, In : Journal of Toxicological Sciences. 37, 5, p. 879-889 11 p.

Research output: Contribution to journalArticle

Open Access
22 Citations (Scopus)

Repeated dose and reproductive/developmental toxicity of perfluorooctadecanoic acid in rats

Hirata-Koizumi, M., Fujii, S., Furukawa, M., Ono, A. & Hirose, A., Feb 1 2012, In : Journal of Toxicological Sciences. 37, 1, p. 63-79 17 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Sub-acute oral toxicity study with fullerene C60 in rats

Takahashi, M., Kato, H., Doi, Y., Hagiwara, A., Hirata-Koizumi, M., Ono, A., Kubota, R., Nishimura, T. & Hirose, A., Apr 1 2012, In : Journal of Toxicological Sciences. 37, 2, p. 353-361 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Toxicogenomic multigene biomarker for predicting the future onset of proximal tubular injury in rats

Minowa, Y., Kondo, C., Uehara, T., Morikawa, Y., Okuno, Y., Nakatsu, N., Ono, A., Maruyama, T., Kato, I., Yamate, J., Yamada, H., Ohno, Y. & Urushidani, T., Jul 16 2012, In : Toxicology. 297, 1-3, p. 47-56 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Validation of the (Q)SAR combination approach for mutagenicity prediction of flavor chemicals

Ono, A., Takahashi, M., Hirose, A., Kamata, E., Kawamura, T., Yamazaki, T., Sato, K., Yamada, M., Fukumoto, T., Okamura, H., Mirokuji, Y. & Honma, M., May 1 2012, In : Food and Chemical Toxicology. 50, 5, p. 1538-1546 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2011

Evaluation of the reproductive and developmental toxicity of aluminium ammonium sulfate in a two-generation study in rats

Hirata-Koizumi, M., Fujii, S., Ono, A., Hirose, A., Imai, T., Ogawa, K., Ema, M. & Nishikawa, A., Sep 1 2011, In : Food and Chemical Toxicology. 49, 9, p. 1948-1959 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Prediction model of potential hepatocarcinogenicity of rat hepatocarcinogens using a large-scale toxicogenomics database

Uehara, T., Minowa, Y., Morikawa, Y., Kondo, C., Maruyama, T., Kato, I., Nakatsu, N., Igarashi, Y., Ono, A., Hayashi, H., Mitsumori, K., Yamada, H., Ohno, Y. & Urushidani, T., Sep 15 2011, In : Toxicology and Applied Pharmacology. 255, 3, p. 297-306 10 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Two-generation reproductive toxicity study of aluminium sulfate in rats

Hirata-Koizumi, M., Fujii, S., Ono, A., Hirose, A., Imai, T., Ogawa, K., Ema, M. & Nishikawa, A., Feb 1 2011, In : Reproductive Toxicology. 31, 2, p. 219-230 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2010

Proposal of new uncertainty factor application to derive tolerable daily intake

Hasegawa, R., Hirata-Koizumi, M., Dourson, M. L., Parker, A., Sweeney, L. M., Nishikawa, A., Yoshida, M., Ono, A. & Hirose, A., Nov 1 2010, In : Regulatory Toxicology and Pharmacology. 58, 2, p. 237-242 6 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2009

Gene expression profiling in rat liver treated with compounds inducing elevation of bilirubin

Hirode, M., Horinouchi, A., Uehara, T., Ono, A., Miyagishima, T., Yamada, H., Nagao, T., Ohno, Y. & Urushidani, T., Apr 1 2009, In : Human and Experimental Toxicology. 28, 4, p. 231-244 14 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Gene expression profiling in rat liver treated with various hepatotoxic-compounds inducing coagulopathy

Hirode, M., Omura, K., Kiyosawa, N., Uehara, T., Shimuzu, T., Ono, A., Miyagishima, T., Nagao, T., Ohno, Y. & Urushidani, T., Jun 1 2009, In : Journal of Toxicological Sciences. 34, 3, p. 281-293 13 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database

Kondo, C., Minowa, Y., Uehara, T., Okuno, Y., Nakatsu, N., Ono, A., Maruyama, T., Kato, I., Yamate, J., Yamada, H., Ohno, Y. & Urushidani, T., Nov 9 2009, In : Toxicology. 265, 1-2, p. 15-26 12 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
2008

A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats

Uehara, T., Hirode, M., Ono, A., Kiyosawa, N., Omura, K., Shimizu, T., Mizukawa, Y., Miyagishima, T., Nagao, T. & Urushidani, T., Aug 19 2008, In : Toxicology. 250, 1, p. 15-26 12 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

Gene expression profiling in rat liver treated with compounds inducing phospholipidosis

Hirode, M., Ono, A., Miyagishima, T., Nagao, T., Ohno, Y. & Urushidani, T., Jun 15 2008, In : Toxicology and Applied Pharmacology. 229, 3, p. 290-299 10 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Gene expression profiling of methapyrilene-induced hepatotoxicity in rat

Uehara, T., Kiyosawa, N., Hirode, M., Omura, K., Shimizu, T., Ono, A., Mizukawa, Y., Miyagishima, T., Nagao, T. & Urushidani, T., Feb 1 2008, In : Journal of Toxicological Sciences. 33, 1, p. 37-50 14 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Species-specific differences in coumarin-induced hepatotoxicity as an example toxicogenomics-based approach to assessing risk of toxicity to humans

Uehara, T., Kiyosawa, N., Shimizu, T., Omura, K., Hirode, M., Imazawa, T., Mizukawa, Y., Ono, A., Miyagishima, T., Nagao, T. & Urushidani, T., Jan 1 2008, In : Human and Experimental Toxicology. 27, 1, p. 23-35 13 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)